On the cover: H&E-stained sagittal section of a hind paw from a wild-type BALB/c mouse after immunization with human aggregan G1-domain protein in adjuvant. The authors show that mice immunized by different routes, i.p. versus s.c., develop a similar histological appearance of joint inflammation despite different requirements for Th1 and Th17 cytokines. Rodeghero, R., Y. Cao, S. A. Olalekan, Y. Iwakua, T. T. Glant, and A. Finnegan. 2013. Location of CD4⁺ T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis. J. Immunol. 190: 5423–5435.