On the cover: Absence of the principal PGE₂ synthesizing enzyme permits marked remodeling of the pulmonary vasculature in response to dust mite allergen-induced lung inflammation. Image shows a ×200 magnification of a section of the lung of a ptges^−/− mouse stained with an antibody against α-smooth muscle actin. Lundequist, A., S. N. Nallamshetty, W. Xing, C. Feng, T. M. Laidlaw, S. Uematsu, S. Akira, and J. A. Boyce. 2010. Prostaglandin E₂ exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation. J. Immunol. 184: 433–441.