The Journal of Immunology: 194 (2)

January 15, 2015; Volume 194,Issue 2

IN THIS ISSUE

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In This Issue
Preventing Memories of Weakness See article p. 553
Marginalizing B Cells See article p. 606
Aiming for Potent Vaccine Responses See article p. 630
A-Salt-ing NK Cell Inhibition See article p. 781

J Immunol January 15, 2015, 194 (2) 489-490; DOI: https://doi.org/10.4049/jimmunol.1490052

BRIEF REVIEWS

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Granzymes Regulate Proinflammatory Cytokine Responses
Annette C. Wensink, C. Erik Hack and Niels Bovenschen

J Immunol January 15, 2015, 194 (2) 491-497; DOI: https://doi.org/10.4049/jimmunol.1401214

CUTTING EDGE

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Cutting Edge: IL-1α Is a Crucial Danger Signal Triggering Acute Myocardial Inflammation during Myocardial Infarction
Jérôme Lugrin, Roumen Parapanov, Nathalie Rosenblatt-Velin, Stéphanie Rignault-Clerc, François Feihl, Bernard Waeber, Olivier Müller, Catherine Vergely, Marianne Zeller, Aubry Tardivel, Pascal Schneider, Pal Pacher and Lucas Liaudet

J Immunol January 15, 2015, 194 (2) 499-503; DOI: https://doi.org/10.4049/jimmunol.1401948

ANTIGEN RECOGNITION AND RESPONSES

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CCR6-Dependent Positioning of Memory B Cells Is Essential for Their Ability To Mount a Recall Response to Antigen
Raul Elgueta, Ellen Marks, Elizabeth Nowak, Shinelle Menezes, Micah Benson, Vanitha S. Raman, Carla Ortiz, Samuel O’Connell, Henry Hess, Graham M. Lord and Randolph Noelle

J Immunol January 15, 2015, 194 (2) 505-513; DOI: https://doi.org/10.4049/jimmunol.1401553

AUTOIMMUNITY

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Ig Gene Analysis Reveals Altered Selective Pressures on Ig-Producing Cells in Parotid Glands of Primary Sjögren’s Syndrome Patients
Nishath Hamza, Uri Hershberg, Cees G. M. Kallenberg, Arjan Vissink, Frederik K. L. Spijkervet, Hendrika Bootsma, Frans G. M. Kroese and Nicolaas A. Bos

J Immunol January 15, 2015, 194 (2) 514-521; DOI: https://doi.org/10.4049/jimmunol.1302644
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Antigen Recognition in the Islets Changes with Progression of Autoimmune Islet Infiltration
Robin S. Lindsay, Kaitlin Corbin, Ashley Mahne, Bonnie E. Levitt, Matthew J. Gebert, Eric J. Wigton, Brenda J. Bradley, Kathryn Haskins, Jordan Jacobelli, Qizhi Tang, Matthew F. Krummel and Rachel S. Friedman

J Immunol January 15, 2015, 194 (2) 522-530; DOI: https://doi.org/10.4049/jimmunol.1400626
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CCR2-Dependent Dendritic Cell Accumulation in the Central Nervous System during Early Effector Experimental Autoimmune Encephalomyelitis Is Essential for Effector T Cell Restimulation In Situ and Disease Progression
Benjamin D. Clarkson, Alec Walker, Melissa G. Harris, Aditya Rayasam, Matyas Sandor and Zsuzsanna Fabry

J Immunol January 15, 2015, 194 (2) 531-541; DOI: https://doi.org/10.4049/jimmunol.1401320

IMMUNE REGULATION

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The Immunoregulator Soluble TACI Is Released by ADAM10 and Reflects B Cell Activation in Autoimmunity
Franziska S. Hoffmann, Peer-Hendrik Kuhn, Sarah A. Laurent, Stefanie M. Hauck, Kerstin Berer, Simone A. Wendlinger, Markus Krumbholz, Mohsen Khademi, Tomas Olsson, Martin Dreyling, Hans-Walter Pfister, Tobias Alexander, Falk Hiepe, Tania Kümpfel, Howard C. Crawford, Hartmut Wekerle, Reinhard Hohlfeld, Stefan F. Lichtenthaler and Edgar Meinl

J Immunol January 15, 2015, 194 (2) 542-552; DOI: https://doi.org/10.4049/jimmunol.1402070
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IFN-γ Regulates CD8⁺ Memory T Cell Differentiation and Survival in Response to Weak, but Not Strong, TCR Signals
Diana Stoycheva, Katrin Deiser, Lilian Stärck, Gopala Nishanth, Dirk Schlüter, Wolfgang Uckert and Thomas Schüler

J Immunol January 15, 2015, 194 (2) 553-559; DOI: https://doi.org/10.4049/jimmunol.1402058
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B7H1/CD80 Interaction Augments PD-1–Dependent T Cell Apoptosis and Ameliorates Graft-versus-Host Disease
Ruishu Deng, Kaniel Cassady, Xiaofan Li, Sheng Yao, Mingfeng Zhang, Jeremy Racine, Jeffrey Lin, Lieping Chen and Defu Zeng

J Immunol January 15, 2015, 194 (2) 560-574; DOI: https://doi.org/10.4049/jimmunol.1402157
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Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8
Selina K. Fassl, Judith Austermann, Olympia Papantonopoulou, Mona Riemenschneider, Jia Xue, Damien Bertheloot, Nicole Freise, Christoph Spiekermann, Anika Witten, Dorothee Viemann, Susanne Kirschnek, Monika Stoll, Eicke Latz, Joachim L. Schultze, Johannes Roth and Thomas Vogl

J Immunol January 15, 2015, 194 (2) 575-583; DOI: https://doi.org/10.4049/jimmunol.1401085
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Adenosine 5′-Monophosphate–Activated Protein Kinase Regulates IL-10–Mediated Anti-Inflammatory Signaling Pathways in Macrophages
Yanfang Peipei Zhu, Jonathan R. Brown, Duygu Sag, Lihua Zhang and Jill Suttles

J Immunol January 15, 2015, 194 (2) 584-594; DOI: https://doi.org/10.4049/jimmunol.1401024

IMMUNE SYSTEM DEVELOPMENT

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PU.1 Opposes IL-7–Dependent Proliferation of Developing B Cells with Involvement of the Direct Target Gene Bruton Tyrosine Kinase
Darah A. Christie, Li S. Xu, Shereen A. Turkistany, Lauren A. Solomon, Stephen K. H. Li, Edmund Yim, Ian Welch, Gillian I. Bell, David A. Hess and Rodney P. DeKoter

J Immunol January 15, 2015, 194 (2) 595-605; DOI: https://doi.org/10.4049/jimmunol.1401569
Open Access
Natural Anti-Intestinal Goblet Cell Autoantibody Production from Marginal Zone B Cells
Author Choice Article

Daiju Ichikawa, Masanao Asano, Susan A. Shinton, Joni Brill-Dashoff, Anthony M. Formica, Anna Velcich, Richard R. Hardy and Kyoko Hayakawa

J Immunol January 15, 2015, 194 (2) 606-614; DOI: https://doi.org/10.4049/jimmunol.1402383

IMMUNOGENETICS

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A Functional Polymorphism of Ptpn22 Is Associated with Type 1 Diabetes in the BioBreeding Rat
Janice Sarmiento, Robert H. Wallis, Terri Ning, Leili Marandi, Gary Chao, André Veillette, Åke Lernmark, Andrew D. Paterson and Philippe Poussier

J Immunol January 15, 2015, 194 (2) 615-629; DOI: https://doi.org/10.4049/jimmunol.1302689

IMMUNOTHERAPY AND VACCINES

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Identification of Aim2 as a Sensor for DNA Vaccines
John J. Suschak, Shixia Wang, Katherine A. Fitzgerald and Shan Lu

J Immunol January 15, 2015, 194 (2) 630-636; DOI: https://doi.org/10.4049/jimmunol.1402530

INFECTIOUS DISEASE AND HOST RESPONSE

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The Orientation of HIV-1 gp120 Binding to the CD4 Receptor Differentially Modulates CD4⁺ T Cell Activation
Kathrin Zimmermann, Thomas Liechti, Anna Haas, Manuela Rehr, Alexandra Trkola, Huldrych F. Günthard and Annette Oxenius

J Immunol January 15, 2015, 194 (2) 637-649; DOI: https://doi.org/10.4049/jimmunol.1401863
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IL-17A–Mediated Protection against Acanthamoeba Keratitis
Amol Suryawanshi, Zhiyi Cao, James F. Sampson and Noorjahan Panjwani

J Immunol January 15, 2015, 194 (2) 650-663; DOI: https://doi.org/10.4049/jimmunol.1302707
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Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity–Mediated Antimicrobial Responses with Caseation during Mycobacterium tuberculosis Infection
Nicholas A. Cilfone, Christopher B. Ford, Simeone Marino, Joshua T. Mattila, Hannah P. Gideon, JoAnne L. Flynn, Denise E. Kirschner and Jennifer J. Linderman

J Immunol January 15, 2015, 194 (2) 664-677; DOI: https://doi.org/10.4049/jimmunol.1400734
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CD8⁺ T Cells Control Ross River Virus Infection in Musculoskeletal Tissues of Infected Mice
Kristina S. Burrack, Stephanie A. Montgomery, Dirk Homann and Thomas E. Morrison

J Immunol January 15, 2015, 194 (2) 678-689; DOI: https://doi.org/10.4049/jimmunol.1401833
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The Effects of Cytokines on Spontaneous Hepatitis B Surface Antigen Seroconversion in Chronic Hepatitis B Virus Infection
Jia-Feng Wu, Hong-Yuan Hsu, Yu-Chun Chiu, Huey-Ling Chen, Yen-Hsuan Ni and Mei-Hwei Chang

J Immunol January 15, 2015, 194 (2) 690-696; DOI: https://doi.org/10.4049/jimmunol.1401659
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Plasmodium Suppresses Expansion of T Cell Responses to Heterologous Infections
Chelsi E. White, Nicolas F. Villarino, Sarah S. Sloan, Vitaly V. Ganusov and Nathan W. Schmidt

J Immunol January 15, 2015, 194 (2) 697-708; DOI: https://doi.org/10.4049/jimmunol.1401745

INNATE IMMUNITY AND INFLAMMATION

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TGF-β1, but Not Bone Morphogenetic Proteins, Activates Smad1/5 Pathway in Primary Human Macrophages and Induces Expression of Proatherogenic Genes
Dinara Nurgazieva, Amanda Mickley, Kondaiah Moganti, Wen Ming, Illya Ovsyi, Anna Popova, Sachindra, Kareem Awad, Nan Wang, Karen Bieback, Sergij Goerdt, Julia Kzhyshkowska and Alexei Gratchev

J Immunol January 15, 2015, 194 (2) 709-718; DOI: https://doi.org/10.4049/jimmunol.1300272
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Chronic Lymphocytic Leukemia: A Paradigm of Innate Immune Cross-Tolerance
Teresa Jurado-Camino, Raúl Córdoba, Laura Esteban-Burgos, Enrique Hernández-Jiménez, Victor Toledano, Jose-Angel Hernandez-Rivas, Elena Ruiz-Sainz, Teresa Cobo, María Siliceo, Rebeca Perez de Diego, Cristobal Belda, Carolina Cubillos-Zapata and Eduardo López-Collazo

J Immunol January 15, 2015, 194 (2) 719-727; DOI: https://doi.org/10.4049/jimmunol.1402272
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Mutation in the CD45 Inhibitory Wedge Modulates Integrin Activation and Leukocyte Recruitment during Inflammation
Giulia Germena, Stephanie Volmering, Charlotte Sohlbach and Alexander Zarbock

J Immunol January 15, 2015, 194 (2) 728-738; DOI: https://doi.org/10.4049/jimmunol.1401646
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The P2X₁ Receptor Is Required for Neutrophil Extravasation during Lipopolysaccharide-Induced Lethal Endotoxemia in Mice
Blandine Maître, Stéphanie Magnenat, Véronique Heim, Catherine Ravanat, Richard J. Evans, Henri de la Salle, Christian Gachet and Béatrice Hechler

J Immunol January 15, 2015, 194 (2) 739-749; DOI: https://doi.org/10.4049/jimmunol.1401786
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Severe Neutrophil-Dominated Inflammation and Enhanced Myelopoiesis in IL-33–Overexpressing CMV/IL33 Mice
Dominique Talabot-Ayer, Praxedis Martin, Christian Vesin, Christian Alexander Seemayer, Solenne Vigne, Cem Gabay and Gaby Palmer

J Immunol January 15, 2015, 194 (2) 750-760; DOI: https://doi.org/10.4049/jimmunol.1402057
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Direct and Indirect Effects of Immune and Central Nervous System–Resident Cells on Human Oligodendrocyte Progenitor Cell Differentiation
Craig S. Moore, Qiao-Ling Cui, Nebras M. Warsi, Bryce A. Durafourt, Nika Zorko, David R. Owen, Jack P. Antel and Amit Bar-Or

J Immunol January 15, 2015, 194 (2) 761-772; DOI: https://doi.org/10.4049/jimmunol.1401156
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Activation of an Innate Immune Receptor, Nod1, Accelerates Atherogenesis in Apoe^−/− Mice
Shunsuke Kanno, Hisanori Nishio, Tamami Tanaka, Yoshitomo Motomura, Kenji Murata, Kenji Ihara, Mitsuho Onimaru, Sho Yamasaki, Hajime Kono, Katsuo Sueishi and Toshiro Hara

J Immunol January 15, 2015, 194 (2) 773-780; DOI: https://doi.org/10.4049/jimmunol.1302841

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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The Interaction of KIR3DL1*001 with HLA Class I Molecules Is Dependent upon Molecular Microarchitecture within the Bw4 Epitope
Philippa M. Saunders, Julian P. Vivian, Nikola Baschuk, Travis Beddoe, Jacqueline Widjaja, Geraldine M. O’Connor, Corinne Hitchen, Phillip Pymm, Daniel M. Andrews, Stephanie Gras, Daniel W. McVicar, Jamie Rossjohn and Andrew G. Brooks

J Immunol January 15, 2015, 194 (2) 781-789; DOI: https://doi.org/10.4049/jimmunol.1402542
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Specification of Vδ and Vα Usage by Tcra/Tcrd Locus V Gene Segment Promoters
Abani Kanta Naik, Abbas Hawwari and Michael S. Krangel

J Immunol January 15, 2015, 194 (2) 790-794; DOI: https://doi.org/10.4049/jimmunol.1402423
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Focal Adhesion Kinase–Mediated Activation of Glycogen Synthase Kinase 3β Regulates IL-33 Receptor Internalization and IL-33 Signaling
Jing Zhao, Jianxin Wei, Rachel K. Bowser, Russell S. Traister, Ming-Hui Fan and Yutong Zhao

J Immunol January 15, 2015, 194 (2) 795-802; DOI: https://doi.org/10.4049/jimmunol.1401414
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HLA-DMA Polymorphisms Differentially Affect MHC Class II Peptide Loading
Miguel Álvaro-Benito, Marek Wieczorek, Jana Sticht, Claudia Kipar and Christian Freund

J Immunol January 15, 2015, 194 (2) 803-816; DOI: https://doi.org/10.4049/jimmunol.1401389
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A Single Amino Acid Change in Inhibitory Killer Cell Ig-like Receptor Results in Constitutive Receptor Self-Association and Phosphorylation
Santosh Kumar, Pabak Sarkar, Malcolm J. W. Sim, Sumati Rajagopalan, Steven S. Vogel and Eric O. Long

J Immunol January 15, 2015, 194 (2) 817-826; DOI: https://doi.org/10.4049/jimmunol.1401830

TUMOR IMMUNOLOGY

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Chronic Lymphocytic Leukemia Cells Express CD38 in Response to Th1 Cell–Derived IFN-γ by a T-bet–Dependent Mechanism
Simone Bürgler, Aleix Gimeno, Anna Parente-Ribes, Dong Wang, Audun Os, Stephen Devereux, Peter Jebsen, Bjarne Bogen, Geir E. Tjønnfjord and Ludvig A. Munthe

J Immunol January 15, 2015, 194 (2) 827-835; DOI: https://doi.org/10.4049/jimmunol.1401350

NOVEL IMMUNOLOGICAL METHODS

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Profiling T Cell Activation Using Single-Molecule Fluorescence In Situ Hybridization and Flow Cytometry
Yuri Bushkin, Felix Radford, Richard Pine, Alfred Lardizabal, Bonita T. Mangura, Maria Laura Gennaro and Sanjay Tyagi

J Immunol January 15, 2015, 194 (2) 836-841; DOI: https://doi.org/10.4049/jimmunol.1401515

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Table of Contents

IN THIS ISSUE

BRIEF REVIEWS

CUTTING EDGE

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

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