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TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection

Ivett Jelinek, Joshua N. Leonard, Graeme E. Price, Kevin N. Brown, Anna Meyer-Manlapat, Paul K. Goldsmith, Yan Wang, David Venzon, Suzanne L. Epstein and David M. Segal
J Immunol February 15, 2011, 186 (4) 2422-2429; DOI: https://doi.org/10.4049/jimmunol.1002845
Ivett Jelinek
*Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
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Joshua N. Leonard
*Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
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Graeme E. Price
†Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852;
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Kevin N. Brown
*Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
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Anna Meyer-Manlapat
*Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
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Paul K. Goldsmith
‡Antibody and Protein Purification Unit, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and
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Yan Wang
*Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
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David Venzon
§Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Suzanne L. Epstein
†Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852;
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David M. Segal
*Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
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Article Information

vol. 186 no. 4 2422-2429
DOI 
https://doi.org/10.4049/jimmunol.1002845
PubMed 
21242525

Published By 
The American Association of Immunologists, Inc.
Print ISSN 
0022-1767
Online ISSN 
1550-6606
History 
  • Received August 24, 2010
  • Accepted December 14, 2010
  • Published online February 2, 2011.

Article Versions

  • Older version (January 17, 2011 - 13:44).
  • You are viewing the most recent version of this article.

Author Information

  1. Ivett Jelinek*,
  2. Joshua N. Leonard*,1,
  3. Graeme E. Price†,
  4. Kevin N. Brown*,
  5. Anna Meyer-Manlapat*,2,
  6. Paul K. Goldsmith‡,
  7. Yan Wang*,
  8. David Venzon§,
  9. Suzanne L. Epstein† and
  10. David M. Segal*
  1. *Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
  2. †Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852;
  3. ‡Antibody and Protein Purification Unit, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and
  4. §Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
  1. Address correspondence and reprint requests to Dr. David M. Segal, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 4B36, 10 Center Drive, Bethesda, MD 20892-1360. E-mail address: dave_segal{at}nih.gov
  • ↵1 Current address: Department of Chemical and Biological Engineering, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL.

  • ↵2 Current address: Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC.

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AbstractFullPdf
Jan 20114954266
Feb 2011803109188
Mar 201124892103
Apr 2011956955
May 2011749470
Jun 2011747854
Jul 2011586950
Aug 2011764234
Sep 2011586453
Oct 2011545131
Nov 2011676046
Dec 2011613427
Total 20112163766977
Jan 2012484436
Feb 2012485934
Mar 2012335748
Apr 2012375330
May 2012335131
Jun 2012264026
Jul 2012205038
Aug 2012223423
Sep 2012384532
Oct 2012435740
Nov 2012273936
Dec 2012284518
Total 2012403574392
Jan 2013384519
Feb 2013243527
Mar 2013354028
Apr 2013305240
May 2013344624
Jun 2013362321
Jul 2013143028
Aug 2013152926
Sep 2013264623
Oct 2013234418
Nov 2013143714
Dec 2013284426
Total 2013317471294
Jan 2014253616
Feb 201413204
Mar 2014194634
Apr 2014223620
May 2014163420
Jun 2014222821
Jul 201428527
Aug 2014233916
Sep 2014243110
Oct 2014334111
Nov 2014193414
Dec 2014133213
Total 2014257429186
Jan 2015283419
Feb 2015162919
Mar 2015265017
Apr 2015364535
May 2015204327
Jun 2015102917
Jul 2015134325
Aug 201519246
Sep 2015301915
Oct 2015102313
Nov 2015152615
Dec 2015273719
Total 2015250402227
Jan 2016271911
Feb 2016181616
Mar 2016162013
Apr 2016232316
May 2016182415
Jun 201610219
Jul 201619813
Aug 2016171711
Sep 2016162911
Oct 2016173316
Nov 2016122411
Dec 201617159
Total 2016210249151
Jan 2017144110
Feb 201762615
Mar 201763917
Apr 201733014
May 201733624
Jun 201704213
Jul 20171239
Aug 201721610
Sep 201772728
Oct 201793332
Nov 2017323515
Dec 201731916
Total 201786367203
Jan 201822818
Feb 20183168
Mar 2018122014
Apr 201812223
May 20183326
Jun 20183296
Jul 201831714
Aug 201812215
Sep 201802110
Oct 201852714
Nov 201832417
Dec 20182208
Total 201838278153
Jan 2019102514
Feb 201942812
Mar 201972816
Apr 201943819
May 201942418
Jun 201922313
Jul 201923211
Aug 201941914
Sep 201911618
Oct 2019123628
Nov 201921811
Dec 201971818
Total 201959305192
Jan 20205267
Feb 20203189
Mar 2020101613
Apr 202091410
May 20202228
Jun 202091719
Jul 20207199
Aug 202032213
Sep 20208209
Oct 202062823
Nov 202073927
Dec 20205117
Total 202074252154
Jan 202131719
Total 202131719
Total386041102948

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The Journal of Immunology: 186 (4)
The Journal of Immunology
Vol. 186, Issue 4
15 Feb 2011
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TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection
Ivett Jelinek, Joshua N. Leonard, Graeme E. Price, Kevin N. Brown, Anna Meyer-Manlapat, Paul K. Goldsmith, Yan Wang, David Venzon, Suzanne L. Epstein, David M. Segal
The Journal of Immunology February 15, 2011, 186 (4) 2422-2429; DOI: 10.4049/jimmunol.1002845

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TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection
Ivett Jelinek, Joshua N. Leonard, Graeme E. Price, Kevin N. Brown, Anna Meyer-Manlapat, Paul K. Goldsmith, Yan Wang, David Venzon, Suzanne L. Epstein, David M. Segal
The Journal of Immunology February 15, 2011, 186 (4) 2422-2429; DOI: 10.4049/jimmunol.1002845
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