On the cover: Focal adhesion formation on peritoneal macrophages treated with PGE₂ for 18 h. Vinculin (red) accumulates in focal adhesion plaques, and anchors filamentous actin stress fibers (green) to the cytoplasmic membrane. M. D. Díaz-Muoz, I. C. Osma-García, M. A. Íñiguez, and M. Fresno. 2013. Cyclooxygenase-2 deficiency in macrophages leads to defective p110γ PI3K signaling and impairs cell adhesion and migration. J. Immunol. 191: 395–406.