On the cover: High macrophage infiltration (DAB staining) following Helicobacter pylori–induced gastritis in mice with specific deletion of hypoxia inducible factor-1 (HIF-1) in the myeloid lineage. This figure illustrates a global increase in inflammation, which leads to the worsening of the gastritis in the absence of myeloid HIF-1. Image credit: Andrija Matak. Matak, P., M. Heinis, J. R. R. Mathieu, R. Corriden, S. Cuvellier, S. Delga, R. Mounier, A. Rouquette, J. Raymond, D. Lamarque, J.-F. Emile, V. Nizet, E. Touati, and C. Peyssonnaux. 2015. Myeloid HIF-1 is protective in Helicobacter pylori–mediated gastritis. J. Immunol. 194: 3259–3266.