The Journal of Immunology: 192 (6)

March 15, 2014; Volume 192,Issue 6

IN THIS ISSUE

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In This Issue
Tempering IL-17 in Psoriasis See article p. 2564
Mighty MDSCs Suppress EAE See article p. 2576
Nasal NE Takes a Toll See article p. 2722
TLR Signaling TAKedown See article p. 2846

J Immunol March 15, 2014, 192 (6) 2527-2528; DOI: https://doi.org/10.4049/jimmunol.1490005

BRIEF REVIEWS

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The Immunology of Food Allergy
Laura K. Johnston, Karen B. Chien and Paul J. Bryce

J Immunol March 15, 2014, 192 (6) 2529-2534; DOI: https://doi.org/10.4049/jimmunol.1303026

CUTTING EDGE

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Cutting Edge: IFN-γR Signaling in Non–T Cell Targets Regulates T Cell–Mediated Intestinal Inflammation through Multiple Mechanisms
Jeong-su Do, Kewal Asosingh, William M. Baldwin III and Booki Min

J Immunol March 15, 2014, 192 (6) 2537-2541; DOI: https://doi.org/10.4049/jimmunol.1303101

ANTIGEN RECOGNITION AND RESPONSES

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Coexpression of TLR2 or TLR4 with HLA-DR Potentiates the Superantigenic Activities of Mycoplasma arthritidis–Derived Mitogen
Marina T. Shio, Ghada S. Hassan, Waris A. Shah, Amal Nadiri, Youssef El Fakhry, Hogmin Li and Walid Mourad

J Immunol March 15, 2014, 192 (6) 2543-2550; DOI: https://doi.org/10.4049/jimmunol.1300591

AUTOIMMUNITY

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Comprehensive Immunophenotyping of Cerebrospinal Fluid Cells in Patients with Neuroimmunological Diseases
Sungpil Han, Yen Chih Lin, Tianxia Wu, Alan D. Salgado, Ina Mexhitaj, Simone C. Wuest, Elena Romm, Joan Ohayon, Raphaela Goldbach-Mansky, Adeline Vanderver, Adriana Marques, Camilo Toro, Peter Williamson, Irene Cortese and Bibiana Bielekova

J Immunol March 15, 2014, 192 (6) 2551-2563; DOI: https://doi.org/10.4049/jimmunol.1302884
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Pharmacologic Inhibition of RORγt Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation In Vivo
Jill Skepner, Radha Ramesh, Mark Trocha, Darby Schmidt, Erkan Baloglu, Mercedes Lobera, Thaddeus Carlson, Jonathan Hill, Lisa A. Orband-Miller, Ashley Barnes, Mohamed Boudjelal, Mark Sundrud, Shomir Ghosh and Jianfei Yang

J Immunol March 15, 2014, 192 (6) 2564-2575; DOI: https://doi.org/10.4049/jimmunol.1302190
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The DC-HIL/Syndecan-4 Pathway Regulates Autoimmune Responses through Myeloid-Derived Suppressor Cells
Jin-Sung Chung, Kyoichi Tamura, Hideo Akiyoshi, Ponciano D. Cruz Jr. and Kiyoshi Ariizumi

J Immunol March 15, 2014, 192 (6) 2576-2584; DOI: https://doi.org/10.4049/jimmunol.1301857
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Temporal Lineage Tracing of Aire-Expressing Cells Reveals a Requirement for Aire in Their Maturation Program
Yumiko Nishikawa, Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Fumiko Hirota, Satoru Takahashi, Hervé Luche, Hans Joerg Fehling, Yasuhiro Mouri and Mitsuru Matsumoto

J Immunol March 15, 2014, 192 (6) 2585-2592; DOI: https://doi.org/10.4049/jimmunol.1302786
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Gene Therapy Delivery of Myelin Oligodendrocyte Glycoprotein (MOG) via Hematopoietic Stem Cell Transfer Induces MOG-Specific B Cell Deletion
Jie-Yu Chung, William Figgett, Kirsten Fairfax, Claude Bernard, James Chan, Ban-Hock Toh, Fabienne Mackay and Frank Alderuccio

J Immunol March 15, 2014, 192 (6) 2593-2601; DOI: https://doi.org/10.4049/jimmunol.1203563

CLINICAL AND HUMAN IMMUNOLOGY

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NK Cell Killer Ig-like Receptor Repertoire Acquisition and Maturation Are Strongly Modulated by HLA Class I Molecules
Marwan Sleiman, Nicolaas H. C. Brons, Tony Kaoma, Figen Dogu, Alexandra Villa-Forte, Patrick Lenoble, François Hentges, Katja Kotsch, Stephan D. Gadola, Carlos Vilches and Jacques Zimmer

J Immunol March 15, 2014, 192 (6) 2602-2610; DOI: https://doi.org/10.4049/jimmunol.1302843
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Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22–Secreting T Cells and the Influence of PD-1 on Effector T Cell Function
Andrew Gibson, Monday Ogese, Andrew Sullivan, Eryi Wang, Katy Saide, Paul Whitaker, Daniel Peckham, Lee Faulkner, B. Kevin Park and Dean J. Naisbitt

J Immunol March 15, 2014, 192 (6) 2611-2621; DOI: https://doi.org/10.4049/jimmunol.1302720
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Pan-Bcl-2 Inhibitor, GX15-070 (Obatoclax), Decreases Human T Regulatory Lymphocytes while Preserving Effector T Lymphocytes: A Rationale for Its Use in Combination Immunotherapy
Peter S. Kim, Caroline Jochems, Italia Grenga, Renee N. Donahue, Kwong Y. Tsang, James L. Gulley, Jeffrey Schlom and Benedetto Farsaci

J Immunol March 15, 2014, 192 (6) 2622-2633; DOI: https://doi.org/10.4049/jimmunol.1301369

IMMUNE REGULATION

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IL-27 in Human Secondary Lymphoid Organs Attracts Myeloid Dendritic Cells and Impairs HLA Class I–Restricted Antigen Presentation
Fabio Morandi, Emma Di Carlo, Soldano Ferrone, Andrea Petretto, Vito Pistoia and Irma Airoldi

J Immunol March 15, 2014, 192 (6) 2634-2642; DOI: https://doi.org/10.4049/jimmunol.1302656
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Tuberous Sclerosis 1 Promotes Invariant NKT Cell Anergy and Inhibits Invariant NKT Cell–Mediated Antitumor Immunity
Jinhong Wu, Jinwook Shin, Danli Xie, Hongxia Wang, Jimin Gao and Xiao-Ping Zhong

J Immunol March 15, 2014, 192 (6) 2643-2650; DOI: https://doi.org/10.4049/jimmunol.1302076
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TRIF Signaling Is Essential for TLR4-Driven IgE Class Switching
Erin Janssen, Esra Ozcan, Kyriaki Liadaki, Haifa H. Jabara, John Manis, Sumana Ullas, Shizuo Akira, Katherine A. Fitzgerald, Douglas T. Golenbock and Raif S. Geha

J Immunol March 15, 2014, 192 (6) 2651-2658; DOI: https://doi.org/10.4049/jimmunol.1300909

IMMUNE SYSTEM DEVELOPMENT

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An Essential Role for Medullary Thymic Epithelial Cells during the Intrathymic Development of Invariant NKT Cells
Author Choice Article

Andrea J. White, William E. Jenkinson, Jennifer E. Cowan, Sonia M. Parnell, Andrea Bacon, Nick D. Jones, Eric J. Jenkinson and Graham Anderson

J Immunol March 15, 2014, 192 (6) 2659-2666; DOI: https://doi.org/10.4049/jimmunol.1303057
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Differential Requirement for Nfil3 during NK Cell Development
Cyril Seillet, Nicholas D. Huntington, Pradnya Gangatirkar, Elin Axelsson, Martina Minnich, Hugh J. M. Brady, Meinrad Busslinger, Mark J. Smyth, Gabrielle T. Belz and Sebastian Carotta

J Immunol March 15, 2014, 192 (6) 2667-2676; DOI: https://doi.org/10.4049/jimmunol.1302605
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The Transcription Factor E4BP4 Is Not Required for Extramedullary Pathways of NK Cell Development
Author Choice Article

Stefania Crotta, Annita Gkioka, Victoria Male, João H. Duarte, Sophia Davidson, Ilaria Nisoli, Hugh J. M. Brady and Andreas Wack

J Immunol March 15, 2014, 192 (6) 2677-2688; DOI: https://doi.org/10.4049/jimmunol.1302765

IMMUNOGENETICS

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Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling
Olga V. Britanova, Ekaterina V. Putintseva, Mikhail Shugay, Ekaterina M. Merzlyak, Maria A. Turchaninova, Dmitriy B. Staroverov, Dmitriy A. Bolotin, Sergey Lukyanov, Ekaterina A. Bogdanova, Ilgar Z. Mamedov, Yuriy B. Lebedev and Dmitriy M. Chudakov

J Immunol March 15, 2014, 192 (6) 2689-2698; DOI: https://doi.org/10.4049/jimmunol.1302064
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B Cells in Teleost Fish Act as Pivotal Initiating APCs in Priming Adaptive Immunity: An Evolutionary Perspective on the Origin of the B-1 Cell Subset and B7 Molecules
Lv-yun Zhu, Ai-fu Lin, Tong Shao, Li Nie, Wei-ren Dong, Li-xin Xiang and Jian-zhong Shao

J Immunol March 15, 2014, 192 (6) 2699-2714; DOI: https://doi.org/10.4049/jimmunol.1301312
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Haplotypes of FcγRIIa and FcγRIIIb Polymorphic Variants Influence IgG-Mediated Responses in Neutrophils
Joris van der Heijden, Sietse Nagelkerke, Xiwen Zhao, Judy Geissler, Theo Rispens, Timo K. van den Berg and Taco W. Kuijpers

J Immunol March 15, 2014, 192 (6) 2715-2721; DOI: https://doi.org/10.4049/jimmunol.1203570

IMMUNOTHERAPY AND VACCINES

Open Access
Distinct Pathways of Humoral and Cellular Immunity Induced with the Mucosal Administration of a Nanoemulsion Adjuvant
Author Choice Article

Anna U. Bielinska, Paul E. Makidon, Katarzyna W. Janczak, Luz P. Blanco, Benjamin Swanson, Douglas M. Smith, Tiffany Pham, Zsuzsanna Szabo, Jolanta F. Kukowska-Latallo and James R. Baker Jr.

J Immunol March 15, 2014, 192 (6) 2722-2733; DOI: https://doi.org/10.4049/jimmunol.1301424

INFECTIOUS DISEASE AND HOST RESPONSE

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Critical Role of MicroRNA-155 in Herpes Simplex Encephalitis
Siddheshvar Bhela, Sachin Mulik, Pradeep B. J. Reddy, Raphael L. Richardson, Fernanda Gimenez, Naveen K. Rajasagi, Tamara Veiga-Parga, Alexander P. Osmand and Barry T. Rouse

J Immunol March 15, 2014, 192 (6) 2734-2743; DOI: https://doi.org/10.4049/jimmunol.1302326
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Tick-Borne Flaviviruses Antagonize Both IRF-1 and Type I IFN Signaling To Inhibit Dendritic Cell Function
Shelly J. Robertson, Kirk J. Lubick, Brett A. Freedman, Aaron B. Carmody and Sonja M. Best

J Immunol March 15, 2014, 192 (6) 2744-2755; DOI: https://doi.org/10.4049/jimmunol.1302110
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Specific Recognition of Mycobacterial Protein and Peptide Antigens by γδ T Cell Subsets following Infection with Virulent Mycobacterium bovis
Jodi L. McGill, Randy E. Sacco, Cynthia L. Baldwin, Janice C. Telfer, Mitchell V. Palmer and W. Ray Waters

J Immunol March 15, 2014, 192 (6) 2756-2769; DOI: https://doi.org/10.4049/jimmunol.1302567
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IPS-1 Is Essential for Type III IFN Production by Hepatocytes and Dendritic Cells in Response to Hepatitis C Virus Infection
Masaaki Okamoto, Hiroyuki Oshiumi, Masahiro Azuma, Nobuyuki Kato, Misako Matsumoto and Tsukasa Seya

J Immunol March 15, 2014, 192 (6) 2770-2777; DOI: https://doi.org/10.4049/jimmunol.1301459

INNATE IMMUNITY AND INFLAMMATION

Open Access
Zhankuic Acid A Isolated from Taiwanofungus camphoratus Is a Novel Selective TLR4/MD-2 Antagonist with Anti-Inflammatory Properties
Author Choice Article

Yu-Fon Chen, Ai-Li Shiau, Sheng-Hung Wang, Jai-Sing Yang, Sue-Joan Chang, Chao-Liang Wu and Tian-Shung Wu

J Immunol March 15, 2014, 192 (6) 2778-2786; DOI: https://doi.org/10.4049/jimmunol.1301931
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A TNF-α–CCL20–CCR6 Axis Regulates Nod1-Induced B Cell Responses
Maude Paradis, Barbara C. Mindt, Claudia U. Duerr, Olga L. Rojas, Dennis Ng, Bryant Boulianne, Doug D. McCarthy, Mingxi Dennis Yu, Leslie E. Summers deLuca, Lesley A. Ward, James B. Waldron, Dana J. Philpott, Jennifer L. Gommerman and Jörg H. Fritz

J Immunol March 15, 2014, 192 (6) 2787-2799; DOI: https://doi.org/10.4049/jimmunol.1203310
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S100A8 Induces IL-10 and Protects against Acute Lung Injury
Yuka Hiroshima, Kenneth Hsu, Nicodemus Tedla, Yuen Ming Chung, Sharron Chow, Cristan Herbert and Carolyn L. Geczy

J Immunol March 15, 2014, 192 (6) 2800-2811; DOI: https://doi.org/10.4049/jimmunol.1302556
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Mouse Mast Cell Proteases 4 and 5 Mediate Epidermal Injury through Disruption of Tight Junctions
Lora G. Bankova, Cecilia Lezcano, Gunnar Pejler, Richard L. Stevens, George F. Murphy, K. Frank Austen and Michael F. Gurish

J Immunol March 15, 2014, 192 (6) 2812-2820; DOI: https://doi.org/10.4049/jimmunol.1301794
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In Vivo Characterization of Alveolar and Interstitial Lung Macrophages in Rhesus Macaques: Implications for Understanding Lung Disease in Humans
Yanhui Cai, Chie Sugimoto, Mariluz Arainga, Xavier Alvarez, Elizabeth S. Didier and Marcelo J. Kuroda

J Immunol March 15, 2014, 192 (6) 2821-2829; DOI: https://doi.org/10.4049/jimmunol.1302269
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A Key Regulatory Role for Vav1 in Controlling Lipopolysaccharide Endotoxemia via Macrophage-Derived IL-6
Stefanie Zenker, Julia Panteleev-Ivlev, Stefan Wirtz, Tadamitsu Kishimoto, Maximilian J. Waldner, Olga Ksionda, Victor L. J. Tybulewicz, Markus F. Neurath and Imke Atreya

J Immunol March 15, 2014, 192 (6) 2830-2836; DOI: https://doi.org/10.4049/jimmunol.1300157
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Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release
Eivind O. Samstad, Nathalie Niyonzima, Stig Nymo, Marie H. Aune, Liv Ryan, Siril S. Bakke, Knut T. Lappegård, Ole-Lars Brekke, John D. Lambris, Jan K. Damås, Eicke Latz, Tom E. Mollnes and Terje Espevik

J Immunol March 15, 2014, 192 (6) 2837-2845; DOI: https://doi.org/10.4049/jimmunol.1302484
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Phosphatase Holoenzyme PP1/GADD34 Negatively Regulates TLR Response by Inhibiting TAK1 Serine 412 Phosphorylation
Meidi Gu, Chuan Ouyang, Wenlong Lin, Ting Zhang, Xuetao Cao, Zongping Xia and Xiaojian Wang

J Immunol March 15, 2014, 192 (6) 2846-2856; DOI: https://doi.org/10.4049/jimmunol.1302537
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Combined Inhibition of Complement and CD14 Efficiently Attenuated the Inflammatory Response Induced by Staphylococcus aureus in a Human Whole Blood Model
Espen W. Skjeflo, Dorte Christiansen, Terje Espevik, Erik W. Nielsen and Tom E. Mollnes

J Immunol March 15, 2014, 192 (6) 2857-2864; DOI: https://doi.org/10.4049/jimmunol.1300755

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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The Role of LAT–PLCγ1 Interaction in γδ T Cell Development and Homeostasis
Sarah A. Sullivan, Minghua Zhu, Steven Bao, Catherine A. Lewis, Chih-wen Ou-Yang and Weiguo Zhang

J Immunol March 15, 2014, 192 (6) 2865-2874; DOI: https://doi.org/10.4049/jimmunol.1302493
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Mutational and Structural Analysis of KIR3DL1 Reveals a Lineage-Defining Allotypic Dimorphism That Impacts Both HLA and Peptide Sensitivity
Author Choice Article

Geraldine M. O’Connor, Julian P. Vivian, Jacqueline M. Widjaja, John S. Bridgeman, Emma Gostick, Bernard A. P. Lafont, Stephen K. Anderson, David A. Price, Andrew G. Brooks, Jamie Rossjohn and Daniel W. McVicar

J Immunol March 15, 2014, 192 (6) 2875-2884; DOI: https://doi.org/10.4049/jimmunol.1303142
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TCR Scanning of Peptide/MHC through Complementary Matching of Receptor and Ligand Molecular Flexibility
William F. Hawse, Soumya De, Alex I. Greenwood, Linda K. Nicholson, Jaroslav Zajicek, Evgenii L. Kovrigin, David M. Kranz, K. Christopher Garcia and Brian M. Baker

J Immunol March 15, 2014, 192 (6) 2885-2891; DOI: https://doi.org/10.4049/jimmunol.1302953
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Regulation of MHC Class I Expression by Foxp3 and Its Effect on Regulatory T Cell Function
Jie Mu, Xuguang Tai, Shankar S. Iyer, Jocelyn D. Weissman, Alfred Singer and Dinah S. Singer

J Immunol March 15, 2014, 192 (6) 2892-2903; DOI: https://doi.org/10.4049/jimmunol.1302847

MUCOSAL IMMUNOLOGY

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Regulatory T Cells Limit Induction of Protective Immunity and Promote Immune Pathology following Intestinal Helminth Infection
Deepali V. Sawant, David M. Gravano, Peter Vogel, Paul Giacomin, David Artis and Dario A. A. Vignali

J Immunol March 15, 2014, 192 (6) 2904-2912; DOI: https://doi.org/10.4049/jimmunol.1202502

TUMOR IMMUNOLOGY

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Cutaneous T Cell Lymphoma Expresses Immunosuppressive CD80 (B7-1) Cell Surface Protein in a STAT5-Dependent Manner
Qian Zhang, Hong Yi Wang, Fang Wei, Xiaobin Liu, Jennifer C. Paterson, Darshan Roy, Daniela Mihova, Anders Woetmann, Andrzej Ptasznik, Niels Odum, Stephen J. Schuster, Teresa Marafioti, James L. Riley and Mariusz A. Wasik

J Immunol March 15, 2014, 192 (6) 2913-2919; DOI: https://doi.org/10.4049/jimmunol.1302951
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Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer
Wei Cao, Rupal Ramakrishnan, Vladimir A. Tuyrin, Filippo Veglia, Thomas Condamine, Andrew Amoscato, Dariush Mohammadyani, Joseph J. Johnson, Lan Min Zhang, Judith Klein-Seetharaman, Esteban Celis, Valerian E. Kagan and Dmitry I. Gabrilovich

J Immunol March 15, 2014, 192 (6) 2920-2931; DOI: https://doi.org/10.4049/jimmunol.1302801

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Table of Contents

IN THIS ISSUE

BRIEF REVIEWS

CUTTING EDGE

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOGENETICS

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

TUMOR IMMUNOLOGY

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