The Journal of Immunology: 191 (10)

November 15, 2013; Volume 191,Issue 10

IN THIS ISSUE

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In This Issue
Modulating To Escape Abs See article p. 5013
Approaches to NK Cell Education See article p. 5044
A Small Molecule Step toward Treating MS See article p. 5074
Provoking Platelets See article p. 5196

J Immunol November 15, 2013, 191 (10) 4891-4892; DOI: https://doi.org/10.4049/jimmunol.1390057

LETTERS TO THE EDITOR

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Comment on “Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans”
Andrew Conway Morris, Thomas S. Wilkinson, Timothy S. Walsh and A. John Simpson

J Immunol November 15, 2013, 191 (10) 4893; DOI: https://doi.org/10.4049/jimmunol.1390060

BRIEF REVIEWS

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Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease
J. Michelle Kahlenberg and Mariana J. Kaplan

J Immunol November 15, 2013, 191 (10) 4895-4901; DOI: https://doi.org/10.4049/jimmunol.1302005

CUTTING EDGE

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Cutting Edge: Identification of the Thymic Stromal Lymphopoietin–Responsive Dendritic Cell Subset Critical for Initiation of Type 2 Contact Hypersensitivity
Masayuki Kitajima and Steven F. Ziegler

J Immunol November 15, 2013, 191 (10) 4903-4907; DOI: https://doi.org/10.4049/jimmunol.1302175
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Cutting Edge: Smad2 and Smad4 Regulate TGF-β–Mediated Il9 Gene Expression via EZH2 Displacement
Aibo Wang, Deng Pan, Young-Hee Lee, Gustavo J. Martinez, Xin-hua Feng and Chen Dong

J Immunol November 15, 2013, 191 (10) 4908-4912; DOI: https://doi.org/10.4049/jimmunol.1300433
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Cutting Edge: Type 1 Diabetes Occurs despite Robust Anergy among Endogenous Insulin-Specific CD4 T Cells in NOD Mice
Kristen E. Pauken, Jonathan L. Linehan, Justin A. Spanier, Nathanael L. Sahli, Lokesh A. Kalekar, Bryce A. Binstadt, James J. Moon, Daniel L. Mueller, Marc K. Jenkins and Brian T. Fife

J Immunol November 15, 2013, 191 (10) 4913-4917; DOI: https://doi.org/10.4049/jimmunol.1301927

ANTIGEN RECOGNITION AND RESPONSES

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Evolution of B Cell Responses to Clec9A-Targeted Antigen
Hae-Young Park, Amanda Light, Mireille H. Lahoud, Irina Caminschi, David M. Tarlinton and Ken Shortman

J Immunol November 15, 2013, 191 (10) 4919-4925; DOI: https://doi.org/10.4049/jimmunol.1301947

AUTOIMMUNITY

Open Access
Molecular Basis of 9G4 B Cell Autoreactivity in Human Systemic Lupus Erythematosus
Author Choice Article

Christopher Richardson, Asiya Seema Chida, Diana Adlowitz, Lin Silver, Erin Fox, Scott A. Jenks, Elise Palmer, Youliang Wang, Jamie Heimburg-Molinaro, Quan-Zhen Li, Chandra Mohan, Richard Cummings, Christopher Tipton and Ignacio Sanz

J Immunol November 15, 2013, 191 (10) 4926-4939; DOI: https://doi.org/10.4049/jimmunol.1202263
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Reduced Effectiveness of CD4⁺Foxp3⁺ Regulatory T Cells in CD28-Deficient NOD.H-2h4 Mice Leads to Increased Severity of Spontaneous Autoimmune Thyroiditis
Jason S. Ellis, So-Hee Hong, Habib Zaghouani and Helen Braley-Mullen

J Immunol November 15, 2013, 191 (10) 4940-4949; DOI: https://doi.org/10.4049/jimmunol.1301253
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T Cell–Independent Modulation of Experimental Autoimmune Encephalomyelitis in ADAP-Deficient Mice
Swen Engelmann, Mauro Togni, Anja Thielitz, Peter Reichardt, Stefanie Kliche, Dirk Reinhold, Burkhart Schraven and Annegret Reinhold

J Immunol November 15, 2013, 191 (10) 4950-4959; DOI: https://doi.org/10.4049/jimmunol.1203340
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The Role of CD8⁺ T Cells and Their Local Interaction with CD4⁺ T Cells in Myelin Oligodendrocyte Glycoprotein_35–55–Induced Experimental Autoimmune Encephalomyelitis
Tina Leuenberger, Magdalena Paterka, Eva Reuter, Josephine Herz, Raluca A. Niesner, Helena Radbruch, Tobias Bopp, Frauke Zipp and Volker Siffrin

J Immunol November 15, 2013, 191 (10) 4960-4968; DOI: https://doi.org/10.4049/jimmunol.1300822
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A Novel Disease-Modifying Antirheumatic Drug, Iguratimod, Ameliorates Murine Arthritis by Blocking IL-17 Signaling, Distinct from Methotrexate and Leflunomide
Qiong Luo, Yang Sun, Wen Liu, Cheng Qian, Biao Jin, Feifei Tao, Yanhong Gu, Xingxin Wu, Yan Shen and Qiang Xu

J Immunol November 15, 2013, 191 (10) 4969-4978; DOI: https://doi.org/10.4049/jimmunol.1300832
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Reduced T Cell–Dependent Humoral Immune Response in Microsomal Prostaglandin E Synthase-1 Null Mice Is Mediated by Nonhematopoietic Cells
Fumiaki Kojima, Andrey Frolov, Rahul Matnani, Jerold G. Woodward and Leslie J. Crofford

J Immunol November 15, 2013, 191 (10) 4979-4988; DOI: https://doi.org/10.4049/jimmunol.1301942

CLINICAL AND HUMAN IMMUNOLOGY

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A Distinct Subpopulation of Human NK Cells Restricts B Cell Transformation by EBV
Anna Lünemann, Liliana D. Vanoaica, Tarik Azzi, David Nadal and Christian Münz

J Immunol November 15, 2013, 191 (10) 4989-4995; DOI: https://doi.org/10.4049/jimmunol.1301046
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STAT-3 Activation by Differential Cytokines Is Critical for Human In Vivo–Generated Plasma Cell Survival and Ig Secretion
Beatriz Rodríguez-Bayona, Ana Ramos-Amaya, Rubén López-Blanco, Antonio Campos-Caro and José A. Brieva

J Immunol November 15, 2013, 191 (10) 4996-5004; DOI: https://doi.org/10.4049/jimmunol.1301559

IMMUNE REGULATION

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Targeting Uptake Receptors on Human Plasmacytoid Dendritic Cells Triggers Antigen Cross-Presentation and Robust Type I IFN Secretion
Jurjen Tel, Simone P. Sittig, Rebecca A. M. Blom, Luis J. Cruz, Gerty Schreibelt, Carl G. Figdor and I. Jolanda M. de Vries

J Immunol November 15, 2013, 191 (10) 5005-5012; DOI: https://doi.org/10.4049/jimmunol.1300787
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Antigen Modulation Confers Protection to Red Blood Cells from Antibody through Fcγ Receptor Ligation
Sean R. Stowell, Justine S. Liepkalns, Jeanne E. Hendrickson, Kathryn R. Girard-Pierce, Nicole H. Smith, C. Maridith Arthur and James C. Zimring

J Immunol November 15, 2013, 191 (10) 5013-5025; DOI: https://doi.org/10.4049/jimmunol.1300885
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Exogenous OX40 Stimulation during Lymphocytic Choriomeningitis Virus Infection Impairs Follicular Th Cell Differentiation and Diverts CD4 T Cells into the Effector Lineage by Upregulating Blimp-1
Tobias Boettler, Youn Soo Choi, Shahram Salek-Ardakani, Yang Cheng, Friedrich Moeckel, Michael Croft, Shane Crotty and Matthias von Herrath

J Immunol November 15, 2013, 191 (10) 5026-5035; DOI: https://doi.org/10.4049/jimmunol.1300013
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SOCS3 Deletion in T Lymphocytes Suppresses Development of Chronic Ocular Inflammation via Upregulation of CTLA-4 and Expansion of Regulatory T Cells
Cheng-Rong Yu, Sung-Hye Kim, Rashid M. Mahdi and Charles E. Egwuagu

J Immunol November 15, 2013, 191 (10) 5036-5043; DOI: https://doi.org/10.4049/jimmunol.1301132

IMMUNE SYSTEM DEVELOPMENT

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Education of Murine NK Cells Requires Both cis and trans Recognition of MHC Class I Molecules
Stéphanie Bessoles, Georgi S. Angelov, Jonathan Back, Georges Leclercq, Eric Vivier and Werner Held

J Immunol November 15, 2013, 191 (10) 5044-5051; DOI: https://doi.org/10.4049/jimmunol.1301971
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Combined Deletion of Id2 and Id3 Genes Reveals Multiple Roles for E Proteins in Invariant NKT Cell Development and Expansion
Jia Li, Di Wu, Ning Jiang and Yuan Zhuang

J Immunol November 15, 2013, 191 (10) 5052-5064; DOI: https://doi.org/10.4049/jimmunol.1301252
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Increased Level of E Protein Activity during Invariant NKT Development Promotes Differentiation of Invariant NKT2 and Invariant NKT17 Subsets
Taishan Hu, Hongcheng Wang, Amie Simmons, Sandra Bajaña, Ying Zhao, Susan Kovats, Xiao-Hong Sun and Jose Alberola-Ila

J Immunol November 15, 2013, 191 (10) 5065-5073; DOI: https://doi.org/10.4049/jimmunol.1301546

IMMUNOTHERAPY AND VACCINES

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Small Molecule Inhibitor of Antigen Binding and Presentation by HLA-DR2b as a Therapeutic Strategy for the Treatment of Multiple Sclerosis
Niannian Ji, Animesh Somanaboeina, Aakanksha Dixit, Kazuyuki Kawamura, Neil J. Hayward, Christopher Self, Gary L. Olson and Thomas G. Forsthuber

J Immunol November 15, 2013, 191 (10) 5074-5084; DOI: https://doi.org/10.4049/jimmunol.1300407
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Coadministration of Polyinosinic:Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific T Cell Immunity
Kylie M. Quinn, Ayako Yamamoto, Andreia Costa, Patricia A. Darrah, Ross W. B. Lindsay, Sonia T. Hegde, Teresa R. Johnson, Barbara J. Flynn, Karin Loré and Robert A. Seder

J Immunol November 15, 2013, 191 (10) 5085-5096; DOI: https://doi.org/10.4049/jimmunol.1301730
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Structure-Based Design of Altered MHC Class II–Restricted Peptide Ligands with Heterogeneous Immunogenicity
Shuming Chen, Yili Li, Florence R. Depontieu, Tracee L. McMiller, A. Michelle English, Jeffrey Shabanowitz, Ferdynand Kos, John Sidney, Alessandro Sette, Steven A. Rosenberg, Donald F. Hunt, Roy A. Mariuzza and Suzanne L. Topalian

J Immunol November 15, 2013, 191 (10) 5097-5106; DOI: https://doi.org/10.4049/jimmunol.1300467
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Selective Activation of Antigen-Experienced T Cells by Anti-CD3 Constrained on Nanoparticles
Ying-Chun Lo, Michael A. Edidin and Jonathan D. Powell

J Immunol November 15, 2013, 191 (10) 5107-5114; DOI: https://doi.org/10.4049/jimmunol.1301433

INFECTIOUS DISEASE AND HOST RESPONSE

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Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase–Dependent Inflammation
Rudra Bhowmick, Nang H. Tin Maung, Bryan P. Hurley, Elsa Bou Ghanem, Karsten Gronert, Beth A. McCormick and John M. Leong

J Immunol November 15, 2013, 191 (10) 5115-5123; DOI: https://doi.org/10.4049/jimmunol.1300522
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Asymptomatic HLA-A*02:01–Restricted Epitopes from Herpes Simplex Virus Glycoprotein B Preferentially Recall Polyfunctional CD8⁺ T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice against Ocular Herpes
Xavier Dervillez, Huma Qureshi, Aziz A. Chentoufi, Arif A. Khan, Elizabeth Kritzer, David C. Yu, Oscar R. Diaz, Chetan Gottimukkala, Mina Kalantari, Maria C. Villacres, Vanessa M. Scarfone, Denise M. McKinney, John Sidney, Alessandro Sette, Anthony B. Nesburn, Steven L. Wechsler and Lbachir BenMohamed

J Immunol November 15, 2013, 191 (10) 5124-5138; DOI: https://doi.org/10.4049/jimmunol.1301415
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Disparate Epitopes Mediating Protective Heterologous Immunity to Unrelated Viruses Share Peptide–MHC Structural Features Recognized by Cross-Reactive T Cells
Zu T. Shen, Tina T. Nguyen, Keith A. Daniels, Raymond M. Welsh and Lawrence J. Stern

J Immunol November 15, 2013, 191 (10) 5139-5152; DOI: https://doi.org/10.4049/jimmunol.1300852
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Influenza A Exacerbates Staphylococcus aureus Pneumonia by Attenuating IL-1β Production in Mice
Keven M. Robinson, Sun Mi Choi, Kevin J. McHugh, Sivanarayana Mandalapu, Richard I. Enelow, Jay K. Kolls and John F. Alcorn

J Immunol November 15, 2013, 191 (10) 5153-5159; DOI: https://doi.org/10.4049/jimmunol.1301237
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IFN-γ–Induced Priming Maintains Long-Term Strain-Transcending Immunity against Blood-Stage Plasmodium chabaudi Malaria
Henrique Borges da Silva, Érika Machado de Salles, Raquel Hoffmann Panatieri, Silvia Beatriz Boscardin, Sérgio Marcelo Rodríguez-Málaga, José Maria Álvarez and Maria Regina D’Império Lima

J Immunol November 15, 2013, 191 (10) 5160-5169; DOI: https://doi.org/10.4049/jimmunol.1300462

INNATE IMMUNITY AND INFLAMMATION

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Novel Regulatory Action of Ribosomal Inactivation on Epithelial Nod2-Linked Proinflammatory Signals in Two Convergent ATF3-Associated Pathways
Seong-Hwan Park, Kee Hun Do, Hye Jin Choi, Juil Kim, Ki-Hyung Kim, Jiyeon Park, Chang Gyu Oh and Yuseok Moon

J Immunol November 15, 2013, 191 (10) 5170-5181; DOI: https://doi.org/10.4049/jimmunol.1301145
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Wnt6 Is Expressed in Granulomatous Lesions of Mycobacterium tuberculosis–Infected Mice and Is Involved in Macrophage Differentiation and Proliferation
Kolja Schaale, Julius Brandenburg, Andreas Kispert, Michael Leitges, Stefan Ehlers and Norbert Reiling

J Immunol November 15, 2013, 191 (10) 5182-5195; DOI: https://doi.org/10.4049/jimmunol.1201819
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Lipopolysaccharide Stimulates Platelets through an IL-1β Autocrine Loop
G. Thomas Brown, Padmini Narayanan, Wei Li, Roy L. Silverstein and Thomas M. McIntyre

J Immunol November 15, 2013, 191 (10) 5196-5203; DOI: https://doi.org/10.4049/jimmunol.1300354
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Phenotypic Polarization of Activated Astrocytes: The Critical Role of Lipocalin-2 in the Classical Inflammatory Activation of Astrocytes
Eunha Jang, Jong-Heon Kim, Shinrye Lee, Jae-Hong Kim, Jung-Wan Seo, Myungwon Jin, Maan-Gee Lee, Il-Sung Jang, Won-Ha Lee and Kyoungho Suk

J Immunol November 15, 2013, 191 (10) 5204-5219; DOI: https://doi.org/10.4049/jimmunol.1301637
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IL-13 Immunotoxin Accelerates Resolution of Lung Pathological Changes Triggered by Silica Particles in Mice
Tatiana Paula T. Ferreira, Ana Carolina S. de Arantes, Caio Victor M. F. do Nascimento, Priscilla C. Olsen, Patrícia G. Trentin, Patricia R. M. Rocco, Cory M. Hogaboam, Raj K. Puri, Marco Aurélio Martins and Patrícia Machado Rodrigues e Silva

J Immunol November 15, 2013, 191 (10) 5220-5229; DOI: https://doi.org/10.4049/jimmunol.1203551
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Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation
Michelle E. Heid, Peter A. Keyel, Christelle Kamga, Sruti Shiva, Simon C. Watkins and Russell D. Salter

J Immunol November 15, 2013, 191 (10) 5230-5238; DOI: https://doi.org/10.4049/jimmunol.1301490
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Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1β Production
Si Ming Man, Panagiotis Tourlomousis, Lee Hopkins, Tom P. Monie, Katherine A. Fitzgerald and Clare E. Bryant

J Immunol November 15, 2013, 191 (10) 5239-5246; DOI: https://doi.org/10.4049/jimmunol.1301581
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Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation
Rama K. Mallampalli, Tiffany A. Coon, Jennifer R. Glasser, Claire Wang, Sarah R. Dunn, Nathaniel M. Weathington, Jing Zhao, Chunbin Zou, Yutong Zhao and Bill B. Chen

J Immunol November 15, 2013, 191 (10) 5247-5255; DOI: https://doi.org/10.4049/jimmunol.1300456
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Genome-Wide siRNA Screen Reveals a New Cellular Partner of NK Cell Receptor KIR2DL4: Heparan Sulfate Directly Modulates KIR2DL4-Mediated Responses
Michael Brusilovsky, Moti Cordoba, Benyamin Rosental, Oren Hershkovitz, Mark D. Andrake, Anna Pecherskaya, Margret B. Einarson, Yan Zhou, Alex Braiman, Kerry S. Campbell and Angel Porgador

J Immunol November 15, 2013, 191 (10) 5256-5267; DOI: https://doi.org/10.4049/jimmunol.1302079

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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MAIT Recognition of a Stimulatory Bacterial Antigen Bound to MR1
Jacinto López-Sagaseta, Charles L. Dulberger, Amanda McFedries, Mark Cushman, Alan Saghatelian and Erin J. Adams

J Immunol November 15, 2013, 191 (10) 5268-5277; DOI: https://doi.org/10.4049/jimmunol.1301958

MUCOSAL IMMUNOLOGY

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Differential Uptake of Nanoparticles and Microparticles by Pulmonary APC Subsets Induces Discrete Immunological Imprints
Charles L. Hardy, Jeanne S. LeMasurier, Rohimah Mohamud, Jun Yao, Sue D. Xiang, Jennifer M. Rolland, Robyn E. O’Hehir and Magdalena Plebanski

J Immunol November 15, 2013, 191 (10) 5278-5290; DOI: https://doi.org/10.4049/jimmunol.1203131

TRANSPLANTATION

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Induced Regulatory T Cells Promote Tolerance When Stabilized by Rapamycin and IL-2 In Vivo
Ping Zhang, Siok-Keen Tey, Motoko Koyama, Rachel D. Kuns, Stuart D. Olver, Katie E. Lineburg, Mary Lor, Bianca E. Teal, Neil C. Raffelt, Jyothy Raju, Lucie Leveque, Kate A. Markey, Antiopi Varelias, Andrew D. Clouston, Steven W. Lane, Kelli P. A. MacDonald and Geoffrey R. Hill

J Immunol November 15, 2013, 191 (10) 5291-5303; DOI: https://doi.org/10.4049/jimmunol.1301181

TUMOR IMMUNOLOGY

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Cooperativity of CD44 and CD49d in Leukemia Cell Homing, Migration, and Survival Offers a Means for Therapeutic Attack
Vibuthi Singh, Ulrike Erb and Margot Zöller

J Immunol November 15, 2013, 191 (10) 5304-5316; DOI: https://doi.org/10.4049/jimmunol.1301543

CORRECTIONS

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Correction: Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice
Eduardo Pauls, Sambit K. Nanda, Hilary Smith, Rachel Toth, J. Simon C. Arthur and Philip Cohen

J Immunol November 15, 2013, 191 (10) 5317; DOI: https://doi.org/10.4049/jimmunol.1390056
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Correction: T cell–derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia
Laura K. Fogli, Mark S. Sundrud, Swati Goel, Sofia Bajwa, Kari Jensen, Emmanuel Derudder, Amy Sun, Maryaline Coffre, Catherine Uyttenhove, Jacques Van Snick, Marc Schmidt-Supprian, Anjana Rao, Gabriele Grunig, Joan Durbin, Stefano S. Casola, Klaus Rajewsky and Sergei B. Koralov

J Immunol November 15, 2013, 191 (10) 5318; DOI: https://doi.org/10.4049/jimmunol.1390058
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Correction: Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma
Anusha-Preethi Ganesan, Magnus Johansson, Brian Ruffell, Adam Yagui-Beltrán, Jonathan Lau, David M. Jablons and Lisa M. Coussens

J Immunol November 15, 2013, 191 (10) 5319; DOI: https://doi.org/10.4049/jimmunol.1390059

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Table of Contents

IN THIS ISSUE

LETTERS TO THE EDITOR

BRIEF REVIEWS

CUTTING EDGE

ANTIGEN RECOGNITION AND RESPONSES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

TRANSPLANTATION

TUMOR IMMUNOLOGY

CORRECTIONS

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