On the cover: The first specific TCR–peptide interaction to be identified was a charge–charge interaction between TCR and the central lysine of the cytochrome c peptide presented by I-E^k (Jorgensen et al., 1992). This and several other coordinating interactions are shown for the 226 TCR, a relative of the well-studied 5c.c7 and 2B4 TCRs. Newell, E. W., L. K. Ely, A. C. Kruse, P. A. Reay, S. N. Rodriguez, A. Lin, M. S. Kuhns, K. C. Garcia, and M. M. Davis. 2011. Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E^k. J. Immunol. 186: 5823–5832.