The Journal of Immunology: 184 (9)

May 1, 2010; Volume 184,Issue 9

IN THIS ISSUE

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IN THIS ISSUE
J Immunol May 1, 2010, 184 (9) 4581-4582; DOI: https://doi.org/10.4049/jimmunol.1090024

LETTERS TO THE EDITOR

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Comment on “Human Pregnancy Up-regulates Tim-3 in Innate Immune Cells for Systemic Immunity”
Hai-Feng Pan, Qing-Qing Zhu, Ting-Ting Li, Dong-Qing Ye and Xiang-Pei Li

J Immunol May 1, 2010, 184 (9) 4583; DOI: https://doi.org/10.4049/jimmunol.1090027
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Response to Comment on “Human Pregnancy Up-regulates Tim-3 in Innate Immune Cells for Systemic Immunity”
Jie Zhao and Bo Huang

J Immunol May 1, 2010, 184 (9) 4583-4584; DOI: https://doi.org/10.4049/jimmunol.1090028

PILLARS OF IMMUNOLOGY

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The Earliest Knockouts
Michael J. Bevan

J Immunol May 1, 2010, 184 (9) 4585-4586; DOI: https://doi.org/10.4049/jimmunol.1090023
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Pillars Article: β2-Microglobulin Deficient Mice Lack CD4⁻8⁺ Cytolytic T Cells. Nature. 1990. 344: 742–746
Maarten Zijlstra, Mark Bix, Neil E. Simister, Janet M. Loring, David H. Raulet and Rudolf Jaenisch

J Immunol May 1, 2010, 184 (9) 4587-4591;
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Pillars Article: Normal Development of Mice Deficient in β₂M, MHC Class I Proteins, and CD8⁺ T Cells. Science. 248: 1227–1230
Beverly H. Koller, Philippa Marrack, John W. Kappler and Oliver Smithies

J Immunol May 1, 2010, 184 (9) 4592-4595;

BRIEF REVIEWS

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IgM, FcμRs, and Malarial Immune Evasion
Daniel M. Czajkowsky, Ali Salanti, Sisse B. Ditlev, Zhifeng Shao, Ashfaq Ghumra, J. Alexandra Rowe and Richard J. Pleass

J Immunol May 1, 2010, 184 (9) 4597-4603; DOI: https://doi.org/10.4049/jimmunol.1000203

CUTTING EDGE

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Cutting Edge: IL-23 Receptor Deficiency Prevents the Development of Lupus Nephritis in C57BL/6–lpr/lpr Mice
Vasileios C. Kyttaris, Zheng Zhang, Vijay K. Kuchroo, Mohamed Oukka and George C. Tsokos

J Immunol May 1, 2010, 184 (9) 4605-4609; DOI: https://doi.org/10.4049/jimmunol.0903595
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Cutting Edge: Critical Role for PYCARD/ASC in the Development of Experimental Autoimmune Encephalomyelitis
Patrick J. Shaw, John R. Lukens, Samir Burns, Hongbo Chi, Maureen A. McGargill and Thirumala-Devi Kanneganti

J Immunol May 1, 2010, 184 (9) 4610-4614; DOI: https://doi.org/10.4049/jimmunol.1000217
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Cutting Edge: IL-21 and TLR Signaling Regulate Germinal Center Responses in a B Cell-Intrinsic Manner
Juliana Bessa, Manfred Kopf and Martin F. Bachmann

J Immunol May 1, 2010, 184 (9) 4615-4619; DOI: https://doi.org/10.4049/jimmunol.0903949
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Cutting Edge: Human Latency-Associated Peptide⁺ T Cells: A Novel Regulatory T Cell Subset
Roopali Gandhi, Mauricio F. Farez, Yue Wang, Deneen Kozoriz, Francisco J. Quintana and Howard L. Weiner

J Immunol May 1, 2010, 184 (9) 4620-4624; DOI: https://doi.org/10.4049/jimmunol.0903329
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Cutting Edge: Granulocyte-Macrophage Colony-Stimulating Factor Is the Major CD8⁺ T Cell-Derived Licensing Factor for Dendritic Cell Activation
Lin Min, Siti Aminah Bte Mohammad Isa, Wang Shuai, Cher Boon Piang, Fam Wee Nih, Masayo Kotaka and Christiane Ruedl

J Immunol May 1, 2010, 184 (9) 4625-4629; DOI: https://doi.org/10.4049/jimmunol.0903873

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

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Histone Acetylation at the Single-Cell Level: A Marker of Memory CD8⁺ T Cell Differentiation and Functionality
Joanna R. DiSpirito and Hao Shen

J Immunol May 1, 2010, 184 (9) 4631-4636; DOI: https://doi.org/10.4049/jimmunol.0903830
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CD22 Expression Mediates the Regulatory Functions of Peritoneal B-1a Cells during the Remission Phase of Contact Hypersensitivity Reactions
Hiroko Nakashima, Yasuhito Hamaguchi, Rei Watanabe, Nobuko Ishiura, Yoshihiro Kuwano, Hitoshi Okochi, Yoshimasa Takahashi, Kunihiko Tamaki, Shinichi Sato, Thomas F. Tedder and Manabu Fujimoto

J Immunol May 1, 2010, 184 (9) 4637-4645; DOI: https://doi.org/10.4049/jimmunol.0901719
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Naive CD4⁺ T Lymphocytes Circulate through Lymphoid Organs To Interact with Endogenous Antigens and Upregulate Their Function
Michio Tomura, Kikuji Itoh and Osami Kanagawa

J Immunol May 1, 2010, 184 (9) 4646-4653; DOI: https://doi.org/10.4049/jimmunol.0903946
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HLA-B35 Upregulates Endothelin-1 and Downregulates Endothelial Nitric Oxide Synthase via Endoplasmic Reticulum Stress Response in Endothelial Cells
Stefania Lenna, Danyelle M. Townsend, Filemon K. Tan, Bagrat Kapanadze, Malgorzata Markiewicz, Maria Trojanowska and Raffaella Scorza

J Immunol May 1, 2010, 184 (9) 4654-4661; DOI: https://doi.org/10.4049/jimmunol.0903188
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TLR4 Promotes B Cell Maturation: Independence and Cooperation with B Lymphocyte-Activating Factor
Elize A. Hayashi, Alessandra Granato, Luciana S. Paiva, Álvaro L. Bertho, Maria Bellio and Alberto Nobrega

J Immunol May 1, 2010, 184 (9) 4662-4672; DOI: https://doi.org/10.4049/jimmunol.0903253
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Notch2 Signaling Is Required for Potent Antitumor Immunity In Vivo
Koji Sugimoto, Yoichi Maekawa, Akiko Kitamura, Jun Nishida, Akemi Koyanagi, Hideo Yagita, Hidefumi Kojima, Shigeru Chiba, Mitsuo Shimada and Koji Yasutomo

J Immunol May 1, 2010, 184 (9) 4673-4678; DOI: https://doi.org/10.4049/jimmunol.0903661
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Soluble IL-7Rα (sCD127) Inhibits IL-7 Activity and Is Increased in HIV Infection
Angela M. Crawley, Sylvie Faucher and Jonathan B. Angel

J Immunol May 1, 2010, 184 (9) 4679-4687; DOI: https://doi.org/10.4049/jimmunol.0903758
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IL-4 and TGF-β1 Counterbalance One Another while Regulating Mast Cell Homeostasis
Matthew R. Macey, Jamie L. Sturgill, Johanna K. Morales, Yves T. Falanga, Joshua Morales, Sarah K. Norton, Nitin Yerram, Hoon Shim, Josephine Fernando, Alasdair M. Gifillan, Gregorio Gomez, Lawrence Schwartz, Carole Oskeritzian, Sarah Spiegel, Daniel Conrad and John J. Ryan

J Immunol May 1, 2010, 184 (9) 4688-4695; DOI: https://doi.org/10.4049/jimmunol.0903477
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Premature Terminal Exhaustion of Friend Virus-Specific Effector CD8⁺ T Cells by Rapid Induction of Multiple Inhibitory Receptors
Shiki Takamura, Sachiyo Tsuji-Kawahara, Hideo Yagita, Hisaya Akiba, Mayumi Sakamoto, Tomomi Chikaishi, Maiko Kato and Masaaki Miyazawa

J Immunol May 1, 2010, 184 (9) 4696-4707; DOI: https://doi.org/10.4049/jimmunol.0903478
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The Effector T Cell Response to Ryegrass Pollen Is Counterregulated by Simultaneous Induction of Regulatory T Cells
Diana Mittag, Anja Scholzen, Nirupama Varese, Lorraine Baxter, Geza Paukovics, Leonard C. Harrison, Jennifer M. Rolland and Robyn E. O’Hehir

J Immunol May 1, 2010, 184 (9) 4708-4716; DOI: https://doi.org/10.4049/jimmunol.0901036
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CXC Chemokine Ligand 2 Induced by Receptor Activator of NF-κB Ligand Enhances Osteoclastogenesis
Jeongim Ha, Hyo-Sun Choi, Youngkyun Lee, Hyung-Joo Kwon, Yeong Wook Song and Hong-Hee Kim

J Immunol May 1, 2010, 184 (9) 4717-4724; DOI: https://doi.org/10.4049/jimmunol.0902444
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Characterizing the Specificity and Cooperation of Aminopeptidases in the Cytosol and Endoplasmic Reticulum during MHC Class I Antigen Presentation
Arron Hearn, Ian A. York, Courtney Bishop and Kenneth L. Rock

J Immunol May 1, 2010, 184 (9) 4725-4732; DOI: https://doi.org/10.4049/jimmunol.0903125
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Differential but Direct Abolishment of Human Regulatory T Cell Suppressive Capacity by Various TLR2 Ligands
Hans-Heinrich Oberg, Thi Thuy Hoa Ly, Sandra Ussat, Tim Meyer, Dieter Kabelitz and Daniela Wesch

J Immunol May 1, 2010, 184 (9) 4733-4740; DOI: https://doi.org/10.4049/jimmunol.0804279
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Signal Inhibitory Receptor on Leukocytes-1 Is a Novel Functional Inhibitory Immune Receptor Expressed on Human Phagocytes
Tessa A. M. Steevels, Robert Jan Lebbink, Geertje H. A. Westerlaken, Paul J. Coffer and Linde Meyaard

J Immunol May 1, 2010, 184 (9) 4741-4748; DOI: https://doi.org/10.4049/jimmunol.0902039
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CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells Optimize Diversity of the Conventional T Cell Repertoire during Reconstitution from Lymphopenia
Colleen J. Winstead, Cavan S. Reilly, James J. Moon, Marc K. Jenkins, Sara E. Hamilton, Stephen C. Jameson, Sing Sing Way and Alexander Khoruts

J Immunol May 1, 2010, 184 (9) 4749-4760; DOI: https://doi.org/10.4049/jimmunol.0904076
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TAp63 Regulates VLA-4 Expression and Chronic Lymphocytic Leukemia Cell Migration to the Bone Marrow in a CD74-Dependent Manner
Inbal Binsky, Frida Lantner, Valentin Grabovsky, Nurit Harpaz, Lev Shvidel, Alain Berrebi, David M. Goldenberg, Lin Leng, Richard Bucala, Ronen Alon, Michal Haran and Idit Shachar

J Immunol May 1, 2010, 184 (9) 4761-4769; DOI: https://doi.org/10.4049/jimmunol.0904149
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Dendritic Cells and Stat3 Are Essential for CD137-Induced CD8 T Cell Activation-Induced Cell Death
Benyue Zhang, Yuanyuan Zhang, Liguo Niu, Anthony T. Vella and Robert S. Mittler

J Immunol May 1, 2010, 184 (9) 4770-4778; DOI: https://doi.org/10.4049/jimmunol.0902713
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Th17 Polarized Cells from Nonobese Diabetic Mice Following Mycobacterial Adjuvant Immunotherapy Delay Type 1 Diabetes
Enayat Nikoopour, Jordan A. Schwartz, Katrina Huszarik, Christian Sandrock, Olga Krougly, Edwin Lee-Chan and Bhagirath Singh

J Immunol May 1, 2010, 184 (9) 4779-4788; DOI: https://doi.org/10.4049/jimmunol.0902822
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Protective and Pathogenic Roles for B Cells during Systemic Autoimmunity in NZB/W F₁ Mice
Karen M. Haas, Rei Watanabe, Takashi Matsushita, Hiroko Nakashima, Nobuko Ishiura, Hitoshi Okochi, Manabu Fujimoto and Thomas F. Tedder

J Immunol May 1, 2010, 184 (9) 4789-4800; DOI: https://doi.org/10.4049/jimmunol.0902391
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Regulatory B Cells (B10 Cells) Have a Suppressive Role in Murine Lupus: CD19 and B10 Cell Deficiency Exacerbates Systemic Autoimmunity
Rei Watanabe, Nobuko Ishiura, Hiroko Nakashima, Yoshihiro Kuwano, Hitoshi Okochi, Kunihiko Tamaki, Shinichi Sato, Thomas F. Tedder and Manabu Fujimoto

J Immunol May 1, 2010, 184 (9) 4801-4809; DOI: https://doi.org/10.4049/jimmunol.0902385
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CXC Chemokine Ligand 4 Induces a Unique Transcriptome in Monocyte-Derived Macrophages
Christian A. Gleissner, Iftach Shaked, Kristina M. Little and Klaus Ley

J Immunol May 1, 2010, 184 (9) 4810-4818; DOI: https://doi.org/10.4049/jimmunol.0901368
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B Cell-Derived Vascular Endothelial Growth Factor A Promotes Lymphangiogenesis and High Endothelial Venule Expansion in Lymph Nodes
Binita Shrestha, Teruto Hashiguchi, Takashi Ito, Naoki Miura, Kazunori Takenouchi, Yoko Oyama, Ko-ichi Kawahara, Salunya Tancharoen, Yuya Ki-i, Noboru Arimura, Narimasa Yoshinaga, Satoshi Noma, Chandan Shrestha, Takao Nitanda, Shinichi Kitajima, Kimiyoshi Arimura, Masahiro Sato, Taiji Sakamoto and Ikuro Maruyama

J Immunol May 1, 2010, 184 (9) 4819-4826; DOI: https://doi.org/10.4049/jimmunol.0903063
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Mitochondrial Reactive Oxygen Species Control T Cell Activation by Regulating IL-2 and IL-4 Expression: Mechanism of Ciprofloxacin-Mediated Immunosuppression
Marcin M. Kamiński, Sven W. Sauer, Claus-Detlev Klemke, Dorothee Süss, Jürgen G. Okun, Peter H. Krammer and Karsten Gülow

J Immunol May 1, 2010, 184 (9) 4827-4841; DOI: https://doi.org/10.4049/jimmunol.0901662
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Langerhans Cells Prime IL-17–Producing T Cells and Dampen Genital Cytotoxic Responses following Mucosal Immunization
Catherine Hervouet, Carmelo Luci, Nicolas Rol, Déborah Rousseau, Adrien Kissenpfennig, Bernard Malissen, Cecil Czerkinsky and Fabienne Anjuère

J Immunol May 1, 2010, 184 (9) 4842-4851; DOI: https://doi.org/10.4049/jimmunol.0901695
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Cytokine Secretion Is Distinct from Secretion of Cytotoxic Granules in NK Cells
Esther Reefman, Jason G. Kay, Stephanie M. Wood, Carolin Offenhäuser, Darren L. Brown, Sandrine Roy, Amanda C. Stanley, Pei Ching Low, Anthony P. Manderson and Jennifer L. Stow

J Immunol May 1, 2010, 184 (9) 4852-4862; DOI: https://doi.org/10.4049/jimmunol.0803954
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Central Nervous System Destruction Mediated by Glutamic Acid Decarboxylase-Specific CD4⁺ T Cells
Amanda R. Burton, Zachary Baquet, George S. Eisenbarth, Roland Tisch, Richard Smeyne, Creg J. Workman and Dario A. A. Vignali

J Immunol May 1, 2010, 184 (9) 4863-4870; DOI: https://doi.org/10.4049/jimmunol.0903728
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Expression of Cellular FLIP by B Cells Is Required for Their Participation in an Immune Response
Francis Coffey and Tim Manser

J Immunol May 1, 2010, 184 (9) 4871-4879; DOI: https://doi.org/10.4049/jimmunol.0903506
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IL-17 Amplifies Human Contact Hypersensitivity by Licensing Hapten Nonspecific Th1 Cells to Kill Autologous Keratinocytes
Davide Pennino, Kilian Eyerich, Claudia Scarponi, Teresa Carbone, Stefanie Eyerich, Francesca Nasorri, Simone Garcovich, Claudia Traidl-Hoffmann, Cristina Albanesi and Andrea Cavani

J Immunol May 1, 2010, 184 (9) 4880-4888; DOI: https://doi.org/10.4049/jimmunol.0901767
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The Role of Skin-Derived Dendritic Cells in CD8⁺ T Cell Priming Following Immunization with Lentivectors
Karina Furmanov, Mazal Elnekave, Dan Lehmann, Bjorn E. Clausen, Darrell N. Kotton and Avi-Hai Hovav

J Immunol May 1, 2010, 184 (9) 4889-4897; DOI: https://doi.org/10.4049/jimmunol.0903062
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IL-17 Enhancement of the IL-6 Signaling Cascade in Astrocytes
Xiangyu Ma, Stephanie L. Reynolds, Brandi J. Baker, Xingang Li, Etty N. Benveniste and Hongwei Qin

J Immunol May 1, 2010, 184 (9) 4898-4906; DOI: https://doi.org/10.4049/jimmunol.1000142
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Gene Coexpression Analysis in Single Cells Indicates Lymphomyeloid Copriming in Short-Term Hematopoietic Stem Cells and Multipotent Progenitors
Laetitia Gautreau, Amine Boudil, Valérie Pasqualetto, Lamia Skhiri, Laure Grandin, Marta Monteiro, Jean-Philippe Jais and Sophie Ezine

J Immunol May 1, 2010, 184 (9) 4907-4917; DOI: https://doi.org/10.4049/jimmunol.0902184
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Keratinocyte-Associated B7-H1 Directly Regulates Cutaneous Effector CD8⁺ T Cell Responses
Patcharee Ritprajak, Masaaki Hashiguchi, Fumihiko Tsushima, Narumon Chalermsarp and Miyuki Azuma

J Immunol May 1, 2010, 184 (9) 4918-4925; DOI: https://doi.org/10.4049/jimmunol.0902478
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A Steady State of CD4⁺ T Cell Memory Maturation and Activation Is Established during Primary Subtype C HIV-1 Infection
Pholo Maenetje, Catherine Riou, Joseph P. Casazza, David Ambrozak, Brenna Hill, Glenda Gray, Richard A. Koup, Guy de Bruyn and Clive M. Gray

J Immunol May 1, 2010, 184 (9) 4926-4935; DOI: https://doi.org/10.4049/jimmunol.0903771
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Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function
Daphné A. Schmid, Melita B. Irving, Vilmos Posevitz, Michael Hebeisen, Anita Posevitz-Fejfar, J-C. Floyd Sarria, Raquel Gomez-Eerland, Margot Thome, Ton N. M. Schumacher, Pedro Romero, Daniel E. Speiser, Vincent Zoete, Olivier Michielin and Nathalie Rufer

J Immunol May 1, 2010, 184 (9) 4936-4946; DOI: https://doi.org/10.4049/jimmunol.1000173
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Plasma Cells and Nonplasma B Cells Express Differing IgE Repertoires in Allergic Sensitization
Tobias Rogosch, Sebastian Kerzel, Larisa Sikula, Katrin Gentil, Michael Liebetruth, Karl-Peter Schlingmann, Rolf F. Maier and Michael Zemlin

J Immunol May 1, 2010, 184 (9) 4947-4954; DOI: https://doi.org/10.4049/jimmunol.0900859
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miR-146a Is Differentially Expressed by Myeloid Dendritic Cell Subsets and Desensitizes Cells to TLR2-Dependent Activation
Jennifer Jurkin, Yvonne M. Schichl, Rene Koeffel, Thomas Bauer, Susanne Richter, Sabine Konradi, Bernhard Gesslbauer and Herbert Strobl

J Immunol May 1, 2010, 184 (9) 4955-4965; DOI: https://doi.org/10.4049/jimmunol.0903021

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Isoallergen Variations Contribute to the Overall Complexity of Effector Cell Degranulation: Effect Mediated through Differentiated IgE Affinity
Lars H. Christensen, Erik Riise, Lærke Bang, Chunqing Zhang and Kaare Lund

J Immunol May 1, 2010, 184 (9) 4966-4972; DOI: https://doi.org/10.4049/jimmunol.0904038
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A Threonine-Based Targeting Signal in the Human CD1d Cytoplasmic Tail Controls Its Functional Expression
Jianyun Liu, Daniel Shaji, Sungyoo Cho, Wenjun Du, Jacquelyn Gervay-Hague and Randy R. Brutkiewicz

J Immunol May 1, 2010, 184 (9) 4973-4981; DOI: https://doi.org/10.4049/jimmunol.0901448
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Functional Characterization of the Recombinant Human C1 Inhibitor Serpin Domain: Insights into Heparin Binding
Véronique Rossi, Isabelle Bally, Sarah Ancelet, Yuanyuan Xu, Véronique Frémeaux-Bacchi, Romain R. Vivès, Rabia Sadir, Nicole Thielens and Gérard J. Arlaud

J Immunol May 1, 2010, 184 (9) 4982-4989; DOI: https://doi.org/10.4049/jimmunol.0902016
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Activating Transcription Factor 3 Is a Positive Regulator of Human IFNG Gene Expression
Sanna Filén, Emmi Ylikoski, Subhash Tripathi, Anne West, Mari Björkman, Joel Nyström, Helena Ahlfors, Eleanor Coffey, Kanury V. S. Rao, Omid Rasool and Riitta Lahesmaa

J Immunol May 1, 2010, 184 (9) 4990-4999; DOI: https://doi.org/10.4049/jimmunol.0903106
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Functional Analysis of Lyn Kinase A and B Isoforms Reveals Redundant and Distinct Roles in FcεRI-Dependent Mast Cell Activation
Damiana Alvarez-Errico, Yumi Yamashita, Ryo Suzuki, Sandra Odom, Yasuko Furumoto, Toshiyuki Yamashita and Juan Rivera

J Immunol May 1, 2010, 184 (9) 5000-5008; DOI: https://doi.org/10.4049/jimmunol.0904064
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Multiple RNA Surveillance Mechanisms Cooperate to Reduce the Amount of Nonfunctional Igκ Transcripts
Guillaume Chemin, Aurélien Tinguely, Christophe Sirac, Fabien Lechouane, Sophie Duchez, Michel Cogné and Laurent Delpy

J Immunol May 1, 2010, 184 (9) 5009-5017; DOI: https://doi.org/10.4049/jimmunol.0902949
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PU.1 Binds to a Distal Regulatory Element That Is Necessary for B Cell-Specific Expression of CIITA
Hyesuk Yoon and Jeremy M. Boss

J Immunol May 1, 2010, 184 (9) 5018-5028; DOI: https://doi.org/10.4049/jimmunol.1000079
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Estradiol Suppresses NF-κB Activation through Coordinated Regulation of let-7a and miR-125b in Primary Human Macrophages
Amy J. Murphy, Paul M. Guyre and Patricia A. Pioli

J Immunol May 1, 2010, 184 (9) 5029-5037; DOI: https://doi.org/10.4049/jimmunol.0903463

IMMUNOGENETICS

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Intron-Containing Type I and Type III IFN Coexist in Amphibians: Refuting the Concept That a Retroposition Event Gave Rise to Type I IFNs
Zhitao Qi, Pin Nie, Chris J. Secombes and Jun Zou

J Immunol May 1, 2010, 184 (9) 5038-5046; DOI: https://doi.org/10.4049/jimmunol.0903374
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Human CD1D Gene Expression Is Regulated by LEF-1 through Distal Promoter Regulatory Elements
Qiao-Yi Chen, Tao Zhang, Seth H. Pincus, Shixiu Wu, David Ricks, Donald Liu, Zhongsheng Sun, Noel Maclaren and Michael S. Lan

J Immunol May 1, 2010, 184 (9) 5047-5054; DOI: https://doi.org/10.4049/jimmunol.0901912
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Evolution of the Pentraxin Family: The New Entry PTX4
Yeny Martinez de la Torre, Marco Fabbri, Sebastien Jaillon, Antonio Bastone, Manuela Nebuloni, Annunciata Vecchi, Alberto Mantovani and Cecilia Garlanda

J Immunol May 1, 2010, 184 (9) 5055-5064; DOI: https://doi.org/10.4049/jimmunol.0901672
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SHIP Influences Signals from CD48 and MHC Class I Ligands That Regulate NK Cell Homeostasis, Effector Function, and Repertoire Formation
Nicole R. Fortenbery, Kim H. T. Paraiso, Masaru Taniguchi, Colin Brooks, Leina Ibrahim and William G. Kerr

J Immunol May 1, 2010, 184 (9) 5065-5074; DOI: https://doi.org/10.4049/jimmunol.0901862
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Nonobese Diabetic Congenic Strain Analysis of Autoimmune Diabetes Reveals Genetic Complexity of the Idd18 Locus and Identifies Vav3 as a Candidate Gene
Heather I. Fraser, Calliope A. Dendrou, Barry Healy, Daniel B. Rainbow, Sarah Howlett, Luc J. Smink, Simon Gregory, Charles A. Steward, John A. Todd, Laurence B. Peterson and Linda S. Wicker

J Immunol May 1, 2010, 184 (9) 5075-5084; DOI: https://doi.org/10.4049/jimmunol.0903734

HOST DEFENSE

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Impaired Germinal Center Responses and Suppression of Local IgG Production during Intracellular Bacterial Infection
Rachael Racine, Derek D. Jones, Madhumouli Chatterjee, Maura McLaughlin, Katherine C. MacNamara and Gary M. Winslow

J Immunol May 1, 2010, 184 (9) 5085-5093; DOI: https://doi.org/10.4049/jimmunol.0902710
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Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling
Yue Guan, Diana Rose E. Ranoa, Song Jiang, Sarita K. Mutha, Xinyan Li, Jerome Baudry and Richard I. Tapping

J Immunol May 1, 2010, 184 (9) 5094-5103; DOI: https://doi.org/10.4049/jimmunol.0901888
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Alterations in Ceramide Concentration and pH Determine the Release of Reactive Oxygen Species by Cftr-Deficient Macrophages on Infection
Yang Zhang, Xiang Li, Heike Grassmé, Gerd Döring and Erich Gulbins

J Immunol May 1, 2010, 184 (9) 5104-5111; DOI: https://doi.org/10.4049/jimmunol.0902851
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Disordered Lymphoid Purine Metabolism Contributes to the Pathogenesis of Persistent Borrelia garinii Infection in Mice
Gennady G. Yegutkin, Jukka Hytönen, Sergei S. Samburski, Heta Yrjänäinen, Sirpa Jalkanen and Matti K. Viljanen

J Immunol May 1, 2010, 184 (9) 5112-5120; DOI: https://doi.org/10.4049/jimmunol.0902760
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Helicobacter pylori-Induced Th17 Responses Modulate Th1 Cell Responses, Benefit Bacterial Growth, and Contribute to Pathology in Mice
Yun Shi, Xiao-Fei Liu, Yuan Zhuang, Jin-Yu Zhang, Tao Liu, Zhinan Yin, Chao Wu, Xu-Hu Mao, Ke-Ran Jia, Feng-Jun Wang, Hong Guo, Richard A. Flavell, Zhuo Zhao, Kai-Yun Liu, Bin Xiao, Ying Guo, Wei-Jun Zhang, Wei-Ying Zhou, Gang Guo and Quan-Ming Zou

J Immunol May 1, 2010, 184 (9) 5121-5129; DOI: https://doi.org/10.4049/jimmunol.0901115
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Induction of TGF-β1, Not Regulatory T Cells, Impairs Antiviral Immunity in the Lung following Bone Marrow Transplant
Stephanie M. Coomes, Carol A. Wilke, Thomas A. Moore and Bethany B. Moore

J Immunol May 1, 2010, 184 (9) 5130-5140; DOI: https://doi.org/10.4049/jimmunol.0901871
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Francisella Acid Phosphatases Inactivate the NADPH Oxidase in Human Phagocytes
Nrusingh P. Mohapatra, Shilpa Soni, Murugesan V. S. Rajaram, Pham My-Chan Dang, Tom J. Reilly, Jamel El-Benna, Corey D. Clay, Larry S. Schlesinger and John S. Gunn

J Immunol May 1, 2010, 184 (9) 5141-5150; DOI: https://doi.org/10.4049/jimmunol.0903413
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Cell-Intrinsic Defects in the Proliferative Response of Antiviral Memory CD8 T Cells in Aged Mice upon Secondary Infection
Vilma Decman, Brian J. Laidlaw, Lauren J. DiMenna, Sarah Abdulla, Krystyna Mozdzanowska, Jan Erikson, Hildegund C. J. Ertl and E. John Wherry

J Immunol May 1, 2010, 184 (9) 5151-5159; DOI: https://doi.org/10.4049/jimmunol.0902063
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Suppression of Host Innate Immune Response by Burkholderia pseudomallei through the Virulence Factor TssM
Kai Soo Tan, Yahua Chen, Yaw-Chyn Lim, Gek-Yen Gladys Tan, Yichun Liu, Yan-Ting Lim, Paul MacAry and Yunn-Hwen Gan

J Immunol May 1, 2010, 184 (9) 5160-5171; DOI: https://doi.org/10.4049/jimmunol.0902663
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Activation of Naive NK Cells in Response to Listeria monocytogenes Requires IL-18 and Contact with Infected Dendritic Cells
Jessica Humann and Laurel L. Lenz

J Immunol May 1, 2010, 184 (9) 5172-5178; DOI: https://doi.org/10.4049/jimmunol.0903759
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IFN Regulatory Factor-1 Bypasses IFN-Mediated Antiviral Effects through Viperin Gene Induction
Anja Stirnweiss, Antje Ksienzyk, Katjana Klages, Ulfert Rand, Martina Grashoff, Hansjörg Hauser and Andrea Kröger

J Immunol May 1, 2010, 184 (9) 5179-5185; DOI: https://doi.org/10.4049/jimmunol.0902264
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Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Block Distinct Steps in Transendothelial Migration of Effector Memory CD4+ T Cells by Targeting Different Endothelial Proteins
Thomas D. Manes, Simon Hoer, William A. Muller, Paul J. Lehner and Jordan S. Pober

J Immunol May 1, 2010, 184 (9) 5186-5192; DOI: https://doi.org/10.4049/jimmunol.0902938
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Caspases in Virus-Infected Cells Contribute to Recognition by CD8⁺ T Lymphocytes
Daniel López, Margarita García-Calvo, Geoffrey L. Smith and Margarita Del Val

J Immunol May 1, 2010, 184 (9) 5193-5199; DOI: https://doi.org/10.4049/jimmunol.1000050
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The Protein Moiety of Brucella abortus Outer Membrane Protein 16 Is a New Bacterial Pathogen-Associated Molecular Pattern That Activates Dendritic Cells In Vivo, Induces a Th1 Immune Response, and Is a Promising Self-Adjuvanting Vaccine against Systemic and Oral Acquired Brucellosis
Karina A. Pasquevich, Clara García Samartino, Lorena M. Coria, Silvia M. Estein, Astrid Zwerdling, Andrés E. Ibañez, Paula Barrionuevo, Fernanda Souza de Oliveira, Natalia Barbosa Carvalho, Julia Borkowski, Sergio Costa Oliveira, Heribert Warzecha, Guillermo H. Giambartolomei and Juliana Cassataro

J Immunol May 1, 2010, 184 (9) 5200-5212; DOI: https://doi.org/10.4049/jimmunol.0902209
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B Cells Have Distinct Roles in Host Protection against Different Nematode Parasites
Qian Liu, Timothy Kreider, Scott Bowdridge, Zhugong Liu, Youngmia Song, Andrew G. Gaydo, Joseph F. Urban and William C. Gause

J Immunol May 1, 2010, 184 (9) 5213-5223; DOI: https://doi.org/10.4049/jimmunol.0902879
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CCR5 Dictates the Equilibrium of Proinflammatory IL-17⁺ and Regulatory Foxp3⁺ T Cells in Fungal Infection
Danielle N. Kroetz and George S. Deepe

J Immunol May 1, 2010, 184 (9) 5224-5231; DOI: https://doi.org/10.4049/jimmunol.1000032

INFLAMMATION

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Production of Vascular Endothelial Growth Factors from Human Lung Macrophages Induced by Group IIA and Group X Secreted Phospholipases A₂
Francescopaolo Granata, Annunziata Frattini, Stefania Loffredo, Rosaria I. Staiano, Angelica Petraroli, Domenico Ribatti, Rob Oslund, Michael H. Gelb, Gerard Lambeau, Gianni Marone and Massimo Triggiani

J Immunol May 1, 2010, 184 (9) 5232-5241; DOI: https://doi.org/10.4049/jimmunol.0902501
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Intercellular Adhesion Molecule-1 Enrichment near Tricellular Endothelial Junctions Is Preferentially Associated with Leukocyte Transmigration and Signals for Reorganization of These Junctions To Accommodate Leukocyte Passage
Ronen Sumagin and Ingrid H. Sarelius

J Immunol May 1, 2010, 184 (9) 5242-5252; DOI: https://doi.org/10.4049/jimmunol.0903319
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Hypertonicity-Induced Expression of Monocyte Chemoattractant Protein-1 through a Novel Cis-Acting Element and MAPK Signaling Pathways
Ryoji Kojima, Hajime Taniguchi, Aya Tsuzuki, Kanako Nakamura, Yumi Sakakura and Mikio Ito

J Immunol May 1, 2010, 184 (9) 5253-5262; DOI: https://doi.org/10.4049/jimmunol.0901298
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Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1α, and TNF-α Recapitulates Some Features of Psoriasis
Karline Guilloteau, Isabelle Paris, Nathalie Pedretti, Katia Boniface, Franck Juchaux, Vincent Huguier, Gerard Guillet, François-Xavier Bernard, Jean-Claude Lecron and Franck Morel

J Immunol May 1, 2010, 184 (9) 5263-5270; DOI: https://doi.org/10.4049/jimmunol.0902464
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Signaling through the A2B Adenosine Receptor Dampens Endotoxin-Induced Acute Lung Injury
Ulrich Schingnitz, Katherine Hartmann, Christopher F. MacManus, Tobias Eckle, Stephanie Zug, Sean P. Colgan and Holger K. Eltzschig

J Immunol May 1, 2010, 184 (9) 5271-5279; DOI: https://doi.org/10.4049/jimmunol.0903035
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Docosahexaenoic Acid-Enriched Fish Oil Attenuates Kidney Disease and Prolongs Median and Maximal Life Span of Autoimmune Lupus-Prone Mice
Ganesh V. Halade, Md Mizanur Rahman, Arunabh Bhattacharya, Jeffrey L. Barnes, Bysani Chandrasekar and Gabriel Fernandes

J Immunol May 1, 2010, 184 (9) 5280-5286; DOI: https://doi.org/10.4049/jimmunol.0903282
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Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF-κB Signaling
Claudia Toma, Naomi Higa, Yukiko Koizumi, Noboru Nakasone, Yasunori Ogura, Andrea J. McCoy, Luigi Franchi, Satoshi Uematsu, Junji Sagara, Shun’ichiro Taniguchi, Hiroko Tsutsui, Shizuo Akira, Jürg Tschopp, Gabriel Núñez and Toshihiko Suzuki

J Immunol May 1, 2010, 184 (9) 5287-5297; DOI: https://doi.org/10.4049/jimmunol.0903536
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Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050
Jordan S. Fridman, Peggy A. Scherle, Robert Collins, Timothy C. Burn, Yanlong Li, Jun Li, Maryanne B. Covington, Beth Thomas, Paul Collier, Margaret F. Favata, Xiaoming Wen, Jack Shi, Ryan McGee, Patrick J. Haley, Stacey Shepard, James D. Rodgers, Swamy Yeleswaram, Greg Hollis, Robert C. Newton, Brian Metcalf, Steven M. Friedman and Kris Vaddi

J Immunol May 1, 2010, 184 (9) 5298-5307; DOI: https://doi.org/10.4049/jimmunol.0902819
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TLR4 Is a Negative Regulator in Noninfectious Lung Inflammation
Hang Zhao, Shaw-Wei Leu, Liyun Shi, Rejmon Dedaj, Gaofeng Zhao, Hari G. Garg, Lianjun Shen, Egil Lien, Katherine A. Fitzgerald, Aviva Shiedlin, Huahao Shen, Deborah A. Quinn and Charles A. Hales

J Immunol May 1, 2010, 184 (9) 5308-5314; DOI: https://doi.org/10.4049/jimmunol.1000009
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Chemerin Peptides Promote Phagocytosis in a ChemR23- and Syk-Dependent Manner
Jenna L. Cash, Annabel R. Christian and David R. Greaves

J Immunol May 1, 2010, 184 (9) 5315-5324; DOI: https://doi.org/10.4049/jimmunol.0903378
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Fas-Activated Serine/Threonine Phosphoprotein Promotes Immune-Mediated Pulmonary Inflammation
Maria Simarro, Giorgio Giannattasio, Miguel A. De la Fuente, Charaf Benarafa, Kulandayan K. Subramanian, Rumey Ishizawar, Barbara Balestrieri, Emma M. Andersson, Hongbo R. Luo, Antonio Orduña, Joshua Boyce and Paul Anderson

J Immunol May 1, 2010, 184 (9) 5325-5332; DOI: https://doi.org/10.4049/jimmunol.1000104
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IFN-γ Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid β Precursor Protein Transgenic Mice
Paramita Chakrabarty, Carolina Ceballos-Diaz, Amanda Beccard, Christopher Janus, Dennis Dickson, Todd E. Golde and Pritam Das

J Immunol May 1, 2010, 184 (9) 5333-5343; DOI: https://doi.org/10.4049/jimmunol.0903382

CLINICAL IMMUNOLOGY

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Intragraft Th17 Infiltrate Promotes Lymphoid Neogenesis and Hastens Clinical Chronic Rejection
Clémence Deteix, Valérie Attuil-Audenis, Aurélie Duthey, Natacha Patey, Brigitte McGregor, Valérie Dubois, Giuseppina Caligiuri, Stéphanie Graff-Dubois, Emmanuel Morelon and Olivier Thaunat

J Immunol May 1, 2010, 184 (9) 5344-5351; DOI: https://doi.org/10.4049/jimmunol.0902999
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Transgenic Expression of TGF-β on Thyrocytes Inhibits Development of Spontaneous Autoimmune Thyroiditis and Increases Regulatory T Cells in Thyroids of NOD.H-2h4 Mice
Shiguang Yu, Yujiang Fang, Gordon C. Sharp and Helen Braley-Mullen

J Immunol May 1, 2010, 184 (9) 5352-5359; DOI: https://doi.org/10.4049/jimmunol.0903620
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Treatment Failure of a TLR-7 Agonist Occurs Due to Self-Regulation of Acute Inflammation and Can Be Overcome by IL-10 Blockade
Hailing Lu, Wolfgang M. Wagner, Ekram Gad, Yi Yang, Hangjun Duan, Lynn M. Amon, Nathaniel Van Denend, Emily R. Larson, Amy Chang, Helena Tufvesson and Mary L. Disis

J Immunol May 1, 2010, 184 (9) 5360-5367; DOI: https://doi.org/10.4049/jimmunol.0902997
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An Imbalance of Two Functionally and Phenotypically Different Subsets of Plasmacytoid Dendritic Cells Characterizes the Dysfunctional Immune Regulation in Multiple Sclerosis
Nicholas Schwab, Alla L. Zozulya, Bernd C. Kieseier, Klaus V. Toyka and Heinz Wiendl

J Immunol May 1, 2010, 184 (9) 5368-5374; DOI: https://doi.org/10.4049/jimmunol.0903662
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At Homeostasis Filarial Infections Have Expanded Adaptive T Regulatory but Not Classical Th2 Cells
Simon Metenou, Benoit Dembele, Siaka Konate, Housseini Dolo, Siaka Y. Coulibaly, Yaya I. Coulibaly, Abdallah A. Diallo, Lamine Soumaoro, Michel E. Coulibaly, Dramane Sanogo, Salif S. Doumbia, Sekou F. Traoré, Siddhartha Mahanty, Amy Klion and Thomas B. Nutman

J Immunol May 1, 2010, 184 (9) 5375-5382; DOI: https://doi.org/10.4049/jimmunol.0904067
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Interdisciplinary Analysis of HIV-Specific CD8⁺ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity
Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund and Annika C. Karlsson

J Immunol May 1, 2010, 184 (9) 5383-5391; DOI: https://doi.org/10.4049/jimmunol.0903516
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Ezrin, Maspin, Peroxiredoxin 2, and Heat Shock Protein 27: Potential Targets of a Streptococcal-Induced Autoimmune Response in Psoriasis
Petra Besgen, Paul Trommler, Sigrid Vollmer and Joerg Christoph Prinz

J Immunol May 1, 2010, 184 (9) 5392-5402; DOI: https://doi.org/10.4049/jimmunol.0903520
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Identification, Recombinant Expression, and Characterization of the 100 kDa High Molecular Weight Hymenoptera Venom Allergens Api m 5 and Ves v 3
Simon Blank, Henning Seismann, Benjamin Bockisch, Ingke Braren, Liliana Cifuentes, Mareike McIntyre, Dana Rühl, Johannes Ring, Reinhard Bredehorst, Markus W. Ollert, Thomas Grunwald and Edzard Spillner

J Immunol May 1, 2010, 184 (9) 5403-5413; DOI: https://doi.org/10.4049/jimmunol.0803709

CORRECTIONS

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Predominant expression of CCL2 at the tumor site of prostate cancer patients directs a selective loss of immunological tolerance to CCL2 that could be amplified in a beneficial manner
Liat Izhak, Gizi Wildbaum, Weinberg Uri, Yuval Shaked, Jennifer Alami, Daniel Dumont, Daniel Dumont, Avi Stein and Nathan Karin

J Immunol May 1, 2010, 184 (9) 5414; DOI: https://doi.org/10.4049/jimmunol.1090025
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Contribution of mutation, recombination, and gene conversion to chicken Mhc-B haplotype diversity
Kazuyoshi Hosomichi, Marcia M. Miller, Ronald M. Goto, Yujun Wang, Shingo Suzuki, Jerzy K. Kulski, Masahide Nishibori, Hidetoshi Inoko, Kei Hanzawa and Takashi Shiina

J Immunol May 1, 2010, 184 (9) 5415; DOI: https://doi.org/10.4049/jimmunol.1090026

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IN THIS ISSUE

LETTERS TO THE EDITOR

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

IMMUNOGENETICS

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

CORRECTIONS

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