The Journal of Immunology: 187 (7)

October 1, 2011; Volume 187,Issue 7

IN THIS ISSUE

Open Access
In This Issue
The Journal of Immunology October 1, 2011, 187 (7) 3455-3456; DOI: https://doi.org/10.4049/jimmunol.1190054

PILLARS OF IMMUNOLOGY

Open Access
CTLA-4: Not All Costimulation Is Stimulatory
Hugh Auchincloss and Laurence A. Turka

The Journal of Immunology October 1, 2011, 187 (7) 3457-3458; DOI: https://doi.org/10.4049/jimmunol.1102316
Open Access
Pillars Article: CD28 and CTLA-4 Have Opposing Effects on the Response of T Cells to Stimulation. The Journal of Experimental Medicine. 1995. 182: 459–465
Matthew F. Krummel and James P. Allison

The Journal of Immunology October 1, 2011, 187 (7) 3459-3465;
Open Access
Pillars Article: CTLA-4 Can Function as a Negative Regulator of T Cell Activation. Immunity. 1994. 1: 405–413
Theresa L. Walunas, Deborah J. Lenschow, Christina Y. Bakker, Peter S. Linsley, Gordon J. Freeman, Jonathan M. Green, Craig B. Thompson and Jeffrey A. Bluestone

The Journal of Immunology October 1, 2011, 187 (7) 3466-3474;

BRIEF REVIEWS

Open Access
Antimicrobial Aspects of Inflammatory Resolution in the Mucosa: A Role for Proresolving Mediators
Eric L. Campbell, Charles N. Serhan and Sean P. Colgan

The Journal of Immunology October 1, 2011, 187 (7) 3475-3481; DOI: https://doi.org/10.4049/jimmunol.1100150

CUTTING EDGE

Open Access
Cutting Edge: Mouse CD300f (CMRF-35–Like Molecule-1) Recognizes Outer Membrane-Exposed Phosphatidylserine and Can Promote Phagocytosis
Seung-Chul Choi, Venkateswara R. Simhadri, Linjie Tian, Aleksandra Gil-Krzewska, Konrad Krzewski, Francisco Borrego and John E. Coligan

The Journal of Immunology October 1, 2011, 187 (7) 3483-3487; DOI: https://doi.org/10.4049/jimmunol.1101549
Open Access
Cutting Edge: Virus Selectively Primes Human Langerhans Cells for CD70 Expression Promoting CD8⁺ T Cell Responses
Angelic M. G. van der Aar, Rosa de Groot, Marta Sanchez-Hernandez, Esther W. M. Taanman, René A. W. van Lier, Marcel B. M. Teunissen, Esther C. de Jong and Martien L. Kapsenberg

The Journal of Immunology October 1, 2011, 187 (7) 3488-3492; DOI: https://doi.org/10.4049/jimmunol.1101105
Open Access
Cutting Edge: Accelerated Autoimmune Diabetes in the Absence of LAG-3
Maria Bettini, Andrea L. Szymczak-Workman, Karen Forbes, Ashley H. Castellaw, Mark Selby, Xiaoyu Pan, Charles G. Drake, Alan J. Korman and Dario A. A. Vignali

The Journal of Immunology October 1, 2011, 187 (7) 3493-3498; DOI: https://doi.org/10.4049/jimmunol.1100714

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

Open Access
Modulation of IL-7 Thresholds by SOCS Proteins in Developing B Lineage Cells
Steven A. Corfe, Robert Rottapel and Christopher J. Paige

The Journal of Immunology October 1, 2011, 187 (7) 3499-3510; DOI: https://doi.org/10.4049/jimmunol.1100424
Open Access
Low-Dose Antigen Promotes Induction of FOXP3 in Human CD4⁺ T Cells
S. Alice Long, Mary Rieck, Megan Tatum, Paul L. Bollyky, Rebecca P. Wu, Isabelle Muller, Jhon-Chun Ho, Heather G. Shilling and Jane H. Buckner

The Journal of Immunology October 1, 2011, 187 (7) 3511-3520; DOI: https://doi.org/10.4049/jimmunol.1003880
Open Access
Foxp3⁺-Inducible Regulatory T Cells Suppress Endothelial Activation and Leukocyte Recruitment
Elena Maganto-García, De-xiu Bu, Margarite L. Tarrio, Pilar Alcaide, Gail Newton, Gabriel K. Griffin, Kevin J. Croce, Francis W. Luscinskas, Andrew H. Lichtman and Nir Grabie

The Journal of Immunology October 1, 2011, 187 (7) 3521-3529; DOI: https://doi.org/10.4049/jimmunol.1003947
Open Access
Dual TCR Expression Biases Lung Inflammation in DO11.10 Transgenic Mice and Promotes Neutrophilia via Microbiota-Induced Th17 Differentiation
Muriel M. Lemaire, Laure Dumoutier, Guy Warnier, Catherine Uyttenhove, Jacques Van Snick, Magali de Heusch, Monique Stevens and Jean-Christophe Renauld

The Journal of Immunology October 1, 2011, 187 (7) 3530-3537; DOI: https://doi.org/10.4049/jimmunol.1101720
Open Access
Cancer Immunoediting of the NK Group 2D Ligand H60a
Timothy O’Sullivan, Gavin P. Dunn, Daphne Y. Lacoursiere, Robert D. Schreiber and Jack D. Bui

The Journal of Immunology October 1, 2011, 187 (7) 3538-3545; DOI: https://doi.org/10.4049/jimmunol.1100413
Open Access
Selenite Induces Posttranscriptional Blockade of HLA-E Expression and Sensitizes Tumor Cells to CD94/NKG2A-Positive NK Cells
Monika Enqvist, Gustav Nilsonne, Oscar Hammarfjord, Robert P. A. Wallin, Niklas K. Björkström, Mikael Björnstedt, Anders Hjerpe, Hans-Gustaf Ljunggren, Katalin Dobra, Karl-Johan Malmberg and Mattias Carlsten

The Journal of Immunology October 1, 2011, 187 (7) 3546-3554; DOI: https://doi.org/10.4049/jimmunol.1100610
Open Access
CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells To Program Cytotoxic Th1 Differentiation
Harry Z. Qui, Adam T. Hagymasi, Suman Bandyopadhyay, Marie-Clare St. Rose, Raghunath Ramanarasimhaiah, Antoine Ménoret, Robert S. Mittler, Scott M. Gordon, Steven L. Reiner, Anthony T. Vella and Adam J. Adler

The Journal of Immunology October 1, 2011, 187 (7) 3555-3564; DOI: https://doi.org/10.4049/jimmunol.1101244
Open Access
Differential Expression of the Adaptor Protein HSH2 Controls the Quantitative and Qualitative Nature of the Humoral Response
R. Glenn King, Brantley R. Herrin and Louis B. Justement

The Journal of Immunology October 1, 2011, 187 (7) 3565-3577; DOI: https://doi.org/10.4049/jimmunol.1101534
Open Access
MicroRNA-155 Is Essential for the T Cell-Mediated Control of Helicobacter pylori Infection and for the Induction of Chronic Gastritis and Colitis
Mathias Oertli, Daniela B. Engler, Esther Kohler, Manuel Koch, Thomas F. Meyer and Anne Müller

The Journal of Immunology October 1, 2011, 187 (7) 3578-3586; DOI: https://doi.org/10.4049/jimmunol.1101772
Open Access
IL-7 Is Required for the Development of the Intrinsic Function of Marginal Zone B Cells and the Marginal Zone Microenvironment
Leen Willems, Shengqiao Li, Omer Rutgeerts, Caroline Lenaerts, Mark Waer and An D. Billiau

The Journal of Immunology October 1, 2011, 187 (7) 3587-3594; DOI: https://doi.org/10.4049/jimmunol.1004012
Open Access
Transgenic Eimeria tenella Expressing Enhanced Yellow Fluorescent Protein Targeted to Different Cellular Compartments Stimulated Dichotomic Immune Responses in Chickens
Xiaoxi Huang, Jun Zou, Hanqian Xu, Ye Ding, Guangwen Yin, Xianyong Liu and Xun Suo

The Journal of Immunology October 1, 2011, 187 (7) 3595-3602; DOI: https://doi.org/10.4049/jimmunol.1100043
Open Access
Mycophenolic Acid Differentially Impacts B Cell Function Depending on the Stage of Differentiation
Jodi L. Karnell, Fredrick G. Karnell III, Geoffrey L. Stephens, Bhargavi Rajan, Chris Morehouse, Ying Li, Bonnie Swerdlow, Mildred Wilson, Raphaela Goldbach-Mansky, Christopher Groves, Anthony J. Coyle, Ronald Herbst and Rachel Ettinger

The Journal of Immunology October 1, 2011, 187 (7) 3603-3612; DOI: https://doi.org/10.4049/jimmunol.1003319
Open Access
TCR-Induced Activation of LFA-1 Involves Signaling through Tiam1
Mikaela Grönholm, Farhana Jahan, Silvia Marchesan, Ulla Karvonen, Maria Aatonen, Suneeta Narumanchi and Carl G. Gahmberg

The Journal of Immunology October 1, 2011, 187 (7) 3613-3619; DOI: https://doi.org/10.4049/jimmunol.1100704
Open Access
ORAI1 Deficiency Impairs Activated T Cell Death and Enhances T Cell Survival
Kyun-Do Kim, Sonal Srikanth, Ma-Khin Win Yee, Dennis C. Mock, Gregory W. Lawson and Yousang Gwack

The Journal of Immunology October 1, 2011, 187 (7) 3620-3630; DOI: https://doi.org/10.4049/jimmunol.1100847
Open Access
An Age-Specific CD8⁺ T Cell Pathway That Impairs the Effectiveness of Strategies To Prolong Allograft Survival
Wei Du, Hua Shen, Anjela Galan and Daniel R. Goldstein

The Journal of Immunology October 1, 2011, 187 (7) 3631-3640; DOI: https://doi.org/10.4049/jimmunol.1100441
Open Access
Complement Activation and Complement Receptors on Follicular Dendritic Cells Are Critical for the Function of a Targeted Adjuvant
Johan Mattsson, Ulf Yrlid, Anneli Stensson, Karin Schön, Mikael C. I. Karlsson, Jeffrey V. Ravetch and Nils Y. Lycke

The Journal of Immunology October 1, 2011, 187 (7) 3641-3652; DOI: https://doi.org/10.4049/jimmunol.1101107
Open Access
Ocular Surface APCs Are Necessary for Autoreactive T Cell-Mediated Experimental Autoimmune Lacrimal Keratoconjunctivitis
Chris S. Schaumburg, Karyn F. Siemasko, Cintia S. De Paiva, Larry A. Wheeler, Jerry Y. Niederkorn, Stephen C. Pflugfelder and Michael E. Stern

The Journal of Immunology October 1, 2011, 187 (7) 3653-3662; DOI: https://doi.org/10.4049/jimmunol.1101442
Open Access
A Live Imaging Cell Motility Screen Identifies Prostaglandin E₂ as a T Cell Stop Signal Antagonist
Andrew J. Wiemer, Subramanya Hegde, Jenny E. Gumperz and Anna Huttenlocher

The Journal of Immunology October 1, 2011, 187 (7) 3663-3670; DOI: https://doi.org/10.4049/jimmunol.1100103
Open Access
Macrophages at the Fetal–Maternal Interface Express Markers of Alternative Activation and Are Induced by M-CSF and IL-10
Judit Svensson, Maria C. Jenmalm, Andreas Matussek, Robert Geffers, Göran Berg and Jan Ernerudh

The Journal of Immunology October 1, 2011, 187 (7) 3671-3682; DOI: https://doi.org/10.4049/jimmunol.1100130

MOLECULAR AND STRUCTURAL IMMUNOLOGY

Open Access
Genome-Wide Expression Profiling and Mutagenesis Studies Reveal that Lipopolysaccharide Responsiveness Appears To Be Absolutely Dependent on TLR4 and MD-2 Expression and Is Dependent upon Intermolecular Ionic Interactions
Jianmin Meng, Mei Gong, Harry Björkbacka and Douglas T. Golenbock

The Journal of Immunology October 1, 2011, 187 (7) 3683-3693; DOI: https://doi.org/10.4049/jimmunol.1101397
Open Access
Mutagenesis of Beryllium-Specific TCRs Suggests an Unusual Binding Topology for Antigen Recognition
Natalie A. Bowerman, Michael T. Falta, Douglas G. Mack, John W. Kappler and Andrew P. Fontenot

The Journal of Immunology October 1, 2011, 187 (7) 3694-3703; DOI: https://doi.org/10.4049/jimmunol.1101872
Open Access
Epitope-Specific Human Influenza Antibody Repertoires Diversify by B Cell Intraclonal Sequence Divergence and Interclonal Convergence
Jens C. Krause, Tshidi Tsibane, Terrence M. Tumpey, Chelsey J. Huffman, Bryan S. Briney, Scott A. Smith, Christopher F. Basler and James E. Crowe Jr.

The Journal of Immunology October 1, 2011, 187 (7) 3704-3711; DOI: https://doi.org/10.4049/jimmunol.1101823
Open Access
Modulation of the Murine CD8 Gene Complex Following the Targeted Integration of Human CD2-Locus Control Region Sequences
Ursula Menzel, Theodoros Kosteas, Mauro Tolaini, Nigel Killeen, Kathleen Roderick and Dimitris Kioussis

The Journal of Immunology October 1, 2011, 187 (7) 3712-3720; DOI: https://doi.org/10.4049/jimmunol.1100709
Open Access
IL-2 Regulates Expression of C-MAF in Human CD4 T Cells
Aradhana Rani, Behdad Afzali, Audrey Kelly, Lemlem Tewolde-Berhan, Mark Hackett, Aditi S. Kanhere, Isabela Pedroza-Pacheco, Holly Bowen, Stipo Jurcevic, Richard G. Jenner, David J. Cousins, Jack A. Ragheb, Paul Lavender and Susan John

The Journal of Immunology October 1, 2011, 187 (7) 3721-3729; DOI: https://doi.org/10.4049/jimmunol.1002354

IMMUNOGENETICS

Open Access
Virus-Specific CD8⁺ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication
Gennadiy Zelinskyy, Lara Myers, Kirsten K. Dietze, Kathrin Gibbert, Michael Roggendorf, Jia Liu, Mengji Lu, Anke R. Kraft, Volker Teichgräber, Kim J. Hasenkrug and Ulf Dittmer

The Journal of Immunology October 1, 2011, 187 (7) 3730-3737; DOI: https://doi.org/10.4049/jimmunol.1101612

HOST DEFENSE

Open Access
Combining Liver- and Blood-Stage Malaria Viral-Vectored Vaccines: Investigating Mechanisms of CD8⁺ T Cell Interference
Emily K. Forbes, Sumi Biswas, Katharine A. Collins, Sarah C. Gilbert, Adrian V. S. Hill and Simon J. Draper

The Journal of Immunology October 1, 2011, 187 (7) 3738-3750; DOI: https://doi.org/10.4049/jimmunol.1003783
Open Access
The Role of Mannose-Binding Lectin-Associated Serine Protease-3 in Activation of the Alternative Complement Pathway
Daisuke Iwaki, Kazuko Kanno, Minoru Takahashi, Yuichi Endo, Misao Matsushita and Teizo Fujita

The Journal of Immunology October 1, 2011, 187 (7) 3751-3758; DOI: https://doi.org/10.4049/jimmunol.1100280
Open Access
Functional CD8 T Cell Memory Responding to Persistent Latent Infection Is Maintained for Life
Anna Lang and Janko Nikolich-Žugich

The Journal of Immunology October 1, 2011, 187 (7) 3759-3768; DOI: https://doi.org/10.4049/jimmunol.1100666
Open Access
Host Immunity and Pathogen Strain Contribute to Intestinal Disaccharidase Impairment following Gut Infection
Shahram Solaymani-Mohammadi and Steven M. Singer

The Journal of Immunology October 1, 2011, 187 (7) 3769-3775; DOI: https://doi.org/10.4049/jimmunol.1100606
Open Access
Expression of the Leptin Receptor outside of Bone Marrow-Derived Cells Regulates Tuberculosis Control and Lung Macrophage MHC Expression
Maria P. Lemos, Kyu Y. Rhee and John D. McKinney

The Journal of Immunology October 1, 2011, 187 (7) 3776-3784; DOI: https://doi.org/10.4049/jimmunol.1003226
Open Access
Rescue of HIV-1 Broad Neutralizing Antibody-Expressing B Cells in 2F5 V_H × V_L Knockin Mice Reveals Multiple Tolerance Controls
Laurent Verkoczy, Yao Chen, Hilary Bouton-Verville, Jinsong Zhang, Marilyn Diaz, Jennifer Hutchinson, Ying-Bin Ouyang, S. Munir Alam, T. Matt Holl, Kwan-Ki Hwang, Garnett Kelsoe and Barton F. Haynes

The Journal of Immunology October 1, 2011, 187 (7) 3785-3797; DOI: https://doi.org/10.4049/jimmunol.1101633
Open Access
TLR Regulation of SPSB1 Controls Inducible Nitric Oxide Synthase Induction
Rowena S. Lewis, Tatiana B. Kolesnik, Zhihe Kuang, Akshay A. D’Cruz, Marnie E. Blewitt, Seth L. Masters, Andrew Low, Tracy Willson, Raymond S. Norton and Sandra E. Nicholson

The Journal of Immunology October 1, 2011, 187 (7) 3798-3805; DOI: https://doi.org/10.4049/jimmunol.1002993

INFLAMMATION

Open Access
The Process of Macrophage Migration Promotes Matrix Metalloproteinase-Independent Invasion by Tumor Cells
Romain Guiet, Emeline Van Goethem, Céline Cougoule, Stéphanie Balor, Annie Valette, Talal Al Saati, Clifford A. Lowell, Véronique Le Cabec and Isabelle Maridonneau-Parini

The Journal of Immunology October 1, 2011, 187 (7) 3806-3814; DOI: https://doi.org/10.4049/jimmunol.1101245
Open Access
IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway Disease
Charlotte Mitchell, Karin Provost, Naiqian Niu, Robert Homer and Lauren Cohn

The Journal of Immunology October 1, 2011, 187 (7) 3815-3820; DOI: https://doi.org/10.4049/jimmunol.1100436
Open Access
Experimental Arthritis Triggers Periodontal Disease in Mice: Involvement of TNF-α and the Oral Microbiota
Celso Martins Queiroz-Junior, Mila Fernandes Moreira Madeira, Fernanda Matos Coelho, Vivian Vasconcelos Costa, Rafaela Leal Costa Bessoni, Larissa Fonseca da Cunha Sousa, Gustavo Pompermaier Garlet, Danielle da Glória de Souza, Mauro Martins Teixeira and Tarcília Aparecida da Silva

The Journal of Immunology October 1, 2011, 187 (7) 3821-3830; DOI: https://doi.org/10.4049/jimmunol.1101195
Open Access
A TLR5 Agonist Inhibits Acute Renal Ischemic Failure
Nobuyuki Fukuzawa, Marianne Petro, William M. Baldwin III, Andrei V. Gudkov and Robert L. Fairchild

The Journal of Immunology October 1, 2011, 187 (7) 3831-3839; DOI: https://doi.org/10.4049/jimmunol.1003238
Open Access
Depletion of Autoreactive Plasma Cells and Treatment of Lupus Nephritis in Mice Using CEP-33779, a Novel, Orally Active, Selective Inhibitor of JAK2
Lily D. Lu, Kristine L. Stump, Nate H. Wallace, Pawel Dobrzanski, Cynthia Serdikoff, Diane E. Gingrich, Benjamin J. Dugan, Thelma S. Angeles, Mark S. Albom, Jennifer L. Mason, Mark A. Ator, Bruce D. Dorsey, Bruce A. Ruggeri and Matthew M. Seavey

The Journal of Immunology October 1, 2011, 187 (7) 3840-3853; DOI: https://doi.org/10.4049/jimmunol.1101228
Open Access
Myeloid-Specific Expression of Human Lysosomal Acid Lipase Corrects Malformation and Malfunction of Myeloid-Derived Suppressor Cells in lal^−/− Mice
Peng Qu, Cong Yan, Janice S. Blum, Reuben Kapur and Hong Du

The Journal of Immunology October 1, 2011, 187 (7) 3854-3866; DOI: https://doi.org/10.4049/jimmunol.1003358
Open Access
Glycogen Synthase Kinase-3 Facilitates Con A-Induced IFN-γ–Mediated Immune Hepatic Injury
Cheng-Chieh Tsai, Wei-Ching Huang, Chia-Ling Chen, Chia-Yuan Hsieh, Yee-Shin Lin, Shun-Hua Chen, Kao-Chi Yang and Chiou-Feng Lin

The Journal of Immunology October 1, 2011, 187 (7) 3867-3877; DOI: https://doi.org/10.4049/jimmunol.1100770
Open Access
The P2X₇ Receptor and Pannexin-1 Are Both Required for the Promotion of Multinucleated Macrophages by the Inflammatory Cytokine GM-CSF
Irma Lemaire, Simonetta Falzoni, Bin Zhang, Patrizia Pellegatti and Francesco Di Virgilio

The Journal of Immunology October 1, 2011, 187 (7) 3878-3887; DOI: https://doi.org/10.4049/jimmunol.1002780

CLINICAL IMMUNOLOGY

Open Access
An Acquired Defect in IgG-Dependent Phagocytosis Explains the Impairment in Antibody-Mediated Cellular Depletion in Lupus
Anupama Ahuja, Lino L. Teichmann, Haowei Wang, Robert Dunn, Marilyn R. Kehry and Mark J. Shlomchik

The Journal of Immunology October 1, 2011, 187 (7) 3888-3894; DOI: https://doi.org/10.4049/jimmunol.1101629
Open Access
Human Natural Regulatory T Cell Development, Suppressive Function, and Postthymic Maturation in a Humanized Mouse Model
Takashi Onoe, Hannes Kalscheuer, Nichole Danzl, Meredith Chittenden, Guiling Zhao, Yong-Guang Yang and Megan Sykes

The Journal of Immunology October 1, 2011, 187 (7) 3895-3903; DOI: https://doi.org/10.4049/jimmunol.1100394

IN THIS ISSUE

You have accessRestricted access
In This Issue
J Immunol October 1, 2011, 187 (7) 3455-3456; DOI: https://doi.org/10.4049/jimmunol.1190054

PILLARS OF IMMUNOLOGY

You have accessRestricted access
CTLA-4: Not All Costimulation Is Stimulatory
Hugh Auchincloss and Laurence A. Turka

J Immunol October 1, 2011, 187 (7) 3457-3458; DOI: https://doi.org/10.4049/jimmunol.1102316
You have accessRestricted access
Pillars Article: CD28 and CTLA-4 Have Opposing Effects on the Response of T Cells to Stimulation. The Journal of Experimental Medicine. 1995. 182: 459–465
Matthew F. Krummel and James P. Allison

J Immunol October 1, 2011, 187 (7) 3459-3465;
You have accessRestricted access
Pillars Article: CTLA-4 Can Function as a Negative Regulator of T Cell Activation. Immunity. 1994. 1: 405–413
Theresa L. Walunas, Deborah J. Lenschow, Christina Y. Bakker, Peter S. Linsley, Gordon J. Freeman, Jonathan M. Green, Craig B. Thompson and Jeffrey A. Bluestone

J Immunol October 1, 2011, 187 (7) 3466-3474;

BRIEF REVIEWS

You have accessRestricted access
Antimicrobial Aspects of Inflammatory Resolution in the Mucosa: A Role for Proresolving Mediators
Eric L. Campbell, Charles N. Serhan and Sean P. Colgan

J Immunol October 1, 2011, 187 (7) 3475-3481; DOI: https://doi.org/10.4049/jimmunol.1100150

CUTTING EDGE

You have accessRestricted access
Cutting Edge: Mouse CD300f (CMRF-35–Like Molecule-1) Recognizes Outer Membrane-Exposed Phosphatidylserine and Can Promote Phagocytosis
Seung-Chul Choi, Venkateswara R. Simhadri, Linjie Tian, Aleksandra Gil-Krzewska, Konrad Krzewski, Francisco Borrego and John E. Coligan

J Immunol October 1, 2011, 187 (7) 3483-3487; DOI: https://doi.org/10.4049/jimmunol.1101549
You have accessRestricted access
Cutting Edge: Virus Selectively Primes Human Langerhans Cells for CD70 Expression Promoting CD8⁺ T Cell Responses
Angelic M. G. van der Aar, Rosa de Groot, Marta Sanchez-Hernandez, Esther W. M. Taanman, René A. W. van Lier, Marcel B. M. Teunissen, Esther C. de Jong and Martien L. Kapsenberg

J Immunol October 1, 2011, 187 (7) 3488-3492; DOI: https://doi.org/10.4049/jimmunol.1101105
You have accessRestricted access
Cutting Edge: Accelerated Autoimmune Diabetes in the Absence of LAG-3
Maria Bettini, Andrea L. Szymczak-Workman, Karen Forbes, Ashley H. Castellaw, Mark Selby, Xiaoyu Pan, Charles G. Drake, Alan J. Korman and Dario A. A. Vignali

J Immunol October 1, 2011, 187 (7) 3493-3498; DOI: https://doi.org/10.4049/jimmunol.1100714

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

You have accessRestricted access
Modulation of IL-7 Thresholds by SOCS Proteins in Developing B Lineage Cells
Steven A. Corfe, Robert Rottapel and Christopher J. Paige

J Immunol October 1, 2011, 187 (7) 3499-3510; DOI: https://doi.org/10.4049/jimmunol.1100424
You have accessRestricted access
Low-Dose Antigen Promotes Induction of FOXP3 in Human CD4⁺ T Cells
S. Alice Long, Mary Rieck, Megan Tatum, Paul L. Bollyky, Rebecca P. Wu, Isabelle Muller, Jhon-Chun Ho, Heather G. Shilling and Jane H. Buckner

J Immunol October 1, 2011, 187 (7) 3511-3520; DOI: https://doi.org/10.4049/jimmunol.1003880
You have accessRestricted access
Foxp3⁺-Inducible Regulatory T Cells Suppress Endothelial Activation and Leukocyte Recruitment
Elena Maganto-García, De-xiu Bu, Margarite L. Tarrio, Pilar Alcaide, Gail Newton, Gabriel K. Griffin, Kevin J. Croce, Francis W. Luscinskas, Andrew H. Lichtman and Nir Grabie

J Immunol October 1, 2011, 187 (7) 3521-3529; DOI: https://doi.org/10.4049/jimmunol.1003947
You have accessRestricted access
Dual TCR Expression Biases Lung Inflammation in DO11.10 Transgenic Mice and Promotes Neutrophilia via Microbiota-Induced Th17 Differentiation
Muriel M. Lemaire, Laure Dumoutier, Guy Warnier, Catherine Uyttenhove, Jacques Van Snick, Magali de Heusch, Monique Stevens and Jean-Christophe Renauld

J Immunol October 1, 2011, 187 (7) 3530-3537; DOI: https://doi.org/10.4049/jimmunol.1101720
You have accessRestricted access
Cancer Immunoediting of the NK Group 2D Ligand H60a
Timothy O’Sullivan, Gavin P. Dunn, Daphne Y. Lacoursiere, Robert D. Schreiber and Jack D. Bui

J Immunol October 1, 2011, 187 (7) 3538-3545; DOI: https://doi.org/10.4049/jimmunol.1100413
You have accessRestricted access
Selenite Induces Posttranscriptional Blockade of HLA-E Expression and Sensitizes Tumor Cells to CD94/NKG2A-Positive NK Cells
Monika Enqvist, Gustav Nilsonne, Oscar Hammarfjord, Robert P. A. Wallin, Niklas K. Björkström, Mikael Björnstedt, Anders Hjerpe, Hans-Gustaf Ljunggren, Katalin Dobra, Karl-Johan Malmberg and Mattias Carlsten

J Immunol October 1, 2011, 187 (7) 3546-3554; DOI: https://doi.org/10.4049/jimmunol.1100610
You have accessRestricted access
CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells To Program Cytotoxic Th1 Differentiation
Harry Z. Qui, Adam T. Hagymasi, Suman Bandyopadhyay, Marie-Clare St. Rose, Raghunath Ramanarasimhaiah, Antoine Ménoret, Robert S. Mittler, Scott M. Gordon, Steven L. Reiner, Anthony T. Vella and Adam J. Adler

J Immunol October 1, 2011, 187 (7) 3555-3564; DOI: https://doi.org/10.4049/jimmunol.1101244
You have accessRestricted access
Differential Expression of the Adaptor Protein HSH2 Controls the Quantitative and Qualitative Nature of the Humoral Response
R. Glenn King, Brantley R. Herrin and Louis B. Justement

J Immunol October 1, 2011, 187 (7) 3565-3577; DOI: https://doi.org/10.4049/jimmunol.1101534
You have accessRestricted access
MicroRNA-155 Is Essential for the T Cell-Mediated Control of Helicobacter pylori Infection and for the Induction of Chronic Gastritis and Colitis
Mathias Oertli, Daniela B. Engler, Esther Kohler, Manuel Koch, Thomas F. Meyer and Anne Müller

J Immunol October 1, 2011, 187 (7) 3578-3586; DOI: https://doi.org/10.4049/jimmunol.1101772
You have accessRestricted access
IL-7 Is Required for the Development of the Intrinsic Function of Marginal Zone B Cells and the Marginal Zone Microenvironment
Leen Willems, Shengqiao Li, Omer Rutgeerts, Caroline Lenaerts, Mark Waer and An D. Billiau

J Immunol October 1, 2011, 187 (7) 3587-3594; DOI: https://doi.org/10.4049/jimmunol.1004012
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Transgenic Eimeria tenella Expressing Enhanced Yellow Fluorescent Protein Targeted to Different Cellular Compartments Stimulated Dichotomic Immune Responses in Chickens
Xiaoxi Huang, Jun Zou, Hanqian Xu, Ye Ding, Guangwen Yin, Xianyong Liu and Xun Suo

J Immunol October 1, 2011, 187 (7) 3595-3602; DOI: https://doi.org/10.4049/jimmunol.1100043
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Mycophenolic Acid Differentially Impacts B Cell Function Depending on the Stage of Differentiation
Jodi L. Karnell, Fredrick G. Karnell III, Geoffrey L. Stephens, Bhargavi Rajan, Chris Morehouse, Ying Li, Bonnie Swerdlow, Mildred Wilson, Raphaela Goldbach-Mansky, Christopher Groves, Anthony J. Coyle, Ronald Herbst and Rachel Ettinger

J Immunol October 1, 2011, 187 (7) 3603-3612; DOI: https://doi.org/10.4049/jimmunol.1003319
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TCR-Induced Activation of LFA-1 Involves Signaling through Tiam1
Mikaela Grönholm, Farhana Jahan, Silvia Marchesan, Ulla Karvonen, Maria Aatonen, Suneeta Narumanchi and Carl G. Gahmberg

J Immunol October 1, 2011, 187 (7) 3613-3619; DOI: https://doi.org/10.4049/jimmunol.1100704
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ORAI1 Deficiency Impairs Activated T Cell Death and Enhances T Cell Survival
Kyun-Do Kim, Sonal Srikanth, Ma-Khin Win Yee, Dennis C. Mock, Gregory W. Lawson and Yousang Gwack

J Immunol October 1, 2011, 187 (7) 3620-3630; DOI: https://doi.org/10.4049/jimmunol.1100847
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An Age-Specific CD8⁺ T Cell Pathway That Impairs the Effectiveness of Strategies To Prolong Allograft Survival
Wei Du, Hua Shen, Anjela Galan and Daniel R. Goldstein

J Immunol October 1, 2011, 187 (7) 3631-3640; DOI: https://doi.org/10.4049/jimmunol.1100441
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Complement Activation and Complement Receptors on Follicular Dendritic Cells Are Critical for the Function of a Targeted Adjuvant
Johan Mattsson, Ulf Yrlid, Anneli Stensson, Karin Schön, Mikael C. I. Karlsson, Jeffrey V. Ravetch and Nils Y. Lycke

J Immunol October 1, 2011, 187 (7) 3641-3652; DOI: https://doi.org/10.4049/jimmunol.1101107
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Ocular Surface APCs Are Necessary for Autoreactive T Cell-Mediated Experimental Autoimmune Lacrimal Keratoconjunctivitis
Chris S. Schaumburg, Karyn F. Siemasko, Cintia S. De Paiva, Larry A. Wheeler, Jerry Y. Niederkorn, Stephen C. Pflugfelder and Michael E. Stern

J Immunol October 1, 2011, 187 (7) 3653-3662; DOI: https://doi.org/10.4049/jimmunol.1101442
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A Live Imaging Cell Motility Screen Identifies Prostaglandin E₂ as a T Cell Stop Signal Antagonist
Andrew J. Wiemer, Subramanya Hegde, Jenny E. Gumperz and Anna Huttenlocher

J Immunol October 1, 2011, 187 (7) 3663-3670; DOI: https://doi.org/10.4049/jimmunol.1100103
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Macrophages at the Fetal–Maternal Interface Express Markers of Alternative Activation and Are Induced by M-CSF and IL-10
Judit Svensson, Maria C. Jenmalm, Andreas Matussek, Robert Geffers, Göran Berg and Jan Ernerudh

J Immunol October 1, 2011, 187 (7) 3671-3682; DOI: https://doi.org/10.4049/jimmunol.1100130

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Genome-Wide Expression Profiling and Mutagenesis Studies Reveal that Lipopolysaccharide Responsiveness Appears To Be Absolutely Dependent on TLR4 and MD-2 Expression and Is Dependent upon Intermolecular Ionic Interactions
Jianmin Meng, Mei Gong, Harry Björkbacka and Douglas T. Golenbock

J Immunol October 1, 2011, 187 (7) 3683-3693; DOI: https://doi.org/10.4049/jimmunol.1101397
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Mutagenesis of Beryllium-Specific TCRs Suggests an Unusual Binding Topology for Antigen Recognition
Natalie A. Bowerman, Michael T. Falta, Douglas G. Mack, John W. Kappler and Andrew P. Fontenot

J Immunol October 1, 2011, 187 (7) 3694-3703; DOI: https://doi.org/10.4049/jimmunol.1101872
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Epitope-Specific Human Influenza Antibody Repertoires Diversify by B Cell Intraclonal Sequence Divergence and Interclonal Convergence
Jens C. Krause, Tshidi Tsibane, Terrence M. Tumpey, Chelsey J. Huffman, Bryan S. Briney, Scott A. Smith, Christopher F. Basler and James E. Crowe Jr.

J Immunol October 1, 2011, 187 (7) 3704-3711; DOI: https://doi.org/10.4049/jimmunol.1101823
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Modulation of the Murine CD8 Gene Complex Following the Targeted Integration of Human CD2-Locus Control Region Sequences
Ursula Menzel, Theodoros Kosteas, Mauro Tolaini, Nigel Killeen, Kathleen Roderick and Dimitris Kioussis

J Immunol October 1, 2011, 187 (7) 3712-3720; DOI: https://doi.org/10.4049/jimmunol.1100709
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IL-2 Regulates Expression of C-MAF in Human CD4 T Cells
Aradhana Rani, Behdad Afzali, Audrey Kelly, Lemlem Tewolde-Berhan, Mark Hackett, Aditi S. Kanhere, Isabela Pedroza-Pacheco, Holly Bowen, Stipo Jurcevic, Richard G. Jenner, David J. Cousins, Jack A. Ragheb, Paul Lavender and Susan John

J Immunol October 1, 2011, 187 (7) 3721-3729; DOI: https://doi.org/10.4049/jimmunol.1002354

IMMUNOGENETICS

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Virus-Specific CD8⁺ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication
Gennadiy Zelinskyy, Lara Myers, Kirsten K. Dietze, Kathrin Gibbert, Michael Roggendorf, Jia Liu, Mengji Lu, Anke R. Kraft, Volker Teichgräber, Kim J. Hasenkrug and Ulf Dittmer

J Immunol October 1, 2011, 187 (7) 3730-3737; DOI: https://doi.org/10.4049/jimmunol.1101612

HOST DEFENSE

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Combining Liver- and Blood-Stage Malaria Viral-Vectored Vaccines: Investigating Mechanisms of CD8⁺ T Cell Interference
Emily K. Forbes, Sumi Biswas, Katharine A. Collins, Sarah C. Gilbert, Adrian V. S. Hill and Simon J. Draper

J Immunol October 1, 2011, 187 (7) 3738-3750; DOI: https://doi.org/10.4049/jimmunol.1003783
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The Role of Mannose-Binding Lectin-Associated Serine Protease-3 in Activation of the Alternative Complement Pathway
Daisuke Iwaki, Kazuko Kanno, Minoru Takahashi, Yuichi Endo, Misao Matsushita and Teizo Fujita

J Immunol October 1, 2011, 187 (7) 3751-3758; DOI: https://doi.org/10.4049/jimmunol.1100280
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Functional CD8 T Cell Memory Responding to Persistent Latent Infection Is Maintained for Life
Anna Lang and Janko Nikolich-Žugich

J Immunol October 1, 2011, 187 (7) 3759-3768; DOI: https://doi.org/10.4049/jimmunol.1100666
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Host Immunity and Pathogen Strain Contribute to Intestinal Disaccharidase Impairment following Gut Infection
Shahram Solaymani-Mohammadi and Steven M. Singer

J Immunol October 1, 2011, 187 (7) 3769-3775; DOI: https://doi.org/10.4049/jimmunol.1100606
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Expression of the Leptin Receptor outside of Bone Marrow-Derived Cells Regulates Tuberculosis Control and Lung Macrophage MHC Expression
Maria P. Lemos, Kyu Y. Rhee and John D. McKinney

J Immunol October 1, 2011, 187 (7) 3776-3784; DOI: https://doi.org/10.4049/jimmunol.1003226
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Rescue of HIV-1 Broad Neutralizing Antibody-Expressing B Cells in 2F5 V_H × V_L Knockin Mice Reveals Multiple Tolerance Controls
Laurent Verkoczy, Yao Chen, Hilary Bouton-Verville, Jinsong Zhang, Marilyn Diaz, Jennifer Hutchinson, Ying-Bin Ouyang, S. Munir Alam, T. Matt Holl, Kwan-Ki Hwang, Garnett Kelsoe and Barton F. Haynes

J Immunol October 1, 2011, 187 (7) 3785-3797; DOI: https://doi.org/10.4049/jimmunol.1101633
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TLR Regulation of SPSB1 Controls Inducible Nitric Oxide Synthase Induction
Rowena S. Lewis, Tatiana B. Kolesnik, Zhihe Kuang, Akshay A. D’Cruz, Marnie E. Blewitt, Seth L. Masters, Andrew Low, Tracy Willson, Raymond S. Norton and Sandra E. Nicholson

J Immunol October 1, 2011, 187 (7) 3798-3805; DOI: https://doi.org/10.4049/jimmunol.1002993

INFLAMMATION

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The Process of Macrophage Migration Promotes Matrix Metalloproteinase-Independent Invasion by Tumor Cells
Romain Guiet, Emeline Van Goethem, Céline Cougoule, Stéphanie Balor, Annie Valette, Talal Al Saati, Clifford A. Lowell, Véronique Le Cabec and Isabelle Maridonneau-Parini

J Immunol October 1, 2011, 187 (7) 3806-3814; DOI: https://doi.org/10.4049/jimmunol.1101245
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IFN-γ Acts on the Airway Epithelium To Inhibit Local and Systemic Pathology in Allergic Airway Disease
Charlotte Mitchell, Karin Provost, Naiqian Niu, Robert Homer and Lauren Cohn

J Immunol October 1, 2011, 187 (7) 3815-3820; DOI: https://doi.org/10.4049/jimmunol.1100436
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Experimental Arthritis Triggers Periodontal Disease in Mice: Involvement of TNF-α and the Oral Microbiota
Celso Martins Queiroz-Junior, Mila Fernandes Moreira Madeira, Fernanda Matos Coelho, Vivian Vasconcelos Costa, Rafaela Leal Costa Bessoni, Larissa Fonseca da Cunha Sousa, Gustavo Pompermaier Garlet, Danielle da Glória de Souza, Mauro Martins Teixeira and Tarcília Aparecida da Silva

J Immunol October 1, 2011, 187 (7) 3821-3830; DOI: https://doi.org/10.4049/jimmunol.1101195
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A TLR5 Agonist Inhibits Acute Renal Ischemic Failure
Nobuyuki Fukuzawa, Marianne Petro, William M. Baldwin III, Andrei V. Gudkov and Robert L. Fairchild

J Immunol October 1, 2011, 187 (7) 3831-3839; DOI: https://doi.org/10.4049/jimmunol.1003238
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Depletion of Autoreactive Plasma Cells and Treatment of Lupus Nephritis in Mice Using CEP-33779, a Novel, Orally Active, Selective Inhibitor of JAK2
Lily D. Lu, Kristine L. Stump, Nate H. Wallace, Pawel Dobrzanski, Cynthia Serdikoff, Diane E. Gingrich, Benjamin J. Dugan, Thelma S. Angeles, Mark S. Albom, Jennifer L. Mason, Mark A. Ator, Bruce D. Dorsey, Bruce A. Ruggeri and Matthew M. Seavey

J Immunol October 1, 2011, 187 (7) 3840-3853; DOI: https://doi.org/10.4049/jimmunol.1101228
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Myeloid-Specific Expression of Human Lysosomal Acid Lipase Corrects Malformation and Malfunction of Myeloid-Derived Suppressor Cells in lal^−/− Mice
Peng Qu, Cong Yan, Janice S. Blum, Reuben Kapur and Hong Du

J Immunol October 1, 2011, 187 (7) 3854-3866; DOI: https://doi.org/10.4049/jimmunol.1003358
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Glycogen Synthase Kinase-3 Facilitates Con A-Induced IFN-γ–Mediated Immune Hepatic Injury
Cheng-Chieh Tsai, Wei-Ching Huang, Chia-Ling Chen, Chia-Yuan Hsieh, Yee-Shin Lin, Shun-Hua Chen, Kao-Chi Yang and Chiou-Feng Lin

J Immunol October 1, 2011, 187 (7) 3867-3877; DOI: https://doi.org/10.4049/jimmunol.1100770
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The P2X₇ Receptor and Pannexin-1 Are Both Required for the Promotion of Multinucleated Macrophages by the Inflammatory Cytokine GM-CSF
Irma Lemaire, Simonetta Falzoni, Bin Zhang, Patrizia Pellegatti and Francesco Di Virgilio

J Immunol October 1, 2011, 187 (7) 3878-3887; DOI: https://doi.org/10.4049/jimmunol.1002780

CLINICAL IMMUNOLOGY

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An Acquired Defect in IgG-Dependent Phagocytosis Explains the Impairment in Antibody-Mediated Cellular Depletion in Lupus
Anupama Ahuja, Lino L. Teichmann, Haowei Wang, Robert Dunn, Marilyn R. Kehry and Mark J. Shlomchik

J Immunol October 1, 2011, 187 (7) 3888-3894; DOI: https://doi.org/10.4049/jimmunol.1101629
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Human Natural Regulatory T Cell Development, Suppressive Function, and Postthymic Maturation in a Humanized Mouse Model
Takashi Onoe, Hannes Kalscheuer, Nichole Danzl, Meredith Chittenden, Guiling Zhao, Yong-Guang Yang and Megan Sykes

J Immunol October 1, 2011, 187 (7) 3895-3903; DOI: https://doi.org/10.4049/jimmunol.1100394

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IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

IMMUNOGENETICS

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

IMMUNOGENETICS

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

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