Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory Functions

^*Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115;
^†Department of Medical Genetics, Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, University of Cambridge, Cambridge, United Kingdom;
^‡Neurology Department, Yale Medical School, New Haven, CT 06510;
^§Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142;
^¶Department of Immunology, ZymoGenetics, Seattle, WA 98102; and
^‖Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115

Address correspondence and reprint requests to Dr. Vijay K. Kuchroo, Center for Neurologic Diseases, Brigham and Women’s Hospital, 77 Avenue Louis Pasteur, HIM 785, Boston, MA 02115-5817. E-mail address: vkuchroo{at}rics.bwh.harvard.edu

↵1 Current address: Novo Nordisk Inflammation Research Center, Seattle, WA.

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Article usage

Article usage: January 2011 to July 2022

	Abstract	Full	Pdf
Jan 2011	1522	131	340
Feb 2011	545	179	164
Mar 2011	248	150	112
Apr 2011	136	87	69
May 2011	79	85	56
Jun 2011	90	55	40
Jul 2011	74	54	45
Aug 2011	96	52	45
Sep 2011	75	43	40
Oct 2011	79	64	52
Nov 2011	67	49	35
Dec 2011	60	32	36
Total 2011	3071	981	1034
Jan 2012	75	49	36
Feb 2012	86	39	51
Mar 2012	66	48	29
Apr 2012	73	49	39
May 2012	67	40	33
Jun 2012	37	30	26
Jul 2012	46	54	49
Aug 2012	53	25	22
Sep 2012	67	27	35
Oct 2012	65	30	45
Nov 2012	49	38	31
Dec 2012	34	28	21
Total 2012	718	457	417
Jan 2013	51	43	31
Feb 2013	39	37	28
Mar 2013	50	38	40
Apr 2013	44	64	44
May 2013	48	42	33
Jun 2013	30	35	33
Jul 2013	24	37	28
Aug 2013	31	51	39
Sep 2013	22	48	48
Oct 2013	29	28	25
Nov 2013	21	30	37
Dec 2013	23	26	35
Total 2013	412	479	421
Jan 2014	37	42	38
Feb 2014	24	26	38
Mar 2014	38	54	57
Apr 2014	30	43	51
May 2014	45	73	74
Jun 2014	41	66	55
Jul 2014	22	35	23
Aug 2014	24	32	38
Sep 2014	29	49	66
Oct 2014	27	51	61
Nov 2014	54	38	52
Dec 2014	27	37	40
Total 2014	398	546	593
Jan 2015	38	35	46
Feb 2015	28	60	54
Mar 2015	90	55	63
Apr 2015	26	67	57
May 2015	32	57	67
Jun 2015	36	49	61
Jul 2015	20	41	62
Aug 2015	22	28	43
Sep 2015	38	34	38
Oct 2015	26	47	48
Nov 2015	32	47	54
Dec 2015	19	41	41
Total 2015	407	561	634
Jan 2016	44	52	74
Feb 2016	24	41	56
Mar 2016	39	46	55
Apr 2016	30	62	54
May 2016	49	55	58
Jun 2016	40	55	87
Jul 2016	34	39	66
Aug 2016	61	46	90
Sep 2016	40	69	56
Oct 2016	57	44	61
Nov 2016	38	29	51
Dec 2016	33	21	35
Total 2016	489	559	743
Jan 2017	36	55	58
Feb 2017	10	59	57
Mar 2017	13	86	68
Apr 2017	8	58	29
May 2017	11	84	61
Jun 2017	6	67	73
Jul 2017	10	44	64
Aug 2017	10	31	39
Sep 2017	5	33	35
Oct 2017	5	49	37
Nov 2017	5	52	40
Dec 2017	10	44	35
Total 2017	129	662	596
Jan 2018	10	52	48
Feb 2018	13	55	47
Mar 2018	15	48	48
Apr 2018	11	116	64
May 2018	16	81	34
Jun 2018	7	77	43
Jul 2018	16	68	52
Aug 2018	22	82	50
Sep 2018	10	88	59
Oct 2018	11	69	37
Nov 2018	15	69	44
Dec 2018	8	48	40
Total 2018	154	853	566
Jan 2019	19	80	47
Feb 2019	11	60	35
Mar 2019	19	72	44
Apr 2019	16	69	52
May 2019	13	62	45
Jun 2019	14	56	45
Jul 2019	9	54	61
Aug 2019	14	54	67
Sep 2019	10	63	51
Oct 2019	11	85	60
Nov 2019	12	62	54
Dec 2019	14	68	64
Total 2019	162	785	625
Jan 2020	11	75	43
Feb 2020	25	58	49
Mar 2020	22	63	44
Apr 2020	27	61	70
May 2020	9	87	65
Jun 2020	15	79	73
Jul 2020	26	66	38
Aug 2020	15	85	65
Sep 2020	21	67	45
Oct 2020	12	80	64
Nov 2020	17	81	55
Dec 2020	19	73	50
Total 2020	219	875	661
Jan 2021	22	68	64
Feb 2021	21	49	49
Mar 2021	20	83	61
Apr 2021	22	117	57
May 2021	24	76	67
Jun 2021	24	58	54
Jul 2021	38	65	56
Aug 2021	19	79	72
Sep 2021	19	64	68
Oct 2021	22	85	90
Nov 2021	29	74	85
Dec 2021	29	70	63
Total 2021	289	888	786
Jan 2022	21	101	87
Feb 2022	15	75	53
Mar 2022	99	110	106
Apr 2022	27	93	91
May 2022	14	116	75
Jun 2022	15	103	72
Jul 2022	16	66	59
Total 2022	207	664	543
Total	6655	8310	7619