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Immune enhancing effects of fucoidan-agaricus mix under treatment of an immunosuppressive anti-cancer agent (TUM7P.939)

Yoshiyuki Miyazaki, Masaji Nakamizo, Tetsuya Shibasaki, Tomomi Kirino, Kazuhiro Kawahara, Ken Otsuka, Hirofumi Tachibana, Koji Yamada and Daisuke Tachikawa
J Immunol May 1, 2014, 192 (1 Supplement) 203.21;
Yoshiyuki Miyazaki
1NPO Research Institute of Fucoidan, Fukuoka, Japan
2Dept. of Biosci. Biotechnol., Kyushu University, Fukuoka, Japan
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Masaji Nakamizo
3Ventuno Co., LTD., Fukuoka, Japan
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Tetsuya Shibasaki
3Ventuno Co., LTD., Fukuoka, Japan
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Tomomi Kirino
3Ventuno Co., LTD., Fukuoka, Japan
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Kazuhiro Kawahara
4KAISOU-SAIENSUNOKAI. Co., LTD., Tokyo, Japan
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Ken Otsuka
5KAMERYCAH INC., Torrance, CA
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Hirofumi Tachibana
2Dept. of Biosci. Biotechnol., Kyushu University, Fukuoka, Japan
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Koji Yamada
2Dept. of Biosci. Biotechnol., Kyushu University, Fukuoka, Japan
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Daisuke Tachikawa
1NPO Research Institute of Fucoidan, Fukuoka, Japan
6Wakamiya Hospital, Oita, Japan
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Abstract

Fucoidan is a series of sulfated polysaccharides derived from brown algae that mainly consist of L-fucose. Fucoidan have various biological activities, and our investigation with experimental animal models and a healthy human trial demonstrated fucoidan from Cladosiphon okamuranus and Undaria pinnatifida effectively augmented anti-tumor immunity in combination with agaricus mycelium extract. In this context, we have reported that feeding of the fucoidan-agaricus mix (FAM) protected mice from immunosuppressive effect of 5-fluorouracil (5-FU). In current study, we confirmed dose-dependent immunoprotective effects of the dietary FAM (at 20 and 40 mg/day) by observing recovery in spleen weight, NK cell activity and IFN-γ production in 5-FU-treated mice. Furthermore, we investigated in vitro effects of FAM against 5-FU on growth and function of primary cultured immune-related cells. As the results with thioglycollate-induced peritoneal exudates cells (PEC), 5-FU dose-dependently suppressed the growth whereas FAM exerted no effects. However, production of cytokines such as IL-12p40 and TNF-α in PEC were stimulated by FAM treatment even in the presence of 5-FU. In the case of bone marrow derived cells differentiated with GM-CSF and M-CSF, FAM markedly enhanced the growth and IL-12 production of these cells. From these results, it was suggested that FAM contributed to amelioration of decline in anti-tumor immune function by 5-FU treatment through activation of innate immune cells.

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The Journal of Immunology
Vol. 192, Issue 1 Supplement
1 May 2014
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Immune enhancing effects of fucoidan-agaricus mix under treatment of an immunosuppressive anti-cancer agent (TUM7P.939)
Yoshiyuki Miyazaki, Masaji Nakamizo, Tetsuya Shibasaki, Tomomi Kirino, Kazuhiro Kawahara, Ken Otsuka, Hirofumi Tachibana, Koji Yamada, Daisuke Tachikawa
The Journal of Immunology May 1, 2014, 192 (1 Supplement) 203.21;

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Immune enhancing effects of fucoidan-agaricus mix under treatment of an immunosuppressive anti-cancer agent (TUM7P.939)
Yoshiyuki Miyazaki, Masaji Nakamizo, Tetsuya Shibasaki, Tomomi Kirino, Kazuhiro Kawahara, Ken Otsuka, Hirofumi Tachibana, Koji Yamada, Daisuke Tachikawa
The Journal of Immunology May 1, 2014, 192 (1 Supplement) 203.21;
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