On the cover: A single linear polypeptide comprising a pentameric (green) and trimeric (blue) coiled-coil domain self-assembles into an icosahedral nanoparticle composed of 60 peptide chains. Peptide B cell epitopes (red) cloned onto the end of the gene are displayed on the surface in a highly ordered repetitive array that is extremely immunogenic. Kaba, S. A., C. Brando, Q. Guo, C. Mittelholzer, S. Raman, D. Tropel, U. Aebi, P. Burkhard, and D. E. Lanar. 2009. A non-adjuvanted polypeptide nanoparticle vaccine confers long-lasting protection against rodent malaria. J. Immunol 183: 7268–7277.