On the cover: A CTL clone (center) is surrounded by three different target cells and beads coated with anti–LFA-1. Experiments using beads coated with anti-LFA or anti-TCR or both revealed that both TCR and LFA-1 ligation are required for the recruitment of the cytoskeletal adaptor protein paxillin to the contact site. Robertson, L. K. and H. L. Ostergaard. 2011. Paxillin associates with the microtubule cytoskeleton and the immunological synapse of CTL through its leucine-aspartic acid domains and contributes to microtubule organizing center reorientation. J. Immunol. 187: 5824–5833.