About the Cover
Cover image

On the cover: B cell–intrinsic TLR7 and TLR9 exert opposing impacts on immune complex glomerulonephritis. Image shows kidney section stained with Jones' methenamine silver, demonstrating absent glomerulonephritis in chimeric model of B cell tlr7 and Wiskott–Aldrich syndrome protein deletion. In contrast, was−/−.tlr9−/− B cell chimeras exhibit marked mesangial expansion and glomerular hypercellularity. Jackson, S. W., N. E. Scharping, N. S. Kolhatkar, S. Khim, M. A. Schwartz, Q.-Z. Li, K. L. Hudkins, C. E. Alpers, D. Liggitt, and D. J. Rawlings. 2014. Opposing impact of B cell–intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. J. Immunol. 192: 4525–4532.