Tannic acid and quercetin display a therapeutic effect on atopic dermatitis via suppression of angiogenesis and Th2 polarization. (97.7)

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by inflammation, abnormal angiogenesis and elevated Th2 polarization. Tannic acid (TA) and quercetin are well known polypenolic compounds, have documented anti-inflammatory effect. However, little is known about the effects of TA and quercetin on atopic dermatitis and related mechanisms. The present study investigated whether TA and quercetin had a therapeutic effect on atopic dermatitis. In vitro, we found that TA and quercetins reduced pro-angiogenic factor and Th2-inducing cytokine in human keratinocytes. The inhibitory effect was higher in the combined application of the two agents than in the application of one agent alone. To investigate the effect of combined application with TA and quercetin in vivo, an AD-induced Nc/Nga mouse model was used. The group receiving TA and quercetin showed disease improvement with down-regulation of serum IgE, TARC production and angiogenesis level compare to non-treated group. Taken together, these data demonstrate that TA and quercetin have a therapeutic effect on AD by suppressing angiogenesis, Th2 polarization.