The Journal of Immunology: 185 (2)

July 15, 2010; Volume 185,Issue 2

EDITORIAL

Open Access
Translating and Communicating Immunology
Jeremy M. Boss and Betty Diamond

The Journal of Immunology July 15, 2010, 185 (2) 785; DOI: https://doi.org/10.4049/jimmunol.1090050

IN THIS ISSUE

Open Access
In This Issue
The Journal of Immunology July 15, 2010, 185 (2) 787-788; DOI: https://doi.org/10.4049/jimmunol.1090055

LETTERS TO THE EDITOR

Open Access
Comment on “IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis” and Comment on “IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis”
Enitan D. Carrol

The Journal of Immunology July 15, 2010, 185 (2) 789; DOI: https://doi.org/10.4049/jimmunol.1090052
Open Access
Response to Comment on “IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis” and Comment on “IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis”
Richard S. Hotchkiss, Jacqueline Unsinger, Charles C. Caldwell and David A. Hildeman

The Journal of Immunology July 15, 2010, 185 (2) 789-790; DOI: https://doi.org/10.4049/jimmunol.1090053

TRANSLATING IMMUNOLOGY

Open Access
Anti-TNF Therapy, from Rationale to Standard of Care: What Lessons Has It Taught Us?
Marc Feldmann and Ravinder N. Maini

The Journal of Immunology July 15, 2010, 185 (2) 791-794; DOI: https://doi.org/10.4049/jimmunol.1090051

BRIEF REVIEWS

Open Access
Dendritic Cell Apoptosis: Regulation of Tolerance versus Immunity
Rahul Kushwah and Jim Hu

The Journal of Immunology July 15, 2010, 185 (2) 795-802; DOI: https://doi.org/10.4049/jimmunol.1000325

CUTTING EDGE

Open Access
Cutting Edge: Programmed Death-1 Defines CD8⁺CD122⁺ T Cells as Regulatory versus Memory T Cells
Hehua Dai, Ni Wan, Shuzi Zhang, Yolonda Moore, Fusheng Wan and Zhenhua Dai

The Journal of Immunology July 15, 2010, 185 (2) 803-807; DOI: https://doi.org/10.4049/jimmunol.1000661
Open Access
Cutting Edge: C1q Binds Deoxyribose and Heparan Sulfate through Neighboring Sites of Its Recognition Domain
Virginie Garlatti, Anne Chouquet, Thomas Lunardi, Romain Vivès, Helena Païdassi, Hugues Lortat-Jacob, Nicole M. Thielens, Gérard J. Arlaud and Christine Gaboriaud

The Journal of Immunology July 15, 2010, 185 (2) 808-812; DOI: https://doi.org/10.4049/jimmunol.1000184
Open Access
Cutting Edge: Type I IFN Reverses Human Th2 Commitment and Stability by Suppressing GATA3
Jonathan P. Huber, Hilario J. Ramos, Michelle A. Gill and J. David Farrar

The Journal of Immunology July 15, 2010, 185 (2) 813-817; DOI: https://doi.org/10.4049/jimmunol.1000469
Open Access
Cutting Edge: Cytosolic Bacterial DNA Activates the Inflammasome via Aim2
Sarah E. Warren, Abraham Armstrong, M. Kristina Hamilton, Dat P. Mao, Irina A. Leaf, Edward A. Miao and Alan Aderem

The Journal of Immunology July 15, 2010, 185 (2) 818-821; DOI: https://doi.org/10.4049/jimmunol.1000724

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

Open Access
Mechanism and Localization of CD8 Regulatory T Cells in a Heart Transplant Model of Tolerance
Xian Liang Li, Séverine Ménoret, Séverine Bezie, Lise Caron, Dominique Chabannes, Marcelo Hill, Franck Halary, Mathieu Angin, Michèle Heslan, Claire Usal, Liang Liang, Carole Guillonneau, Brigitte Le Mauff, Maria Cristina Cuturi, Régis Josien and Ignacio Anegon

The Journal of Immunology July 15, 2010, 185 (2) 823-833; DOI: https://doi.org/10.4049/jimmunol.1000120
Open Access
The Overexpression of Heparin-Binding Epidermal Growth Factor Is Responsible for Th17-Induced Airway Remodeling in an Experimental Asthma Model
Qing Wang, Hequan Li, Yinan Yao, Dajing Xia and Jianying Zhou

The Journal of Immunology July 15, 2010, 185 (2) 834-841; DOI: https://doi.org/10.4049/jimmunol.0901490
Open Access
Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development
Tomohito Takimoto, Yu Wakabayashi, Takashi Sekiya, Naoko Inoue, Rimpei Morita, Kenji Ichiyama, Reiko Takahashi, Mayako Asakawa, Go Muto, Tomoaki Mori, Eiichi Hasegawa, Saika Shizuya, Toshiro Hara, Masatoshi Nomura and Akihiko Yoshimura

The Journal of Immunology July 15, 2010, 185 (2) 842-855; DOI: https://doi.org/10.4049/jimmunol.0904100
Open Access
Umbilical Cord Blood T Cells Respond against the Melan-A/MART-1 Tumor Antigen and Exhibit Reduced Alloreactivity as Compared with Adult Blood-Derived T Cells
Natacha Merindol, Anne-Julie Grenier, Martine Caty, Emily Charrier, Arnaud Duval, Michel Duval, Martin A. Champagne and Hugo Soudeyns

The Journal of Immunology July 15, 2010, 185 (2) 856-866; DOI: https://doi.org/10.4049/jimmunol.0902613
Open Access
Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes
Mahmood Mohtashami, Divya K. Shah, Hiroshi Nakase, Korosh Kianizad, Howard T. Petrie and Juan Carlos Zúñiga-Pflücker

The Journal of Immunology July 15, 2010, 185 (2) 867-876; DOI: https://doi.org/10.4049/jimmunol.1000782
Open Access
Serine Protease Inhibitor 6 Protects iNKT Cells from Self-Inflicted Damage
A. Wahid Ansari, Jeff N. Temblay, Syarifah H. Alyahya and Philip G. Ashton-Rickardt

The Journal of Immunology July 15, 2010, 185 (2) 877-883; DOI: https://doi.org/10.4049/jimmunol.1000651
Open Access
Regulation of Th2 Responses and Allergic Inflammation through Bystander Activation of CD8⁺ T Lymphocytes in Early Life
Aurore Dubois, Nathalie Deruytter, Brigitte Adams, Akira Kanda, Sandrine Delbauve, Sebastien Fleury, David Torres, Angélique François, Michel Pétein, Michel Goldman, David Dombrowicz and Véronique Flamand

The Journal of Immunology July 15, 2010, 185 (2) 884-891; DOI: https://doi.org/10.4049/jimmunol.0903287
Open Access
Long Peptide Vaccination Can Lead to Lethality through CD4⁺ T Cell-Mediated Cytokine Storm
Hiroshi Kitamura, Christine Sedlik, Alexandra Jacquet, Bruno Zaragoza, Mathilde Dusseaux, Virginie Premel, Xavier Sastre-Garau and Olivier Lantz

The Journal of Immunology July 15, 2010, 185 (2) 892-901; DOI: https://doi.org/10.4049/jimmunol.1000933
Open Access
Concomitant Tumor and Autoantigen Vaccination Supports Renal Cell Carcinoma Rejection
Nicolás Herbert, Axel Haferkamp, Hubertus F. Schmitz-Winnenthal and Margot Zöller

The Journal of Immunology July 15, 2010, 185 (2) 902-916; DOI: https://doi.org/10.4049/jimmunol.0902683
Open Access
Suppressor of Cytokine Signaling 2 Regulates IL-15–Primed Human NK Cell Function via Control of Phosphorylated Pyk2
Suk Hyung Lee, Sohyun Yun, Zheng-Hao Piao, Mira Jeong, Dong Oh Kim, Haiyoung Jung, Jiwon Lee, Mi Jeong Kim, Mi Sun Kim, Jin Woong Chung, Tae-Don Kim, Suk Ran Yoon, Philip D. Greenberg and Inpyo Choi

The Journal of Immunology July 15, 2010, 185 (2) 917-928; DOI: https://doi.org/10.4049/jimmunol.1000784
Open Access
Mycobacterium tuberculosis Activates Human Macrophage Peroxisome Proliferator-Activated Receptor γ Linking Mannose Receptor Recognition to Regulation of Immune Responses
Murugesan V. S. Rajaram, Michelle N. Brooks, Jessica D. Morris, Jordi B. Torrelles, Abul K. Azad and Larry S. Schlesinger

The Journal of Immunology July 15, 2010, 185 (2) 929-942; DOI: https://doi.org/10.4049/jimmunol.1000866
Open Access
Molecular Determinants of T Cell Epitope Recognition to the Common Timothy Grass Allergen
Carla Oseroff, John Sidney, Maya F. Kotturi, Ravi Kolla, Rafeul Alam, David H. Broide, Stephen I. Wasserman, Daniela Weiskopf, Denise M. McKinney, Jo L. Chung, Arnd Petersen, Howard Grey, Bjoern Peters and Alessandro Sette

The Journal of Immunology July 15, 2010, 185 (2) 943-955; DOI: https://doi.org/10.4049/jimmunol.1000405
Open Access
Synergistic Antitumor Effects of Regulatory T Cell Blockade Combined with Pemetrexed in Murine Malignant Mesothelioma
Masaki Anraku, Tetsuzo Tagawa, Licun Wu, Zhihong Yun, Shaf Keshavjee, Li Zhang, Michael R. Johnston and Marc de Perrot

The Journal of Immunology July 15, 2010, 185 (2) 956-966; DOI: https://doi.org/10.4049/jimmunol.0900437
Open Access
Osteopontin Expressed in Tubular Epithelial Cells Regulates NK Cell-Mediated Kidney Ischemia Reperfusion Injury
Zhu-Xu Zhang, Kelvin Shek, Shuang Wang, Xuyan Huang, Arthur Lau, Ziqin Yin, Hongtao Sun, Weihua Liu, Bertha Garcia, Susan Rittling and Anthony M. Jevnikar

The Journal of Immunology July 15, 2010, 185 (2) 967-973; DOI: https://doi.org/10.4049/jimmunol.0903245
Open Access
NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses
Denis Gris, Zhengmao Ye, Heather A. Iocca, Haitao Wen, Robin R. Craven, Pavel Gris, Max Huang, Monika Schneider, Stephen D. Miller and Jenny P.-Y. Ting

The Journal of Immunology July 15, 2010, 185 (2) 974-981; DOI: https://doi.org/10.4049/jimmunol.0904145
Open Access
Low-Level Exposure to HIV Induces Virus-Specific T Cell Responses and Immune Activation in Exposed HIV-Seronegative Individuals
Clara Restrepo, Norma I. Rallón, Jorge del Romero, Carmen Rodríguez, Victoria Hernando, Mariola López, Alejandra Peris, Sara Lozano, José M. Sempere-Ortells, Vincent Soriano and José M. Benito

The Journal of Immunology July 15, 2010, 185 (2) 982-989; DOI: https://doi.org/10.4049/jimmunol.1000221
Open Access
Costimulation-Dependent Expression of MicroRNA-214 Increases the Ability of T Cells To Proliferate by Targeting Pten
Peter T. Jindra, Jessamyn Bagley, Jonathan G. Godwin and John Iacomini

The Journal of Immunology July 15, 2010, 185 (2) 990-997; DOI: https://doi.org/10.4049/jimmunol.1000793
Open Access
IFN-γ Inhibits IL-4–Induced Type 2 Cytokine Expression by CD8 T Cells In Vivo and Modulates the Anti-Tumor Response
Simon H. Apte, Penny Groves, Stuart Olver, Adriana Baz, Denise L. Doolan, Anne Kelso and Norbert Kienzle

The Journal of Immunology July 15, 2010, 185 (2) 998-1004; DOI: https://doi.org/10.4049/jimmunol.0903372
Open Access
The Exocytosis of Lytic Granules Is Impaired in Vti1b- or Vamp8-Deficient CTL Leading to a Reduced Cytotoxic Activity following Antigen-Specific Activation
Ralf Dressel, Leslie Elsner, Peter Novota, Namita Kanwar and Gabriele Fischer von Mollard

The Journal of Immunology July 15, 2010, 185 (2) 1005-1014; DOI: https://doi.org/10.4049/jimmunol.1000770
Open Access
Deletion of IgG-Switched Autoreactive B Cells and Defects in Fas^lpr Lupus Mice
Djemel Aït-Azzouzene, Dwight H. Kono, Rosana Gonzalez-Quintial, Louise J. McHeyzer-Williams, Min Lim, Dilki Wickramarachchi, Tobias Gerdes, Amanda L. Gavin, Patrick Skog, Michael G. McHeyzer-Williams, David Nemazee and Argyrios N. Theofilopoulos

The Journal of Immunology July 15, 2010, 185 (2) 1015-1027; DOI: https://doi.org/10.4049/jimmunol.1000698
Open Access
Direct CD4 Help Provision following Interaction of Memory CD4 and CD8 T Cells with Distinct Antigen-Presenting Dendritic Cells
Marie-Ghislaine de Goër de Herve, Bamory Dembele, Mélissa Vallée, Florence Herr, Anne Cariou and Yassine Taoufik

The Journal of Immunology July 15, 2010, 185 (2) 1028-1036; DOI: https://doi.org/10.4049/jimmunol.0904209
Open Access
Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
Erikka L. Carr, Alina Kelman, Glendon S. Wu, Ravindra Gopaul, Emilee Senkevitch, Anahit Aghvanyan, Achmed M. Turay and Kenneth A. Frauwirth

The Journal of Immunology July 15, 2010, 185 (2) 1037-1044; DOI: https://doi.org/10.4049/jimmunol.0903586

MOLECULAR AND STRUCTURAL IMMUNOLOGY

Open Access
The Structure of the TNFRSF13C Promoter Enables Differential Expression of BAFF-R during B Cell Ontogeny and Terminal Differentiation
Stephen A. Mihalcik, Paul M. Huddleston III, Xiaosheng Wu and Diane F. Jelinek

The Journal of Immunology July 15, 2010, 185 (2) 1045-1054; DOI: https://doi.org/10.4049/jimmunol.1001120
Open Access
Posttranscriptional Silencing of VβDJβCβ Genes Contributes to TCRβ Allelic Exclusion in Mammalian Lymphocytes
Natalie C. Steinel, Brenna L. Brady, Andrea C. Carpenter, Katherine S. Yang-Iott and Craig H. Bassing

The Journal of Immunology July 15, 2010, 185 (2) 1055-1062; DOI: https://doi.org/10.4049/jimmunol.0903099
Open Access
IL-17RC Is Required for Immune Signaling via an Extended SEF/IL-17R Signaling Domain in the Cytoplasmic Tail
Allen W. Ho, Fang Shen, Heather R. Conti, Nayan Patel, Erin E. Childs, Alanna C. Peterson, Nydiaris Hernández-Santos, Jay K. Kolls, Lawrence P. Kane, Wenjun Ouyang and Sarah L. Gaffen

The Journal of Immunology July 15, 2010, 185 (2) 1063-1070; DOI: https://doi.org/10.4049/jimmunol.0903739
Open Access
Genome-Wide Identification of Human FOXP3 Target Genes in Natural Regulatory T Cells
Timothy J. Sadlon, Bridget G. Wilkinson, Stephen Pederson, Cheryl Y. Brown, Suzanne Bresatz, Tessa Gargett, Elizabeth L. Melville, Kaimen Peng, Richard J. D’Andrea, Gary G. Glonek, Gregory J. Goodall, Heddy Zola, M. Frances Shannon and Simon C. Barry

The Journal of Immunology July 15, 2010, 185 (2) 1071-1081; DOI: https://doi.org/10.4049/jimmunol.1000082
Open Access
Ternary Complex Factors SAP-1 and Elk-1, but Not Net, Are Functionally Equivalent in Thymocyte Development
Patrick Costello, Robert Nicolas, Jane Willoughby, Bohdan Wasylyk, Alfred Nordheim and Richard Treisman

The Journal of Immunology July 15, 2010, 185 (2) 1082-1092; DOI: https://doi.org/10.4049/jimmunol.1000472

HOST DEFENSE

Open Access
Intracellular Sequestration of the NKG2D Ligand ULBP3 by Human Cytomegalovirus
Neil J. Bennett, Omodele Ashiru, Fiona J. E. Morgan, Yin Pang, Georgina Okecha, Rob A. Eagle, John Trowsdale, J. G. Patrick Sissons and Mark R. Wills

The Journal of Immunology July 15, 2010, 185 (2) 1093-1102; DOI: https://doi.org/10.4049/jimmunol.1000789
Open Access
Enhancement of Antiviral Immunity by Small Molecule Antagonist of Suppressor of Cytokine Signaling
Chulbul M. I. Ahmed, Rea Dabelic, James P. Martin, Lindsey D. Jager, S. Mohammad Haider and Howard M. Johnson

The Journal of Immunology July 15, 2010, 185 (2) 1103-1113; DOI: https://doi.org/10.4049/jimmunol.0902895
Open Access
Innate Retroviral Restriction by Apobec3 Promotes Antibody Affinity Maturation In Vivo
Mario L. Santiago, Robert L. Benitez, Mauricio Montano, Kim J. Hasenkrug and Warner C. Greene

The Journal of Immunology July 15, 2010, 185 (2) 1114-1123; DOI: https://doi.org/10.4049/jimmunol.1001143
Open Access
Francisella tularensis Suppresses the Proinflammatory Response of Endothelial Cells via the Endothelial Protein C Receptor
DeAnna C. Bublitz, Courtney E. Noah, Jorge L. Benach and Martha B. Furie

The Journal of Immunology July 15, 2010, 185 (2) 1124-1131; DOI: https://doi.org/10.4049/jimmunol.0902429
Open Access
T Cell Epitope Specificity and Pathogenesis of Mouse Hepatitis Virus-1–Induced Disease in Susceptible and Resistant Hosts
Aaruni Khanolkar, Ross B. Fulton, Lecia L. Epping, Nhat-Long Pham, Dilea Tifrea, Steven M. Varga and John T. Harty

The Journal of Immunology July 15, 2010, 185 (2) 1132-1141; DOI: https://doi.org/10.4049/jimmunol.0902749
Open Access
Flagellin Stimulates Protective Lung Mucosal Immunity: Role of Cathelicidin-Related Antimicrobial Peptide
Fu-shin Yu, Matthew D. Cornicelli, Melissa A. Kovach, Michael W. Newstead, Xianying Zeng, Ashok Kumar, Nan Gao, Sang Gi Yoon, Richard L. Gallo and Theodore J. Standiford

The Journal of Immunology July 15, 2010, 185 (2) 1142-1149; DOI: https://doi.org/10.4049/jimmunol.1000509
Open Access
IL-17 Is Necessary for Host Protection against Acute-Phase Trypanosoma cruzi Infection
Yoshiyuki Miyazaki, Shinjiro Hamano, Seng Wang, Yohei Shimanoe, Yoichiro Iwakura and Hiroki Yoshida

The Journal of Immunology July 15, 2010, 185 (2) 1150-1157; DOI: https://doi.org/10.4049/jimmunol.0900047
Open Access
The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein
Congwen Wei, Caifei Ni, Ting Song, Yu Liu, XiaoLi Yang, Zirui Zheng, Yongxia Jia, Yuan Yuan, Kai Guan, Yang Xu, Xiaozhong Cheng, Yanhong Zhang, Xiao Yang, Youliang Wang, Chaoyang Wen, Qing Wu, Wei Shi and Hui Zhong

The Journal of Immunology July 15, 2010, 185 (2) 1158-1168; DOI: https://doi.org/10.4049/jimmunol.0903874

INFLAMMATION

Open Access
17β-Estradiol Promotes TLR4-Triggered Proinflammatory Mediator Production through Direct Estrogen Receptor α Signaling in Macrophages In Vivo
Bertrand Calippe, Victorine Douin-Echinard, Laurent Delpy, Muriel Laffargue, Karine Lélu, Andrée Krust, Bernard Pipy, Francis Bayard, Jean-François Arnal, Jean-Charles Guéry and Pierre Gourdy

The Journal of Immunology July 15, 2010, 185 (2) 1169-1176; DOI: https://doi.org/10.4049/jimmunol.0902383
Open Access
TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3^negCD127⁺ Immune Cells in Spleen and Mucosa
Laurye Van Maele, Christophe Carnoy, Delphine Cayet, Pascal Songhet, Laure Dumoutier, Isabel Ferrero, Laure Janot, François Erard, Julie Bertout, Hélène Leger, Florent Sebbane, Arndt Benecke, Jean-Christophe Renauld, Wolf-Dietrich Hardt, Bernhard Ryffel and Jean-Claude Sirard

The Journal of Immunology July 15, 2010, 185 (2) 1177-1185; DOI: https://doi.org/10.4049/jimmunol.1000115
Open Access
Involvement of Absent in Melanoma 2 in Inflammasome Activation in Macrophages Infected with Listeria monocytogenes
Kohsuke Tsuchiya, Hideki Hara, Ikuo Kawamura, Takamasa Nomura, Takeshi Yamamoto, Sylvia Daim, Sita R. Dewamitta, Yanna Shen, Rendong Fang and Masao Mitsuyama

The Journal of Immunology July 15, 2010, 185 (2) 1186-1195; DOI: https://doi.org/10.4049/jimmunol.1001058
Open Access
Heme Impairs Prostaglandin E₂ and TGF-β Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria
Bruno B. Andrade, Théo Araújo-Santos, Nívea F. Luz, Ricardo Khouri, Marcelo T. Bozza, Luís M. A. Camargo, Aldina Barral, Valéria M. Borges and Manoel Barral-Netto

The Journal of Immunology July 15, 2010, 185 (2) 1196-1204; DOI: https://doi.org/10.4049/jimmunol.0904179
Open Access
Allergen-Induced Airway Remodeling Is Impaired in Galectin-3–Deficient Mice
Xiao Na Ge, Nooshin S. Bahaie, Bit Na Kang, M. Reza Hosseinkhani, Sung Gil Ha, Elizabeth M. Frenzel, Fu-Tong Liu, Savita P. Rao and P. Sriramarao

The Journal of Immunology July 15, 2010, 185 (2) 1205-1214; DOI: https://doi.org/10.4049/jimmunol.1000039
Open Access
Mechanical Signals Activate Vascular Endothelial Growth Factor Receptor-2 To Upregulate Endothelial Cell Proliferation during Inflammation
Jie Liu and Sudha Agarwal

The Journal of Immunology July 15, 2010, 185 (2) 1215-1221; DOI: https://doi.org/10.4049/jimmunol.0903660
Open Access
IL-33 Reduces Macrophage Foam Cell Formation
James E. McLaren, Daryn R. Michael, Rebecca C. Salter, Tim G. Ashlin, Claudia J. Calder, Ashley M. Miller, Foo Y. Liew and Dipak P. Ramji

The Journal of Immunology July 15, 2010, 185 (2) 1222-1229; DOI: https://doi.org/10.4049/jimmunol.1000520
Open Access
Paroxetine Prevents Loss of Nigrostriatal Dopaminergic Neurons by Inhibiting Brain Inflammation and Oxidative Stress in an Experimental Model of Parkinson’s Disease
Young C. Chung, Sang R. Kim and Byung K. Jin

The Journal of Immunology July 15, 2010, 185 (2) 1230-1237; DOI: https://doi.org/10.4049/jimmunol.1000208
Open Access
Macrophage Migration Inhibitory Factor Increases Leukocyte–Endothelial Interactions in Human Endothelial Cells via Promotion of Expression of Adhesion Molecules
Qiang Cheng, Sonja J. McKeown, Leilani Santos, Fernando S. Santiago, Levon M. Khachigian, Eric F. Morand and Michael J. Hickey

The Journal of Immunology July 15, 2010, 185 (2) 1238-1247; DOI: https://doi.org/10.4049/jimmunol.0904104
Open Access
Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor
Ingrid Cardenas, Robert E. Means, Paulomi Aldo, Kaori Koga, Sabine M. Lang, Carmen Booth, Alejandro Manzur, Enrique Oyarzun, Roberto Romero and Gil Mor

The Journal of Immunology July 15, 2010, 185 (2) 1248-1257; DOI: https://doi.org/10.4049/jimmunol.1000289
Open Access
Injury-Induced Type I IFN Signaling Regulates Inflammatory Responses in the Central Nervous System
Reza Khorooshi and Trevor Owens

The Journal of Immunology July 15, 2010, 185 (2) 1258-1264; DOI: https://doi.org/10.4049/jimmunol.0901753
Open Access
The Relative Timing of Exposure to Phagocytosable Particulates and to Osteoclastogenic Cytokines Is Critically Important in the Determination of Myeloid Cell Fate
Douglas E. James, Bryan J. Nestor, Thomas P. Sculco, Lionel B. Ivashkiv, F. Patrick Ross, Steven R. Goldring and P. Edward Purdue

The Journal of Immunology July 15, 2010, 185 (2) 1265-1273; DOI: https://doi.org/10.4049/jimmunol.0902808
Open Access
Wnt5a Induces Endothelial Inflammation via β-Catenin–Independent Signaling
Jihun Kim, Jungtae Kim, Dong Wook Kim, Yunhi Ha, Min Hwan Ihm, Hyeri Kim, Kyuyoung Song and Inchul Lee

The Journal of Immunology July 15, 2010, 185 (2) 1274-1282; DOI: https://doi.org/10.4049/jimmunol.1000181
Open Access
IFN-γ Primes Intact Human Coronary Arteries and Cultured Coronary Smooth Muscle Cells to Double-Stranded RNA- and Self-RNA–Induced Inflammatory Responses by Upregulating TLR3 and Melanoma Differentiation-Associated Gene 5
Usman Ahmad, Rahmat Ali, Amir H. Lebastchi, Lingfeng Qin, Sheng-fu L. Lo, Alexander O. Yakimov, Salman F. Khan, Jonathan C. Choy, Arnar Geirsson, Jordan S. Pober and George Tellides

The Journal of Immunology July 15, 2010, 185 (2) 1283-1294; DOI: https://doi.org/10.4049/jimmunol.0902283
Open Access
Skin Inflammation Arising from Cutaneous Regulatory T Cell Deficiency Leads to Impaired Viral Immune Responses
Eva-Jasmin Freyschmidt, Clinton B. Mathias, Natalia Diaz, Daniel H. MacArthur, Amale Laouar, Narasimhaswamy Manjunath, Matthias D. Hofer, Marc-Andre Wurbel, James J. Campbell, Talal A. Chatila and Hans C. Oettgen

The Journal of Immunology July 15, 2010, 185 (2) 1295-1302; DOI: https://doi.org/10.4049/jimmunol.0903144
Open Access
Stimulation of FcγRI on Primary Sensory Neurons Increases Insulin-Like Growth Factor-I Production, Thereby Reducing Reperfusion-Induced Renal Injury in Mice
Naoaki Harada, Juan Zhao, Hiroki Kurihara, Naomi Nakagata and Kenji Okajima

The Journal of Immunology July 15, 2010, 185 (2) 1303-1310; DOI: https://doi.org/10.4049/jimmunol.0902051

CLINICAL IMMUNOLOGY

Open Access
An IL-2 Paradox: Blocking CD25 on T Cells Induces IL-2–Driven Activation of CD56^bright NK Cells
Jayne F. Martin, Justin S. A. Perry, Neha R. Jakhete, Xiang Wang and Bibiana Bielekova

The Journal of Immunology July 15, 2010, 185 (2) 1311-1320; DOI: https://doi.org/10.4049/jimmunol.0902238
Open Access
Ecto-5′-Nucleotidase (CD73) Attenuates Allograft Airway Rejection through Adenosine 2A Receptor Stimulation
Takashi Ohtsuka, Paul S. Changelian, Diane Bouïs, Kathleen Noon, Hiroaki Harada, Vibha N. Lama and David J. Pinsky

The Journal of Immunology July 15, 2010, 185 (2) 1321-1329; DOI: https://doi.org/10.4049/jimmunol.0901847
Open Access
Resistance of CD45RA⁻ T Cells to Apoptosis and Functional Impairment, and Activation of Tumor-Antigen Specific T Cells during Radiation Therapy of Prostate Cancer
Zsuzsanna Tabi, Lisa K. Spary, Sharon Coleman, Aled Clayton, Malcolm D. Mason and John Staffurth

The Journal of Immunology July 15, 2010, 185 (2) 1330-1339; DOI: https://doi.org/10.4049/jimmunol.1000488

CORRECTIONS

Open Access
Correction: Mathematical Modeling of Chimeric TCR Triggering Predicts the Magnitude of Target Lysis and Its Impairment by TCR Downmodulation
Scott E. James, Philip D. Greenberg, Michael C. Jensen, Yukang Lin, Jinjuan Wang, Lihua E. Budde, Brian G. Till, Andrew A. Raubitschek, Stephen J. Forman and Oliver W. Press

The Journal of Immunology July 15, 2010, 185 (2) 1340; DOI: https://doi.org/10.4049/jimmunol.1090049
Open Access
Correction: Isoforms of Vitamin E Have Opposing Immunoregulatory Functions during Inflammation by Regulating Leukocyte Recruitment
Sergejs Berdnikovs, Hiam Abdala-Valencia, Christine McCary, Michelle Somand, Rokeisha Cole, Alex Garcia, Paul Bryce and Joan M. Cook-Mills

The Journal of Immunology July 15, 2010, 185 (2) 1341; DOI: https://doi.org/10.4049/jimmunol.1090054

EDITORIAL

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Translating and Communicating Immunology
Jeremy M. Boss and Betty Diamond

J Immunol July 15, 2010, 185 (2) 785; DOI: https://doi.org/10.4049/jimmunol.1090050

IN THIS ISSUE

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In This Issue
J Immunol July 15, 2010, 185 (2) 787-788; DOI: https://doi.org/10.4049/jimmunol.1090055

LETTERS TO THE EDITOR

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Comment on “IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis” and Comment on “IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis”
Enitan D. Carrol

J Immunol July 15, 2010, 185 (2) 789; DOI: https://doi.org/10.4049/jimmunol.1090052
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Response to Comment on “IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis” and Comment on “IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis”
Richard S. Hotchkiss, Jacqueline Unsinger, Charles C. Caldwell and David A. Hildeman

J Immunol July 15, 2010, 185 (2) 789-790; DOI: https://doi.org/10.4049/jimmunol.1090053

TRANSLATING IMMUNOLOGY

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Anti-TNF Therapy, from Rationale to Standard of Care: What Lessons Has It Taught Us?
Marc Feldmann and Ravinder N. Maini

J Immunol July 15, 2010, 185 (2) 791-794; DOI: https://doi.org/10.4049/jimmunol.1090051

BRIEF REVIEWS

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Dendritic Cell Apoptosis: Regulation of Tolerance versus Immunity
Rahul Kushwah and Jim Hu

J Immunol July 15, 2010, 185 (2) 795-802; DOI: https://doi.org/10.4049/jimmunol.1000325

CUTTING EDGE

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Cutting Edge: Programmed Death-1 Defines CD8⁺CD122⁺ T Cells as Regulatory versus Memory T Cells
Hehua Dai, Ni Wan, Shuzi Zhang, Yolonda Moore, Fusheng Wan and Zhenhua Dai

J Immunol July 15, 2010, 185 (2) 803-807; DOI: https://doi.org/10.4049/jimmunol.1000661
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Cutting Edge: C1q Binds Deoxyribose and Heparan Sulfate through Neighboring Sites of Its Recognition Domain
Virginie Garlatti, Anne Chouquet, Thomas Lunardi, Romain Vivès, Helena Païdassi, Hugues Lortat-Jacob, Nicole M. Thielens, Gérard J. Arlaud and Christine Gaboriaud

J Immunol July 15, 2010, 185 (2) 808-812; DOI: https://doi.org/10.4049/jimmunol.1000184
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Cutting Edge: Type I IFN Reverses Human Th2 Commitment and Stability by Suppressing GATA3
Jonathan P. Huber, Hilario J. Ramos, Michelle A. Gill and J. David Farrar

J Immunol July 15, 2010, 185 (2) 813-817; DOI: https://doi.org/10.4049/jimmunol.1000469
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Cutting Edge: Cytosolic Bacterial DNA Activates the Inflammasome via Aim2
Sarah E. Warren, Abraham Armstrong, M. Kristina Hamilton, Dat P. Mao, Irina A. Leaf, Edward A. Miao and Alan Aderem

J Immunol July 15, 2010, 185 (2) 818-821; DOI: https://doi.org/10.4049/jimmunol.1000724

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

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Mechanism and Localization of CD8 Regulatory T Cells in a Heart Transplant Model of Tolerance
Xian Liang Li, Séverine Ménoret, Séverine Bezie, Lise Caron, Dominique Chabannes, Marcelo Hill, Franck Halary, Mathieu Angin, Michèle Heslan, Claire Usal, Liang Liang, Carole Guillonneau, Brigitte Le Mauff, Maria Cristina Cuturi, Régis Josien and Ignacio Anegon

J Immunol July 15, 2010, 185 (2) 823-833; DOI: https://doi.org/10.4049/jimmunol.1000120
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The Overexpression of Heparin-Binding Epidermal Growth Factor Is Responsible for Th17-Induced Airway Remodeling in an Experimental Asthma Model
Qing Wang, Hequan Li, Yinan Yao, Dajing Xia and Jianying Zhou

J Immunol July 15, 2010, 185 (2) 834-841; DOI: https://doi.org/10.4049/jimmunol.0901490
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Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development
Tomohito Takimoto, Yu Wakabayashi, Takashi Sekiya, Naoko Inoue, Rimpei Morita, Kenji Ichiyama, Reiko Takahashi, Mayako Asakawa, Go Muto, Tomoaki Mori, Eiichi Hasegawa, Saika Shizuya, Toshiro Hara, Masatoshi Nomura and Akihiko Yoshimura

J Immunol July 15, 2010, 185 (2) 842-855; DOI: https://doi.org/10.4049/jimmunol.0904100
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Umbilical Cord Blood T Cells Respond against the Melan-A/MART-1 Tumor Antigen and Exhibit Reduced Alloreactivity as Compared with Adult Blood-Derived T Cells
Natacha Merindol, Anne-Julie Grenier, Martine Caty, Emily Charrier, Arnaud Duval, Michel Duval, Martin A. Champagne and Hugo Soudeyns

J Immunol July 15, 2010, 185 (2) 856-866; DOI: https://doi.org/10.4049/jimmunol.0902613
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Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes
Mahmood Mohtashami, Divya K. Shah, Hiroshi Nakase, Korosh Kianizad, Howard T. Petrie and Juan Carlos Zúñiga-Pflücker

J Immunol July 15, 2010, 185 (2) 867-876; DOI: https://doi.org/10.4049/jimmunol.1000782
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Serine Protease Inhibitor 6 Protects iNKT Cells from Self-Inflicted Damage
A. Wahid Ansari, Jeff N. Temblay, Syarifah H. Alyahya and Philip G. Ashton-Rickardt

J Immunol July 15, 2010, 185 (2) 877-883; DOI: https://doi.org/10.4049/jimmunol.1000651
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Regulation of Th2 Responses and Allergic Inflammation through Bystander Activation of CD8⁺ T Lymphocytes in Early Life
Aurore Dubois, Nathalie Deruytter, Brigitte Adams, Akira Kanda, Sandrine Delbauve, Sebastien Fleury, David Torres, Angélique François, Michel Pétein, Michel Goldman, David Dombrowicz and Véronique Flamand

J Immunol July 15, 2010, 185 (2) 884-891; DOI: https://doi.org/10.4049/jimmunol.0903287
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Long Peptide Vaccination Can Lead to Lethality through CD4⁺ T Cell-Mediated Cytokine Storm
Hiroshi Kitamura, Christine Sedlik, Alexandra Jacquet, Bruno Zaragoza, Mathilde Dusseaux, Virginie Premel, Xavier Sastre-Garau and Olivier Lantz

J Immunol July 15, 2010, 185 (2) 892-901; DOI: https://doi.org/10.4049/jimmunol.1000933
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Concomitant Tumor and Autoantigen Vaccination Supports Renal Cell Carcinoma Rejection
Nicolás Herbert, Axel Haferkamp, Hubertus F. Schmitz-Winnenthal and Margot Zöller

J Immunol July 15, 2010, 185 (2) 902-916; DOI: https://doi.org/10.4049/jimmunol.0902683
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Suppressor of Cytokine Signaling 2 Regulates IL-15–Primed Human NK Cell Function via Control of Phosphorylated Pyk2
Suk Hyung Lee, Sohyun Yun, Zheng-Hao Piao, Mira Jeong, Dong Oh Kim, Haiyoung Jung, Jiwon Lee, Mi Jeong Kim, Mi Sun Kim, Jin Woong Chung, Tae-Don Kim, Suk Ran Yoon, Philip D. Greenberg and Inpyo Choi

J Immunol July 15, 2010, 185 (2) 917-928; DOI: https://doi.org/10.4049/jimmunol.1000784
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Mycobacterium tuberculosis Activates Human Macrophage Peroxisome Proliferator-Activated Receptor γ Linking Mannose Receptor Recognition to Regulation of Immune Responses
Murugesan V. S. Rajaram, Michelle N. Brooks, Jessica D. Morris, Jordi B. Torrelles, Abul K. Azad and Larry S. Schlesinger

J Immunol July 15, 2010, 185 (2) 929-942; DOI: https://doi.org/10.4049/jimmunol.1000866
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Molecular Determinants of T Cell Epitope Recognition to the Common Timothy Grass Allergen
Carla Oseroff, John Sidney, Maya F. Kotturi, Ravi Kolla, Rafeul Alam, David H. Broide, Stephen I. Wasserman, Daniela Weiskopf, Denise M. McKinney, Jo L. Chung, Arnd Petersen, Howard Grey, Bjoern Peters and Alessandro Sette

J Immunol July 15, 2010, 185 (2) 943-955; DOI: https://doi.org/10.4049/jimmunol.1000405
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Synergistic Antitumor Effects of Regulatory T Cell Blockade Combined with Pemetrexed in Murine Malignant Mesothelioma
Masaki Anraku, Tetsuzo Tagawa, Licun Wu, Zhihong Yun, Shaf Keshavjee, Li Zhang, Michael R. Johnston and Marc de Perrot

J Immunol July 15, 2010, 185 (2) 956-966; DOI: https://doi.org/10.4049/jimmunol.0900437
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Osteopontin Expressed in Tubular Epithelial Cells Regulates NK Cell-Mediated Kidney Ischemia Reperfusion Injury
Zhu-Xu Zhang, Kelvin Shek, Shuang Wang, Xuyan Huang, Arthur Lau, Ziqin Yin, Hongtao Sun, Weihua Liu, Bertha Garcia, Susan Rittling and Anthony M. Jevnikar

J Immunol July 15, 2010, 185 (2) 967-973; DOI: https://doi.org/10.4049/jimmunol.0903245
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NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses
Denis Gris, Zhengmao Ye, Heather A. Iocca, Haitao Wen, Robin R. Craven, Pavel Gris, Max Huang, Monika Schneider, Stephen D. Miller and Jenny P.-Y. Ting

J Immunol July 15, 2010, 185 (2) 974-981; DOI: https://doi.org/10.4049/jimmunol.0904145
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Low-Level Exposure to HIV Induces Virus-Specific T Cell Responses and Immune Activation in Exposed HIV-Seronegative Individuals
Clara Restrepo, Norma I. Rallón, Jorge del Romero, Carmen Rodríguez, Victoria Hernando, Mariola López, Alejandra Peris, Sara Lozano, José M. Sempere-Ortells, Vincent Soriano and José M. Benito

J Immunol July 15, 2010, 185 (2) 982-989; DOI: https://doi.org/10.4049/jimmunol.1000221
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Costimulation-Dependent Expression of MicroRNA-214 Increases the Ability of T Cells To Proliferate by Targeting Pten
Peter T. Jindra, Jessamyn Bagley, Jonathan G. Godwin and John Iacomini

J Immunol July 15, 2010, 185 (2) 990-997; DOI: https://doi.org/10.4049/jimmunol.1000793
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IFN-γ Inhibits IL-4–Induced Type 2 Cytokine Expression by CD8 T Cells In Vivo and Modulates the Anti-Tumor Response
Simon H. Apte, Penny Groves, Stuart Olver, Adriana Baz, Denise L. Doolan, Anne Kelso and Norbert Kienzle

J Immunol July 15, 2010, 185 (2) 998-1004; DOI: https://doi.org/10.4049/jimmunol.0903372
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The Exocytosis of Lytic Granules Is Impaired in Vti1b- or Vamp8-Deficient CTL Leading to a Reduced Cytotoxic Activity following Antigen-Specific Activation
Ralf Dressel, Leslie Elsner, Peter Novota, Namita Kanwar and Gabriele Fischer von Mollard

J Immunol July 15, 2010, 185 (2) 1005-1014; DOI: https://doi.org/10.4049/jimmunol.1000770
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Deletion of IgG-Switched Autoreactive B Cells and Defects in Fas^lpr Lupus Mice
Djemel Aït-Azzouzene, Dwight H. Kono, Rosana Gonzalez-Quintial, Louise J. McHeyzer-Williams, Min Lim, Dilki Wickramarachchi, Tobias Gerdes, Amanda L. Gavin, Patrick Skog, Michael G. McHeyzer-Williams, David Nemazee and Argyrios N. Theofilopoulos

J Immunol July 15, 2010, 185 (2) 1015-1027; DOI: https://doi.org/10.4049/jimmunol.1000698
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Direct CD4 Help Provision following Interaction of Memory CD4 and CD8 T Cells with Distinct Antigen-Presenting Dendritic Cells
Marie-Ghislaine de Goër de Herve, Bamory Dembele, Mélissa Vallée, Florence Herr, Anne Cariou and Yassine Taoufik

J Immunol July 15, 2010, 185 (2) 1028-1036; DOI: https://doi.org/10.4049/jimmunol.0904209
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Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
Erikka L. Carr, Alina Kelman, Glendon S. Wu, Ravindra Gopaul, Emilee Senkevitch, Anahit Aghvanyan, Achmed M. Turay and Kenneth A. Frauwirth

J Immunol July 15, 2010, 185 (2) 1037-1044; DOI: https://doi.org/10.4049/jimmunol.0903586

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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The Structure of the TNFRSF13C Promoter Enables Differential Expression of BAFF-R during B Cell Ontogeny and Terminal Differentiation
Stephen A. Mihalcik, Paul M. Huddleston III, Xiaosheng Wu and Diane F. Jelinek

J Immunol July 15, 2010, 185 (2) 1045-1054; DOI: https://doi.org/10.4049/jimmunol.1001120
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Posttranscriptional Silencing of VβDJβCβ Genes Contributes to TCRβ Allelic Exclusion in Mammalian Lymphocytes
Natalie C. Steinel, Brenna L. Brady, Andrea C. Carpenter, Katherine S. Yang-Iott and Craig H. Bassing

J Immunol July 15, 2010, 185 (2) 1055-1062; DOI: https://doi.org/10.4049/jimmunol.0903099
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IL-17RC Is Required for Immune Signaling via an Extended SEF/IL-17R Signaling Domain in the Cytoplasmic Tail
Allen W. Ho, Fang Shen, Heather R. Conti, Nayan Patel, Erin E. Childs, Alanna C. Peterson, Nydiaris Hernández-Santos, Jay K. Kolls, Lawrence P. Kane, Wenjun Ouyang and Sarah L. Gaffen

J Immunol July 15, 2010, 185 (2) 1063-1070; DOI: https://doi.org/10.4049/jimmunol.0903739
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Genome-Wide Identification of Human FOXP3 Target Genes in Natural Regulatory T Cells
Timothy J. Sadlon, Bridget G. Wilkinson, Stephen Pederson, Cheryl Y. Brown, Suzanne Bresatz, Tessa Gargett, Elizabeth L. Melville, Kaimen Peng, Richard J. D’Andrea, Gary G. Glonek, Gregory J. Goodall, Heddy Zola, M. Frances Shannon and Simon C. Barry

J Immunol July 15, 2010, 185 (2) 1071-1081; DOI: https://doi.org/10.4049/jimmunol.1000082
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Ternary Complex Factors SAP-1 and Elk-1, but Not Net, Are Functionally Equivalent in Thymocyte Development
Patrick Costello, Robert Nicolas, Jane Willoughby, Bohdan Wasylyk, Alfred Nordheim and Richard Treisman

J Immunol July 15, 2010, 185 (2) 1082-1092; DOI: https://doi.org/10.4049/jimmunol.1000472

HOST DEFENSE

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Intracellular Sequestration of the NKG2D Ligand ULBP3 by Human Cytomegalovirus
Neil J. Bennett, Omodele Ashiru, Fiona J. E. Morgan, Yin Pang, Georgina Okecha, Rob A. Eagle, John Trowsdale, J. G. Patrick Sissons and Mark R. Wills

J Immunol July 15, 2010, 185 (2) 1093-1102; DOI: https://doi.org/10.4049/jimmunol.1000789
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Enhancement of Antiviral Immunity by Small Molecule Antagonist of Suppressor of Cytokine Signaling
Chulbul M. I. Ahmed, Rea Dabelic, James P. Martin, Lindsey D. Jager, S. Mohammad Haider and Howard M. Johnson

J Immunol July 15, 2010, 185 (2) 1103-1113; DOI: https://doi.org/10.4049/jimmunol.0902895
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Innate Retroviral Restriction by Apobec3 Promotes Antibody Affinity Maturation In Vivo
Mario L. Santiago, Robert L. Benitez, Mauricio Montano, Kim J. Hasenkrug and Warner C. Greene

J Immunol July 15, 2010, 185 (2) 1114-1123; DOI: https://doi.org/10.4049/jimmunol.1001143
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Francisella tularensis Suppresses the Proinflammatory Response of Endothelial Cells via the Endothelial Protein C Receptor
DeAnna C. Bublitz, Courtney E. Noah, Jorge L. Benach and Martha B. Furie

J Immunol July 15, 2010, 185 (2) 1124-1131; DOI: https://doi.org/10.4049/jimmunol.0902429
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T Cell Epitope Specificity and Pathogenesis of Mouse Hepatitis Virus-1–Induced Disease in Susceptible and Resistant Hosts
Aaruni Khanolkar, Ross B. Fulton, Lecia L. Epping, Nhat-Long Pham, Dilea Tifrea, Steven M. Varga and John T. Harty

J Immunol July 15, 2010, 185 (2) 1132-1141; DOI: https://doi.org/10.4049/jimmunol.0902749
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Flagellin Stimulates Protective Lung Mucosal Immunity: Role of Cathelicidin-Related Antimicrobial Peptide
Fu-shin Yu, Matthew D. Cornicelli, Melissa A. Kovach, Michael W. Newstead, Xianying Zeng, Ashok Kumar, Nan Gao, Sang Gi Yoon, Richard L. Gallo and Theodore J. Standiford

J Immunol July 15, 2010, 185 (2) 1142-1149; DOI: https://doi.org/10.4049/jimmunol.1000509
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IL-17 Is Necessary for Host Protection against Acute-Phase Trypanosoma cruzi Infection
Yoshiyuki Miyazaki, Shinjiro Hamano, Seng Wang, Yohei Shimanoe, Yoichiro Iwakura and Hiroki Yoshida

J Immunol July 15, 2010, 185 (2) 1150-1157; DOI: https://doi.org/10.4049/jimmunol.0900047
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The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein
Congwen Wei, Caifei Ni, Ting Song, Yu Liu, XiaoLi Yang, Zirui Zheng, Yongxia Jia, Yuan Yuan, Kai Guan, Yang Xu, Xiaozhong Cheng, Yanhong Zhang, Xiao Yang, Youliang Wang, Chaoyang Wen, Qing Wu, Wei Shi and Hui Zhong

J Immunol July 15, 2010, 185 (2) 1158-1168; DOI: https://doi.org/10.4049/jimmunol.0903874

INFLAMMATION

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17β-Estradiol Promotes TLR4-Triggered Proinflammatory Mediator Production through Direct Estrogen Receptor α Signaling in Macrophages In Vivo
Bertrand Calippe, Victorine Douin-Echinard, Laurent Delpy, Muriel Laffargue, Karine Lélu, Andrée Krust, Bernard Pipy, Francis Bayard, Jean-François Arnal, Jean-Charles Guéry and Pierre Gourdy

J Immunol July 15, 2010, 185 (2) 1169-1176; DOI: https://doi.org/10.4049/jimmunol.0902383
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TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3^negCD127⁺ Immune Cells in Spleen and Mucosa
Laurye Van Maele, Christophe Carnoy, Delphine Cayet, Pascal Songhet, Laure Dumoutier, Isabel Ferrero, Laure Janot, François Erard, Julie Bertout, Hélène Leger, Florent Sebbane, Arndt Benecke, Jean-Christophe Renauld, Wolf-Dietrich Hardt, Bernhard Ryffel and Jean-Claude Sirard

J Immunol July 15, 2010, 185 (2) 1177-1185; DOI: https://doi.org/10.4049/jimmunol.1000115
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Involvement of Absent in Melanoma 2 in Inflammasome Activation in Macrophages Infected with Listeria monocytogenes
Kohsuke Tsuchiya, Hideki Hara, Ikuo Kawamura, Takamasa Nomura, Takeshi Yamamoto, Sylvia Daim, Sita R. Dewamitta, Yanna Shen, Rendong Fang and Masao Mitsuyama

J Immunol July 15, 2010, 185 (2) 1186-1195; DOI: https://doi.org/10.4049/jimmunol.1001058
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Heme Impairs Prostaglandin E₂ and TGF-β Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria
Bruno B. Andrade, Théo Araújo-Santos, Nívea F. Luz, Ricardo Khouri, Marcelo T. Bozza, Luís M. A. Camargo, Aldina Barral, Valéria M. Borges and Manoel Barral-Netto

J Immunol July 15, 2010, 185 (2) 1196-1204; DOI: https://doi.org/10.4049/jimmunol.0904179
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Allergen-Induced Airway Remodeling Is Impaired in Galectin-3–Deficient Mice
Xiao Na Ge, Nooshin S. Bahaie, Bit Na Kang, M. Reza Hosseinkhani, Sung Gil Ha, Elizabeth M. Frenzel, Fu-Tong Liu, Savita P. Rao and P. Sriramarao

J Immunol July 15, 2010, 185 (2) 1205-1214; DOI: https://doi.org/10.4049/jimmunol.1000039
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Mechanical Signals Activate Vascular Endothelial Growth Factor Receptor-2 To Upregulate Endothelial Cell Proliferation during Inflammation
Jie Liu and Sudha Agarwal

J Immunol July 15, 2010, 185 (2) 1215-1221; DOI: https://doi.org/10.4049/jimmunol.0903660
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IL-33 Reduces Macrophage Foam Cell Formation
James E. McLaren, Daryn R. Michael, Rebecca C. Salter, Tim G. Ashlin, Claudia J. Calder, Ashley M. Miller, Foo Y. Liew and Dipak P. Ramji

J Immunol July 15, 2010, 185 (2) 1222-1229; DOI: https://doi.org/10.4049/jimmunol.1000520
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Paroxetine Prevents Loss of Nigrostriatal Dopaminergic Neurons by Inhibiting Brain Inflammation and Oxidative Stress in an Experimental Model of Parkinson’s Disease
Young C. Chung, Sang R. Kim and Byung K. Jin

J Immunol July 15, 2010, 185 (2) 1230-1237; DOI: https://doi.org/10.4049/jimmunol.1000208
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Macrophage Migration Inhibitory Factor Increases Leukocyte–Endothelial Interactions in Human Endothelial Cells via Promotion of Expression of Adhesion Molecules
Qiang Cheng, Sonja J. McKeown, Leilani Santos, Fernando S. Santiago, Levon M. Khachigian, Eric F. Morand and Michael J. Hickey

J Immunol July 15, 2010, 185 (2) 1238-1247; DOI: https://doi.org/10.4049/jimmunol.0904104
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Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor
Ingrid Cardenas, Robert E. Means, Paulomi Aldo, Kaori Koga, Sabine M. Lang, Carmen Booth, Alejandro Manzur, Enrique Oyarzun, Roberto Romero and Gil Mor

J Immunol July 15, 2010, 185 (2) 1248-1257; DOI: https://doi.org/10.4049/jimmunol.1000289
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Injury-Induced Type I IFN Signaling Regulates Inflammatory Responses in the Central Nervous System
Reza Khorooshi and Trevor Owens

J Immunol July 15, 2010, 185 (2) 1258-1264; DOI: https://doi.org/10.4049/jimmunol.0901753
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The Relative Timing of Exposure to Phagocytosable Particulates and to Osteoclastogenic Cytokines Is Critically Important in the Determination of Myeloid Cell Fate
Douglas E. James, Bryan J. Nestor, Thomas P. Sculco, Lionel B. Ivashkiv, F. Patrick Ross, Steven R. Goldring and P. Edward Purdue

J Immunol July 15, 2010, 185 (2) 1265-1273; DOI: https://doi.org/10.4049/jimmunol.0902808
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Wnt5a Induces Endothelial Inflammation via β-Catenin–Independent Signaling
Jihun Kim, Jungtae Kim, Dong Wook Kim, Yunhi Ha, Min Hwan Ihm, Hyeri Kim, Kyuyoung Song and Inchul Lee

J Immunol July 15, 2010, 185 (2) 1274-1282; DOI: https://doi.org/10.4049/jimmunol.1000181
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IFN-γ Primes Intact Human Coronary Arteries and Cultured Coronary Smooth Muscle Cells to Double-Stranded RNA- and Self-RNA–Induced Inflammatory Responses by Upregulating TLR3 and Melanoma Differentiation-Associated Gene 5
Usman Ahmad, Rahmat Ali, Amir H. Lebastchi, Lingfeng Qin, Sheng-fu L. Lo, Alexander O. Yakimov, Salman F. Khan, Jonathan C. Choy, Arnar Geirsson, Jordan S. Pober and George Tellides

J Immunol July 15, 2010, 185 (2) 1283-1294; DOI: https://doi.org/10.4049/jimmunol.0902283
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Skin Inflammation Arising from Cutaneous Regulatory T Cell Deficiency Leads to Impaired Viral Immune Responses
Eva-Jasmin Freyschmidt, Clinton B. Mathias, Natalia Diaz, Daniel H. MacArthur, Amale Laouar, Narasimhaswamy Manjunath, Matthias D. Hofer, Marc-Andre Wurbel, James J. Campbell, Talal A. Chatila and Hans C. Oettgen

J Immunol July 15, 2010, 185 (2) 1295-1302; DOI: https://doi.org/10.4049/jimmunol.0903144
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Stimulation of FcγRI on Primary Sensory Neurons Increases Insulin-Like Growth Factor-I Production, Thereby Reducing Reperfusion-Induced Renal Injury in Mice
Naoaki Harada, Juan Zhao, Hiroki Kurihara, Naomi Nakagata and Kenji Okajima

J Immunol July 15, 2010, 185 (2) 1303-1310; DOI: https://doi.org/10.4049/jimmunol.0902051

CLINICAL IMMUNOLOGY

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An IL-2 Paradox: Blocking CD25 on T Cells Induces IL-2–Driven Activation of CD56^bright NK Cells
Jayne F. Martin, Justin S. A. Perry, Neha R. Jakhete, Xiang Wang and Bibiana Bielekova

J Immunol July 15, 2010, 185 (2) 1311-1320; DOI: https://doi.org/10.4049/jimmunol.0902238
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Ecto-5′-Nucleotidase (CD73) Attenuates Allograft Airway Rejection through Adenosine 2A Receptor Stimulation
Takashi Ohtsuka, Paul S. Changelian, Diane Bouïs, Kathleen Noon, Hiroaki Harada, Vibha N. Lama and David J. Pinsky

J Immunol July 15, 2010, 185 (2) 1321-1329; DOI: https://doi.org/10.4049/jimmunol.0901847
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Resistance of CD45RA⁻ T Cells to Apoptosis and Functional Impairment, and Activation of Tumor-Antigen Specific T Cells during Radiation Therapy of Prostate Cancer
Zsuzsanna Tabi, Lisa K. Spary, Sharon Coleman, Aled Clayton, Malcolm D. Mason and John Staffurth

J Immunol July 15, 2010, 185 (2) 1330-1339; DOI: https://doi.org/10.4049/jimmunol.1000488

CORRECTIONS

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Correction: Mathematical Modeling of Chimeric TCR Triggering Predicts the Magnitude of Target Lysis and Its Impairment by TCR Downmodulation
Scott E. James, Philip D. Greenberg, Michael C. Jensen, Yukang Lin, Jinjuan Wang, Lihua E. Budde, Brian G. Till, Andrew A. Raubitschek, Stephen J. Forman and Oliver W. Press

J Immunol July 15, 2010, 185 (2) 1340; DOI: https://doi.org/10.4049/jimmunol.1090049
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Correction: Isoforms of Vitamin E Have Opposing Immunoregulatory Functions during Inflammation by Regulating Leukocyte Recruitment
Sergejs Berdnikovs, Hiam Abdala-Valencia, Christine McCary, Michelle Somand, Rokeisha Cole, Alex Garcia, Paul Bryce and Joan M. Cook-Mills

J Immunol July 15, 2010, 185 (2) 1341; DOI: https://doi.org/10.4049/jimmunol.1090054

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Table of Contents

EDITORIAL

IN THIS ISSUE

LETTERS TO THE EDITOR

TRANSLATING IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

CORRECTIONS

EDITORIAL

IN THIS ISSUE

LETTERS TO THE EDITOR

TRANSLATING IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

CORRECTIONS

This Issue

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