On the cover: Red signals represent immunofluorescence detection of an adherens junction component E-cadherin in the colonic epithelium of mice with intestinal epithelium-specific deletion of Rbpj, a transcription factor that is responsible for Notch signaling. Nuclei were counterstained with DAPI (blue). Obata, Y., D. Takahashi, M. Ebisawa, K. Kakiguchi, S. Yonemura, T. Jinnohara, T. Kanaya, Y. Fujimura, M. Ohmae, K. Hase and H. Ohno. 2012. Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis. J. Immunol. 188: 2427–2436.