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The Journal of Immunology

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Table of Contents

July 15, 2013; Volume 191,Issue 2

IN THIS ISSUE

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    In This Issue

    Selecting for Length See article p. 561

    Orchestrating Tolerance with p38α See article p. 650

    Innate CD4 TCRs Regulate Selection See article p. 737

    Malaria in the Crosshairs See article p. 795

    Complementing CD14 Blockade See article p. 819

    SARM Deficit Shields CNS from Harm See article p. 875

    J Immunol July 15, 2013, 191 (2) 523-524; DOI: https://doi.org/10.4049/jimmunol.1390038

LETTERS TO THE EDITOR

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    Comment on “CXCL9 Causes Heterologous Desensitization of CXCL12-Mediated Memory T Lymphocyte Activation”
    Graeme O’Boyle, Simi Ali and John A. Kirby
    J Immunol July 15, 2013, 191 (2) 525; DOI: https://doi.org/10.4049/jimmunol.1390036
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    Response to Comment on “CXCL9 Causes Heterologous Desensitization of CXCL12-Mediated Memory T Lymphocyte Activation”
    Oliver Giegold, Nadine Ogrissek and Heinfried H. Radeke
    J Immunol July 15, 2013, 191 (2) 525-526; DOI: https://doi.org/10.4049/jimmunol.1390037

BRIEF REVIEWS

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    Immune Regulation in Obesity-Associated Adipose Inflammation
    Jonathan M. Han and Megan K. Levings
    J Immunol July 15, 2013, 191 (2) 527-532; DOI: https://doi.org/10.4049/jimmunol.1301035

CUTTING EDGE

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    Cutting Edge: ABIN-1 Protects against Psoriasis by Restricting MyD88 Signals in Dendritic Cells
    Joseph A. Callahan, Gianna E. Hammer, Alexander Agelides, Bao H. Duong, Shigeru Oshima, Jeffrey North, Rommel Advincula, Nataliya Shifrin, Hong-An Truong, Jonathan Paw, Julio Barrera, Anthony DeFranco, Michael D. Rosenblum, Barbara A. Malynn and Averil Ma
    J Immunol July 15, 2013, 191 (2) 535-539; DOI: https://doi.org/10.4049/jimmunol.1203335
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    Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells
    Ben Youngblood, Alessandra Noto, Filippos Porichis, Rama S. Akondy, Zaza M. Ndhlovu, James W. Austin, Rebeka Bordi, Francesco A. Procopio, Toshiyuki Miura, Todd M. Allen, John Sidney, Alessandro Sette, Bruce D. Walker, Rafi Ahmed, Jeremy M. Boss, Rafick-Pierre Sékaly and Daniel E. Kaufmann
    J Immunol July 15, 2013, 191 (2) 540-544; DOI: https://doi.org/10.4049/jimmunol.1203161
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    Cutting Edge: Conditional MHC Class II Expression Reveals a Limited Role for B Cell Antigen Presentation in Primary and Secondary CD4 T Cell Responses
    Angela S. Archambault, Javier A. Carrero, Lisa G. Barnett, Nigel G. McGee, Julia Sim, Jonathan O. Wright, Tobias Raabe, Peiquin Chen, Hua Ding, Eric J. Allenspach, Ioannis Dragatsis, Terri M. Laufer and Gregory F. Wu
    J Immunol July 15, 2013, 191 (2) 545-550; DOI: https://doi.org/10.4049/jimmunol.1201598

ANTIGEN RECOGNITION AND RESPONSES

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    Phl p 1–Specific Human Monoclonal IgE and Design of a Hypoallergenic Group 1 Grass Pollen Allergen Fragment
    Mattias Levin, Frida Rydnert, Eva Källström, Lor Wai Tan, Peter J. Wormald, Malin Lindstedt, Lennart Greiff and Mats Ohlin
    J Immunol July 15, 2013, 191 (2) 551-560; DOI: https://doi.org/10.4049/jimmunol.1202051
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    HLA Peptide Length Preferences Control CD8+ T Cell Responses
    Melissa J. Rist, Alex Theodossis, Nathan P. Croft, Michelle A. Neller, Andrew Welland, Zhenjun Chen, Lucy C. Sullivan, Jacqueline M. Burrows, John J. Miles, Rebekah M. Brennan, Stephanie Gras, Rajiv Khanna, Andrew G. Brooks, James McCluskey, Anthony W. Purcell, Jamie Rossjohn and Scott R. Burrows
    J Immunol July 15, 2013, 191 (2) 561-571; DOI: https://doi.org/10.4049/jimmunol.1300292
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    The Mechanism of Splenic Invariant NKT Cell Activation Dictates Localization In Vivo
    Irah L. King, Eyal Amiel, Mike Tighe, Katja Mohrs, Natacha Veerapen, Gurdyal Besra, Markus Mohrs and Elizabeth A. Leadbetter
    J Immunol July 15, 2013, 191 (2) 572-582; DOI: https://doi.org/10.4049/jimmunol.1300299
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    HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 Monochain Transgenic/H-2 Class I Null Mice: Novel Versatile Preclinical Models of Human T Cell Responses
    Rachid Boucherma, Hédia Kridane-Miledi, Romain Bouziat, Michael Rasmussen, Tanja Gatard, Francina Langa-Vives, Brigitte Lemercier, Annick Lim, Marion Bérard, Lbachir BenMohamed, Søren Buus, Ronald Rooke and François A. Lemonnier
    J Immunol July 15, 2013, 191 (2) 583-593; DOI: https://doi.org/10.4049/jimmunol.1300483

AUTOIMMUNITY

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    Different Modulation of Ptpn22 in Effector and Regulatory T Cells Leads to Attenuation of Autoimmune Diabetes in Transgenic Nonobese Diabetic Mice
    Li-Tzu Yeh, Shi-Chuen Miaw, Ming-Hong Lin, Feng-Cheng Chou, Shing-Jia Shieh, Yi-Ping Chuang, Shih-Hua Lin, Deh-Ming Chang and Huey-Kang Sytwu
    J Immunol July 15, 2013, 191 (2) 594-607; DOI: https://doi.org/10.4049/jimmunol.1203380
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    Different Stages of Primary Sjögren’s Syndrome Involving Lymphotoxin and Type 1 IFN
    Long Shen, Lakshmanan Suresh, Kishore Malyavantham, Przemek Kowal, Jingxiu Xuan, Matthew J. Lindemann and Julian L. Ambrus Jr.
    J Immunol July 15, 2013, 191 (2) 608-613; DOI: https://doi.org/10.4049/jimmunol.1203440
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    Systemic Lack of Canonical Histamine Receptor Signaling Results in Increased Resistance to Autoimmune Encephalomyelitis
    Naresha Saligrama, Laure K. Case, Roxana del Rio, Rajkumar Noubade and Cory Teuscher
    J Immunol July 15, 2013, 191 (2) 614-622; DOI: https://doi.org/10.4049/jimmunol.1203137

CLINICAL AND HUMAN IMMUNOLOGY

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    Longitudinal and Integrative Biomodeling of Effector and Memory Immune Compartments after Inactivated Influenza Vaccination
    Olivia Bonduelle, Nora Yahia, Sophie Siberil, Nora Benhabiles, Fabrice Carrat, Anne Krivine, Flore Rozenberg, Jordan Dimitrov, Srini V. Kaveri, Angélique Curjol, Malka Tindel, Martine Louet, Florent Desert, Odile Launay, Pierre Loulergue, Gwenaelle Badre, Christine Katlama, François Bricaire, Assia Samri, Dominique Rousset, Sylvie van der Werf, Stephane Jauréguiberry and Behazine Combadiere
    J Immunol July 15, 2013, 191 (2) 623-631; DOI: https://doi.org/10.4049/jimmunol.1203483

IMMUNE REGULATION

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    T Cell Activation Threshold Regulated by E3 Ubiquitin Ligase Cbl-b Determines Fate of Inducible Regulatory T Cells
    Guilin Qiao, Yixia Zhao, Zhenping Li, Peter Q. Tang, Wallace Y. Langdon, Tianlan Yang and Jian Zhang
    J Immunol July 15, 2013, 191 (2) 632-639; DOI: https://doi.org/10.4049/jimmunol.1202068
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    HuR Is Required for IL-17–Induced Act1-Mediated CXCL1 and CXCL5 mRNA Stabilization
    Tomasz Herjan, Peng Yao, Wen Qian, Xiao Li, Caini Liu, Katarzyna Bulek, Dongxu Sun, Wen-Pin Yang, Jun Zhu, Aiqing He, Julie A. Carman, Serpil C. Erzurum, Howard D. Lipshitz, Paul L. Fox, Thomas A. Hamilton and Xiaoxia Li
    J Immunol July 15, 2013, 191 (2) 640-649; DOI: https://doi.org/10.4049/jimmunol.1203315
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    Control of T Cell Fates and Immune Tolerance by p38α Signaling in Mucosal CD103+ Dendritic Cells
    Gonghua Huang, Yanyan Wang and Hongbo Chi
    J Immunol July 15, 2013, 191 (2) 650-659; DOI: https://doi.org/10.4049/jimmunol.1300398
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    Human Bocavirus VP2 Upregulates IFN-β Pathway by Inhibiting Ring Finger Protein 125–Mediated Ubiquitination of Retinoic Acid–Inducible Gene-I
    Huanle Luo, Zhenfeng Zhang, Zhenhua Zheng, Xianliang Ke, Xiaowei Zhang, Qian Li, Yan Liu, Bingke Bai, Panyong Mao, Qinxue Hu and Hanzhong Wang
    J Immunol July 15, 2013, 191 (2) 660-669; DOI: https://doi.org/10.4049/jimmunol.1202933
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    IL-4 Upregulates Igα and Igβ Protein, Resulting in Augmented IgM Maturation and B Cell Receptor–Triggered B Cell Activation
    Benchang Guo and Thomas L. Rothstein
    J Immunol July 15, 2013, 191 (2) 670-677; DOI: https://doi.org/10.4049/jimmunol.1203211
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    STAT4 and T-bet Are Required for the Plasticity of IFN-γ Expression across Th2 Ontogeny and Influence Changes in Ifng Promoter DNA Methylation
    Christopher L. Williams, Marcia M. Schilling, Sung Hoon Cho, Keunwook Lee, Mei Wei, Aditi and Mark Boothby
    J Immunol July 15, 2013, 191 (2) 678-687; DOI: https://doi.org/10.4049/jimmunol.1203360
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    Contrasting Effects of Anti-Ly49A Due to MHC Class I cis Binding on NK Cell–Mediated Allogeneic Bone Marrow Cell Resistance
    Maite Alvarez, Can M. Sungur, Erik Ames, Stephen K. Anderson, Claire Pomeroy and William J. Murphy
    J Immunol July 15, 2013, 191 (2) 688-698; DOI: https://doi.org/10.4049/jimmunol.1300202
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    Critical Role of the Tumor Suppressor Tuberous Sclerosis Complex 1 in Dendritic Cell Activation of CD4 T Cells by Promoting MHC Class II Expression via IRF4 and CIITA
    Hongjie Pan, Thomas F. O’Brien, Gabriela Wright, Jialong Yang, Jinwook Shin, Kenneth L. Wright and Xiao-Ping Zhong
    J Immunol July 15, 2013, 191 (2) 699-707; DOI: https://doi.org/10.4049/jimmunol.1201443
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    RKIP Contributes to IFN-γ Synthesis by CD8+ T Cells after Serial TCR Triggering in Systemic Inflammatory Response Syndrome
    Kyle T. Wright and Anthony T. Vella
    J Immunol July 15, 2013, 191 (2) 708-716; DOI: https://doi.org/10.4049/jimmunol.1203486
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    An Alternative Role for Foxp3 As an Effector T Cell Regulator Controlled through CD40
    Gisela M. Vaitaitis, Jessica R. Carter, Dan M. Waid, Michael H. Olmstead and David H. Wagner Jr.
    J Immunol July 15, 2013, 191 (2) 717-725; DOI: https://doi.org/10.4049/jimmunol.1300625

IMMUNE SYSTEM DEVELOPMENT

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    Notch-Regulated Periphery B Cell Differentiation Involves Suppression of E Protein Function
    Ping Zhang, Ying Zhao and Xiao-Hong Sun
    J Immunol July 15, 2013, 191 (2) 726-736; DOI: https://doi.org/10.4049/jimmunol.1202134
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    A Transgenic TCR Directs the Development of IL-4+ and PLZF+ Innate CD4 T Cells
    Lingqiao Zhu, Yu Qiao, Esther S. Choi, Joy Das, Derek B. Sant’Angelo and Cheong-Hee Chang
    J Immunol July 15, 2013, 191 (2) 737-744; DOI: https://doi.org/10.4049/jimmunol.1300862
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    Hoxa9 and Flt3 Signaling Synergistically Regulate an Early Checkpoint in Lymphopoiesis
    Kimberly A. Gwin, Mariya B. Shapiro, Joseph J. Dolence, Zhixin L. Huang and Kay L. Medina
    J Immunol July 15, 2013, 191 (2) 745-754; DOI: https://doi.org/10.4049/jimmunol.1203294

IMMUNOTHERAPY AND VACCINES

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    Immunotherapy of Radioresistant Mammary Tumors with Early Metastasis Using Molecular Chaperone Vaccines Combined with Ionizing Radiation
    Desheng Weng, Baizheng Song, Shigeo Koido, Stuart K. Calderwood and Jianlin Gong
    J Immunol July 15, 2013, 191 (2) 755-763; DOI: https://doi.org/10.4049/jimmunol.1203286
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    Orchestration of CD4 T Cell Epitope Preferences after Multipeptide Immunization
    Jacqueline Tung and Andrea J. Sant
    J Immunol July 15, 2013, 191 (2) 764-772; DOI: https://doi.org/10.4049/jimmunol.1300312

INFECTIOUS DISEASE AND HOST RESPONSE

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    Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms
    Joshua T. Mattila, Olabisi O. Ojo, Diane Kepka-Lenhart, Simeone Marino, Jin Hee Kim, Seok Yong Eum, Laura E. Via, Clifton E. Barry III, Edwin Klein, Denise E. Kirschner, Sidney M. Morris Jr., Philana Ling Lin and JoAnne L. Flynn
    J Immunol July 15, 2013, 191 (2) 773-784; DOI: https://doi.org/10.4049/jimmunol.1300113
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    Erythrocyte-Binding Antigens of Plasmodium falciparum Are Targets of Human Inhibitory Antibodies and Function To Evade Naturally Acquired Immunity
    Kristina E. M. Persson, Freya J. I. Fowkes, Fiona J. McCallum, Nimmo Gicheru, Linda Reiling, Jack S. Richards, Danny W. Wilson, Sash Lopaticki, Alan F. Cowman, Kevin Marsh and James G. Beeson
    J Immunol July 15, 2013, 191 (2) 785-794; DOI: https://doi.org/10.4049/jimmunol.1300444
  • Open Access
    Identification and Prioritization of Merozoite Antigens as Targets of Protective Human Immunity to Plasmodium falciparum Malaria for Vaccine and Biomarker Development

    Author Choice Article

    Jack S. Richards, Thangavelu U. Arumugam, Linda Reiling, Julie Healer, Anthony N. Hodder, Freya J. I. Fowkes, Nadia Cross, Christine Langer, Satoru Takeo, Alex D. Uboldi, Jennifer K. Thompson, Paul R. Gilson, Ross L. Coppel, Peter M. Siba, Christopher L. King, Motomi Torii, Chetan E. Chitnis, David L. Narum, Ivo Mueller, Brendan S. Crabb, Alan F. Cowman, Takafumi Tsuboi and James G. Beeson
    J Immunol July 15, 2013, 191 (2) 795-809; DOI: https://doi.org/10.4049/jimmunol.1300778
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    B Cell–Intrinsic TLR7 Signaling Is Required for Optimal B Cell Responses during Chronic Viral Infection
    Jonathan M. Clingan and Mehrdad Matloubian
    J Immunol July 15, 2013, 191 (2) 810-818; DOI: https://doi.org/10.4049/jimmunol.1300244

INNATE IMMUNITY AND INFLAMMATION

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    Combined Inhibition of Complement (C5) and CD14 Markedly Attenuates Inflammation, Thrombogenicity, and Hemodynamic Changes in Porcine Sepsis
    Andreas Barratt-Due, Ebbe B. Thorgersen, Kjetil Egge, Søren Pischke, Andrey Sokolov, Bernt C. Hellerud, Julie K. Lindstad, Anne Pharo, Anjan K. Bongoni, Robert Rieben, Miles Nunn, Helge Scott and Tom E. Mollnes
    J Immunol July 15, 2013, 191 (2) 819-827; DOI: https://doi.org/10.4049/jimmunol.1201909
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    CD160 Activation by Herpesvirus Entry Mediator Augments Inflammatory Cytokine Production and Cytolytic Function by NK Cells
    John R. Šedý, Ryan L. Bjordahl, Vasileios Bekiaris, Matthew G. Macauley, Brian C. Ware, Paula S. Norris, Nell S. Lurain, Chris A. Benedict and Carl F. Ware
    J Immunol July 15, 2013, 191 (2) 828-836; DOI: https://doi.org/10.4049/jimmunol.1300894
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    Trp53 Deficiency Protects against Acute Intestinal Inflammation
    Martina E. Spehlmann, Carolin F. Manthey, Sara M. Dann, Elaine Hanson, Sukhman S. Sandhu, Linus Y. Liu, Farid K. Abdelmalak, Michaela A. Diamanti, Kristin Retzlaff, Jürgen Scheller, Stefan Rose-John, Florian R. Greten, Jean Y. J. Wang and Lars Eckmann
    J Immunol July 15, 2013, 191 (2) 837-847; DOI: https://doi.org/10.4049/jimmunol.1201716
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    Neutrophil Recruitment to the Lung in Both C5a- and CXCL1-Induced Alveolitis Is Impaired in Vitamin D–Binding Protein–Deficient Mice
    Glenda Trujillo, David M. Habiel, Lingyin Ge, Mahalakshmi Ramadass, Nancy E. Cooke and Richard R. Kew
    J Immunol July 15, 2013, 191 (2) 848-856; DOI: https://doi.org/10.4049/jimmunol.1202941
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    TLR4 Signaling Augments Monocyte Chemotaxis by Regulating G Protein–Coupled Receptor Kinase 2 Translocation
    Zheng Liu, Yong Jiang, Yuehua Li, Juan Wang, Liyan Fan, Melanie J. Scott, Guozhi Xiao, Song Li, Timothy R. Billiar, Mark A. Wilson and Jie Fan
    J Immunol July 15, 2013, 191 (2) 857-864; DOI: https://doi.org/10.4049/jimmunol.1300790
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    β-Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN-α Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation
    Poonam Tewary, Gonzalo de la Rosa, Neeraj Sharma, Luis G. Rodriguez, Sergey G. Tarasov, O. M. Zack Howard, Hidekazu Shirota, Folkert Steinhagen, Dennis M. Klinman, De Yang and Joost J. Oppenheim
    J Immunol July 15, 2013, 191 (2) 865-874; DOI: https://doi.org/10.4049/jimmunol.1201648
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    SARM Is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection
    Ying-Ju Hou, Rebecca Banerjee, Bobby Thomas, Carl Nathan, Adolfo García-Sastre, Aihao Ding and Melissa B. Uccellini
    J Immunol July 15, 2013, 191 (2) 875-883; DOI: https://doi.org/10.4049/jimmunol.1300374

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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    Conformational Shift of a Major Poliovirus Antigen Confirmed by Immuno-Cryogenic Electron Microscopy
    Jun Lin, Naiqian Cheng, James M. Hogle, Alasdair C. Steven and David M. Belnap
    J Immunol July 15, 2013, 191 (2) 884-891; DOI: https://doi.org/10.4049/jimmunol.1202014
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    SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling
    Shauna M. Dauphinee, Ashley Clayton, Angela Hussainkhel, Cindy Yang, Yoo-Jin Park, Megan E. Fuller, Josip Blonder, Timothy D. Veenstra and Aly Karsan
    J Immunol July 15, 2013, 191 (2) 892-901; DOI: https://doi.org/10.4049/jimmunol.1200583
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    Opposing Roles of STAT4 and Dnmt3a in Th1 Gene Regulation
    Duy Pham, Qing Yu, Crystal C. Walline, Rajarajeswari Muthukrishnan, Janice S. Blum and Mark H. Kaplan
    J Immunol July 15, 2013, 191 (2) 902-911; DOI: https://doi.org/10.4049/jimmunol.1203229
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    An Engineered Construct Combining Complement Regulatory and Surface-Recognition Domains Represents a Minimal-Size Functional Factor H
    Mario Hebecker, María Alba-Domínguez, Lubka T. Roumenina, Stefanie Reuter, Satu Hyvärinen, Marie-Agnès Dragon-Durey, T. Sakari Jokiranta, Pilar Sánchez-Corral and Mihály Józsi
    J Immunol July 15, 2013, 191 (2) 912-921; DOI: https://doi.org/10.4049/jimmunol.1300269

MUCOSAL IMMUNOLOGY

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    Inhaled Birch Pollen Extract Induces Airway Hyperresponsiveness via Oxidative Stress but Independently of Pollen-Intrinsic NADPH Oxidase Activity, or the TLR4–TRIF Pathway
    Karim H. Shalaby, Alexandra Allard-Coutu, Michael J. O’Sullivan, Emily Nakada, Salman T. Qureshi, Brian J. Day and James G. Martin
    J Immunol July 15, 2013, 191 (2) 922-933; DOI: https://doi.org/10.4049/jimmunol.1103644
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    Viral Infection of the Pregnant Cervix Predisposes to Ascending Bacterial Infection
    Karen Racicot, Ingrid Cardenas, Vera Wünsche, Paulomi Aldo, Seth Guller, Robert E. Means, Roberto Romero and Gil Mor
    J Immunol July 15, 2013, 191 (2) 934-941; DOI: https://doi.org/10.4049/jimmunol.1300661
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    Critical Role of Dendritic Cells in T Cell Retention in the Interfollicular Region of Peyer’s Patches
    Takashi Obata, Naoko Shibata, Yoshiyuki Goto, Izumi Ishikawa, Shintaro Sato, Jun Kunisawa and Hiroshi Kiyono
    J Immunol July 15, 2013, 191 (2) 942-948; DOI: https://doi.org/10.4049/jimmunol.1200636
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    Paraoxonase-1 Suppresses Experimental Colitis via the Inhibition of IFN-γ Production from CD4 T Cells
    Junji Yamashita, Chiaki Iwamura, Toshihiro Ito, Masakuni Narita, Yukio Hara, Tetsuya Sasaki, Daisuke Masuda, Munehisa Takahashi, Manami Tsuchiya, Kaori Hada, Makoto Ishikawa, Takato Matsuo, Yoichi Ohno, Hitoshi Tanaka, Hideya Maruyama, Yasumasa Ogawa and Toshinori Nakayama
    J Immunol July 15, 2013, 191 (2) 949-960; DOI: https://doi.org/10.4049/jimmunol.1201828

TUMOR IMMUNOLOGY

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    Inflammatory Cytokine–Mediated Evasion of Virus-Induced Tumors from NK Cell Control
    Rabinarayan Mishra, Bojan Polic, Raymond M. Welsh and Eva Szomolanyi-Tsuda
    J Immunol July 15, 2013, 191 (2) 961-970; DOI: https://doi.org/10.4049/jimmunol.1203328
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    Tumor-Derived Vascular Pericytes Anergize Th Cells
    Anamika Bose, Subhasis Barik, Saptak Banerjee, Tithi Ghosh, Atanu Mallick, Suchandra Bhattacharyya Majumdar, Kuntal Kanti Goswami, Avishek Bhuniya, Sayantan Banerjee, Rathindranath Baral, Walter J. Storkus, Partha Sarathi Dasgupta and Subrata Majumdar
    J Immunol July 15, 2013, 191 (2) 971-981; DOI: https://doi.org/10.4049/jimmunol.1300280
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The Journal of Immunology: 191 (2)
The Journal of Immunology
Vol. 191, Issue 2
15 Jul 2013
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  • IN THIS ISSUE
  • LETTERS TO THE EDITOR
  • BRIEF REVIEWS
  • CUTTING EDGE
  • ANTIGEN RECOGNITION AND RESPONSES
  • AUTOIMMUNITY
  • CLINICAL AND HUMAN IMMUNOLOGY
  • IMMUNE REGULATION
  • IMMUNE SYSTEM DEVELOPMENT
  • IMMUNOTHERAPY AND VACCINES
  • INFECTIOUS DISEASE AND HOST RESPONSE
  • INNATE IMMUNITY AND INFLAMMATION
  • MOLECULAR AND STRUCTURAL IMMUNOLOGY
  • MUCOSAL IMMUNOLOGY
  • TUMOR IMMUNOLOGY
  • Highlights
  • Most Cited
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Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
Natural and Induced Tolerogenic Dendritic Cells
Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

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Print ISSN 0022-1767        Online ISSN 1550-6606