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Co-expression network analysis reveals immune response pathways important for pathogenesis of Chlamydial pelvic inflammatory disease (PID). (HUM8P.329)

Xiaojing Zheng, Catherine O'Connell, Uma Nagarajan, Harold Wiesenfeld, Sharon Hillier and Toni Darville
J Immunol May 1, 2014, 192 (1 Supplement) 185.4;
Xiaojing Zheng
1Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC
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Catherine O'Connell
1Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC
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Uma Nagarajan
1Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC
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Harold Wiesenfeld
2Magee Women’s Research Institute and the University of Pittsburgh, Pittsburgh, PA
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Sharon Hillier
2Magee Women’s Research Institute and the University of Pittsburgh, Pittsburgh, PA
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Toni Darville
1Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC
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Abstract

Processes driving development of immune pathology after Chlamydia trachomatis infection are poorly understood. To provide insight into the pathways that may be underappreciated by individual gene analysis, weighted gene co-expression network analysis was performed to identify network modules using blood transcriptional profiles of women with chlamydial PID (N=15) and asymptomatically infected women (N=84). Modules, defined as centrally connected genes, that were significantly associated with chlamydial PID were further accessed via Ingenuity Pathway analysis. Type I and type II interferon (IFN) signaling pathways were significantly up regulated in women with chlamydial PID. Up regulation of both of these pathways has been detected in the transcriptomes of patients with active tuberculosis, suggesting a parallel role in PID. Up regulation of aryl hydrocarbon receptor, agranulocyte/granulocyte adhesion and diapedesis pathways was also noted, while EIF2/EIF4, mTOR and ILK signaling, granzyme A/B signaling, cross talk between dendritic cells and natural killer cells, signaling in T helper cells and T cell receptor pathways were down-regulated. Pathways likely to contribute to immunopathogenesis, including migration of leukocytes and inflammation were activated in chlamydial PID, while those involved in cell growth/proliferation and clearance of infected cells were decreased. Bioinformatics provides a new avenue to improve understanding of chlamydial disease mechanisms.

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The Journal of Immunology
Vol. 192, Issue 1 Supplement
1 May 2014
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Co-expression network analysis reveals immune response pathways important for pathogenesis of Chlamydial pelvic inflammatory disease (PID). (HUM8P.329)
Xiaojing Zheng, Catherine O'Connell, Uma Nagarajan, Harold Wiesenfeld, Sharon Hillier, Toni Darville
The Journal of Immunology May 1, 2014, 192 (1 Supplement) 185.4;

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Co-expression network analysis reveals immune response pathways important for pathogenesis of Chlamydial pelvic inflammatory disease (PID). (HUM8P.329)
Xiaojing Zheng, Catherine O'Connell, Uma Nagarajan, Harold Wiesenfeld, Sharon Hillier, Toni Darville
The Journal of Immunology May 1, 2014, 192 (1 Supplement) 185.4;
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Print ISSN 0022-1767        Online ISSN 1550-6606