On the cover: Heat map of significantly modulated genes by complement protein C1q in LPS-stimulated human macrophages after uptake of apoptotic cells. Ingestion of autologous apoptotic lymphocytes with bound C1q suppresses proinflammatory gene expression induced by 10 ng/ml LPS in human monocyte-derived macrophages. Benoit, M. E., E. V. Clarke, P. Morgado, D. A. Fraser, and A. J. Tenner. 2012. Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J. Immunol. 188: 5682–5693.