On the cover: Intravital 2 photon imaging of islet-Ag–specific T cells (green) in a prediabetic NOD mouse pancreatic islet during autoimmune attack. Vasculature is labeled with dextran-rhodamine (red). Increasing islet infiltration is associated with accelerated T cell motility in the islets due to loss of T cell interactions with APCs. Lindsay, R. S., K. Corbin, A. Mahne, B. E. Levitt, M. J. Gebert, E. J. Wigton, B. J. Bradley, K. Haskins, J. Jacobelli, Q. Tang, M. F. Krummel, and R. S. Friedman. 2015. Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J. Immunol. 194: 522–530.