On the cover: Silver staining of peripheral lymph nodes from Borrelia garinii-infected C3H/He mice. Along with the fine reticular architecture of the lymph node body, which appears brown in color, darker silver impregnated spirochete-like elements can be seen in the infected lymphoid tissues (as easily visualized at higher magnification on inset). Yegutkin, G. G., J. Hytönen, S. S. Samburski, H. Yrjänäinen, S. Jalkanen, and M. K. Viljanen. 2010. Disordered lymphoid purine metabolism contributes to the pathogenesis of persistent Borrelia garinii infection in mice. J. Immunol. 184: 5112–5120.