The Journal of Immunology: 191 (9)

November 1, 2013; Volume 191,Issue 9

IN THIS ISSUE

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In This Issue
Minding the GAP in Asthma See article p. 4514
Tumor Regression Sans Side Effects? See article p. 4589
TNF-α Fazes Circadian Gene Timing See article p. 4656
TLR4 Takes on Toxins See article p. 4748
Tolling Toxoplasma See article p. 4818

J Immunol November 1, 2013, 191 (9) 4469-4470; DOI: https://doi.org/10.4049/jimmunol.1390054

LETTERS TO THE EDITOR

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Comment on “Multiplex B Cell Characterization in Blood, Lymph Nodes, and Tumors from Patients with Malignancies”
Alexander Shimabukuro-Vornhagen, Hans Anton Schlößer, Dirk Ludger Stippel, Sebastian Theurich and Michael von Bergwelt-Baildon

J Immunol November 1, 2013, 191 (9) 4471; DOI: https://doi.org/10.4049/jimmunol.1390052
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Response to Comment on “Multiplex B Cell Characterization in Blood, Lymph Nodes, and Tumors from Patients with Malignancies”
Per Marits, Ali A. Zirakzadeh, Amir Sherif and Ola Winqvist

J Immunol November 1, 2013, 191 (9) 4471-4472; DOI: https://doi.org/10.4049/jimmunol.1390053

PILLARS OF IMMUNOLOGY

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Pattern Recognition Theory and the Launch of Modern Innate Immunity
Ruslan Medzhitov

J Immunol November 1, 2013, 191 (9) 4473-4474; DOI: https://doi.org/10.4049/jimmunol.1302427
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Pillars Article: Approaching the Asymptote? Evolution and Revolution in Immunology. Cold Spring Harb Symp Quant Biol. 1989. 54: 1–13
Charles A. Janeway Jr.

J Immunol November 1, 2013, 191 (9) 4475-4487;

BRIEF REVIEWS

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Taming the Beast within: Regulation of Innate Lymphoid Cell Homeostasis and Function
Wei Xu and James P. Di Santo

J Immunol November 1, 2013, 191 (9) 4489-4496; DOI: https://doi.org/10.4049/jimmunol.1301759

CUTTING EDGE

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Cutting Edge: CD1a Tetramers and Dextramers Identify Human Lipopeptide–Specific T Cells Ex Vivo
Anne G. Kasmar, Ildiko Van Rhijn, Kelly G. Magalhaes, David C. Young, Tan-Yun Cheng, Marie T. Turner, Andre Schiefner, Ravi C. Kalathur, Ian A. Wilson, Mugdha Bhati, Stephanie Gras, Richard W. Birkinshaw, Li L. Tan, Jamie Rossjohn, John Shires, Søren Jakobsen, John D. Altman and D. Branch Moody

J Immunol November 1, 2013, 191 (9) 4499-4503; DOI: https://doi.org/10.4049/jimmunol.1301660

ALLERGY AND OTHER HYPERSENSITIVITIES

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Genotype-Dependent Effects of TGF-β1 on Mast Cell Function: Targeting the Stat5 Pathway
Josephine Fernando, Travis W. Faber, Nicholas A. Pullen, Yves T. Falanga, Elizabeth Motunrayo Kolawole, Carole A. Oskeritzian, Brian O. Barnstein, Geethani Bandara, Geqiang Li, Lawrence B. Schwartz, Sarah Spiegel, David B. Straus, Daniel H. Conrad, Kevin D. Bunting and John J. Ryan

J Immunol November 1, 2013, 191 (9) 4505-4513; DOI: https://doi.org/10.4049/jimmunol.1202723
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Abr, a Negative Regulator of Rac, Attenuates Cockroach Allergen–Induced Asthma in a Mouse Model
Dapeng Gong, Fei Fei, Min Lim, Min Yu, John Groffen and Nora Heisterkamp

J Immunol November 1, 2013, 191 (9) 4514-4520; DOI: https://doi.org/10.4049/jimmunol.1202603

ANTIGEN RECOGNITION AND RESPONSES

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AID-Expressing Germinal Center B Cells Cluster Normally within Lymph Node Follicles in the Absence of FDC-M1⁺ CD35⁺ Follicular Dendritic Cells but Dissipate Prematurely
Bryant Boulianne, Michael X. Le, Lesley A. Ward, Lingjin Meng, Dania Haddad, Conglei Li, Alberto Martin and Jennifer L. Gommerman

J Immunol November 1, 2013, 191 (9) 4521-4530; DOI: https://doi.org/10.4049/jimmunol.1300769

AUTOIMMUNITY

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Neutrophils Amplify Autoimmune Central Nervous System Infiltrates by Maturing Local APCs
Karin Steinbach, Melanie Piedavent, Simone Bauer, Johannes T. Neumann and Manuel A. Friese

J Immunol November 1, 2013, 191 (9) 4531-4539; DOI: https://doi.org/10.4049/jimmunol.1202613
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Selective Inhibition of BTK Prevents Murine Lupus and Antibody-Mediated Glomerulonephritis
Andrew L. Rankin, Nilufer Seth, Sean Keegan, Tatyana Andreyeva, Tim A. Cook, Jason Edmonds, Nagappan Mathialagan, Micah J. Benson, Jameel Syed, Yutian Zhan, Stephen E. Benoit, Joy S. Miyashiro, Nancy Wood, Shashi Mohan, Elena Peeva, Shashi K. Ramaiah, Dean Messing, Bruce L. Homer, Kyri Dunussi-Joannopoulos, Cheryl L. Nickerson-Nutter, Mark E. Schnute and John Douhan III

J Immunol November 1, 2013, 191 (9) 4540-4550; DOI: https://doi.org/10.4049/jimmunol.1301553
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Syndecan-1, a Cell Surface Proteoglycan, Negatively Regulates Initial Leukocyte Recruitment to the Brain across the Choroid Plexus in Murine Experimental Autoimmune Encephalomyelitis
Xueli Zhang, Chuan Wu, Jian Song, Martin Götte and Lydia Sorokin

J Immunol November 1, 2013, 191 (9) 4551-4561; DOI: https://doi.org/10.4049/jimmunol.1300931
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TIM-4 Has Dual Function in the Induction and Effector Phases of Murine Arthritis
Yoshiyuki Abe, Fumitaka Kamachi, Toshio Kawamoto, Fumihiko Makino, Jun Ito, Yuko Kojima, Alaa El Din Hussein Moustapha, Yoshihiko Usui, Hideo Yagita, Yoshinari Takasaki, Ko Okumura and Hisaya Akiba

J Immunol November 1, 2013, 191 (9) 4562-4572; DOI: https://doi.org/10.4049/jimmunol.1203035
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Interruption of the OX40–OX40 Ligand Pathway in LDL Receptor–Deficient Mice Causes Regression of Atherosclerosis
Amanda C. Foks, Gijs H. M. van Puijvelde, Ilze Bot, Mariette N. D. ter Borg, Kim L. L. Habets, Jason L. Johnson, Hideo Yagita, Theo J. C. van Berkel and Johan Kuiper

J Immunol November 1, 2013, 191 (9) 4573-4580; DOI: https://doi.org/10.4049/jimmunol.1200708
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IL-21 Is a Double-Edged Sword in the Systemic Lupus Erythematosus–like Disease of BXSB.Yaa Mice
Caroline G. McPhee, Jason A. Bubier, Thomas J. Sproule, Giljun Park, Martin P. Steinbuck, William H. Schott, Gregory J. Christianson, Herbert C. Morse III and Derry C. Roopenian

J Immunol November 1, 2013, 191 (9) 4581-4588; DOI: https://doi.org/10.4049/jimmunol.1300439

CLINICAL AND HUMAN IMMUNOLOGY

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Preclinical In Vivo Modeling of Cytokine Release Syndrome Induced by ErbB-Retargeted Human T Cells: Identifying a Window of Therapeutic Opportunity?
Sjoukje J. C. van der Stegen, David M. Davies, Scott Wilkie, Julie Foster, Jane K. Sosabowski, Jerome Burnet, Lynsey M. Whilding, Roseanna M. Petrovic, Sadaf Ghaem-Maghami, Stephen Mather, Jean-Pierre Jeannon, Ana C. Parente-Pereira and John Maher

J Immunol November 1, 2013, 191 (9) 4589-4598; DOI: https://doi.org/10.4049/jimmunol.1301523
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A Monovalent Anti-Human CD28 Domain Antibody Antagonist: Preclinical Efficacy and Safety
Suzanne J. Suchard, Patricia M. Davis, Selena Kansal, Dawn K. Stetsko, Ruth Brosius, James Tamura, Lumelle Schneeweis, James Bryson, Theodora Salcedo, Haiqing Wang, Zheng Yang, Catherine A. Fleener, Olga Ignatovich, Christopher Plummer, Steven Grant and Steven G. Nadler

J Immunol November 1, 2013, 191 (9) 4599-4610; DOI: https://doi.org/10.4049/jimmunol.1300470
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Human CD4⁺CD3⁻ Innate-Like T Cells Provide a Source of TNF and Lymphotoxin-αβ and Are Elevated in Rheumatoid Arthritis
Vasileios Bekiaris, John R. Šedý, Maura Rossetti, Roberto Spreafico, Shilpi Sharma, Antje Rhode-Kurnow, Brian C. Ware, Nini Huang, Matthew G. Macauley, Paula S. Norris, Salvatore Albani and Carl F. Ware

J Immunol November 1, 2013, 191 (9) 4611-4618; DOI: https://doi.org/10.4049/jimmunol.1301672

IMMUNE REGULATION

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Human Memory Helios⁻ FOXP3⁺ Regulatory T Cells (Tregs) Encompass Induced Tregs That Express Aiolos and Respond to IL-1β by Downregulating Their Suppressor Functions
Caroline Raffin, Pascale Pignon, Clotilde Celse, Emilie Debien, Danila Valmori and Maha Ayyoub

J Immunol November 1, 2013, 191 (9) 4619-4627; DOI: https://doi.org/10.4049/jimmunol.1301378
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Estrogen Signaling through the G Protein–Coupled Estrogen Receptor Regulates Granulocyte Activation in Fish
Isabel Cabas, M. Carmen Rodenas, Emilia Abellán, José Meseguer, Victoriano Mulero and Alfonsa García-Ayala

J Immunol November 1, 2013, 191 (9) 4628-4639; DOI: https://doi.org/10.4049/jimmunol.1301613
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Inhibition of NF-κB by Opioids in T Cells
Christine Börner and Jürgen Kraus

J Immunol November 1, 2013, 191 (9) 4640-4647; DOI: https://doi.org/10.4049/jimmunol.1300320
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Increased Mammalian Target of Rapamycin Complex 2 Signaling Promotes Age-Related Decline in CD4 T Cell Signaling and Function
Eric Perkey, Diane Fingar, Richard A. Miller and Gonzalo G. Garcia

J Immunol November 1, 2013, 191 (9) 4648-4655; DOI: https://doi.org/10.4049/jimmunol.1300750
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Suprachiasmatic Astrocytes Modulate the Circadian Clock in Response to TNF-α
José M. Duhart, María Juliana Leone, Natalia Paladino, Jennifer A. Evans, Oscar Castanon-Cervantes, Alec J. Davidson and Diego A. Golombek

J Immunol November 1, 2013, 191 (9) 4656-4664; DOI: https://doi.org/10.4049/jimmunol.1300450

IMMUNE SYSTEM DEVELOPMENT

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Identification of a Tissue-Specific, C/EBPβ-Dependent Pathway of Differentiation for Murine Peritoneal Macrophages
Derek W. Cain, Emily G. O’Koren, Matthew J. Kan, Mandy Womble, Gregory D. Sempowski, Kristen Hopper, Michael D. Gunn and Garnett Kelsoe

J Immunol November 1, 2013, 191 (9) 4665-4675; DOI: https://doi.org/10.4049/jimmunol.1300581
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Ebf1 and c-Myb Repress Rag Transcription Downstream of Stat5 during Early B Cell Development
Greg A. Timblin and Mark S. Schlissel

J Immunol November 1, 2013, 191 (9) 4676-4687; DOI: https://doi.org/10.4049/jimmunol.1301675
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The Host Environment Is Responsible for Aging-Related Functional NK Cell Deficiency
Bo-Chin Chiu, Brian E. Martin, Valerie R. Stolberg and Stephen W. Chensue

J Immunol November 1, 2013, 191 (9) 4688-4698; DOI: https://doi.org/10.4049/jimmunol.1301625

INFECTIOUS DISEASE AND HOST RESPONSE

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The Transcription Factor T-bet Regulates Parasitemia and Promotes Pathogenesis during Plasmodium berghei ANKA Murine Malaria
Miranda S. Oakley, Bikash R. Sahu, Leda Lotspeich-Cole, Nehal R. Solanki, Victoria Majam, Phuong Thao Pham, Rajdeep Banerjee, Yukiko Kozakai, Steven C. Derrick, Sanjai Kumar and Sheldon L. Morris

J Immunol November 1, 2013, 191 (9) 4699-4708; DOI: https://doi.org/10.4049/jimmunol.1300396
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Multiparametric Analysis of Host Response to Murine Cytomegalovirus in MHC Class I–Disparate Mice Reveals Primacy of D^k-Licensed Ly49G₂⁺ NK Cells in Viral Control
Jessica Prince, Alyssa Lundgren, Michael D. Stadnisky, William T. Nash, Amira Beeber, Stephen D. Turner and Michael G. Brown

J Immunol November 1, 2013, 191 (9) 4709-4719; DOI: https://doi.org/10.4049/jimmunol.1301388
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Selective Ablation of Lung Epithelial IKK2 Impairs Pulmonary Th17 Responses and Delays the Clearance of Pneumocystis
Nelissa Perez-Nazario, Javier Rangel-Moreno, Michael A. O’Reilly, Manolis Pasparakis, Francis Gigliotti and Terry W. Wright

J Immunol November 1, 2013, 191 (9) 4720-4730; DOI: https://doi.org/10.4049/jimmunol.1301679
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Acute Plasmodium chabaudi Infection Dampens Humoral Responses to a Secondary T-Dependent Antigen but Enhances Responses to a Secondary T-Independent Antigen
Joel R. Wilmore, Alexander C. Maue, Julie S. Lefebvre, Laura Haynes and Rosemary Rochford

J Immunol November 1, 2013, 191 (9) 4731-4739; DOI: https://doi.org/10.4049/jimmunol.1301450
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The MyD88 Pathway in Plasmacytoid and CD4⁺ Dendritic Cells Primarily Triggers Type I IFN Production against Measles Virus in a Mouse Infection Model
Hiromi Takaki, Makoto Takeda, Maino Tahara, Masashi Shingai, Hiroyuki Oshiumi, Misako Matsumoto and Tsukasa Seya

J Immunol November 1, 2013, 191 (9) 4740-4747; DOI: https://doi.org/10.4049/jimmunol.1301744
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Identification of TLR4 as the Receptor That Recognizes Shiga Toxins in Human Neutrophils
Maurizio Brigotti, Domenica Carnicelli, Valentina Arfilli, Nicola Tamassia, Francesca Borsetti, Elena Fabbri, Pier Luigi Tazzari, Francesca Ricci, Pasqualepaolo Pagliaro, Enzo Spisni and Marco A. Cassatella

J Immunol November 1, 2013, 191 (9) 4748-4758; DOI: https://doi.org/10.4049/jimmunol.1300122
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TLR2-Induced IL-10 Production Impairs Neutrophil Recruitment to Infected Tissues during Neonatal Bacterial Sepsis
Elva B. Andrade, Joana Alves, Pedro Madureira, Liliana Oliveira, Adília Ribeiro, Anabela Cordeiro-da-Silva, Margarida Correia-Neves, Patrick Trieu-Cuot and Paula Ferreira

J Immunol November 1, 2013, 191 (9) 4759-4768; DOI: https://doi.org/10.4049/jimmunol.1301752

INNATE IMMUNITY AND INFLAMMATION

Open Access
Chimeric Anti-CD14 IGG2/4 Hybrid Antibodies for Therapeutic Intervention in Pig and Human Models of Inflammation
Author Choice Article

Corinna Lau, Kristin S. Gunnarsen, Lene S. Høydahl, Jan Terje Andersen, Gøril Berntzen, Anne Pharo, Julie K. Lindstad, Judith K. Ludviksen, Ole-Lars Brekke, Andreas Barratt-Due, Erik Waage Nielsen, Christopher R. Stokes, Terje Espevik, Inger Sandlie and Tom Eirik Mollnes

J Immunol November 1, 2013, 191 (9) 4769-4777; DOI: https://doi.org/10.4049/jimmunol.1301653
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Large Spectrum of HLA-C Recognition by Killer Ig–like Receptor (KIR)2DL2 and KIR2DL3 and Restricted C1 Specificity of KIR2DS2: Dominant Impact of KIR2DL2/KIR2DS2 on KIR2D NK Cell Repertoire Formation
Gaëlle David, Zakia Djaoud, Catherine Willem, Nolwenn Legrand, Pauline Rettman, Katia Gagne, Anne Cesbron and Christelle Retière

J Immunol November 1, 2013, 191 (9) 4778-4788; DOI: https://doi.org/10.4049/jimmunol.1301580
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Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells
Christina Antonopoulos, Caroline El Sanadi, William J. Kaiser, Edward S. Mocarski and George R. Dubyak

J Immunol November 1, 2013, 191 (9) 4789-4803; DOI: https://doi.org/10.4049/jimmunol.1300645
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α3/4 Fucosyltransferase 3–Dependent Synthesis of Sialyl Lewis A on CD44 Variant Containing Exon 6 Mediates Polymorphonuclear Leukocyte Detachment from Intestinal Epithelium during Transepithelial Migration
Jennifer C. Brazil, Renpeng Liu, Ronen Sumagin, Keli N. Kolegraff, Asma Nusrat, Richard D. Cummings, Charles A. Parkos and Nancy A. Louis

J Immunol November 1, 2013, 191 (9) 4804-4817; DOI: https://doi.org/10.4049/jimmunol.1301307
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Cooperation of TLR12 and TLR11 in the IRF8-Dependent IL-12 Response to Toxoplasma gondii Profilin
Megan Raetz, Alexey Kibardin, Carolyn R. Sturge, Reed Pifer, Haiying Li, Ezra Burstein, Keiko Ozato, Sergey Larin and Felix Yarovinsky

J Immunol November 1, 2013, 191 (9) 4818-4827; DOI: https://doi.org/10.4049/jimmunol.1301301
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Neuraminidase Reprograms Lung Tissue and Potentiates Lipopolysaccharide-Induced Acute Lung Injury in Mice
Chiguang Feng, Lei Zhang, Chinh Nguyen, Stefanie N. Vogel, Simeon E. Goldblum, William C. Blackwelder and Alan S. Cross

J Immunol November 1, 2013, 191 (9) 4828-4837; DOI: https://doi.org/10.4049/jimmunol.1202673
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IL-1 Induces Proinflammatory Leukocyte Infiltration and Regulates Fibroblast Phenotype in the Infarcted Myocardium
Amit Saxena, Wei Chen, Ya Su, Vikrant Rai, Olisambu U. Uche, Na Li and Nikolaos G. Frangogiannis

J Immunol November 1, 2013, 191 (9) 4838-4848; DOI: https://doi.org/10.4049/jimmunol.1300725
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Enhanced Atherosclerosis in TIPE2-Deficient Mice Is Associated with Increased Macrophage Responses to Oxidized Low-Density Lipoprotein
Yunwei Lou, Suxia Liu, Cheng Zhang, Guizhong Zhang, Jingjing Li, Mei Ni, Guipeng An, Mei Dong, Xiaoling Liu, Faliang Zhu, Wenqian Zhang, Fei Gao, Youhai H. Chen and Yun Zhang

J Immunol November 1, 2013, 191 (9) 4849-4857; DOI: https://doi.org/10.4049/jimmunol.1300053
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Characterization of Human Afferent Lymph Dendritic Cells from Seroma Fluids
Barbara Morandi, Irene Bonaccorsi, Mario Mesiti, Romana Conte, Paolo Carrega, Gregorio Costa, Raffaella Iemmo, Stefania Martini, Soldano Ferrone, Claudia Cantoni, Maria Cristina Mingari, Lorenzo Moretta and Guido Ferlazzo

J Immunol November 1, 2013, 191 (9) 4858-4866; DOI: https://doi.org/10.4049/jimmunol.1300760

MUCOSAL IMMUNOLOGY

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Evidence for a Functional Thymic Stromal Lymphopoietin Signaling Axis in Fibrotic Lung Disease
Arnab Datta, Robert Alexander, Michal G. Sulikowski, Andrew G. Nicholson, Toby M. Maher, Chris J. Scotton and Rachel C. Chambers

J Immunol November 1, 2013, 191 (9) 4867-4879; DOI: https://doi.org/10.4049/jimmunol.1300588

TUMOR IMMUNOLOGY

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Characterization of Distinct Immunophenotypes across Pediatric Brain Tumor Types
Andrea M. Griesinger, Diane K. Birks, Andrew M. Donson, Vladimir Amani, Lindsey M. Hoffman, Allen Waziri, Michael Wang, Michael H. Handler and Nicholas K. Foreman

J Immunol November 1, 2013, 191 (9) 4880-4888; DOI: https://doi.org/10.4049/jimmunol.1301966

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Table of Contents

IN THIS ISSUE

LETTERS TO THE EDITOR

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MUCOSAL IMMUNOLOGY

TUMOR IMMUNOLOGY

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