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The Journal of Immunology

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About the Cover

July 1, 2009; Volume 183,Issue 1

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On the cover: C1q efficiently co-localizes with the therapeutic CD20 Ab ofatumumab bound to Daudi cells. A1647 ofatumumab-opsonized cells (red) were examined for co-localization with bound A1488 C1q (green) by multi-spectral high resolution digital imaging. Light scatter, fluorescence and bright field images, including merged fluorescent (yellow-orange) images are displayed. Pawluczkowycz, A. W., F. J. Beurskens, P. V. Beum, M. A. Lindorfer, J. G. J. van de Winkel, P. W. H. I. Parren, and R. P. Taylor. 2009. Binding of Submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX. J. Immunol. 183: 749–758.

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This Issue

The Journal of Immunology: 183 (1)
The Journal of Immunology
Vol. 183, Issue 1
1 Jul 2009
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  • IN THIS ISSUE
  • PILLARS OF IMMUNOLOGY
  • CUTTING EDGE
  • CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
  • MOLECULAR AND STRUCTURAL IMMUNOLOGY
  • IMMUNOGENETICS
  • HOST DEFENSE
  • INFLAMMATION
  • CLINICAL IMMUNOLOGY
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Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
Natural and Induced Tolerogenic Dendritic Cells
Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

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Print ISSN 0022-1767        Online ISSN 1550-6606