The Journal of Immunology: 195 (12)

December 15, 2015; Volume 195,Issue 12

IN MEMORIAM

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William E. Paul, M.D. (1936–2015), President, The American Association of Immunologists, 1986–1987
Ronald N. Germain

J Immunol December 15, 2015, 195 (12) 5519-5521; DOI: https://doi.org/10.4049/jimmunol.1590025

IN THIS ISSUE

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In This Issue
Dynamic Foxn1 Expression in TECs See article p. 5678
Fly Phagocytosis Foils Infection See article p. 5696
Micromanaging Endotoxin Tolerance See article p. 5750
Purinergic Promotion of GvHD See article p. 5795

J Immunol December 15, 2015, 195 (12) 5523-5524; DOI: https://doi.org/10.4049/jimmunol.1590024

BRIEF REVIEWS

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The Complement System and Antibody-Mediated Transplant Rejection
Erik Stites, Moglie Le Quintrec and Joshua M. Thurman

J Immunol December 15, 2015, 195 (12) 5525-5531; DOI: https://doi.org/10.4049/jimmunol.1501686

CUTTING EDGE

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Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4⁺ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice
Kotaro Otomo, Tomohiro Koga, Masayuki Mizui, Nobuya Yoshida, Christina Kriegel, Sean Bickerton, Tarek M. Fahmy and George C. Tsokos

J Immunol December 15, 2015, 195 (12) 5533-5537; DOI: https://doi.org/10.4049/jimmunol.1501603

ANTIGEN RECOGNITION AND RESPONSES

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Aryl Hydrocarbon Receptor Protects Lungs from Cockroach Allergen–Induced Inflammation by Modulating Mesenchymal Stem Cells
Ting Xu, Yufeng Zhou, Lipeng Qiu, Danh C. Do, Yilin Zhao, Zhuang Cui, Heng Wang, Xiaopeng Liu, Arjun Saradna, Xu Cao, Mei Wan and Peisong Gao

J Immunol December 15, 2015, 195 (12) 5539-5550; DOI: https://doi.org/10.4049/jimmunol.1501198

AUTOIMMUNITY

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FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain
Kamala P. Sundararaj, Thirumagal Thiyagarajan, Ivan Molano, Fahmin Basher, Thomas W. Powers, Richard R. Drake and Tamara K. Nowling

J Immunol December 15, 2015, 195 (12) 5551-5560; DOI: https://doi.org/10.4049/jimmunol.1500961
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Estrogen Receptor α Deficiency Modulates TLR Ligand–Mediated PDC-TREM Expression in Plasmacytoid Dendritic Cells in Lupus-Prone Mice
Jennifer L. Scott, Melissa A. Cunningham, Osama S. Naga, Jena R. Wirth, Jackie G. Eudaly and Gary S. Gilkeson

J Immunol December 15, 2015, 195 (12) 5561-5571; DOI: https://doi.org/10.4049/jimmunol.1500315
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γδ T Cell–Dependent Regulatory T Cells Prevent the Development of Autoimmune Keratitis
Yafei Huang, Zhifang Yang, Chunjian Huang, Jessica McGowan, Tamara Casper, Deming Sun, Willi K. Born and Rebecca L. O’Brien

J Immunol December 15, 2015, 195 (12) 5572-5581; DOI: https://doi.org/10.4049/jimmunol.1501604

CLINICAL AND HUMAN IMMUNOLOGY

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Structural and Functional Changes of the Invariant NKT Clonal Repertoire in Early Rheumatoid Arthritis
Salah Mansour, Anna S. Tocheva, Joseph P. Sanderson, Lyndsey M. Goulston, Helen Platten, Lina Serhal, Camille Parsons, Mark H. Edwards, Christopher H. Woelk, Paul T. Elkington, Tim Elliott, Cyrus Cooper, Christopher J. Edwards and Stephan D. Gadola

J Immunol December 15, 2015, 195 (12) 5582-5591; DOI: https://doi.org/10.4049/jimmunol.1501092
Open Access
The Bacterial Enzyme IdeS Cleaves the IgG-Type of B Cell Receptor (BCR), Abolishes BCR-Mediated Cell Signaling, and Inhibits Memory B Cell Activation
Author Choice Article

Sofia Järnum, Robert Bockermann, Anna Runström, Lena Winstedt and Christian Kjellman

J Immunol December 15, 2015, 195 (12) 5592-5601; DOI: https://doi.org/10.4049/jimmunol.1501929
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Critical Role and Therapeutic Control of the Lectin Pathway of Complement Activation in an Abortion-Prone Mouse Mating
Marie Petitbarat, Paolo Durigutto, Paolo Macor, Roberta Bulla, Alessandro Palmioli, Anna Bernardi, Maria-Grazia De Simoni, Nathalie Ledee, Gerard Chaouat and Francesco Tedesco

J Immunol December 15, 2015, 195 (12) 5602-5607; DOI: https://doi.org/10.4049/jimmunol.1501361
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DNA-PKcs Is Involved in Ig Class Switch Recombination in Human B Cells
Andrea Björkman, Likun Du, Kerstin Felgentreff, Cornelia Rosner, Radhika Pankaj Kamdar, Georgia Kokaraki, Yoshihisa Matsumoto, E. Graham Davies, Mirjam van der Burg, Luigi D. Notarangelo, Lennart Hammarström and Qiang Pan-Hammarström

J Immunol December 15, 2015, 195 (12) 5608-5615; DOI: https://doi.org/10.4049/jimmunol.1501633
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Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression
Author Choice Article

David Bending, Eirini Giannakopoulou, Hannah Lom and Lucy R. Wedderburn

J Immunol December 15, 2015, 195 (12) 5616-5624; DOI: https://doi.org/10.4049/jimmunol.1500391

IMMUNE REGULATION

Open Access
Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection
Author Choice Article

Rafael Cubas, Julien van Grevenynghe, Saintedym Wills, Lela Kardava, Brian H. Santich, Clarisa M. Buckner, Roshell Muir, Virginie Tardif, Carmen Nichols, Francesco Procopio, Zhong He, Talibah Metcalf, Khader Ghneim, Michela Locci, Petronella Ancuta, Jean-Pierre Routy, Lydie Trautmann, Yuxing Li, Adrian B. McDermott, Rick A. Koup, Constantinos Petrovas, Steven A. Migueles, Mark Connors, Georgia D. Tomaras, Susan Moir, Shane Crotty and Elias K. Haddad

J Immunol December 15, 2015, 195 (12) 5625-5636; DOI: https://doi.org/10.4049/jimmunol.1501524
Open Access
FOXO3–NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function
Author Choice Article

Matthew G. Thompson, Michelle Larson, Amy Vidrine, Kelly Barrios, Flor Navarro, Kaitlyn Meyers, Patricia Simms, Kushal Prajapati, Lennox Chitsike, Lance M. Hellman, Brian M. Baker and Stephanie K. Watkins

J Immunol December 15, 2015, 195 (12) 5637-5647; DOI: https://doi.org/10.4049/jimmunol.1501758
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Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity
Siaw-Li Chan, Lonn D. Lindquist, Michael J. Hansen, Megan A. Girtman, Larry R. Pease and Richard J. Bram

J Immunol December 15, 2015, 195 (12) 5648-5656; DOI: https://doi.org/10.4049/jimmunol.1500308
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Characterization of Amphioxus IFN Regulatory Factor Family Reveals an Archaic Signaling Framework for Innate Immune Response
Shaochun Yuan, Tingting Zheng, Peiyi Li, Rirong Yang, Jie Ruan, Shengfeng Huang, Zhenxin Wu and Anlong Xu

J Immunol December 15, 2015, 195 (12) 5657-5666; DOI: https://doi.org/10.4049/jimmunol.1501927

IMMUNE SYSTEM DEVELOPMENT

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MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR
Yogesh Singh, Oliver A. Garden, Florian Lang and Bradley S. Cobb

J Immunol December 15, 2015, 195 (12) 5667-5677; DOI: https://doi.org/10.4049/jimmunol.1401875
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Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus
Immanuel Rode, Vera C. Martins, Günter Küblbeck, Nicole Maltry, Claudia Tessmer and Hans-Reimer Rodewald

J Immunol December 15, 2015, 195 (12) 5678-5687; DOI: https://doi.org/10.4049/jimmunol.1502010

INFECTIOUS DISEASE AND HOST RESPONSE

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Haemophilus influenzae Type f Hijacks Vitronectin Using Protein H To Resist Host Innate Immunity and Adhere to Pulmonary Epithelial Cells
Tamim Al-Jubair, Oindrilla Mukherjee, Sharon Oosterhuis, Birendra Singh, Yu-Ching Su, Christophe Fleury, Anna M. Blom, Susanna Törnroth-Horsefield and Kristian Riesbeck

J Immunol December 15, 2015, 195 (12) 5688-5695; DOI: https://doi.org/10.4049/jimmunol.1501197
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Protection of Insects against Viral Infection by Apoptosis-Dependent Phagocytosis
Firzan Nainu, Yumiko Tanaka, Akiko Shiratsuchi and Yoshinobu Nakanishi

J Immunol December 15, 2015, 195 (12) 5696-5706; DOI: https://doi.org/10.4049/jimmunol.1500613
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IL-17A–Producing γδ T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver
Meru Sheel, Lynette Beattie, Teija C. M. Frame, Fabian de Labastida Rivera, Rebecca J. Faleiro, Patrick T. Bunn, Marcela Montes de Oca, Chelsea L. Edwards, Susanna S. Ng, Rajiv Kumar, Fiona H. Amante, Shannon E. Best, Shaun R. McColl, Antiopi Varelias, Rachel D. Kuns, Kelli P. A. MacDonald, Mark J. Smyth, Ashraful Haque, Geoff R. Hill and Christian R. Engwerda

J Immunol December 15, 2015, 195 (12) 5707-5717; DOI: https://doi.org/10.4049/jimmunol.1501046

INNATE IMMUNITY AND INFLAMMATION

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Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation
Johji Nomura, Alexander So, Mizuho Tamura and Nathalie Busso

J Immunol December 15, 2015, 195 (12) 5718-5724; DOI: https://doi.org/10.4049/jimmunol.1402512
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Identification of a Novel Splice Variant Isoform of TREM-1 in Human Neutrophil Granules
Sankar Baruah, Kathy Keck, Michelle Vrenios, Marshall R. Pope, Merideth Pearl, Kevin Doerschug and Julia Klesney-Tait

J Immunol December 15, 2015, 195 (12) 5725-5731; DOI: https://doi.org/10.4049/jimmunol.1402713
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DDX19A Senses Viral RNA and Mediates NLRP3-Dependent Inflammasome Activation
Jiangnan Li, Liang Hu, Yuanyuan Liu, Li Huang, Yang Mu, Xuehui Cai and Changjiang Weng

J Immunol December 15, 2015, 195 (12) 5732-5749; DOI: https://doi.org/10.4049/jimmunol.1501606
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Coordinated Regulation of miR-155 and miR-146a Genes during Induction of Endotoxin Tolerance in Macrophages
Christina Doxaki, Sotirios C. Kampranis, Aristides G. Eliopoulos, Charalampos Spilianakis and Christos Tsatsanis

J Immunol December 15, 2015, 195 (12) 5750-5761; DOI: https://doi.org/10.4049/jimmunol.1500615
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Role of Sortilin in Models of Autoimmune Neuroinflammation
Eva Reuter, Juliane Weber, Magdalena Paterka, Robert Ploen, Tilman Breiderhoff, Jack van Horssen, Thomas E. Willnow, Volker Siffrin and Frauke Zipp

J Immunol December 15, 2015, 195 (12) 5762-5769; DOI: https://doi.org/10.4049/jimmunol.1403156

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Tetraspanin CD37 Regulates β₂ Integrin–Mediated Adhesion and Migration in Neutrophils
Janet L. Wee, Keith E. Schulze, Eleanor L. Jones, Louisa Yeung, Qiang Cheng, Candida F. Pereira, Adam Costin, Georg Ramm, Annemiek B. van Spriel, Michael J. Hickey and Mark D. Wright

J Immunol December 15, 2015, 195 (12) 5770-5779; DOI: https://doi.org/10.4049/jimmunol.1402414
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Mechanism of Activation-Induced Downregulation of Mitofusin 2 in Human Peripheral Blood T Cells
Asish Dasgupta, Kuang-Hueih Chen, Rachel B. Munk, Carl Y. Sasaki, Jessica Curtis, Dan L. Longo and Paritosh Ghosh

J Immunol December 15, 2015, 195 (12) 5780-5786; DOI: https://doi.org/10.4049/jimmunol.1501023

MUCOSAL IMMUNOLOGY

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IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity
Alexander F. Heiseke, Benjamin H. Jeuk, Anamarija Markota, Tobias Straub, Hans-Anton Lehr, Wolfgang Reindl and Anne B. Krug

J Immunol December 15, 2015, 195 (12) 5787-5794; DOI: https://doi.org/10.4049/jimmunol.1501874

TRANSPLANTATION

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A Novel Function for P2Y2 in Myeloid Recipient–Derived Cells during Graft-versus-Host Disease
Verena Klämbt, Sebastian A. Wohlfeil, Lukas Schwab, Jan Hülsdünker, Korcan Ayata, Petya Apostolova, Annette Schmitt-Graeff, Heide Dierbach, Gabriele Prinz, Marie Follo, Marco Prinz, Marco Idzko and Robert Zeiser

J Immunol December 15, 2015, 195 (12) 5795-5804; DOI: https://doi.org/10.4049/jimmunol.1501357
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Compensatory Regulatory Networks between CD8 T, B, and Myeloid Cells in Organ Transplantation Tolerance
Séverine Bézie, Elodie Picarda, Jason Ossart, Bernard Martinet, Ignacio Anegon and Carole Guillonneau

J Immunol December 15, 2015, 195 (12) 5805-5815; DOI: https://doi.org/10.4049/jimmunol.1500473

TUMOR IMMUNOLOGY

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Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy
Payal Mittal, Marie-Clare St. Rose, Xi Wang, Joseph M. Ryan, Jeffrey S. Wasser, Anthony T. Vella and Adam J. Adler

J Immunol December 15, 2015, 195 (12) 5816-5826; DOI: https://doi.org/10.4049/jimmunol.1502032

NOVEL IMMUNOLOGICAL METHODS

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Enhanced Detection of Antigen-Specific CD4⁺ T Cells Using Altered Peptide Flanking Residue Peptide–MHC Class II Multimers
Author Choice Article

Christopher J. Holland, Garry Dolton, Martin Scurr, Kristin Ladell, Andrea J. Schauenburg, Kelly Miners, Florian Madura, Andrew K. Sewell, David A. Price, David K. Cole and Andrew J. Godkin

J Immunol December 15, 2015, 195 (12) 5827-5836; DOI: https://doi.org/10.4049/jimmunol.1402787

CORRECTIONS

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Correction: Langerhans Cells Suppress CD49a⁺ NK Cell–Mediated Skin Inflammation
Felix Scholz, Shruti Naik, Fayyaz S. Sutterwala and Daniel H. Kaplan

J Immunol December 15, 2015, 195 (12) 5837-5838; DOI: https://doi.org/10.4049/jimmunol.1502162
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Correction: The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells
Arianne C. Richard, Cuiyan Tan, Eric T. Hawley, Julio Gomez-Rodriguez, Ritobrata Goswami, Xiang-Ping Yang, Anthony C. Cruz, Pallavi Penumetcha, Erika T. Hayes, Martin Pelletier, Odile Gabay, Matthew Walsh, John R. Ferdinand, Andrea Keane-Myers, Yongwon Choi, John J. O’Shea, Aymen Al-Shamkhani, Mark H. Kaplan, Igal Gery, Richard M. Siegel and FranÇoise Meylan

J Immunol December 15, 2015, 195 (12) 5839-5840; DOI: https://doi.org/10.4049/jimmunol.1502026
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Correction: PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8⁺ T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8⁺ T Cells
Hyo Jin Park, Joon Seok Park, Yun Hee Jeong, Jimin Son, Young Ho Ban, Byoung-Hee Lee, Lieping Chen, Jun Chang, Doo Hyun Chung, Inhak Choi and Sang-Jun Ha

J Immunol December 15, 2015, 195 (12) 5841-5842; DOI: https://doi.org/10.4049/jimmunol.1502256
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Correction: Decreased T Follicular Regulatory Cell/T Follicular Helper Cell (T_FH) in Simian Immunodeficiency Virus–Infected Rhesus Macaques May Contribute to Accumulation of T_FH in Chronic Infection
Ankita Chowdhury, Perla Mariana Del Rio Estrada, Greg K. Tharp, Ronald P. Trible, Rama R. Amara, Ann Chahroudi, Gustavo Reyes-Teran, Steven E. Bosinger and Guido Silvestri

J Immunol December 15, 2015, 195 (12) 5843; DOI: https://doi.org/10.4049/jimmunol.1502269

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Table of Contents

IN MEMORIAM

IN THIS ISSUE

BRIEF REVIEWS

CUTTING EDGE

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

TRANSPLANTATION

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

CORRECTIONS

This Issue

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