The Journal of Immunology: 192 (12)

June 15, 2014; Volume 192,Issue 12

IN THIS ISSUE

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In This Issue
Tracking TCR Dependence See article p. 5490
Caspase-8’s Tolerance for Autoimmunity See article p. 5548
License To Kill See article p. 5618
A Fas End to Immune Suppression See article p. 5821
Damaging Protection See article p. 5933
Mending Mouths of Mice and Monkeys See article p. 6020

J Immunol June 15, 2014, 192 (12) 5445-5446; DOI: https://doi.org/10.4049/jimmunol.1490020

LETTERS TO THE EDITOR

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The Pro-Factor D Cleaving Activity of MASP-1/-3 Is Not Required for Alternative Pathway Function
Søren E. Degn, Jens C. Jensenius and Steffen Thiel

J Immunol June 15, 2014, 192 (12) 5447-5448; DOI: https://doi.org/10.4049/jimmunol.1400777
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Comment on “The Pro-Factor D Cleaving Activity of MASP-1/-3 Is Not Required for Alternative Pathway Function”
Minoru Takahashi, Hideharu Sekine and Teizo Fujita

J Immunol June 15, 2014, 192 (12) 5448-5449; DOI: https://doi.org/10.4049/jimmunol.1400766

TRANSLATING IMMUNOLOGY

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IL-2: The First Effective Immunotherapy for Human Cancer
Steven A. Rosenberg

J Immunol June 15, 2014, 192 (12) 5451-5458; DOI: https://doi.org/10.4049/jimmunol.1490019

BRIEF REVIEWS

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Type I Interferon in the Pathogenesis of Lupus
Mary K. Crow

J Immunol June 15, 2014, 192 (12) 5459-5468; DOI: https://doi.org/10.4049/jimmunol.1002795

CUTTING EDGE

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Cutting Edge: MMP-9 Inhibits IL-23p19 Expression in Dendritic Cells by Targeting Membrane Stem Cell Factor Affecting Lung IL-17 Response
Timothy B. Oriss, Nandini Krishnamoorthy, Mahesh Raundhal, Christina Morse, Krishnendu Chakraborty, Anupriya Khare, Rachael Huff, Prabir Ray and Anuradha Ray

J Immunol June 15, 2014, 192 (12) 5471-5475; DOI: https://doi.org/10.4049/jimmunol.1303183
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Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice
Scott B. Berger, Viera Kasparcova, Sandy Hoffman, Barb Swift, Lauren Dare, Michelle Schaeffer, Carol Capriotti, Michael Cook, Joshua Finger, Angela Hughes-Earle, Philip A. Harris, William J. Kaiser, Edward S. Mocarski, John Bertin and Peter J. Gough

J Immunol June 15, 2014, 192 (12) 5476-5480; DOI: https://doi.org/10.4049/jimmunol.1400499

ALLERGY AND OTHER HYPERSENSITIVITIES

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Carbonic Anhydrase IV Is Expressed on IL-5–Activated Murine Eosinophils
Ting Wen, Melissa K. Mingler, Benjamin Wahl, M. Eyad Khorki, Oliver Pabst, Nives Zimmermann and Marc E. Rothenberg

J Immunol June 15, 2014, 192 (12) 5481-5489; DOI: https://doi.org/10.4049/jimmunol.1302846

ANTIGEN RECOGNITION AND RESPONSES

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Antigen-Dependent versus -Independent Activation of Invariant NKT Cells during Infection
Keli L. Holzapfel, Aaron J. Tyznik, Mitchell Kronenberg and Kristin A. Hogquist

J Immunol June 15, 2014, 192 (12) 5490-5498; DOI: https://doi.org/10.4049/jimmunol.1400722
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Viral Particles Drive Rapid Differentiation of Memory B Cells into Secondary Plasma Cells Producing Increased Levels of Antibodies
Franziska Zabel, Deepa Mohanan, Juliana Bessa, Alexander Link, Antonia Fettelschoss, Philippe Saudan, Thomas M. Kündig and Martin F. Bachmann

J Immunol June 15, 2014, 192 (12) 5499-5508; DOI: https://doi.org/10.4049/jimmunol.1400065
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N^α-Terminal Acetylation for T Cell Recognition: Molecular Basis of MHC Class I–Restricted N^α-Acetylpeptide Presentation
Mingwei Sun, Jun Liu, Jianxun Qi, Boris Tefsen, Yi Shi, Jinghua Yan and George F. Gao

J Immunol June 15, 2014, 192 (12) 5509-5519; DOI: https://doi.org/10.4049/jimmunol.1400199
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HLA-B27, but Not HLA-B7, Immunodominance to Influenza Is ERAP Dependent
Ali Akram, Aifeng Lin, Eric Gracey, Catherine J. Streutker and Robert D. Inman

J Immunol June 15, 2014, 192 (12) 5520-5528; DOI: https://doi.org/10.4049/jimmunol.1400343
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GANP Regulates the Choice of DNA Repair Pathway by DNA-PKcs Interaction in AID-Dependent IgV Region Diversification
Mohammed Mansour Abbas Eid, Kazuhiko Maeda, Sarah Ameen Almofty, Shailendra Kumar Singh, Mayuko Shimoda and Nobuo Sakaguchi

J Immunol June 15, 2014, 192 (12) 5529-5539; DOI: https://doi.org/10.4049/jimmunol.1400021

AUTOIMMUNITY

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FcγRIIb on Myeloid Cells Rather than on B Cells Protects from Collagen-Induced Arthritis
A. Seda Yilmaz-Elis, Javier Martin Ramirez, Patrick Asmawidjaja, Jos van der Kaa, Anne-Marie Mus, Maarten D. Brem, Jill W. C. Claassens, Cor Breukel, Conny Brouwers, Sara M. Mangsbo, Peter Boross, Erik Lubberts and J. Sjef Verbeek

J Immunol June 15, 2014, 192 (12) 5540-5547; DOI: https://doi.org/10.4049/jimmunol.1303272
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Caspase-8 Acts as a Molecular Rheostat To Limit RIPK1- and MyD88-Mediated Dendritic Cell Activation
Carla M. Cuda, Alexander V. Misharin, Angelica K. Gierut, Rana Saber, G. Kenneth Haines III, Jack Hutcheson, Stephen M. Hedrick, Chandra Mohan, G. Scott Budinger, Christian Stehlik and Harris Perlman

J Immunol June 15, 2014, 192 (12) 5548-5560; DOI: https://doi.org/10.4049/jimmunol.1400122
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Myeloid Glycosylation Defects Lead to a Spontaneous Common Variable Immunodeficiency-like Condition with Associated Hemolytic Anemia and Antilymphocyte Autoimmunity
Sean O. Ryan, Derek W. Abbott and Brian A. Cobb

J Immunol June 15, 2014, 192 (12) 5561-5570; DOI: https://doi.org/10.4049/jimmunol.1400385
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Activation of the STING Adaptor Attenuates Experimental Autoimmune Encephalitis
Henrique Lemos, Lei Huang, Phillip R. Chandler, Eslam Mohamed, Guilherme R. Souza, Lingqian Li, Gabriela Pacholczyk, Glen N. Barber, Yoshihiro Hayakawa, David H. Munn and Andrew L. Mellor

J Immunol June 15, 2014, 192 (12) 5571-5578; DOI: https://doi.org/10.4049/jimmunol.1303258
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The Lupus Susceptibility Locus Sle1 Facilitates the Peripheral Development and Selection of Anti-DNA B Cells through Impaired Receptor Editing
Soog-Hee Chang, Tae-Joo Kim, Young-Joo Kim, Yang Liu, So-Youn Min, Min-Jung Park, Hyun-Sil Park, Sun-Kyung Lee, Ki-Hoan Nam, Ho-Youn Kim, Chandra Mohan and Hang-Rae Kim

J Immunol June 15, 2014, 192 (12) 5579-5585; DOI: https://doi.org/10.4049/jimmunol.1201558
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IFN Priming Is Necessary but Not Sufficient To Turn on a Migratory Dendritic Cell Program in Lupus Monocytes
Alicia Rodriguez-Pla, Pinakeen Patel, Holden T. Maecker, Jose Rossello-Urgell, Nicole Baldwin, Lynda Bennett, Victoria Cantrell, Jeanine Baisch, Marilynn Punaro, Alisa Gotte, Lorien Nassi, Tracey Wright, Anna Karolina Palucka, Jacques Banchereau and Virginia Pascual

J Immunol June 15, 2014, 192 (12) 5586-5598; DOI: https://doi.org/10.4049/jimmunol.1301319
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miR-20b Suppresses Th17 Differentiation and the Pathogenesis of Experimental Autoimmune Encephalomyelitis by Targeting RORγt and STAT3
Endong Zhu, Xi Wang, Bin Zheng, Qian Wang, Jianlei Hao, Siming Chen, Qiang Zhao, Liqing Zhao, Zhenzhou Wu and Zhinan Yin

J Immunol June 15, 2014, 192 (12) 5599-5609; DOI: https://doi.org/10.4049/jimmunol.1303488
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The Role of Endogenous IFN-β in the Regulation of Th17 Responses in Patients with Relapsing-Remitting Multiple Sclerosis
Yazhong Tao, Xin Zhang, Manisha Chopra, Ming-Jeong Kim, Kinnari R. Buch, Dehan Kong, Jianping Jin, Yunan Tang, Hongtu Zhu, Valerie Jewells and Silva Markovic-Plese

J Immunol June 15, 2014, 192 (12) 5610-5617; DOI: https://doi.org/10.4049/jimmunol.1302580

CLINICAL AND HUMAN IMMUNOLOGY

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KIR/HLA Interactions Negatively Affect Rituximab- but Not GA101 (Obinutuzumab)-Induced Antibody-Dependent Cellular Cytotoxicity
Grzegorz Terszowski, Christian Klein and Martin Stern

J Immunol June 15, 2014, 192 (12) 5618-5624; DOI: https://doi.org/10.4049/jimmunol.1400288
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Intravenous Immunoglobulin Treatment in Humans Suppresses Dendritic Cell Function via Stimulation of IL-4 and IL-13 Production
Angela S. W. Tjon, Rogier van Gent, Haziz Jaadar, P. Martin van Hagen, Shanta Mancham, Luc J. W. van der Laan, Peter A. W. te Boekhorst, Herold J. Metselaar and Jaap Kwekkeboom

J Immunol June 15, 2014, 192 (12) 5625-5634; DOI: https://doi.org/10.4049/jimmunol.1301260

IMMUNE REGULATION

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TLR-Induced Cytokines Promote Effective Proinflammatory Natural Th17 Cell Responses
Bérangère Massot, Marie-Laure Michel, Séverine Diem, Caspar Ohnmacht, Sylvain Latour, Michel Dy, Gérard Eberl and Maria C. Leite-de-Moraes

J Immunol June 15, 2014, 192 (12) 5635-5642; DOI: https://doi.org/10.4049/jimmunol.1302089
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Increased Peripheral IL-4 Leads to an Expanded Virtual Memory CD8⁺ Population
Vanessa Kurzweil, Ami LaRoche and Paula M. Oliver

J Immunol June 15, 2014, 192 (12) 5643-5651; DOI: https://doi.org/10.4049/jimmunol.1301755
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The Longevity of Memory CD8 T Cell Responses after Repetitive Antigen Stimulations
Deepa Rai, Matthew D. Martin and Vladimir P. Badovinac

J Immunol June 15, 2014, 192 (12) 5652-5659; DOI: https://doi.org/10.4049/jimmunol.1301063
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IL-2 Phosphorylates STAT5 To Drive IFN-γ Production and Activation of Human Dendritic Cells
Florence Herr, Roxane Lemoine, Fabrice Gouilleux, Daniel Meley, Ihab Kazma, Audrey Heraud, Florence Velge-Roussel, Christophe Baron and Yvon Lebranchu

J Immunol June 15, 2014, 192 (12) 5660-5670; DOI: https://doi.org/10.4049/jimmunol.1300422
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Cathepsins Limit Macrophage Necroptosis through Cleavage of Rip1 Kinase
Scott McComb, Bojan Shutinoski, Susan Thurston, Erin Cessford, Kriti Kumar and Subash Sad

J Immunol June 15, 2014, 192 (12) 5671-5678; DOI: https://doi.org/10.4049/jimmunol.1303380
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Deletion of CD24 Impairs Development of Heat Shock Protein gp96–Driven Autoimmune Disease through Expansion of Myeloid-Derived Suppressor Cells
Jessica E. Thaxton, Bei Liu, Pan Zheng, Yang Liu and Zihai Li

J Immunol June 15, 2014, 192 (12) 5679-5686; DOI: https://doi.org/10.4049/jimmunol.1302755
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IFN-α Suppresses GATA3 Transcription from a Distal Exon and Promotes H3K27 Trimethylation of the CNS-1 Enhancer in Human Th2 Cells
Jonathan P. Huber, Sarah R. Gonzales-van Horn, Kole T. Roybal, Michelle A. Gill and J. David Farrar

J Immunol June 15, 2014, 192 (12) 5687-5694; DOI: https://doi.org/10.4049/jimmunol.1301908
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Skin-Resident T Cells Sense Ultraviolet Radiation–Induced Injury and Contribute to DNA Repair
Amanda S. MacLeod, Ross Rudolph, Ross Corriden, Ivan Ye, Olivia Garijo and Wendy L. Havran

J Immunol June 15, 2014, 192 (12) 5695-5702; DOI: https://doi.org/10.4049/jimmunol.1303297
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KLF13 Cooperates with c-Maf To Regulate IL-4 Expression in CD4⁺ T Cells
Seok Joo Kwon, Juan Crespo-Barreto, Wei Zhang, Tianhong Wang, Dong Seok Kim, Alan Krensky and Carol Clayberger

J Immunol June 15, 2014, 192 (12) 5703-5709; DOI: https://doi.org/10.4049/jimmunol.1302830
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ATP Modulates Acute Inflammation In Vivo through Dual Oxidase 1–Derived H₂O₂ Production and NF-κB Activation
Sofia de Oliveira, Azucena López-Muñoz, Sergio Candel, Pablo Pelegrín, Ângelo Calado and Victoriano Mulero

J Immunol June 15, 2014, 192 (12) 5710-5719; DOI: https://doi.org/10.4049/jimmunol.1302902
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Protein Phosphatase 6 Controls BCR-Induced Apoptosis of WEHI-231 Cells by Regulating Ubiquitination of Bcl-xL
Ryutaro Kajihara, Hitomi Sakamoto, Kano Tanabe, Kazuki Takemoto, Masayoshi Tasaki, Yukio Ando and Seiji Inui

J Immunol June 15, 2014, 192 (12) 5720-5729; DOI: https://doi.org/10.4049/jimmunol.1302643
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Macrophages Engulfing Apoptotic Cells Produce Nonclassical Retinoids To Enhance Their Phagocytic Capacity
Zsolt Sarang, Gergely Joós, Éva Garabuczi, Ralph Rühl, Christopher D. Gregory and Zsuzsa Szondy

J Immunol June 15, 2014, 192 (12) 5730-5738; DOI: https://doi.org/10.4049/jimmunol.1400284

IMMUNE SYSTEM DEVELOPMENT

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Regulation of Embryonic Hematopoiesis by a Cytokine-Inducible SH2 Domain Homolog in Zebrafish
Rowena S. Lewis, Suzita M. Noor, Fiona W. Fraser, Robert Sertori, Clifford Liongue and Alister C. Ward

J Immunol June 15, 2014, 192 (12) 5739-5748; DOI: https://doi.org/10.4049/jimmunol.1301376
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Linkage between Dendritic and T Cell Commitments in Human Circulating Hematopoietic Progenitors
Seishi Kyoizumi, Yoshiko Kubo, Junko Kajimura, Kengo Yoshida, Tomonori Hayashi, Kei Nakachi, Lauren F. Young, Malcolm A. Moore, Marcel R. M. van den Brink and Yoichiro Kusunoki

J Immunol June 15, 2014, 192 (12) 5749-5760; DOI: https://doi.org/10.4049/jimmunol.1303260
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IL-4 Regulates Bim Expression and Promotes B Cell Maturation in Synergy with BAFF Conferring Resistance to Cell Death at Negative Selection Checkpoints
Alessandra Granato, Elize A. Hayashi, Barbara J. A. Baptista, Maria Bellio and Alberto Nobrega

J Immunol June 15, 2014, 192 (12) 5761-5775; DOI: https://doi.org/10.4049/jimmunol.1300749

IMMUNOTHERAPY AND VACCINES

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Induction and Activation of Human Th17 by Targeting Antigens to Dendritic Cells via Dectin-1
Dorothée Duluc, HyeMee Joo, Ling Ni, Wenjie Yin, Katherine Upchurch, Dapeng Li, Yaming Xue, Peter Klucar, Sandra Zurawski, Gerard Zurawski and SangKon Oh

J Immunol June 15, 2014, 192 (12) 5776-5788; DOI: https://doi.org/10.4049/jimmunol.1301661
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Targeting Antigens through Blood Dendritic Cell Antigen 2 on Plasmacytoid Dendritic Cells Promotes Immunologic Tolerance
Craig P. Chappell, Natalia V. Giltiay, Kevin E. Draves, ChangHung Chen, Martha S. Hayden-Ledbetter, Mark J. Shlomchik, Daniel H. Kaplan and Edward A. Clark

J Immunol June 15, 2014, 192 (12) 5789-5801; DOI: https://doi.org/10.4049/jimmunol.1303259
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Boosting of HIV-1 Neutralizing Antibody Responses by a Distally Related Retroviral Envelope Protein
Hannes Uchtenhagen, Torben Schiffner, Emma Bowles, Leo Heyndrickx, Celia LaBranche, Steven E. Applequist, Marianne Jansson, Thushan De Silva, Jaap Willem Back, Adnane Achour, Gabriella Scarlatti, Anders Fomsgaard, David Montefiori, Guillaume Stewart-Jones and Anna-Lena Spetz

J Immunol June 15, 2014, 192 (12) 5802-5812; DOI: https://doi.org/10.4049/jimmunol.1301898
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IgG-Mediated Anaphylaxis to a Synthetic Long Peptide Vaccine Containing a B Cell Epitope Can Be Avoided by Slow-Release Formulation
Esther D. Quakkelaar, Marieke F. Fransen, Wendy W. C. van Maren, Joost Vaneman, Nikki M. Loof, Sandra H. van Heiningen, J. Sjef Verbeek, Ferry Ossendorp and Cornelis J. M. Melief

J Immunol June 15, 2014, 192 (12) 5813-5820; DOI: https://doi.org/10.4049/jimmunol.1302337
Open Access
Regulatory T Cells and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment Undergo Fas-Dependent Cell Death during IL-2/αCD40 Therapy
Author Choice Article

Jonathan M. Weiss, Jeff J. Subleski, Tim Back, Xin Chen, Stephanie K. Watkins, Hideo Yagita, Thomas J. Sayers, William J. Murphy and Robert H. Wiltrout

J Immunol June 15, 2014, 192 (12) 5821-5829; DOI: https://doi.org/10.4049/jimmunol.1400404
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Antigen Delivery to CD11c⁺CD8⁻ Dendritic Cells Induces Protective Immune Responses against Experimental Melanoma in Mice In Vivo
Kirsten Neubert, Christian H. K. Lehmann, Lukas Heger, Anna Baranska, Anna Maria Staedtler, Veit R. Buchholz, Sayuri Yamazaki, Gordon F. Heidkamp, Nathalie Eissing, Henry Zebroski, Michel C. Nussenzweig, Falk Nimmerjahn and Diana Dudziak

J Immunol June 15, 2014, 192 (12) 5830-5838; DOI: https://doi.org/10.4049/jimmunol.1300975

INFECTIOUS DISEASE AND HOST RESPONSE

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Soluble, but Not Transmembrane, TNF-α Is Required during Influenza Infection To Limit the Magnitude of Immune Responses and the Extent of Immunopathology
Matthew P. DeBerge, Kenneth H. Ely and Richard I. Enelow

J Immunol June 15, 2014, 192 (12) 5839-5851; DOI: https://doi.org/10.4049/jimmunol.1302729
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Exosomes Derived from Burkitt’s Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells
Cindy Gutzeit, Noemi Nagy, Maurizio Gentile, Katarina Lyberg, Janine Gumz, Helen Vallhov, Irene Puga, Eva Klein, Susanne Gabrielsson, Andrea Cerutti and Annika Scheynius

J Immunol June 15, 2014, 192 (12) 5852-5862; DOI: https://doi.org/10.4049/jimmunol.1302068
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Human Dendritic Cells Exhibit a Pronounced Type I IFN Signature following Leishmania major Infection That Is Required for IL-12 Induction
Michelle A. Favila, Nicholas S. Geraci, Erliang Zeng, Brent Harker, David Condon, Rachel N. Cotton, Asha Jayakumar, Vinita Tripathi and Mary Ann McDowell

J Immunol June 15, 2014, 192 (12) 5863-5872; DOI: https://doi.org/10.4049/jimmunol.1203230
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Class II MHC/Peptide Interaction in Leishmania donovani Infection: Implications in Vaccine Design
Koushik Roy, Kshudiram Naskar, Moumita Ghosh and Syamal Roy

J Immunol June 15, 2014, 192 (12) 5873-5880; DOI: https://doi.org/10.4049/jimmunol.1302970
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Graded Levels of IRF4 Regulate CD8⁺ T Cell Differentiation and Expansion, but Not Attrition, in Response to Acute Virus Infection
Ribhu Nayar, Elizabeth Schutten, Bianca Bautista, Keith Daniels, Amanda L. Prince, Megan Enos, Michael A. Brehm, Susan L. Swain, Raymond M. Welsh and Leslie J. Berg

J Immunol June 15, 2014, 192 (12) 5881-5893; DOI: https://doi.org/10.4049/jimmunol.1303187
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CD8 T Cell–Evasive Functions of Human Cytomegalovirus Display Pervasive MHC Allele Specificity, Complementarity, and Cooperativity
Stefanie Ameres, Katrin Besold, Bodo Plachter and Andreas Moosmann

J Immunol June 15, 2014, 192 (12) 5894-5905; DOI: https://doi.org/10.4049/jimmunol.1302281
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Lymphopenia Associated with Highly Virulent H5N1 Virus Infection Due to Plasmacytoid Dendritic Cell–Mediated Apoptosis of T Cells
Kobporn Boonnak, Leatrice Vogel, Friederike Feldmann, Heinz Feldmann, Kevin L. Legge and Kanta Subbarao

J Immunol June 15, 2014, 192 (12) 5906-5912; DOI: https://doi.org/10.4049/jimmunol.1302992

INNATE IMMUNITY AND INFLAMMATION

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Identification of a Haemophilus influenzae Factor H–Binding Lipoprotein Involved in Serum Resistance
Christophe Fleury, Yu-Ching Su, Teresia Hallström, Linda Sandblad, Peter F. Zipfel and Kristian Riesbeck

J Immunol June 15, 2014, 192 (12) 5913-5923; DOI: https://doi.org/10.4049/jimmunol.1303449
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The IL18RAP Region Disease Polymorphism Decreases IL-18RAP/IL-18R1/IL-1R1 Expression and Signaling through Innate Receptor–Initiated Pathways
Matija Hedl, Shasha Zheng and Clara Abraham

J Immunol June 15, 2014, 192 (12) 5924-5932; DOI: https://doi.org/10.4049/jimmunol.1302727
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Simian Virus 40 Large T Antigen Induces IFN-Stimulated Genes through ATR Kinase
Adriana Forero, Nicholas S. Giacobbi, Kevin D. McCormick, Ole V. Gjoerup, Christopher J. Bakkenist, James M. Pipas and Saumendra N. Sarkar

J Immunol June 15, 2014, 192 (12) 5933-5942; DOI: https://doi.org/10.4049/jimmunol.1303470
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Spectrum and Mechanisms of Inflammasome Activation by Chitosan
Chelsea L. Bueter, Chrono K. Lee, Jennifer P. Wang, Gary R. Ostroff, Charles A. Specht and Stuart M. Levitz

J Immunol June 15, 2014, 192 (12) 5943-5951; DOI: https://doi.org/10.4049/jimmunol.1301695
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Dectin-1 Pathway Activates Robust Autophagy-Dependent Unconventional Protein Secretion in Human Macrophages
Tiina Öhman, Laura Teirilä, Anna-Maria Lahesmaa-Korpinen, Wojciech Cypryk, Ville Veckman, Shinobu Saijo, Henrik Wolff, Sampsa Hautaniemi, Tuula A. Nyman and Sampsa Matikainen

J Immunol June 15, 2014, 192 (12) 5952-5962; DOI: https://doi.org/10.4049/jimmunol.1303213
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RNA and Imidazoquinolines Are Sensed by Distinct TLR7/8 Ectodomain Sites Resulting in Functionally Disparate Signaling Events
Elif Colak, Alasdair Leslie, Kieran Zausmer, Elham Khatamzas, Andriy V. Kubarenko, Tica Pichulik, Sascha N. Klimosch, Alice Mayer, Owen Siggs, Andreas Hector, Roman Fischer, Benedikt Klesser, Anna Rautanen, Martin Frank, Adrian V. S. Hill, Bénédicte Manoury, Bruce Beutler, Dominik Hartl, Alison Simmons and Alexander N. R. Weber

J Immunol June 15, 2014, 192 (12) 5963-5973; DOI: https://doi.org/10.4049/jimmunol.1303058
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Critical Role for the NLRP3 Inflammasome during Acute Lung Injury
Jamison J. Grailer, Bethany A. Canning, Miriam Kalbitz, Mikel D. Haggadone, Rasika M. Dhond, Anuska V. Andjelkovic, Firas S. Zetoune and Peter A. Ward

J Immunol June 15, 2014, 192 (12) 5974-5983; DOI: https://doi.org/10.4049/jimmunol.1400368
Open Access
CD36-Mediated Hematoma Absorption following Intracerebral Hemorrhage: Negative Regulation by TLR4 Signaling
Author Choice Article

Huang Fang, Jing Chen, Sen Lin, PengFei Wang, YanChun Wang, XiaoYi Xiong and QingWu Yang

J Immunol June 15, 2014, 192 (12) 5984-5992; DOI: https://doi.org/10.4049/jimmunol.1400054
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TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner
Andrea Ablasser, Inga Hemmerling, Jonathan L. Schmid-Burgk, Rayk Behrendt, Axel Roers and Veit Hornung

J Immunol June 15, 2014, 192 (12) 5993-5997; DOI: https://doi.org/10.4049/jimmunol.1400737
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Il-1β and Reactive Oxygen Species Differentially Regulate Neutrophil Directional Migration and Basal Random Motility in a Zebrafish Injury–Induced Inflammation Model
Bo Yan, Peidong Han, Lifeng Pan, Wei Lu, Jingwei Xiong, Mingjie Zhang, Wenqing Zhang, Li Li and Zilong Wen

J Immunol June 15, 2014, 192 (12) 5998-6008; DOI: https://doi.org/10.4049/jimmunol.1301645
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mTOR Signaling Inhibition Modulates Macrophage/Microglia-Mediated Neuroinflammation and Secondary Injury via Regulatory T Cells after Focal Ischemia
Luokun Xie, Fen Sun, Jixian Wang, XiaoOu Mao, Lin Xie, Shao-Hua Yang, Dong-Ming Su, James W. Simpkins, David A. Greenberg and Kunlin Jin

J Immunol June 15, 2014, 192 (12) 6009-6019; DOI: https://doi.org/10.4049/jimmunol.1303492
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Genetic and Intervention Studies Implicating Complement C3 as a Major Target for the Treatment of Periodontitis
Tomoki Maekawa, Toshiharu Abe, Evlambia Hajishengallis, Kavita B. Hosur, Robert A. DeAngelis, Daniel Ricklin, John D. Lambris and George Hajishengallis

J Immunol June 15, 2014, 192 (12) 6020-6027; DOI: https://doi.org/10.4049/jimmunol.1400569
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Free IL-12p40 Monomer Is a Polyfunctional Adaptor for Generating Novel IL-12–like Heterodimers Extracellularly
Kaveh Abdi, Nevil J. Singh, Eric Spooner, Benedikt M. Kessler, Sergei Radaev, Larry Lantz, Tsan Sam Xiao, Polly Matzinger, Peter D. Sun and Hidde L. Ploegh

J Immunol June 15, 2014, 192 (12) 6028-6036; DOI: https://doi.org/10.4049/jimmunol.1400159
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Vitamin D Receptor and Jak–STAT Signaling Crosstalk Results in Calcitriol-Mediated Increase of Hepatocellular Response to IFN-α
Christian M. Lange, Jérôme Gouttenoire, François H. T. Duong, Kenichi Morikawa, Markus H. Heim and Darius Moradpour

J Immunol June 15, 2014, 192 (12) 6037-6044; DOI: https://doi.org/10.4049/jimmunol.1302296
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ARF6 Inhibition Stabilizes the Vasculature and Enhances Survival during Endotoxic Shock
Chadwick T. Davis, Weiquan Zhu, Christopher C. Gibson, Jay A. Bowman-Kirigin, Lise Sorensen, Jing Ling, Huiming Sun, Sutip Navankasattusas and Dean Y. Li

J Immunol June 15, 2014, 192 (12) 6045-6052; DOI: https://doi.org/10.4049/jimmunol.1400309
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IL-36 Promotes Myeloid Cell Infiltration, Activation, and Inflammatory Activity in Skin
Alexander M. Foster, Jaymie Baliwag, Cynthia S. Chen, Andrew M. Guzman, Stefan W. Stoll, Johann E. Gudjonsson, Nicole L. Ward and Andrew Johnston

J Immunol June 15, 2014, 192 (12) 6053-6061; DOI: https://doi.org/10.4049/jimmunol.1301481

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Essential Role of Elmo1 in Dock2-Dependent Lymphocyte Migration
Catherine Stevenson, Gonzalo de la Rosa, Christopher S. Anderson, Patrick S. Murphy, Tara Capece, Minsoo Kim and Michael R. Elliott

J Immunol June 15, 2014, 192 (12) 6062-6070; DOI: https://doi.org/10.4049/jimmunol.1303348
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Effect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR–MHC Contacts and Ligand Specificity
Brian D. Stadinski, Peter Trenh, Brian Duke, Priya G. Huseby, Guoqi Li, Lawrence J. Stern and Eric S. Huseby

J Immunol June 15, 2014, 192 (12) 6071-6082; DOI: https://doi.org/10.4049/jimmunol.1303209

MUCOSAL IMMUNOLOGY

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Plasma Cells in the Mucosa of Patients with Inflammatory Bowel Disease Produce Granzyme B and Possess Cytotoxic Activities
Maria Laura Cupi, Massimiliano Sarra, Irene Marafini, Ivan Monteleone, Eleonora Franzè, Angela Ortenzi, Alfredo Colantoni, Giuseppe Sica, Pierpaolo Sileri, M. Manuela Rosado, Rita Carsetti, Thomas T. MacDonald, Francesco Pallone and Giovanni Monteleone

J Immunol June 15, 2014, 192 (12) 6083-6091; DOI: https://doi.org/10.4049/jimmunol.1302238

TRANSPLANTATION

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Preemptive Donor Apoptotic Cell Infusions Induce IFN-γ–Producing Myeloid-Derived Suppressor Cells for Cardiac Allograft Protection
Jane Bryant, Nadine M. Lerret, Jiao-jing Wang, Hee-Kap Kang, James Tasch, Zheng Zhang and Xunrong Luo

J Immunol June 15, 2014, 192 (12) 6092-6101; DOI: https://doi.org/10.4049/jimmunol.1302771

TUMOR IMMUNOLOGY

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S100A4 and Uric Acid Promote Mesenchymal Stromal Cell Induction of IL-10⁺/IDO⁺ Lymphocytes
Judith Luiza Eisenbacher, Hubert Schrezenmeier, Bernd Jahrsdörfer, Christof Kaltenmeier, Markus Thomas Rojewski, Tatjana Yildiz, Thamara Beyer, Alexander Erle, Denis Sebastian Wiegmann, Stefan Grassl, Regina Hang, Sixten Körper, Markus Wiesneth, Michael T. Lotze and Ramin Lotfi

J Immunol June 15, 2014, 192 (12) 6102-6110; DOI: https://doi.org/10.4049/jimmunol.1303144
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Novel Role for Tumor-Induced Expansion of Myeloid-Derived Cells in Cancer Cachexia
Alex G. Cuenca, Angela L. Cuenca, Robert D. Winfield, Dallas N. Joiner, Lori Gentile, Matthew J. Delano, Kindra M. Kelly-Scumpia, Philip O. Scumpia, Michael K. Matheny, Philip J. Scarpace, Lizette Vila, Philip A. Efron, Drake M. LaFace and Lyle L. Moldawer

J Immunol June 15, 2014, 192 (12) 6111-6119; DOI: https://doi.org/10.4049/jimmunol.1302895

NOVEL IMMUNOLOGICAL METHODS

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Chemokines as Novel and Versatile Reagents for Flow Cytometry and Cell Sorting
Michelle L. Le Brocq, Alasdair R. Fraser, Graham Cotton, Kerry Woznica, Clare V. McCulloch, Kay D. Hewit, Clive S. McKimmie, Robert J. B. Nibbs, John D. M. Campbell and Gerard J. Graham

J Immunol June 15, 2014, 192 (12) 6120-6130; DOI: https://doi.org/10.4049/jimmunol.1303371

CORRECTIONS

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Correction: Naive Idiotype-Specific B and T Cells Collaborate Efficiently in the Absence of Dendritic Cells
J Immunol June 15, 2014, 192 (12) 6131; DOI: https://doi.org/10.4049/jimmunol.1490021

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Table of Contents

IN THIS ISSUE

LETTERS TO THE EDITOR

TRANSLATING IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

TRANSPLANTATION

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

CORRECTIONS

This Issue

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