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Non-steroidal anti-inflammatory drugs reduce optimal antibody production in response to vaccination and vaccinia virus infection (45.18)

Richard Phipps, Simona Bancos, David Topham and Matthew Bernard
J Immunol April 1, 2011, 186 (1 Supplement) 45.18;
Richard Phipps
1University of Rochester, Rochester, NY
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Simona Bancos
1University of Rochester, Rochester, NY
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David Topham
1University of Rochester, Rochester, NY
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Matthew Bernard
1University of Rochester, Rochester, NY
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Abstract

Protective humoral immune responses generated by vaccination, depends on optimal production of antibodies. Non-steroidal anti-inflammatory drugs (NSAIDs) are used to curb undesirable effects of vaccination such as fever. We previously demonstrated that B cells express the “proinflammatory” enzyme cyclooxygenase-2 (Cox-2) in response to activation stimuli such as the TLR9 ligand CpG DNA. Using genetic approaches and small molecule Cox-2 selective inhibitors, we demonstrated that Cox-2 is crucial for optimal antibody production. Expression of plasma cell transcriptional regulatory factors, including Blimp-1 and Xbp-1, were dependent on Cox-2 activity. Significantly fewer antibody secreting plasma cell precursors were generated in the presence of Cox-2 inhibitors, indicating that Cox-2 is essential for human B cell terminal differentiation. Mice chronically treated with Cox-2 inhibitors produced less neutralizing IgG following live virus infection with vaccinia virus. In vitro studies using human B cells show that all commonly used NSAIDs, as well as Tylenol (acetaminophen), at pharmacologic doses, blunt antibody production. Interestingly, a recent clinical trial showed that Tylenol use in infants blunted antibody responses to a variety of vaccines. These new data support the concept that the Cox pathway is necessary for optimal antibody production. The use of NSAIDs, may impair antibody production to vaccination and to certain infections.

  • Copyright © 2011 by The American Association of Immunologists, Inc.
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The Journal of Immunology
Vol. 186, Issue 1 Supplement
April 2011
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Non-steroidal anti-inflammatory drugs reduce optimal antibody production in response to vaccination and vaccinia virus infection (45.18)
Richard Phipps, Simona Bancos, David Topham, Matthew Bernard
The Journal of Immunology April 1, 2011, 186 (1 Supplement) 45.18;

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Non-steroidal anti-inflammatory drugs reduce optimal antibody production in response to vaccination and vaccinia virus infection (45.18)
Richard Phipps, Simona Bancos, David Topham, Matthew Bernard
The Journal of Immunology April 1, 2011, 186 (1 Supplement) 45.18;
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More in this TOC Section

  • Limiting HCDR3 diversity abrogates the antibody response to the bacterial polysaccharide α 1→3 Dextran (45.20)
  • CD4 T cells must be present during B cell development for B cells to respond to a T-dependent foreign antigen (45.19)
  • FCRLA is an intracellular FcR-related protein that binds IgM, IgG and IgA isotypes in B cells (45.11)
Show more B Cell Generation and Function

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Print ISSN 0022-1767        Online ISSN 1550-6606