The Journal of Immunology: 184 (7)

April 1, 2010; Volume 184,Issue 7

IN THIS ISSUE

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In This Issue
J Immunol April 1, 2010, 184 (7) 3301-3302; DOI: https://doi.org/10.4049/jimmunol.1090010

PILLARS OF IMMUNOLOGY

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An Alternative Path for Antigen Presentation: Group 1 CD1 Proteins
Jack L. Strominger

J Immunol April 1, 2010, 184 (7) 3303-3305; DOI: https://doi.org/10.4049/jimmunol.1090008
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Pillars Article: Recognition of Cluster of Differentiation 1 Antigens by Human CD4⁻CD8⁻ CytolyticT Lymphocyte. Nature. 1989. 341: 447–450
Steven Porcelli, Michael B. Brenner, Julia L. Greenstein, Cox Terhorst, Steven P. Balk and Paul A. Bleicher

J Immunol April 1, 2010, 184 (7) 3306-3309;

BRIEF REVIEWS

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Translation Control: A Multifaceted Regulator of Inflammatory Response
Barsanjit Mazumder, Xiaoxia Li and Sailen Barik

J Immunol April 1, 2010, 184 (7) 3311-3319; DOI: https://doi.org/10.4049/jimmunol.0903778

CUTTING EDGE

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Cutting Edge: Novel Function of B Cell-Activating Factor in the Induction of IL-10–Producing Regulatory B Cells
Min Yang, Lingyun Sun, Shengjun Wang, King-Hung Ko, Huaxi Xu, Bo-Jian Zheng, Xuetao Cao and Liwei Lu

J Immunol April 1, 2010, 184 (7) 3321-3325; DOI: https://doi.org/10.4049/jimmunol.0902551
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Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo
Katrin D. Mayer-Barber, Daniel L. Barber, Kevin Shenderov, Sandra D. White, Mark S. Wilson, Allen Cheever, David Kugler, Sara Hieny, Patricia Caspar, Gabriel Núñez, Dirk Schlueter, Richard A. Flavell, Fayyaz S. Sutterwala and Alan Sher

J Immunol April 1, 2010, 184 (7) 3326-3330; DOI: https://doi.org/10.4049/jimmunol.0904189
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Cutting Edge: A Critical Role for the G Protein-Coupled Receptor mFPR2 in Airway Inflammation and Immune Responses
Keqiang Chen, Yingying Le, Ying Liu, Wanghua Gong, Guoguang Ying, Jian Huang, Teizo Yoshimura, Lino Tessarollo and Ji Ming Wang

J Immunol April 1, 2010, 184 (7) 3331-3335; DOI: https://doi.org/10.4049/jimmunol.0903022
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Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis Synovium
Axel J. Hueber, Darren L. Asquith, Ashley M. Miller, Jim Reilly, Shauna Kerr, Jan Leipe, Alirio J. Melendez and Iain B. McInnes

J Immunol April 1, 2010, 184 (7) 3336-3340; DOI: https://doi.org/10.4049/jimmunol.0903566
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Cutting Edge: Critical Role of IκB Kinase α in TLR7/9-Induced Type I IFN Production by Conventional Dendritic Cells
Katsuaki Hoshino, Izumi Sasaki, Takahiro Sugiyama, Takahiro Yano, Chihiro Yamazaki, Teruhito Yasui, Hitoshi Kikutani and Tsuneyasu Kaisho

J Immunol April 1, 2010, 184 (7) 3341-3345; DOI: https://doi.org/10.4049/jimmunol.0901648
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Cutting Edge: The Membrane Type Matrix Metalloproteinase MMP14 Mediates Constitutive Shedding of MHC Class I Chain-Related Molecule A Independent of A Disintegrin and Metalloproteinases
Gang Liu, Catherine L. Atteridge, Xuanjun Wang, Ashley D. Lundgren and Jennifer D. Wu

J Immunol April 1, 2010, 184 (7) 3346-3350; DOI: https://doi.org/10.4049/jimmunol.0903789
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Cutting Edge: H-2L^d Class I Molecule Protects an HIV N-Extended Epitope from In Vitro Trimming by Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing
Susana Infantes, Yolanda Samino, Elena Lorente, Mercedes Jiménez, Ruth García, Margarita Del Val and Daniel López

J Immunol April 1, 2010, 184 (7) 3351-3355; DOI: https://doi.org/10.4049/jimmunol.0901560

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

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MHC Class I Molecules with Superenhanced CD8 Binding Properties Bypass the Requirement for Cognate TCR Recognition and Nonspecifically Activate CTLs
Linda Wooldridge, Mathew Clement, Anna Lissina, Emily S. J. Edwards, Kristin Ladell, Julia Ekeruche, Rachel E. Hewitt, Bruno Laugel, Emma Gostick, David K. Cole, Reno Debets, Cor Berrevoets, John J. Miles, Scott R. Burrows, David A. Price and Andrew K. Sewell

J Immunol April 1, 2010, 184 (7) 3357-3366; DOI: https://doi.org/10.4049/jimmunol.0902398
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CpG-B Oligodeoxynucleotides Inhibit TLR-Dependent and -Independent Induction of Type I IFN in Dendritic Cells
Yi C. Liu, Reginald C. Gray, Gareth A. D. Hardy, John Kuchtey, Derek W. Abbott, Steven N. Emancipator and Clifford V. Harding

J Immunol April 1, 2010, 184 (7) 3367-3376; DOI: https://doi.org/10.4049/jimmunol.0903079
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FoxP3⁺RORγt⁺ T Helper Intermediates Display Suppressive Function against Autoimmune Diabetes
Danielle M. Tartar, Amie M. VanMorlan, Xiaoxiao Wan, F. Betul Guloglu, Renu Jain, Cara L. Haymaker, Jason S. Ellis, Christine M. Hoeman, Jason A. Cascio, Mermagya Dhakal, Mohamed Oukka and Habib Zaghouani

J Immunol April 1, 2010, 184 (7) 3377-3385; DOI: https://doi.org/10.4049/jimmunol.0903324
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Secreted IgM Enhances B Cell Receptor Signaling and Promotes Splenic but Impairs Peritoneal B Cell Survival
Clare A. Notley, Nicole Baker and Michael R. Ehrenstein

J Immunol April 1, 2010, 184 (7) 3386-3393; DOI: https://doi.org/10.4049/jimmunol.0902640
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Activation of Tolerogenic Dendritic Cells in the Tumor Draining Lymph Nodes by CD8⁺ T Cells Engineered to Express CD40 Ligand
Eileen M. Higham, K. Dane Wittrup and Jianzhu Chen

J Immunol April 1, 2010, 184 (7) 3394-3400; DOI: https://doi.org/10.4049/jimmunol.0903111
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CD47 Is Required for Suppression of Allograft Rejection by Donor-Specific Transfusion
Hui Wang, Xiaojian Wu, Yuantao Wang, Per-Arne Oldenborg and Yong-Guang Yang

J Immunol April 1, 2010, 184 (7) 3401-3407; DOI: https://doi.org/10.4049/jimmunol.0901550
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ATP Activates Regulatory T Cells In Vivo during Contact Hypersensitivity Reactions
Sabine Ring, Alexander H. Enk and Karsten Mahnke

J Immunol April 1, 2010, 184 (7) 3408-3416; DOI: https://doi.org/10.4049/jimmunol.0901751
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Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool
Pablo J. E. J. van de Berg, Stephen J. Griffiths, Si-La Yong, Richard Macaulay, Frederike J. Bemelman, Sarah Jackson, Sian M. Henson, Ineke J. M. ten Berge, Arne N. Akbar and René A. W. van Lier

J Immunol April 1, 2010, 184 (7) 3417-3423; DOI: https://doi.org/10.4049/jimmunol.0903442
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Effects of MHC Class I Alleles on Licensing of Ly49A⁺ NK Cells
A. Helena Jonsson, Liping Yang, Sungjin Kim, Samantha M. Taffner and Wayne M. Yokoyama

J Immunol April 1, 2010, 184 (7) 3424-3432; DOI: https://doi.org/10.4049/jimmunol.0904057
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Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3⁺ T Regulatory Cells
Angela M. Thornton, Patricia E. Korty, Dat Q. Tran, Elizabeth A. Wohlfert, Patrick E. Murray, Yasmine Belkaid and Ethan M. Shevach

J Immunol April 1, 2010, 184 (7) 3433-3441; DOI: https://doi.org/10.4049/jimmunol.0904028
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Blockade of Programmed Death Ligand 1 Enhances the Therapeutic Efficacy of Combination Immunotherapy against Melanoma
Shari Pilon-Thomas, Amy Mackay, Nasreen Vohra and James J. Mulé

J Immunol April 1, 2010, 184 (7) 3442-3449; DOI: https://doi.org/10.4049/jimmunol.0904114
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CXC Chemokine Ligand (CXCL) 9 and CXCL10 Are Antagonistic Costimulation Molecules during the Priming of Alloreactive T Cell Effectors
Joshua M. Rosenblum, Naohiko Shimoda, Austin D. Schenk, Howard Zhang, Danielle D. Kish, Karen Keslar, Joshua M. Farber and Robert L. Fairchild

J Immunol April 1, 2010, 184 (7) 3450-3460; DOI: https://doi.org/10.4049/jimmunol.0903831
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IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In Vivo
Sarah R. Jacobs, Ryan D. Michalek and Jeffrey C. Rathmell

J Immunol April 1, 2010, 184 (7) 3461-3469; DOI: https://doi.org/10.4049/jimmunol.0902593
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Increased Foxp3⁺ Regulatory T Cells in Poly(ADP-Ribose) Polymerase-1 Deficiency
Francesca Nasta, Federica Laudisi, Manolo Sambucci, Maria M. Rosado and Claudio Pioli

J Immunol April 1, 2010, 184 (7) 3470-3477; DOI: https://doi.org/10.4049/jimmunol.0901568
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IFN-β Inhibits Dendritic Cell Migration through STAT-1–Mediated Transcriptional Suppression of CCR7 and Matrix Metalloproteinase 9
Jui-Hung Yen, Weimin Kong and Doina Ganea

J Immunol April 1, 2010, 184 (7) 3478-3486; DOI: https://doi.org/10.4049/jimmunol.0902542
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Melatonin Protects CD4⁺ T Cells from Activation-Induced Cell Death by Blocking NFAT-Mediated CD95 Ligand Upregulation
Alziana Moreno da Cunha Pedrosa, Ricardo Weinlich, Giuliana Patricia Mognol, Bruno Kaufmann Robbs, João Paulo de Biaso Viola, Ana Campa and Gustavo Pessini Amarante-Mendes

J Immunol April 1, 2010, 184 (7) 3487-3494; DOI: https://doi.org/10.4049/jimmunol.0902961
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PE_PGRS Antigens of Mycobacterium tuberculosis Induce Maturation and Activation of Human Dendritic Cells
Kushagra Bansal, Sri Ramulu Elluru, Yeddula Narayana, Rashmi Chaturvedi, Shripad A. Patil, Srini V. Kaveri, Jagadeesh Bayry and Kithiganahalli N. Balaji

J Immunol April 1, 2010, 184 (7) 3495-3504; DOI: https://doi.org/10.4049/jimmunol.0903299
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Bacterial Teichoic Acids Reverse Predominant IL-12 Production Induced by Certain Lactobacillus Strains into Predominant IL-10 Production via TLR2-Dependent ERK Activation in Macrophages
Rumi Kaji, Junko Kiyoshima-Shibata, Masato Nagaoka, Masanobu Nanno and Kan Shida

J Immunol April 1, 2010, 184 (7) 3505-3513; DOI: https://doi.org/10.4049/jimmunol.0901569
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BTN1A1, the Mammary Gland Butyrophilin, and BTN2A2 Are Both Inhibitors of T Cell Activation
Isobel A. Smith, Brittany R. Knezevic, Johannes U. Ammann, David A. Rhodes, Danielle Aw, Donald B. Palmer, Ian H. Mather and John Trowsdale

J Immunol April 1, 2010, 184 (7) 3514-3525; DOI: https://doi.org/10.4049/jimmunol.0900416
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Antimicrobial Peptides Human β-Defensins and Cathelicidin LL-37 Induce the Secretion of a Pruritogenic Cytokine IL-31 by Human Mast Cells
François Niyonsaba, Hiroko Ushio, Mutsuko Hara, Hidenori Yokoi, Mitsutoshi Tominaga, Kenji Takamori, Naoki Kajiwara, Hirohisa Saito, Isao Nagaoka, Hideoki Ogawa and Ko Okumura

J Immunol April 1, 2010, 184 (7) 3526-3534; DOI: https://doi.org/10.4049/jimmunol.0900712
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TLR4 Signaling in Stromal Cells Is Critical for the Initiation of Allergic Th2 Responses to Inhaled Antigen
Anna M. Tan, Hui-Chen Chen, Pierre Pochard, Stephanie C. Eisenbarth, Christina A. Herrick and H. Kim Bottomly

J Immunol April 1, 2010, 184 (7) 3535-3544; DOI: https://doi.org/10.4049/jimmunol.0900340
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T Cell-Independent IgA Class Switch Recombination Is Restricted to the GALT and Occurs Prior to Manifest Germinal Center Formation
Peter Bergqvist, Anneli Stensson, Nils Y. Lycke and Mats Bemark

J Immunol April 1, 2010, 184 (7) 3545-3553; DOI: https://doi.org/10.4049/jimmunol.0901895
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Depleting Syndecan-4⁺ T Lymphocytes Using Toxin-Bearing Dendritic Cell-Associated Heparan Sulfate Proteoglycan-Dependent Integrin Ligand: A New Opportunity for Treating Activated T Cell-Driven Disease
Hideo Akiyoshi, Jin-Sung Chung, Mizuki Tomihari, Ponciano D. Cruz Jr. and Kiyoshi Ariizumi

J Immunol April 1, 2010, 184 (7) 3554-3561; DOI: https://doi.org/10.4049/jimmunol.0903250
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The IL-7 Signaling Pathway Regulates Lymph Node Development Independent of Peripheral Lymphocytes
Stéphane Chappaz and Daniela Finke

J Immunol April 1, 2010, 184 (7) 3562-3569; DOI: https://doi.org/10.4049/jimmunol.0901647
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TNF Activates a NF-κB–Regulated Cellular Program in Human CD45RA^– Regulatory T Cells that Modulates Their Suppressive Function
Meital Nagar, Jasmine Jacob-Hirsch, Helly Vernitsky, Yackov Berkun, Shomron Ben-Horin, Ninette Amariglio, Ilan Bank, Yoel Kloog, Gideon Rechavi and Itamar Goldstein

J Immunol April 1, 2010, 184 (7) 3570-3581; DOI: https://doi.org/10.4049/jimmunol.0902070
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SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells
Robert Brooks, Gwenny M. Fuhler, Sonia Iyer, Michelle J. Smith, Mi-Young Park, Kim H. T. Paraiso, Robert W. Engelman and William G. Kerr

J Immunol April 1, 2010, 184 (7) 3582-3589; DOI: https://doi.org/10.4049/jimmunol.0902844
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Hemokinin-1 Activates the MAPK Pathway and Enhances B Cell Proliferation and Antibody Production
Wei Wang, Qian Li, Jun Zhang, Hounan Wu, Yanhui Yin, Qing Ge and Yu Zhang

J Immunol April 1, 2010, 184 (7) 3590-3597; DOI: https://doi.org/10.4049/jimmunol.0901278
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Anergic CD4⁺ T Cells Form Mature Immunological Synapses with Enhanced Accumulation of c-Cbl and Cbl-b
Melissa Doherty, Douglas G. Osborne, Diana L. Browning, David C. Parker and Scott A. Wetzel

J Immunol April 1, 2010, 184 (7) 3598-3608; DOI: https://doi.org/10.4049/jimmunol.0902285
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A Protease-Dependent Mechanism for Initiating T-Dependent B Cell Responses to Large Particulate Antigens
Drew M. Catron, Kathryn A. Pape, Brian T. Fife, Nico van Rooijen and Marc K. Jenkins

J Immunol April 1, 2010, 184 (7) 3609-3617; DOI: https://doi.org/10.4049/jimmunol.1000077
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CD22 × Siglec-G Double-Deficient Mice Have Massively Increased B1 Cell Numbers and Develop Systemic Autoimmunity
Julia Jellusova, Ute Wellmann, Kerstin Amann, Thomas H. Winkler and Lars Nitschke

J Immunol April 1, 2010, 184 (7) 3618-3627; DOI: https://doi.org/10.4049/jimmunol.0902711
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The Actin-Bundling Protein l-Plastin Dissociates CCR7 Proximal Signaling from CCR7-Induced Motility
Sharon Celeste Morley, Chen Wang, Wan-Lin Lo, Chan-Wang J. Lio, Bernd H. Zinselmeyer, Mark J. Miller, Eric J. Brown and Paul M. Allen

J Immunol April 1, 2010, 184 (7) 3628-3638; DOI: https://doi.org/10.4049/jimmunol.0903851
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Expression of the Autoimmune Susceptibility Gene FcRL3 on Human Regulatory T Cells Is Associated with Dysfunction and High Levels of Programmed Cell Death-1
Louise A. Swainson, Jeff E. Mold, Urmila D. Bajpai and Joseph M. McCune

J Immunol April 1, 2010, 184 (7) 3639-3647; DOI: https://doi.org/10.4049/jimmunol.0903943
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GP41-Specific Antibody Blocks Cell-Free HIV Type 1 Transcytosis through Human Rectal Mucosa and Model Colonic Epithelium
Ruizhong Shen, Ernesto R. Drelichman, Diane Bimczok, Christina Ochsenbauer, John C. Kappes, Jamie A. Cannon, Daniela Tudor, Morgane Bomsel, Lesley E. Smythies and Phillip D. Smith

J Immunol April 1, 2010, 184 (7) 3648-3655; DOI: https://doi.org/10.4049/jimmunol.0903346

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Impaired Lymphoid Organ Development in Mice Lacking the Heparan Sulfate Modifying Enzyme Glucuronyl C5-Epimerase
Rogier M. Reijmers, Mark F. R. Vondenhoff, Ramon Roozendaal, Annemieke Kuil, Jin-Ping Li, Marcel Spaargaren, Steven T. Pals and Reina E. Mebius

J Immunol April 1, 2010, 184 (7) 3656-3664; DOI: https://doi.org/10.4049/jimmunol.0902200
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Swiprosin-1/EFhd2 Controls B Cell Receptor Signaling through the Assembly of the B Cell Receptor, Syk, and Phospholipase C γ2 in Membrane Rafts
Carmen Kroczek, Christiane Lang, Sebastian Brachs, Marcus Grohmann, Sebastian Dütting, Astrid Schweizer, Lars Nitschke, Stephan M. Feller, Hans-Martin Jäck and Dirk Mielenz

J Immunol April 1, 2010, 184 (7) 3665-3676; DOI: https://doi.org/10.4049/jimmunol.0903642
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Activation of Mast Cells by Trimeric G Protein Gi3; Coupling to the A3 Adenosine Receptor Directly and upon T Cell Contact
Dana Baram, Ornit Dekel, Yoseph A. Mekori and Ronit Sagi-Eisenberg

J Immunol April 1, 2010, 184 (7) 3677-3688; DOI: https://doi.org/10.4049/jimmunol.0901333
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A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling
Pavel Otáhal, Pavla Angelisová, Matouš Hrdinka, Tomáš Brdička, Petr Novák, Karel Drbal and Václav Hořejší

J Immunol April 1, 2010, 184 (7) 3689-3696; DOI: https://doi.org/10.4049/jimmunol.0902075
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Integrin α_Mβ₂ Clustering Triggers Phosphorylation and Activation of Protein Kinase Cδ that Regulates Transcription Factor Foxp1 Expression in Monocytes
Zhi-Hong Xue, Chang-Qing Zhao, Geok-Lin Chua, Sze-Wah Tan, Xiao-Yan Tang, Siew-Cheng Wong and Suet-Mien Tan

J Immunol April 1, 2010, 184 (7) 3697-3709; DOI: https://doi.org/10.4049/jimmunol.0903316
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In Vivo Redundant Function of the 3′ IgH Regulatory Element HS3b in the Mouse
Anne-Gaëlle Bébin, Claire Carrion, Marie Marquet, Nadine Cogné, Sandrine Lecardeur, Michel Cogné and Eric Pinaud

J Immunol April 1, 2010, 184 (7) 3710-3717; DOI: https://doi.org/10.4049/jimmunol.0901978
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The Septic Shock-Associated IL-10 −1082 A > G Polymorphism Mediates Allele-Specific Transcription via Poly(ADP-Ribose) Polymerase 1 in Macrophages Engulfing Apoptotic Cells
Xiaoyan Kang, Ha-Jeong Kim, Michelle Ramirez, Sarah Salameh and Xiaojing Ma

J Immunol April 1, 2010, 184 (7) 3718-3724; DOI: https://doi.org/10.4049/jimmunol.0903613
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Antibody-Dependent Cell-Mediated Cytotoxicity- and Complement-Dependent Cytotoxicity-Independent Bactericidal Activity of an IgG against Pseudomonas aeruginosa O6ad
Xuemei Xie, Michael D. McLean and J. Christopher Hall

J Immunol April 1, 2010, 184 (7) 3725-3733; DOI: https://doi.org/10.4049/jimmunol.0902732

IMMUNOGENETICS

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Antibody Repertoire Development in Fetal and Neonatal Piglets. XI. The Relationship of Variable Heavy Chain Gene Usage and the Genomic Organization of the Variable Heavy Chain Locus
Tomoko Eguchi-Ogawa, Nancy Wertz, Xiu-Zhu Sun, Francois Puimi, Hirohide Uenishi, Kevin Wells, Patrick Chardon, Gregory J. Tobin and John E. Butler

J Immunol April 1, 2010, 184 (7) 3734-3742; DOI: https://doi.org/10.4049/jimmunol.0903616
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Loss of T Cell and B Cell Quiescence Precedes the Onset of Microbial Flora-Dependent Wasting Disease and Intestinal Inflammation in Gimap5-Deficient Mice
Michael J. Barnes, Halil Aksoylar, Philippe Krebs, Tristan Bourdeau, Carrie N. Arnold, Yu Xia, Kevin Khovananth, Isaac Engel, Sosathya Sovath, Kristin Lampe, Eleana Laws, Amy Saunders, Geoffrey W. Butcher, Mitchell Kronenberg, Kris Steinbrecher, David Hildeman, H. Leighton Grimes, Bruce Beutler and Kasper Hoebe

J Immunol April 1, 2010, 184 (7) 3743-3754; DOI: https://doi.org/10.4049/jimmunol.0903164

HOST DEFENSE

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Type I IFN Signaling Constrains IL-17A/F Secretion by γδ T Cells during Bacterial Infections
Thomas Henry, Girish S. Kirimanjeswara, Thomas Ruby, Jonathan W. Jones, Kaitian Peng, Magali Perret, Lena Ho, John-Demian Sauer, Yoichiro Iwakura, Dennis W. Metzger and Denise M. Monack

J Immunol April 1, 2010, 184 (7) 3755-3767; DOI: https://doi.org/10.4049/jimmunol.0902065
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IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis
Jacqueline Unsinger, Margaret McGlynn, Kevin R. Kasten, Andrew S. Hoekzema, Eizo Watanabe, Jared T. Muenzer, Jacquelyn S. McDonough, Johannes Tschoep, Thomas A. Ferguson, Jonathan E. McDunn, Michel Morre, David A. Hildeman, Charles C. Caldwell and Richard S. Hotchkiss

J Immunol April 1, 2010, 184 (7) 3768-3779; DOI: https://doi.org/10.4049/jimmunol.0903151
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Th1 Cytokine Responses Fail to Effectively Control Chlamydia Lung Infection in ICOS Ligand Knockout Mice
Kamran Kadkhoda, Shuhe Wang, Antony George Joyee, Yijun Fan, Jie Yang and Xi Yang

J Immunol April 1, 2010, 184 (7) 3780-3788; DOI: https://doi.org/10.4049/jimmunol.0901384
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Carbohydrate Oxidation Acidifies Endosomes, Regulating Antigen Processing and TLR9 Signaling
Colleen J. Lewis and Brian A. Cobb

J Immunol April 1, 2010, 184 (7) 3789-3800; DOI: https://doi.org/10.4049/jimmunol.0903168
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Febrile-Range Hyperthermia Augments Lipopolysaccharide-Induced Lung Injury by a Mechanism of Enhanced Alveolar Epithelial Apoptosis
Anne B. Lipke, Gustavo Matute-Bello, Raquel Herrero, Kiyoyasu Kurahashi, Venus A. Wong, Stephen M. Mongovin and Thomas R. Martin

J Immunol April 1, 2010, 184 (7) 3801-3813; DOI: https://doi.org/10.4049/jimmunol.0903191
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Natural Exposure to Cutaneous Anthrax Gives Long-Lasting T Cell Immunity Encompassing Infection-Specific Epitopes
Rebecca J. Ingram, Gökhan Metan, Bernard Maillere, Mehmet Doganay, Yusuf Ozkul, Louise U. Kim, Les Baillie, Hugh Dyson, E. Diane Williamson, Karen K. Chu, Stephanie Ascough, Steven Moore, Theresa B. Huwar, John H. Robinson, Shiranee Sriskandan and Daniel M. Altmann

J Immunol April 1, 2010, 184 (7) 3814-3821; DOI: https://doi.org/10.4049/jimmunol.0901581
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Antigenic Variation in Treponema pallidum: TprK Sequence Diversity Accumulates in Response to Immune Pressure during Experimental Syphilis
Lorenzo Giacani, Barbara J. Molini, Eric Y. Kim, B. Charmie Godornes, B. Troy Leader, Lauren C. Tantalo, Arturo Centurion-Lara and Sheila A. Lukehart

J Immunol April 1, 2010, 184 (7) 3822-3829; DOI: https://doi.org/10.4049/jimmunol.0902788
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IL-32 Is a Host Protective Cytokine against Mycobacterium tuberculosis in Differentiated THP-1 Human Macrophages
Xiyuan Bai, Soo-Hyun Kim, Tania Azam, Mischa T. McGibney, Hua Huang, Charles A. Dinarello and Edward D. Chan

J Immunol April 1, 2010, 184 (7) 3830-3840; DOI: https://doi.org/10.4049/jimmunol.0901913
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Identification of a Unique Population of Tissue-Memory CD4⁺ T Cells in the Airways after Influenza Infection That Is Dependent on the Integrin VLA-1
Timothy J. Chapman and David J. Topham

J Immunol April 1, 2010, 184 (7) 3841-3849; DOI: https://doi.org/10.4049/jimmunol.0902281
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Persistent γ-Herpesvirus Infection Induces a CD4 T Cell Response Containing Functionally Distinct Effector Populations
Kathleen A. Stuller, Stephanie S. Cush and Emilio Flaño

J Immunol April 1, 2010, 184 (7) 3850-3856; DOI: https://doi.org/10.4049/jimmunol.0902935

INFLAMMATION

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Markers of Monocyte Activation Revealed by Lipidomic Profiling of Arachidonic Acid-Containing Phospholipids
David Balgoma, Alma M. Astudillo, Gema Pérez-Chacón, Olimpio Montero, María A. Balboa and Jesús Balsinde

J Immunol April 1, 2010, 184 (7) 3857-3865; DOI: https://doi.org/10.4049/jimmunol.0902883
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Triptolide Inhibits IL-12/IL-23 Expression in APCs via CCAAT/Enhancer-Binding Protein α
Yan Zhang and Xiaojing Ma

J Immunol April 1, 2010, 184 (7) 3866-3877; DOI: https://doi.org/10.4049/jimmunol.0903417
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Hypoxia-Mediated Expression of 5-Lipoxygenase–Activating Protein Involves HIF-1α and NF-κB and MicroRNAs 135a and 199a-5p
Caryn S. Gonsalves and Vijay K. Kalra

J Immunol April 1, 2010, 184 (7) 3878-3888; DOI: https://doi.org/10.4049/jimmunol.0902594
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Neutrophil Transmigration Mediated by the Neutrophil-Specific Antigen CD177 Is Influenced by the Endothelial S₅₃₆N Dimorphism of Platelet Endothelial Cell Adhesion Molecule-1
Behnaz Bayat, Silke Werth, Ulrich J. H. Sachs, Debra K. Newman, Peter J. Newman and Sentot Santoso

J Immunol April 1, 2010, 184 (7) 3889-3896; DOI: https://doi.org/10.4049/jimmunol.0903136
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Constitutive Association of TGF-β–Activated Kinase 1 with the IκB Kinase Complex in the Nucleus and Cytoplasm of Human Neutrophils and Its Impact on Downstream Processes
Thornin Ear, Carl F. Fortin, François A. Simard and Patrick P. McDonald

J Immunol April 1, 2010, 184 (7) 3897-3906; DOI: https://doi.org/10.4049/jimmunol.0902958
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Induction of IDO-1 by Immunostimulatory DNA Limits Severity of Experimental Colitis
Matthew A. Ciorba, Ellen E. Bettonville, Keely G. McDonald, Richard Metz, George C. Prendergast, Rodney D. Newberry and William F. Stenson

J Immunol April 1, 2010, 184 (7) 3907-3916; DOI: https://doi.org/10.4049/jimmunol.0900291
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An LFA-1 (α_Lβ₂) Small-Molecule Antagonist Reduces Inflammation and Joint Destruction in Murine Models of Arthritis
Suzanne J. Suchard, Dawn K. Stetsko, Patricia M. Davis, Stacey Skala, Dominique Potin, Michele Launay, T. G. Murali Dhar, Joel C. Barrish, Vojkan Susulic, David J. Shuster, Kim W. McIntyre, Murray McKinnon and Luisa Salter-Cid

J Immunol April 1, 2010, 184 (7) 3917-3926; DOI: https://doi.org/10.4049/jimmunol.0901095
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Fatty Acids from Very Low-Density Lipoprotein Lipolysis Products Induce Lipid Droplet Accumulation in Human Monocytes
Laura J. den Hartigh, Jaime E. Connolly-Rohrbach, Samantha Fore, Thomas R. Huser and John C. Rutledge

J Immunol April 1, 2010, 184 (7) 3927-3936; DOI: https://doi.org/10.4049/jimmunol.0903475
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Identification of New Pathogenic Players in Lupus: Autoantibody-Secreting Cells Are Present in Nephritic Kidneys of (NZBxNZW)F1 Mice
Stéphanie Lacotte, Hélène Dumortier, Marion Décossas, Jean-Paul Briand and Sylviane Muller

J Immunol April 1, 2010, 184 (7) 3937-3945; DOI: https://doi.org/10.4049/jimmunol.0902595
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Proinflammatory Cytokine IL-1β Stimulates IL-8 Synthesis in Mast Cells via a Leukotriene B₄ Receptor 2-Linked Pathway, Contributing to Angiogenesis
Geun-Young Kim, Jin-Wook Lee, Ho-Cheol Ryu, Jun-Dong Wei, Chu-Myong Seong and Jae-Hong Kim

J Immunol April 1, 2010, 184 (7) 3946-3954; DOI: https://doi.org/10.4049/jimmunol.0901735
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Matrix Metalloproteinase 12-Deficiency Augments Extracellular Matrix Degrading Metalloproteinases and Attenuates IL-13–Dependent Fibrosis
Satish K. Madala, John T. Pesce, Thirumalai R. Ramalingam, Mark S. Wilson, Samantha Minnicozzi, Allen W. Cheever, Robert W. Thompson, Margaret M. Mentink-Kane and Thomas A. Wynn

J Immunol April 1, 2010, 184 (7) 3955-3963; DOI: https://doi.org/10.4049/jimmunol.0903008
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Differential Roles of Macrophages in Diverse Phases of Skin Repair
Tina Lucas, Ari Waisman, Rajeev Ranjan, Jürgen Roes, Thomas Krieg, Werner Müller, Axel Roers and Sabine A. Eming

J Immunol April 1, 2010, 184 (7) 3964-3977; DOI: https://doi.org/10.4049/jimmunol.0903356
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5-Lipoxygenase Activating Protein Signals Adipose Tissue Inflammation and Lipid Dysfunction in Experimental Obesity
Raquel Horrillo, Ana González-Périz, Marcos Martínez-Clemente, Marta López-Parra, Natàlia Ferré, Esther Titos, Eva Morán-Salvador, Ramon Deulofeu, Vicente Arroyo and Joan Clària

J Immunol April 1, 2010, 184 (7) 3978-3987; DOI: https://doi.org/10.4049/jimmunol.0901355

CLINICAL IMMUNOLOGY

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Clcn5 Knockout Mice Exhibit Novel Immunomodulatory Effects and Are More Susceptible to Dextran Sulfate Sodium-Induced Colitis
Philip Alex, Mei Ye, Nicholas C. Zachos, Jennifer Sipes, Thuan Nguyen, Maxim Suhodrev, Liberty Gonzales, Zubin Arora, Ting Zhang, Michael Centola, Sandra E. Guggino and Xuhang Li

J Immunol April 1, 2010, 184 (7) 3988-3996; DOI: https://doi.org/10.4049/jimmunol.0901657
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IL-1 Receptor Antagonist Protects against Placental and Neurodevelopmental Defects Induced by Maternal Inflammation
Sylvie Girard, Luc Tremblay, Martin Lepage and Guillaume Sébire

J Immunol April 1, 2010, 184 (7) 3997-4005; DOI: https://doi.org/10.4049/jimmunol.0903349
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B Cells Are Required for Optimal CD4⁺ and CD8⁺ T Cell Tumor Immunity: Therapeutic B Cell Depletion Enhances B16 Melanoma Growth in Mice
David J. DiLillo, Koichi Yanaba and Thomas F. Tedder

J Immunol April 1, 2010, 184 (7) 4006-4016; DOI: https://doi.org/10.4049/jimmunol.0903009
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SP1-Dependent Induction of CD39 Facilitates Hepatic Ischemic Preconditioning
Melanie L. Hart, Iris C. Gorzolla, Jens Schittenhelm, Simon C. Robson and Holger K. Eltzschig

J Immunol April 1, 2010, 184 (7) 4017-4024; DOI: https://doi.org/10.4049/jimmunol.0901851
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Cleavage of Transaldolase by Granzyme B Causes the Loss of Enzymatic Activity with Retention of Antigenicity for Multiple Sclerosis Patients
Brian Niland, Gabriella Miklossy, Katalin Banki, William E. Biddison, Livia Casciola-Rosen, Antony Rosen, Denis Martinvalet, Judy Lieberman and Andras Perl

J Immunol April 1, 2010, 184 (7) 4025-4032; DOI: https://doi.org/10.4049/jimmunol.0804174
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Coordinate Interaction between IL-13 and Epithelial Differentiation Cluster Genes in Eosinophilic Esophagitis
Carine Blanchard, Emily M. Stucke, Karen Burwinkel, Julie M. Caldwell, Margaret H. Collins, Annette Ahrens, Bridget K. Buckmeier, Sean C. Jameson, Allison Greenberg, Ajay Kaul, James P. Franciosi, Jonathan P. Kushner, Lisa J. Martin, Philip E. Putnam, J. Pablo Abonia, Suzanne I. Wells and Marc E. Rothenberg

J Immunol April 1, 2010, 184 (7) 4033-4041; DOI: https://doi.org/10.4049/jimmunol.0903069

LETTERS OF RETRACTION

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Retraction: Activation of Human Oral Epithelial Cells by Neutrophil Proteinase 3 Through Protease-Activated Receptor-2
Shunji Sugawara and Koji Muramoto

J Immunol April 1, 2010, 184 (7) 4042; DOI: https://doi.org/10.4049/jimmunol.1090011
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Retraction: Neutrophil Serine Proteinases Activate Human Nonepithelial Cells to Produce Inflammatory Cytokines Through Protease-Activated Receptor 2
Koji Muramoto and Shunji Sugawara

J Immunol April 1, 2010, 184 (7) 4043; DOI: https://doi.org/10.4049/jimmunol.1090012
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Retraction: Proinflammatory Cytokines Induce Proteinase 3 as Membrane-Bound and Secretory Forms in Human Oral Epithelial Cells and Antibodies to Proteinase 3 Activate the Cells through Protease-Activated Receptor-2
Yumiko Sugawara, Takashi Sasano and Shunji Sugawara

J Immunol April 1, 2010, 184 (7) 4044; DOI: https://doi.org/10.4049/jimmunol.1090013

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CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

IMMUNOGENETICS

HOST DEFENSE

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