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Macrophage Epoxygenase Determines a Profibrotic Transcriptome Signature

Jacques Behmoaras, Ana Garcia Diaz, Lara Venda, Jeong-Hun Ko, Prashant Srivastava, Alex Montoya, Peter Faull, Zoe Webster, Ben Moyon, Charles D. Pusey, David J. Abraham, Enrico Petretto, Terence H. Cook and Timothy J. Aitman
J Immunol May 15, 2015, 194 (10) 4705-4716; DOI: https://doi.org/10.4049/jimmunol.1402979
Jacques Behmoaras
*Centre for Complement and Inflammation Research, Imperial College London, London W12 0NN, United Kingdom;
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Ana Garcia Diaz
†Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
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Lara Venda
†Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
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Jeong-Hun Ko
*Centre for Complement and Inflammation Research, Imperial College London, London W12 0NN, United Kingdom;
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Prashant Srivastava
‡Integrative Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
§Duke–NUS Graduate Medical School Singapore, 169857 Singapore, Republic of Singapore;
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Alex Montoya
¶Biological Mass Spectrometry and Proteomics Laboratory, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
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Peter Faull
¶Biological Mass Spectrometry and Proteomics Laboratory, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
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Zoe Webster
‖Embryonic Stem Cell and Transgenics Facility, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
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Ben Moyon
‖Embryonic Stem Cell and Transgenics Facility, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
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Charles D. Pusey
#Renal Section, Department of Medicine, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom;
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David J. Abraham
**Centre for Rheumatology and Connective Tissue Diseases, University College London Medical School, London WC1E 6BT, United Kingdom; and
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Enrico Petretto
‡Integrative Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
§Duke–NUS Graduate Medical School Singapore, 169857 Singapore, Republic of Singapore;
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Terence H. Cook
*Centre for Complement and Inflammation Research, Imperial College London, London W12 0NN, United Kingdom;
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Timothy J. Aitman
†Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
††Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom
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Article Information

vol. 194 no. 10 4705-4716
DOI 
https://doi.org/10.4049/jimmunol.1402979
PubMed 
25840911

Published By 
The American Association of Immunologists, Inc.
Print ISSN 
0022-1767
Online ISSN 
1550-6606
History 
  • Received December 1, 2014
  • Accepted February 3, 2015
  • Published online May 1, 2015.

Article Versions

  • Older version (April 3, 2015 - 07:54).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Association of Immunologists, Inc.

Author Information

  1. Jacques Behmoaras*,
  2. Ana Garcia Diaz†,1,
  3. Lara Venda†,1,
  4. Jeong-Hun Ko*,1,
  5. Prashant Srivastava‡,§,
  6. Alex Montoya¶,
  7. Peter Faull¶,
  8. Zoe Webster‖,
  9. Ben Moyon‖,
  10. Charles D. Pusey#,
  11. David J. Abraham**,
  12. Enrico Petretto‡,§,
  13. Terence H. Cook* and
  14. Timothy J. Aitman†,††
  1. *Centre for Complement and Inflammation Research, Imperial College London, London W12 0NN, United Kingdom;
  2. †Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
  3. ‡Integrative Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
  4. §Duke–NUS Graduate Medical School Singapore, 169857 Singapore, Republic of Singapore;
  5. ¶Biological Mass Spectrometry and Proteomics Laboratory, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
  6. ‖Embryonic Stem Cell and Transgenics Facility, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom;
  7. #Renal Section, Department of Medicine, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom;
  8. **Centre for Rheumatology and Connective Tissue Diseases, University College London Medical School, London WC1E 6BT, United Kingdom; and
  9. ††Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom
  1. Address correspondence and reprint requests to Dr. Jacques Behmoaras or Dr. Timothy J. Aitman, Centre for Complement and Inflammation Research, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, U.K. (J.B.) or Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, U.K. (T.J.A.). E-mail addresses: jacques.behmoaras{at}imperial.ac.uk (J.B.) or tim.aitman{at}ed.ac.uk (T.J.A.)
  1. ↵1 A.G.D., L.V., and J.-H.K. contributed equally to this work.

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Apr 2015707173
May 201511363374
Jun 20151772927
Jul 2015742316
Aug 2015644113
Sep 2015761618
Oct 2015711110
Nov 201528117
Dec 2015371415
Total 20152370179253
Jan 20162874
Feb 201623127
Mar 201618128
Apr 201628811
May 2016301026
Jun 2016121011
Jul 2016131030
Aug 2016181816
Sep 201621928
Oct 2016181216
Nov 201627717
Dec 201619418
Total 2016255119192
Jan 201762212
Feb 201731920
Mar 201722513
Apr 201731516
May 201751727
Jun 20170922
Jul 201731526
Aug 20172613
Sep 201711616
Oct 20170157
Nov 201722015
Dec 2017323314
Total 201730412201
Jan 201848633
Feb 201821332
Mar 2018593116
Apr 2018111113
May 201842719
Jun 201802911
Jul 201812819
Aug 201827710
Sep 201812220
Oct 201822524
Nov 201843826
Dec 201831614
Total 201829565337
Jan 201932120
Feb 201912014
Mar 201924030
Apr 201931843
May 201921849
Jun 201982535
Jul 201962228
Aug 201992522
Sep 201963825
Oct 201954231
Nov 201901536
Dec 201982228
Total 201953306361
Jan 2020112740
Feb 202011323
Mar 202071530
Apr 202061832
May 202012145
Jun 202011521
Jul 202012116
Aug 20201917
Sep 202022521
Oct 202013332
Nov 202021424
Dec 2020122142
Total 202046232343
Total278318131687

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The Journal of Immunology: 194 (10)
The Journal of Immunology
Vol. 194, Issue 10
15 May 2015
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Macrophage Epoxygenase Determines a Profibrotic Transcriptome Signature
Jacques Behmoaras, Ana Garcia Diaz, Lara Venda, Jeong-Hun Ko, Prashant Srivastava, Alex Montoya, Peter Faull, Zoe Webster, Ben Moyon, Charles D. Pusey, David J. Abraham, Enrico Petretto, Terence H. Cook, Timothy J. Aitman
The Journal of Immunology May 15, 2015, 194 (10) 4705-4716; DOI: 10.4049/jimmunol.1402979

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Macrophage Epoxygenase Determines a Profibrotic Transcriptome Signature
Jacques Behmoaras, Ana Garcia Diaz, Lara Venda, Jeong-Hun Ko, Prashant Srivastava, Alex Montoya, Peter Faull, Zoe Webster, Ben Moyon, Charles D. Pusey, David J. Abraham, Enrico Petretto, Terence H. Cook, Timothy J. Aitman
The Journal of Immunology May 15, 2015, 194 (10) 4705-4716; DOI: 10.4049/jimmunol.1402979
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Print ISSN 0022-1767        Online ISSN 1550-6606