On the cover: CD4 T cells (red) targeting amyloid-β (Aβ) plaques (blue) in the brain of a mouse model of Alzheimer's disease. Aβ-reactive Th1 CD4 T cells were injected into the lateral ventricle of the brain and are shown within the brain parenchyma colocalized with MHCII-expressing cells (green) at sites of Aβ plaques. Fisher, Y., I. Strominger, S. Biton, A. Nemirovsky, R. Baron, and A. Monsonego. 2014. Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance. J. Immunol. 192: 92–102.