The Journal of Immunology: 195 (11)

December 1, 2015; Volume 195,Issue 11

PRESIDENT'S ADDRESS

You have accessRestricted access
Using Autoimmunity To Inform Tumor Immunity
Linda A. Sherman

J Immunol December 1, 2015, 195 (11) 5091-5095; DOI: https://doi.org/10.4049/jimmunol.1590023

IN THIS ISSUE

You have accessRestricted access
In This Issue
Thymocytes Tempted by TEC Wnt Ligands See article p. 5261
Hunting HSV See article p. 5285
Illuminating the History of IL-17 See article p. 5440
Signaling a Switch See article p. 5461

J Immunol December 1, 2015, 195 (11) 5097-5098; DOI: https://doi.org/10.4049/jimmunol.1590022

LETTERS TO THE EDITOR

You have accessRestricted access
Comment on “The B Cell–Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell–Dependent Bone Loss in Experimental Murine Periodontitis.”
Min Zhu and Barbara S. Nikolajczyk

J Immunol December 1, 2015, 195 (11) 5099; DOI: https://doi.org/10.4049/jimmunol.1502059
You have accessRestricted access
Response to Comment on “The B Cell–Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell–Dependent Bone Loss in Experimental Murine Periodontitis”
George Hajishengallis and Jonathan M. Korostoff

J Immunol December 1, 2015, 195 (11) 5099-5100; DOI: https://doi.org/10.4049/jimmunol.1502066
You have accessRestricted access
Comment on “mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT (iNKT) Cells into Immunosuppressive Regulatory iNKT Cells”
Lucia Moreira-Teixeira and Maria Leite-de-Moraes

J Immunol December 1, 2015, 195 (11) 5100-5101; DOI: https://doi.org/10.4049/jimmunol.1502099
You have accessRestricted access
Response to Comment on “mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT (iNKT) Cells into Immunosuppressive Regulatory iNKT Cells”
Charlotte M. Huijts, Tanja D. de Gruijl and Hans J. van der Vliet

J Immunol December 1, 2015, 195 (11) 5101-5102; DOI: https://doi.org/10.4049/jimmunol.1502170

PILLARS OF IMMUNOLOGY

You have accessRestricted access
Beyond Hypothesis: Direct Evidence That V(D)J Recombination Is Regulated by the Accessibility of Chromatin Substrates
Michael S. Krangel

J Immunol December 1, 2015, 195 (11) 5103-5105; DOI: https://doi.org/10.4049/jimmunol.1502150
You have accessRestricted access
Pillars Article: Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro. Cell. 1996. 85: 887–897
Patricia Stanhope-Baker, Karen M. Hudson, Arthur L. Shaffer, Andrei Constantinescu and Mark S. Schlissel

J Immunol December 1, 2015, 195 (11) 5106-5116;

BRIEF REVIEWS

You have accessRestricted access
Landscape of Tumor Antigens in T Cell Immunotherapy
Sadia Ilyas and James C. Yang

J Immunol December 1, 2015, 195 (11) 5117-5122; DOI: https://doi.org/10.4049/jimmunol.1501657

ANTIGEN RECOGNITION AND RESPONSES

You have accessRestricted access
IL-21 and IL-4 Collaborate To Shape T-Dependent Antibody Responses
Helen M. McGuire, Alexis Vogelzang, Joanna Warren, Claudia Loetsch, Karlo D. Natividad, Tyani D. Chan, Robert Brink, Marcel Batten and Cecile King

J Immunol December 1, 2015, 195 (11) 5123-5135; DOI: https://doi.org/10.4049/jimmunol.1501463

AUTOIMMUNITY

Open Access
Adipose-Derived Mesenchymal Stem Cells Prevent Systemic Bone Loss in Collagen-Induced Arthritis
Author Choice Article

Manasa G. Garimella, Supinder Kour, Vikrant Piprode, Monika Mittal, Anil Kumar, Lekha Rani, Satish T. Pote, Gyan C. Mishra, Naibedya Chattopadhyay and Mohan R. Wani

J Immunol December 1, 2015, 195 (11) 5136-5148; DOI: https://doi.org/10.4049/jimmunol.1500332
You have accessRestricted access
Aire Expression Is Inherent to Most Medullary Thymic Epithelial Cells during Their Differentiation Program
Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Fumiko Hirota, Ryoko Morita, Yasuhiro Mouri, Yasuhiko Nishioka and Mitsuru Matsumoto

J Immunol December 1, 2015, 195 (11) 5149-5158; DOI: https://doi.org/10.4049/jimmunol.1501000
Open Access
Igs as Substrates for Transglutaminase 2: Implications for Autoantibody Production in Celiac Disease
Author Choice Article

Rasmus Iversen, M. Fleur du Pré, Roberto Di Niro and Ludvig M. Sollid

J Immunol December 1, 2015, 195 (11) 5159-5168; DOI: https://doi.org/10.4049/jimmunol.1501363

CLINICAL AND HUMAN IMMUNOLOGY

You have accessRestricted access
M2b Monocytes Provoke Bacterial Pneumonia and Gut Bacteria–Associated Sepsis in Alcoholics
Yusuke Tsuchimoto, Akira Asai, Yasuhiro Tsuda, Ichiaki Ito, Tomoki Nishiguchi, Melanie C. Garcia, Sumihiro Suzuki, Makiko Kobayashi, Kazuhide Higuchi and Fujio Suzuki

J Immunol December 1, 2015, 195 (11) 5169-5177; DOI: https://doi.org/10.4049/jimmunol.1501369
You have accessRestricted access
Identification of Cell Surface Straight Chain Poly-N-Acetyl-Lactosamine Bearing Protein Ligands for VH4-34–Encoded Natural IgM Antibodies
Neelima M. Bhat, Christopher M. Adams, Yi Chen, Marcia M. Bieber and Nelson N. H. Teng

J Immunol December 1, 2015, 195 (11) 5178-5188; DOI: https://doi.org/10.4049/jimmunol.1501697

IMMUNE REGULATION

You have accessRestricted access
Antagonizing Peroxisome Proliferator–Activated Receptor α Activity Selectively Enhances Th1 Immunity in Male Mice
Monan Angela Zhang, Jeeyoon Jennifer Ahn, Fei Linda Zhao, Thirumahal Selvanantham, Thierry Mallevaey, Nick Stock, Lucia Correa, Ryan Clark, David Spaner and Shannon E. Dunn

J Immunol December 1, 2015, 195 (11) 5189-5202; DOI: https://doi.org/10.4049/jimmunol.1500449
You have accessRestricted access
Combination Therapy Using IL-2/IL-2 Monoclonal Antibody Complexes, Rapamycin, and Islet Autoantigen Peptides Increases Regulatory T Cell Frequency and Protects against Spontaneous and Induced Type 1 Diabetes in Nonobese Diabetic Mice
Jean N. Manirarora and Cheng-Hong Wei

J Immunol December 1, 2015, 195 (11) 5203-5214; DOI: https://doi.org/10.4049/jimmunol.1402540
You have accessRestricted access
Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow–Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation
Peter I. Lobo, Kailo H. Schlegel, Amandeep Bajwa, Liping Huang, Elvira Kurmaeva, Binru Wang, Hong Ye, Thomas F. Tedder, Gilbert R. Kinsey and Mark D. Okusa

J Immunol December 1, 2015, 195 (11) 5215-5226; DOI: https://doi.org/10.4049/jimmunol.1500052
You have accessRestricted access
CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues
Naveen Sharma, Alexandre P. Benechet, Leo Lefrançois and Kamal M. Khanna

J Immunol December 1, 2015, 195 (11) 5227-5236; DOI: https://doi.org/10.4049/jimmunol.1500993
You have accessRestricted access
Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell–Mediated Control of T Cell Immunity
Cansu Cimen Bozkus, Bennett D. Elzey, Scott A. Crist, Lesley G. Ellies and Timothy L. Ratliff

J Immunol December 1, 2015, 195 (11) 5237-5250; DOI: https://doi.org/10.4049/jimmunol.1500959
You have accessRestricted access
IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8⁺ T Cells
Tia Y. Brodeur, Tara E. Robidoux, Jason S. Weinstein, Joseph Craft, Susan L. Swain and Ann Marshak-Rothstein

J Immunol December 1, 2015, 195 (11) 5251-5260; DOI: https://doi.org/10.4049/jimmunol.1500777

IMMUNE SYSTEM DEVELOPMENT

You have accessRestricted access
Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development
Fabian Brunk, Iris Augustin, Michael Meister, Michael Boutros and Bruno Kyewski

J Immunol December 1, 2015, 195 (11) 5261-5271; DOI: https://doi.org/10.4049/jimmunol.1501265
Open Access
Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2
Author Choice Article

Kyle L. O’Hagan, Jie Zhao, Olga Pryshchep, Chyung-Ru Wang and Hyewon Phee

J Immunol December 1, 2015, 195 (11) 5272-5284; DOI: https://doi.org/10.4049/jimmunol.1501367

INFECTIOUS DISEASE AND HOST RESPONSE

You have accessRestricted access
Subtle CXCR3-Dependent Chemotaxis of CTLs within Infected Tissue Allows Efficient Target Localization
Silvia Ariotti, Joost B. Beltman, Rianne Borsje, Mirjam E. Hoekstra, William P. Halford, John B. A. G. Haanen, Rob J. de Boer and Ton N. M. Schumacher

J Immunol December 1, 2015, 195 (11) 5285-5295; DOI: https://doi.org/10.4049/jimmunol.1500853

INNATE IMMUNITY AND INFLAMMATION

You have accessRestricted access
Myeloid Cell–Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation
Jana Knuever, Sebastian Willenborg, Xiaolei Ding, Mehmet D. Akyüz, Linda Partridge, Carien M. Niessen, Jens C. Brüning and Sabine A. Eming

J Immunol December 1, 2015, 195 (11) 5296-5308; DOI: https://doi.org/10.4049/jimmunol.1501237
You have accessRestricted access
IgM-Dependent Phagocytosis in Microglia Is Mediated by Complement Receptor 3, Not Fcα/μ Receptor
Jonathan R. Weinstein, Yi Quan, Josiah F. Hanson, Lucrezia Colonna, Michael Iorga, Shin-ichiro Honda, Kazuko Shibuya, Akira Shibuya, Keith B. Elkon and Thomas Möller

J Immunol December 1, 2015, 195 (11) 5309-5317; DOI: https://doi.org/10.4049/jimmunol.1401195
You have accessRestricted access
β-Glucan–Activated Human B Lymphocytes Participate in Innate Immune Responses by Releasing Proinflammatory Cytokines and Stimulating Neutrophil Chemotaxis
Mohamed F. Ali, Christopher B. Driscoll, Paula R. Walters, Andrew H. Limper and Eva M. Carmona

J Immunol December 1, 2015, 195 (11) 5318-5326; DOI: https://doi.org/10.4049/jimmunol.1500559
Open Access
Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women
Author Choice Article

Morgane Griesbeck, Susanne Ziegler, Sophie Laffont, Nikaïa Smith, Lise Chauveau, Phillip Tomezsko, Armon Sharei, Georgio Kourjian, Filippos Porichis, Meghan Hart, Christine D. Palmer, Michael Sirignano, Claudia Beisel, Heike Hildebrandt, Claire Cénac, Alexandra-Chloé Villani, Thomas J. Diefenbach, Sylvie Le Gall, Olivier Schwartz, Jean-Philippe Herbeuval, Brigitte Autran, Jean-Charles Guéry, J. Judy Chang and Marcus Altfeld

J Immunol December 1, 2015, 195 (11) 5327-5336; DOI: https://doi.org/10.4049/jimmunol.1501684
You have accessRestricted access
Impact of Notch1 Deletion in Macrophages on Proinflammatory Cytokine Production and the Outcome of Experimental Autoimmune Encephalomyelitis
Wipawee Wongchana, Rebecca G. Lawlor, Barbara A. Osborne and Tanapat Palaga

J Immunol December 1, 2015, 195 (11) 5337-5346; DOI: https://doi.org/10.4049/jimmunol.1401770
You have accessRestricted access
Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during Pneumocystis Lung Infection in Mice
Justin R. Prigge, Teri R. Hoyt, Erin Dobrinen, Mario R. Capecchi, Edward E. Schmidt and Nicole Meissner

J Immunol December 1, 2015, 195 (11) 5347-5357; DOI: https://doi.org/10.4049/jimmunol.1501553
Open Access
WDR82 Negatively Regulates Cellular Antiviral Response by Mediating TRAF3 Polyubiquitination in Multiple Cell Lines
Author Choice Article

Kun Zhu, Xiang Wang, Lin-Gao Ju, Yuan Zhu, Jie Yao, Yanyi Wang, Min Wu and Lian-Yun Li

J Immunol December 1, 2015, 195 (11) 5358-5366; DOI: https://doi.org/10.4049/jimmunol.1500339
Open Access
Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6
Author Choice Article

Tsung-Hsien Chang, Ryusuke Yoshimi and Keiko Ozato

J Immunol December 1, 2015, 195 (11) 5367-5379; DOI: https://doi.org/10.4049/jimmunol.1402064
You have accessRestricted access
CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia
Greg A. Foster, Lu Xu, Alagu A. Chidambaram, Stephanie R. Soderberg, Ehrin J. Armstrong, Huaizhu Wu and Scott I. Simon

J Immunol December 1, 2015, 195 (11) 5380-5392; DOI: https://doi.org/10.4049/jimmunol.1501077
You have accessRestricted access
Activation of TAK1 by Chemotactic and Growth Factors, and Its Impact on Human Neutrophil Signaling and Functional Responses
Stéphanie Sylvain-Prévost, Thornin Ear, François A. Simard, Carl F. Fortin, Claire M. Dubois, Nicolas Flamand and Patrick P. McDonald

J Immunol December 1, 2015, 195 (11) 5393-5403; DOI: https://doi.org/10.4049/jimmunol.1402752
You have accessRestricted access
MicroRNA-26b Modulates the NF-κB Pathway in Alveolar Macrophages by Regulating PTEN
Li Zhang, Chaoqun Huang, Yujie Guo, Xuxu Gou, Myron Hinsdale, Pamela Lloyd and Lin Liu

J Immunol December 1, 2015, 195 (11) 5404-5414; DOI: https://doi.org/10.4049/jimmunol.1402933
You have accessRestricted access
A Truncated Variant of ASCC1, a Novel Inhibitor of NF-κB, Is Associated with Disease Severity in Patients with Rheumatoid Arthritis
Silvia Torices, Lorena Alvarez-Rodríguez, Lara Grande, Ignacio Varela, Pedro Muñoz, Dora Pascual, Alejandro Balsa, Marcos López-Hoyos, Víctor Martinez-Taboada and Jose L. Fernández-Luna

J Immunol December 1, 2015, 195 (11) 5415-5420; DOI: https://doi.org/10.4049/jimmunol.1501532
You have accessRestricted access
Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1–Independent Mechanism
Dominik Stammler, Tatjana Eigenbrod, Sarah Menz, Julia S. Frick, Matthew J. Sweet, Melanie R. Shakespear, Jonathan Jantsch, Isabel Siegert, Sabine Wölfle, Julian D. Langer, Ina Oehme, Liliana Schaefer, Andre Fischer, Judith Knievel, Klaus Heeg, Alexander H. Dalpke and Konrad A. Bode

J Immunol December 1, 2015, 195 (11) 5421-5431; DOI: https://doi.org/10.4049/jimmunol.1501195

MOLECULAR AND STRUCTURAL IMMUNOLOGY

You have accessRestricted access
Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand
Author Choice Article

Hong-Sheng Lim, Shaun-Paul Cordoba, Omer Dushek, Jesse Goyette, Alison Taylor, Christopher E. Rudd and P. Anton van der Merwe

J Immunol December 1, 2015, 195 (11) 5432-5439; DOI: https://doi.org/10.4049/jimmunol.1500707
You have accessRestricted access
Characterization of Lamprey IL-17 Family Members and Their Receptors
Qifeng Han, Sabyasachi Das, Masayuki Hirano, Stephen J. Holland, Nathanael McCurley, Peng Guo, Charles S. Rosenberg, Thomas Boehm and Max D. Cooper

J Immunol December 1, 2015, 195 (11) 5440-5451; DOI: https://doi.org/10.4049/jimmunol.1500892
You have accessRestricted access
Green Turtles (Chelonia mydas) Have Novel Asymmetrical Antibodies
Thierry M. Work, Julie Dagenais, Renee Breeden, Anette Schneemann, Joyce Sung, Brian Hew, George H. Balazs and John M. Berestecky

J Immunol December 1, 2015, 195 (11) 5452-5460; DOI: https://doi.org/10.4049/jimmunol.1501332
You have accessRestricted access
Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination
Zhangguo Chen, Andrew Getahun, Xiaomi Chen, Yonatan Dollin, John C. Cambier and Jing H. Wang

J Immunol December 1, 2015, 195 (11) 5461-5471; DOI: https://doi.org/10.4049/jimmunol.1501375
You have accessRestricted access
Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells
Kavita Reginald, Karima Chaoui, Romain Roncagalli, Mathilde Beau, Marisa Goncalves Menoita, Bernard Monsarrat, Odile Burlet-Schiltz, Marie Malissen, Anne Gonzalez de Peredo and Bernard Malissen

J Immunol December 1, 2015, 195 (11) 5472-5481; DOI: https://doi.org/10.4049/jimmunol.1501300
You have accessRestricted access
Hydrophobic Interactions Are Key To Drive the Association of Tapasin with Peptide Transporter Subunit TAP2
Elke Rufer, Danny Kägebein, Ralf M. Leonhardt and Michael R. Knittler

J Immunol December 1, 2015, 195 (11) 5482-5494; DOI: https://doi.org/10.4049/jimmunol.1500246

TUMOR IMMUNOLOGY

You have accessRestricted access
Monosodium Urate Crystals Induce Upregulation of NK1.1-Dependent Killing by Macrophages and Support Tumor-Resident NK1.1⁺ Monocyte/Macrophage Populations in Antitumor Therapy
Stefanie Steiger, Sabine Kuhn, Franca Ronchese and Jacquie L. Harper

J Immunol December 1, 2015, 195 (11) 5495-5502; DOI: https://doi.org/10.4049/jimmunol.1401755

NOVEL IMMUNOLOGICAL METHODS

You have accessRestricted access
Development and Characterization of Monoclonal Antibodies Specific for Mouse and Human Fcγ Receptors
Alison L. Tutt, Sonya James, Stéphanie A. Laversin, Thomas R. W. Tipton, Margaret Ashton-Key, Ruth R. French, Khiyam Hussain, Andrew T. Vaughan, Lang Dou, Alexander Earley, Lekh N. Dahal, Chen Lu, Melanie Dunscombe, H. T. Claude Chan, Christine A. Penfold, Jinny H. Kim, Elizabeth A. Potter, C. Ian Mockridge, Ali Roghanian, Robert J. Oldham, Kerry L. Cox, Sean H. Lim, Ingrid Teige, Bjorn Frendéus, Martin J. Glennie, Stephen A. Beers and Mark S. Cragg

J Immunol December 1, 2015, 195 (11) 5503-5516; DOI: https://doi.org/10.4049/jimmunol.1402988

Main menu

User menu

Search

Table of Contents

PRESIDENT'S ADDRESS

IN THIS ISSUE

LETTERS TO THE EDITOR

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

This Issue

Jump to

Navigate

For Authors

General Information

Journal Services