The Journal of Immunology: 183 (1)

July 1, 2009; Volume 183,Issue 1

IN THIS ISSUE

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IN THIS ISSUE

J Immunol July 1, 2009, 183 (1) 1-2; DOI: https://doi.org/10.4049/jimmunol.0990044

PILLARS OF IMMUNOLOGY

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The Original Intrathymic Progenitor from Which T Cells Originate
Juan Carlos Zúñiga-Pflücker

J Immunol July 1, 2009, 183 (1) 3-4; DOI: https://doi.org/10.4049/jimmunol.0990043
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Pillars Article: Early T Lymphocytes. Differentiation In Vivo of Adult Intrathymic Precursor Cells. J. Exp. Med. 1985. 162: 802–822
B. J. Fowlkes, Linette Edison, Bonnie J. Mathieson and Thomas M. Chused

J Immunol July 1, 2009, 183 (1) 5-25;

CUTTING EDGE

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Cutting Edge: Cardiac Myosin Activates Innate Immune Responses through TLRs
Ping Zhang, Carol J. Cox, Kathy M. Alvarez and Madeleine W. Cunningham

J Immunol July 1, 2009, 183 (1) 27-31; DOI: https://doi.org/10.4049/jimmunol.0800861
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Cutting Edge: B and T Lymphocyte Attenuator Signaling on NKT Cells Inhibits Cytokine Release and Tissue Injury in Early Immune Responses
Mendy L. Miller, Yonglian Sun and Yang-Xin Fu

J Immunol July 1, 2009, 183 (1) 32-36; DOI: https://doi.org/10.4049/jimmunol.0900690
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Cutting Edge: Rapid and Efficient In Vivo Cytotoxicity by Cytotoxic T Cells Is Independent of Granzymes A and B
Matthias Regner, Lisa Pavlinovic, Aulikki Koskinen, Nicolie Young, Joseph A. Trapani and Arno Müllbacher

J Immunol July 1, 2009, 183 (1) 37-40; DOI: https://doi.org/10.4049/jimmunol.0900466

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

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CD44^high Memory CD8 T Cells Synergize with CpG DNA to Activate Dendritic Cell IL-12p70 Production
Kok Loon Wong, Li Fang Melissa Tang, Fei Chuin Lew, Hok Sum Kenneth Wong, Yen Leong Chua, Paul A. MacAry and David M. Kemeny

J Immunol July 1, 2009, 183 (1) 41-50; DOI: https://doi.org/10.4049/jimmunol.0803473
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IFN-γ Promotes Generation of IL-10 Secreting CD4⁺ T Cells that Suppress Generation of CD8 Responses in an Antigen-Experienced Host
Xiao Song Liu, Joanne Leerberg, Kelli MacDonald, Graham R. Leggatt and Ian H. Frazer

J Immunol July 1, 2009, 183 (1) 51-58; DOI: https://doi.org/10.4049/jimmunol.0802047
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Restricted Autoantigen Recognition Associated with Deletional and Adaptive Regulatory Mechanisms
John A. Gebe, Betty B. Yue, Kelly A. Unrath, Ben A. Falk and Gerald T. Nepom

J Immunol July 1, 2009, 183 (1) 59-65; DOI: https://doi.org/10.4049/jimmunol.0804046
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Aryl Hydrocarbon Receptor Activation Inhibits In Vitro Differentiation of Human Monocytes and Langerhans Dendritic Cells
Barbara Platzer, Susanne Richter, Doris Kneidinger, Darina Waltenberger, Maximilian Woisetschläger and Herbert Strobl

J Immunol July 1, 2009, 183 (1) 66-74; DOI: https://doi.org/10.4049/jimmunol.0802997
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T-bet-Deficient NOD Mice Are Protected from Diabetes Due to Defects in Both T Cell and Innate Immune System Function
Jonathan H. Esensten, Michael R. Lee, Laurie H. Glimcher and Jeffrey A. Bluestone

J Immunol July 1, 2009, 183 (1) 75-82; DOI: https://doi.org/10.4049/jimmunol.0804154
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Conservation of Structural and Functional Features in a Primordial CD80/86 Molecule from Rainbow Trout (Oncorhynchus mykiss), a Primitive Teleost Fish
Yong-An Zhang, Jun-ichi Hikima, Jun Li, Scott E. LaPatra, Yan-Ping Luo and J. Oriol Sunyer

J Immunol July 1, 2009, 183 (1) 83-96; DOI: https://doi.org/10.4049/jimmunol.0900605
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TGF-β Promotes Th17 Cell Development through Inhibition of SOCS3
Hongwei Qin, Lanfang Wang, Ting Feng, Charles O. Elson, Sandrine A. Niyongere, Sun Jung Lee, Stephanie L. Reynolds, Casey T. Weaver, Kevin Roarty, Rosa Serra, Etty N. Benveniste and Yingzi Cong

J Immunol July 1, 2009, 183 (1) 97-105; DOI: https://doi.org/10.4049/jimmunol.0801986
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The Expression and Function of the NKRP1 Receptor Family in C57BL/6 Mice
Jonathan G. Aust, Frances Gays, Katarzyna M. Mickiewicz, Ella Buchanan and Colin G. Brooks

J Immunol July 1, 2009, 183 (1) 106-116; DOI: https://doi.org/10.4049/jimmunol.0804281
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Modulating the Expression of IFN Regulatory Factor 8 Alters the Protumorigenic Behavior of CD11b⁺Gr-1⁺ Myeloid Cells
Trina J. Stewart, David J. Liewehr, Seth M. Steinberg, Kristy M. Greeneltch and Scott I. Abrams

J Immunol July 1, 2009, 183 (1) 117-128; DOI: https://doi.org/10.4049/jimmunol.0804132
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Increased Antigen Cross-Presentation but Impaired Cross-Priming after Activation of Peroxisome Proliferator-Activated Receptor γ Is Mediated by Up-Regulation of B7H1
Luisa Klotz, Stephanie Hucke, Dominik Thimm, Sabine Classen, Andrea Gaarz, Joachim Schultze, Frank Edenhofer, Christian Kurts, Thomas Klockgether, Andreas Limmer, Percy Knolle and Sven Burgdorf

J Immunol July 1, 2009, 183 (1) 129-136; DOI: https://doi.org/10.4049/jimmunol.0804260
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Chemotherapeutic Agents in Noncytotoxic Concentrations Increase Antigen Presentation by Dendritic Cells via an IL-12-Dependent Mechanism
Galina V. Shurin, Irina L. Tourkova, Ramon Kaneno and Michael R. Shurin

J Immunol July 1, 2009, 183 (1) 137-144; DOI: https://doi.org/10.4049/jimmunol.0900734
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Tryptophan Deprivation Induces Inhibitory Receptors ILT3 and ILT4 on Dendritic Cells Favoring the Induction of Human CD4⁺CD25⁺ Foxp3⁺ T Regulatory Cells
Manuela Brenk, Marina Scheler, Susanne Koch, Jürgen Neumann, Osamu Takikawa, Georg Häcker, Thomas Bieber and Dagmar von Bubnoff

J Immunol July 1, 2009, 183 (1) 145-154; DOI: https://doi.org/10.4049/jimmunol.0803277
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STAT6 Activation Confers upon T Helper Cells Resistance to Suppression by Regulatory T Cells
Brendan B. L. Pillemer, Zengbiao Qi, Barbro Melgert, Timothy B. Oriss, Prabir Ray and Anuradha Ray

J Immunol July 1, 2009, 183 (1) 155-163; DOI: https://doi.org/10.4049/jimmunol.0803733
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The Effects of Cytokines on Suppression of Lymphocyte Proliferation by Dexamethasone
Tom J. Creed, Richard W. Lee, Paul V. Newcomb, Alexandra J. di Mambro, Madhuri Raju and Colin M. Dayan

J Immunol July 1, 2009, 183 (1) 164-171; DOI: https://doi.org/10.4049/jimmunol.0801998
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Role of CD44 in the Differentiation of Th1 and Th2 Cells: CD44-Deficiency Enhances the Development of Th2 Effectors in Response to Sheep RBC and Chicken Ovalbumin
Hongbing Guan, Prakash S. Nagarkatti and Mitzi Nagarkatti

J Immunol July 1, 2009, 183 (1) 172-180; DOI: https://doi.org/10.4049/jimmunol.0802325
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Vaccine-Induced CD8⁺ T Cell-Dependent Suppression of Airway Hyperresponsiveness and Inflammation
Katsuyuki Takeda, Steven W. Dow, Nobuaki Miyahara, Taku Kodama, Toshiyuki Koya, Christian Taube, Anthony Joetham, Jung-Won Park, Azzeddine Dakhama, Ross M. Kedl and Erwin W. Gelfand

J Immunol July 1, 2009, 183 (1) 181-190; DOI: https://doi.org/10.4049/jimmunol.0803967
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A Microbial Polysaccharide Reduces the Severity of Rheumatoid Arthritis by Influencing Th17 Differentiation and Proinflammatory Cytokines Production
Claudia Monari, Sara Bevilacqua, Miranda Piccioni, Eva Pericolini, Stefano Perito, Mario Calvitti, Francesco Bistoni, Thomas R. Kozel and Anna Vecchiarelli

J Immunol July 1, 2009, 183 (1) 191-200; DOI: https://doi.org/10.4049/jimmunol.0804144
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Cytokine-Dependent Modification of IL-12p70 and IL-23 Balance in Dendritic Cells by Ligand Activation of Vα24 Invariant NKT Cells
Yasushi Uemura, Tian-Yi Liu, Yayoi Narita, Motoharu Suzuki, Ryusuke Nakatsuka, Tomoyuki Araki, Masahito Matsumoto, Leo Kei Iwai, Narumi Hirosawa, Yoshikazu Matsuoka, Mari Murakami, Takashi Kimura, Makoto Hase, Hirao Kohno, Yutaka Sasaki, Yasuko Ichihara, Osamu Ishihara, Hirosato Kikuchi, Yasushi Sakamoto, Shun-Chang Jiao, Satoru Senju and Yoshiaki Sonoda

J Immunol July 1, 2009, 183 (1) 201-208; DOI: https://doi.org/10.4049/jimmunol.0900873
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IFN-γ Attenuates Antigen-Induced Overall Immune Response in the Airway As a Th1-Type Immune Regulatory Cytokine
Kazuyuki Nakagome, Katsuhide Okunishi, Mitsuru Imamura, Hiroaki Harada, Taku Matsumoto, Ryoichi Tanaka, Jun-ichi Miyazaki, Kazuhiko Yamamoto and Makoto Dohi

J Immunol July 1, 2009, 183 (1) 209-220; DOI: https://doi.org/10.4049/jimmunol.0802712
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Sphingosine Kinase1 Is Pivotal for FcεRI-Mediated Mast Cell Signaling and Functional Responses In Vitro and In Vivo
Peter N. Pushparaj, Jayapal Manikandan, Hwee Kee Tay, Shiau Chen H'ng, Srinivasan D. Kumar, Josef Pfeilschifter, Andrea Huwiler and Alirio J. Melendez

J Immunol July 1, 2009, 183 (1) 221-227; DOI: https://doi.org/10.4049/jimmunol.0803430
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SHIP1 Is a Repressor of Mast Cell Hyperplasia, Cytokine Production, and Allergic Inflammation In Vivo
D. James Haddon, Frann Antignano, Michael R. Hughes, Marie-Renée Blanchet, Lori Zbytnuik, Gerald Krystal and Kelly M. McNagny

J Immunol July 1, 2009, 183 (1) 228-236; DOI: https://doi.org/10.4049/jimmunol.0900427
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Type V Collagen-Induced Oral Tolerance Plus Low-Dose Cyclosporine Prevents Rejection of MHC Class I and II Incompatible Lung Allografts
Yoshito Yamada, Yasuo Sekine, Shigetoshi Yoshida, Kazuhiro Yasufuku, Irina Petrache, Heather L. Benson, David D. Brand, Ichiro Yoshino and David S. Wilkes

J Immunol July 1, 2009, 183 (1) 237-245; DOI: https://doi.org/10.4049/jimmunol.0804028
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Regulatory Properties of Copolymer I in Th17 Differentiation by Altering STAT3 Phosphorylation
Chunhua Chen, Xuebin Liu, Bing Wan and Jingwu Z. Zhang

J Immunol July 1, 2009, 183 (1) 246-253; DOI: https://doi.org/10.4049/jimmunol.0900193
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Production of Both IL-27 and IFN-γ after the Treatment with a Ligand for Invariant NK T Cells Is Responsible for the Suppression of Th2 Response and Allergic Inflammation in a Mouse Experimental Asthma Model
Hiroyuki Fujita, Annabelle Teng, Risa Nozawa, Yukiko Takamoto-Matsui, Haruka Katagiri-Matsumura, Zenro Ikezawa and Yasuyuki Ishii

J Immunol July 1, 2009, 183 (1) 254-260; DOI: https://doi.org/10.4049/jimmunol.0800520
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MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation
Lorraine A. O'Reilly, Elizabeth A. Kruse, Hamsa Puthalakath, Priscilla N. Kelly, Thomas Kaufmann, David C. S. Huang and Andreas Strasser

J Immunol July 1, 2009, 183 (1) 261-269; DOI: https://doi.org/10.4049/jimmunol.0803853
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Blocking CD27-CD70 Costimulatory Pathway Suppresses Experimental Colitis
Monika Manocha, Rietdijk Svend, Amale Laouar, Gongxian Liao, Atul Bhan, Jannine Borst, Cox Terhorst and N. Manjunath

J Immunol July 1, 2009, 183 (1) 270-276; DOI: https://doi.org/10.4049/jimmunol.0802424
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Gap Junctions at the Dendritic Cell-T Cell Interface Are Key Elements for Antigen-Dependent T Cell Activation
Raul Elgueta, Jaime A. Tobar, Kenji F. Shoji, Jaime De Calisto, Alexis M. Kalergis, Maria R. Bono, Mario Rosemblatt and Juan C. Sáez

J Immunol July 1, 2009, 183 (1) 277-284; DOI: https://doi.org/10.4049/jimmunol.0801854
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Altered Thymic Selection and Increased Autoimmunity Caused by Ectopic Expression of DRAK2 during T Cell Development
Martina Gatzka, Ryan H. Newton and Craig M. Walsh

J Immunol July 1, 2009, 183 (1) 285-297; DOI: https://doi.org/10.4049/jimmunol.0803530
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Early Life Exposure to Lipopolysaccharide Suppresses Experimental Autoimmune Encephalomyelitis by Promoting Tolerogenic Dendritic Cells and Regulatory T Cells
Kristofor K. Ellestad, Shigeki Tsutsui, Farshid Noorbakhsh, Kenneth G. Warren, V. Wee Yong, Quentin J. Pittman and Christopher Power

J Immunol July 1, 2009, 183 (1) 298-309; DOI: https://doi.org/10.4049/jimmunol.0803576
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Vav1 Regulates the Migration and Adhesion of Dendritic Cells
David R. Spurrell, Nancy A. Luckashenak, Derek C. Minney, Anna Chaplin, Joseph M. Penninger, Robert S. Liwski, James L. Clements and Kenneth A. West

J Immunol July 1, 2009, 183 (1) 310-318; DOI: https://doi.org/10.4049/jimmunol.0802096
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Clonotype Selection and Composition of Human CD8 T Cells Specific for Persistent Herpes Viruses Varies with Differentiation but Is Stable Over Time
Emanuela M. Iancu, Patricia Corthesy, Petra Baumgaertner, Estelle Devevre, Verena Voelter, Pedro Romero, Daniel E. Speiser and Nathalie Rufer

J Immunol July 1, 2009, 183 (1) 319-331; DOI: https://doi.org/10.4049/jimmunol.0803647
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The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells
William E. O'Gorman, Hans Dooms, Steve H. Thorne, Wilson F. Kuswanto, Erin F. Simonds, Peter O. Krutzik, Garry P. Nolan and Abul K. Abbas

J Immunol July 1, 2009, 183 (1) 332-339; DOI: https://doi.org/10.4049/jimmunol.0900691
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Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function
Malin Hedlund, Ann-Christin Stenqvist, Olga Nagaeva, Lennart Kjellberg, Marianne Wulff, Vladimir Baranov and Lucia Mincheva-Nilsson

J Immunol July 1, 2009, 183 (1) 340-351; DOI: https://doi.org/10.4049/jimmunol.0803477
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Notch Ligands Expressed by Follicular Dendritic Cells Protect Germinal Center B Cells from Apoptosis
Sun-Ok Yoon, Xin Zhang, Paul Berner, Bianca Blom and Yong Sung Choi

J Immunol July 1, 2009, 183 (1) 352-358; DOI: https://doi.org/10.4049/jimmunol.0803183
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Activated Integrin VLA-4 Localizes to the Lamellipodia and Mediates T Cell Migration on VCAM-1
Young-Min Hyun, Hung-Li Chung, James L. McGrath, Richard E. Waugh and Minsoo Kim

J Immunol July 1, 2009, 183 (1) 359-369; DOI: https://doi.org/10.4049/jimmunol.0803388
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Elimination of Immunodominant Epitopes from Multispecific DNA-Based Vaccines Allows Induction of CD8 T Cells That Have a Striking Antiviral Potential
Petra Riedl, Andreas Wieland, Kasper Lamberth, Soren Buus, Francois Lemonnier, Kurt Reifenberg, Jörg Reimann and Reinhold Schirmbeck

J Immunol July 1, 2009, 183 (1) 370-380; DOI: https://doi.org/10.4049/jimmunol.0900505
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IL-23 Promotes the Production of IL-17 by Antigen-Specific CD8 T Cells in the Absence of IL-12 and Type-I Interferons
Meredith M. Curtis, Sing Sing Way and Christopher B. Wilson

J Immunol July 1, 2009, 183 (1) 381-387; DOI: https://doi.org/10.4049/jimmunol.0900939
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Increased Intracellular, Cell Surface, and Secreted Inducible Heat Shock Protein 70 Responses Are Triggered during the Monocyte to Dendritic Cell (DC) Transition by Cytokines Independently of Heat Stress and Infection and May Positively Regulate DC Growth
Carla A. Martin, Danielle L. Kurkowski, Alisa M. Valentino and Frances Santiago-Schwarz

J Immunol July 1, 2009, 183 (1) 388-399; DOI: https://doi.org/10.4049/jimmunol.0802688
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CD11c⁺CD8α⁺ Dendritic Cells Promote Protective Immunity to Respiratory Infection with Bordetella pertussis
Pádraic J. Dunne, Barry Moran, Robert C. Cummins and Kingston H. G. Mills

J Immunol July 1, 2009, 183 (1) 400-410; DOI: https://doi.org/10.4049/jimmunol.0900169

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Neutrophil Elastase Represses IL-8/CXCL8 Synthesis in Human Airway Smooth Muscle Cells through Induction of NF-κB Repressing Factor
Shu-Chuan Ho, Kang-Yun Lee, Yao-Fei Chan, Lu-Wei Kuo, Kazuhiro Ito, Ian M. Adcock, Bing-Chang Chen, Joen-Rong Sheu, Chien-Huang Lin and Han-Pin Kuo

J Immunol July 1, 2009, 183 (1) 411-420; DOI: https://doi.org/10.4049/jimmunol.0803729
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Structural Basis for Proteolytic Specificity of the Human Apoptosis-Inducing Granzyme M
Lianfeng Wu, Li Wang, Guoqiang Hua, Kan Liu, Xuan Yang, Yujia Zhai, Mark Bartlam, Fei Sun and Zusen Fan

J Immunol July 1, 2009, 183 (1) 421-429; DOI: https://doi.org/10.4049/jimmunol.0803088
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Structural Bases for the Affinity-Driven Selection of a Public TCR against a Dominant Human Cytomegalovirus Epitope
Stéphanie Gras, Xavier Saulquin, Jean-Baptiste Reiser, Emilie Debeaupuis, Klara Echasserieau, Adrien Kissenpfennig, François Legoux, Anne Chouquet, Madalen Le Gorrec, Paul Machillot, Bérangère Neveu, Nicole Thielens, Bernard Malissen, Marc Bonneville and Dominique Housset

J Immunol July 1, 2009, 183 (1) 430-437; DOI: https://doi.org/10.4049/jimmunol.0900556
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The Transmembrane E3 Ligase GRAIL Ubiquitinates and Degrades CD83 on CD4 T Cells
Leon L. Su, Hideyuki Iwai, Jack T. Lin and C. Garrison Fathman

J Immunol July 1, 2009, 183 (1) 438-444; DOI: https://doi.org/10.4049/jimmunol.0900204
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The Coding ECP 434(G>C) Gene Polymorphism Determines the Cytotoxicity of ECP but Has Minor Effects on Fibroblast-Mediated Gel Contraction and No Effect on RNase Activity
Jenny Rubin, Ulrika Zagai, Kristin Blom, Agneta Trulson, Åke Engström and Per Venge

J Immunol July 1, 2009, 183 (1) 445-451; DOI: https://doi.org/10.4049/jimmunol.0803912

IMMUNOGENETICS

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Antibodies in a Heavy Chain Knock-In Mouse Exhibit Characteristics of Early Heavy Chain Rearrangement
Lenka Yunk, Wenzhao Meng, Philip L. Cohen, Robert A. Eisenberg and Eline T. Luning Prak

J Immunol July 1, 2009, 183 (1) 452-461; DOI: https://doi.org/10.4049/jimmunol.0804060
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Identification of a Major Susceptibility Locus for Lethal Graft-versus-Host Disease in MHC-Matched Mice
Thai M. Cao, Laura C. Lazzeroni, Schickwann Tsai, Wendy W. Pang, Amy Kao, Nicola J. Camp, Alun Thomas and Judith A. Shizuru

J Immunol July 1, 2009, 183 (1) 462-469; DOI: https://doi.org/10.4049/jimmunol.0900454

HOST DEFENSE

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Immunization with the DNA-Encoding N-Terminal Domain of Proteophosphoglycan of Leishmania donovani Generates Th1-Type Immunoprotective Response against Experimental Visceral Leishmaniasis
Mukesh Samant, Reema Gupta, Shraddha Kumari, Pragya Misra, Prashant Khare, Pramod Kumar Kushawaha, Amogh Anant Sahasrabuddhe and Anuradha Dube

J Immunol July 1, 2009, 183 (1) 470-479; DOI: https://doi.org/10.4049/jimmunol.0900265
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Multivalent Binding of Carbohydrates by the Human α-Defensin, HD5
Robert I. Lehrer, Grace Jung, Piotr Ruchala, Sabine Andre, Hans J. Gabius and Wuyuan Lu

J Immunol July 1, 2009, 183 (1) 480-490; DOI: https://doi.org/10.4049/jimmunol.0900244
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Downstream Signals for MyD88-Mediated Phagocytosis of Borrelia burgdorferi Can Be Initiated by TRIF and Are Dependent on PI3K
Ok S. Shin, Lloyd S. Miller, Robert L. Modlin, Shizuo Akira, Satoshi Uematsu and Linden T. Hu

J Immunol July 1, 2009, 183 (1) 491-498; DOI: https://doi.org/10.4049/jimmunol.0900724
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The Cannabinoid Receptor 2 Is Critical for the Host Response to Sepsis
Johannes Tschöp, Kevin R. Kasten, Ruben Nogueiras, Holly S. Goetzman, Cynthia M. Cave, Lisa G. England, Jonathan Dattilo, Alex B. Lentsch, Matthias H. Tschöp and Charles C. Caldwell

J Immunol July 1, 2009, 183 (1) 499-505; DOI: https://doi.org/10.4049/jimmunol.0900203
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Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering
Anne-Catherine Raby, Emmanuel Le Bouder, Chantal Colmont, James Davies, Peter Richards, Barbara Coles, Christopher H. George, Simon A. Jones, Paul Brennan, Nicholas Topley and Mario O. Labéta

J Immunol July 1, 2009, 183 (1) 506-517; DOI: https://doi.org/10.4049/jimmunol.0802909
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Generation of Protective T Cell-Independent Antiviral Antibody Responses in SCID Mice Reconstituted with Follicular or Marginal Zone B Cells
Heath M. Guay, Rabinarayan Mishra, Robert L. Garcea, Raymond M. Welsh and Eva Szomolanyi-Tsuda

J Immunol July 1, 2009, 183 (1) 518-523; DOI: https://doi.org/10.4049/jimmunol.0900068
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Follicular Dendritic Cells Activate HIV-1 Replication in Monocytes/Macrophages through a Juxtacrine Mechanism Mediated by P-Selectin Glycoprotein Ligand 1
Kenji Ohba, Akihide Ryo, Md. Zahidunnabi Dewan, Mayuko Nishi, Toshio Naito, Xiaohua Qi, Yoshio Inagaki, Yoji Nagashima, Yuetsu Tanaka, Takashi Okamoto, Kazuo Terashima and Naoki Yamamoto

J Immunol July 1, 2009, 183 (1) 524-532; DOI: https://doi.org/10.4049/jimmunol.0900371
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In Vivo Lipopolysaccharide Exposure of Human Blood Leukocytes Induces Cross-Tolerance to Multiple TLR Ligands
Alex F. de Vos, Jennie M. Pater, Petra S. van den Pangaart, Martijn D. de Kruif, Cornelis van 't Veer and Tom van der Poll

J Immunol July 1, 2009, 183 (1) 533-542; DOI: https://doi.org/10.4049/jimmunol.0802189
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LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline
Gudmundur Bergsson, Emer P. Reeves, Paul McNally, Sanjay H. Chotirmall, Catherine M. Greene, Peter Greally, Philip Murphy, Shane J. O'Neill and Noel G. McElvaney

J Immunol July 1, 2009, 183 (1) 543-551; DOI: https://doi.org/10.4049/jimmunol.0803959

INFLAMMATION

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Cholinergic Neural Signals to the Spleen Down-Regulate Leukocyte Trafficking via CD11b
Jared M. Huston, Mauricio Rosas-Ballina, Xiangying Xue, Oonagh Dowling, Kanta Ochani, Mahendar Ochani, Michael M. Yeboah, Prodyot K. Chatterjee, Kevin J. Tracey and Christine N. Metz

J Immunol July 1, 2009, 183 (1) 552-559; DOI: https://doi.org/10.4049/jimmunol.0802684
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Major Role of γδ T Cells in the Generation of IL-17⁺ Uveitogenic T Cells
Yan Cui, Hui Shao, Chen Lan, Hong Nian, Rebecca L. O'Brien, Willi K. Born, Henry J. Kaplan and Deming Sun

J Immunol July 1, 2009, 183 (1) 560-567; DOI: https://doi.org/10.4049/jimmunol.0900241
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IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease
Kirk A. Staschke, Sucai Dong, Joy Saha, Jingyong Zhao, Nathan A. Brooks, Deena L. Hepburn, Jinqi Xia, Muhammet F. Gulen, Zizhen Kang, Cengiz Z. Altuntas, Vincent K. Tuohy, Raymond Gilmour, Xiaoxia Li and Songqing Na

J Immunol July 1, 2009, 183 (1) 568-577; DOI: https://doi.org/10.4049/jimmunol.0802361
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Differential Regulation of P2X₇ Receptor Activation by Extracellular Nicotinamide Adenine Dinucleotide and Ecto-ADP-Ribosyltransferases in Murine Macrophages and T Cells
Shiyuan Hong, Nicole Schwarz, Anette Brass, Michel Seman, Friedrich Haag, Friedrich Koch-Nolte, William P. Schilling and George R. Dubyak

J Immunol July 1, 2009, 183 (1) 578-592; DOI: https://doi.org/10.4049/jimmunol.0900120
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Pleiotropic Roles of S100A12 in Coronary Atherosclerotic Plaque Formation and Rupture
Jesse Goyette, Wei Xing Yan, Eric Yamen, Yuen Ming Chung, Su Yin Lim, Kenneth Hsu, Farid Rahimi, Nick Di Girolamo, Changjie Song, Wendy Jessup, Maaike Kockx, Yuri V. Bobryshev, S. Ben Freedman and Carolyn L. Geczy

J Immunol July 1, 2009, 183 (1) 593-603; DOI: https://doi.org/10.4049/jimmunol.0900373
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Pulmonary Eosinophils and Their Role in Immunopathologic Responses to Formalin-Inactivated Pneumonia Virus of Mice
Caroline M. Percopo, Zhijun Qiu, Simon Phipps, Paul S. Foster, Joseph B. Domachowske and Helene F. Rosenberg

J Immunol July 1, 2009, 183 (1) 604-612; DOI: https://doi.org/10.4049/jimmunol.0802270
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IL-1R Signaling within the Central Nervous System Regulates CXCL12 Expression at the Blood-Brain Barrier and Disease Severity during Experimental Autoimmune Encephalomyelitis
Erin E. McCandless, Matthew Budde, Jason R. Lees, Denise Dorsey, Eric Lyng and Robyn S. Klein

J Immunol July 1, 2009, 183 (1) 613-620; DOI: https://doi.org/10.4049/jimmunol.0802258
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The Presumed Hyporesponsive Behavior of Rheumatoid Arthritis T Lymphocytes Can Be Attributed to Spontaneous Ex Vivo Apoptosis rather than Defects in T Cell Receptor Signaling
Joana R. F. Abreu, Aleksander M. Grabiec, Sarah Krausz, René Spijker, Tomasz Burakowski, Wlodzimierz Maslinski, Eric Eldering, Paul P. Tak and Kris A. Reedquist

J Immunol July 1, 2009, 183 (1) 621-630; DOI: https://doi.org/10.4049/jimmunol.0803278
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Aberrant Tissue Localization of Fungus-Specific CD4⁺ T Cells in IL-10-Deficient Mice
Amariliz Rivera, Nichole Collins, Matthias T. Stephan, Lauren Lipuma, Ingrid Leiner and Eric G. Pamer

J Immunol July 1, 2009, 183 (1) 631-641; DOI: https://doi.org/10.4049/jimmunol.0900396
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T-bet Knockout Prevents Helicobacter felis-Induced Gastric Cancer
Calin Stoicov, Xueli Fan, Jian Hua Liu, Glennice Bowen, Mark Whary, Evelyn Kurt-Jones and JeanMarie Houghton

J Immunol July 1, 2009, 183 (1) 642-649; DOI: https://doi.org/10.4049/jimmunol.0900511
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Fusion Loop Peptide of the West Nile Virus Envelope Protein Is Essential for Pathogenesis and Is Recognized by a Therapeutic Cross-Reactive Human Monoclonal Antibody
Hameeda Sultana, Harald G. Foellmer, Girish Neelakanta, Theodore Oliphant, Michael Engle, Michel Ledizet, Manoj N. Krishnan, Nathalie Bonafé, Karen G. Anthony, Wayne A. Marasco, Paul Kaplan, Ruth R. Montgomery, Michael S. Diamond, Raymond A. Koski and Erol Fikrig

J Immunol July 1, 2009, 183 (1) 650-660; DOI: https://doi.org/10.4049/jimmunol.0900093
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Macrophage Delivery of Nanoformulated Antiretroviral Drug to the Brain in a Murine Model of NeuroAIDS
Huanyu Dou, Cassi B. Grotepas, JoEllyn M. McMillan, Christopher J. Destache, Mahesh Chaubal, Jane Werling, James Kipp, Barrett Rabinow and Howard E. Gendelman

J Immunol July 1, 2009, 183 (1) 661-669; DOI: https://doi.org/10.4049/jimmunol.0900274
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Lack of MyD88 Protects the Immunodeficient Host Against Fatal Lung Inflammation Triggered by the Opportunistic Bacteria Burkholderia cenocepacia
Grasiella M. de C. Ventura, Viviane Balloy, Reuben Ramphal, Huot Khun, Michel Huerre, Bernhard Ryffel, Maria-Cristina M. Plotkowski, Michel Chignard and Mustapha Si-Tahar

J Immunol July 1, 2009, 183 (1) 670-676; DOI: https://doi.org/10.4049/jimmunol.0801497

CLINICAL IMMUNOLOGY

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Evidence for the Specificity for Platelet HPA-1a Alloepitope and the Presenting HLA-DR52a of Diverse Antigen-Specific Helper T Cell Clones from Alloimmunized Mothers
Rachel Rayment, Taco W. Kooij, Wei Zhang, Christian Siebold, Mike F. Murphy, Dave Allen, Nick Willcox and David J. Roberts

J Immunol July 1, 2009, 183 (1) 677-686; DOI: https://doi.org/10.4049/jimmunol.0801473
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Expression of IL-24, an Activator of the JAK1/STAT3/SOCS3 Cascade, Is Enhanced in Inflammatory Bowel Disease
Akira Andoh, Makoto Shioya, Atsushi Nishida, Shigeki Bamba, Tomoyuki Tsujikawa, Shokei Kim-Mitsuyama and Yoshihide Fujiyama

J Immunol July 1, 2009, 183 (1) 687-695; DOI: https://doi.org/10.4049/jimmunol.0804169
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Selective Reduction of Graft-versus-Host Disease-Mediating Human T Cells by Ex Vivo Treatment with Soluble Fas Ligand
Osnat Bohana-Kashtan, Sebastien Morisot, Richard Hildreth, Cory Brayton, Hyam I. Levitsky and Curt I. Civin

J Immunol July 1, 2009, 183 (1) 696-705; DOI: https://doi.org/10.4049/jimmunol.0800561
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Vaccine-Induced, Simian Immunodeficiency Virus-Specific CD8⁺ T Cells Reduce Virus Replication but Do Not Protect from Simian Immunodeficiency Virus Disease Progression
Jessica C. Engram, Richard M. Dunham, George Makedonas, Thomas H. Vanderford, Beth Sumpter, Nichole R. Klatt, Sarah J. Ratcliffe, Seema Garg, Mirko Paiardini, Monica McQuoid, John D. Altman, Silvija I. Staprans, Michael R. Betts, David A. Garber, Mark B. Feinberg and Guido Silvestri

J Immunol July 1, 2009, 183 (1) 706-717; DOI: https://doi.org/10.4049/jimmunol.0803746
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Tuberculosis Is Associated with a Down-Modulatory Lung Immune Response That Impairs Th1-Type Immunity
Alexandre S. Almeida, Patrícia M. Lago, Neio Boechat, Richard C. Huard, Luiz C. O. Lazzarini, Adalberto R. Santos, Marcelo Nociari, Hongxia Zhu, Beatriz M. Perez-Sweeney, Heejung Bang, Quanhong Ni, Jie Huang, Andrea L. Gibson, Vera C. Flores, Lorena R. Pecanha, Afrânio L. Kritski, José R. Lapa e Silva and John L. Ho

J Immunol July 1, 2009, 183 (1) 718-731; DOI: https://doi.org/10.4049/jimmunol.0801212
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A Novel Recombinant Fusion Protein Encoding a 20-Amino Acid Residue of the Third Extracellular (E3) Domain of CCR2 Neutralizes the Biological Activity of CCL2
Liat Izhak, Gizi Wildbaum, Yaniv Zohar, Rachel Anunu, Leah Klapper, Adi Elkeles, Jane Seagal, Eitan Yefenof, Michal Ayalon-Soffer and Nathan Karin

J Immunol July 1, 2009, 183 (1) 732-739; DOI: https://doi.org/10.4049/jimmunol.0802746
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Coexpression of IL-18 Strongly Attenuates IL-12-Induced Systemic Toxicity through a Rapid Induction of IL-10 without Affecting its Antitumor Capacity
Maria Cecilia Rodriguez-Galan, Della Reynolds, Silvia G. Correa, Pablo Iribarren, Morihiro Watanabe and Howard A. Young

J Immunol July 1, 2009, 183 (1) 740-748; DOI: https://doi.org/10.4049/jimmunol.0804166
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Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX
Andrew W. Pawluczkowycz, Frank J. Beurskens, Paul V. Beum, Margaret A. Lindorfer, Jan G. J. van de Winkel, Paul W. H. I. Parren and Ronald P. Taylor

J Immunol July 1, 2009, 183 (1) 749-758; DOI: https://doi.org/10.4049/jimmunol.0900632
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Systemic Reduction of Functionally Suppressive CD4^dimCD25^highFoxp3⁺ Tregs in Human Second Trimester Pregnancy Is Induced by Progesterone and 17β-Estradiol
Jenny Mjösberg, Judit Svensson, Emma Johansson, Lotta Hellström, Rosaura Casas, Maria C. Jenmalm, Roland Boij, Leif Matthiesen, Jan-Ingvar Jönsson, Göran Berg and Jan Ernerudh

J Immunol July 1, 2009, 183 (1) 759-769; DOI: https://doi.org/10.4049/jimmunol.0803654

CORRECTIONS

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The cyclic AMP response element modulator α suppresses CD86 expression and APC function
M. Ahlmann, G. Varga, K. Sturm, R. Lippe, K. Benedyk, D. Viemann, T. Scholzen, J. Ehrchen, F. U. Müller, M. Seidl, M. Matus, G. C. Tsokos, J. Roth and K. Tenbrock

J Immunol July 1, 2009, 183 (1) 770; DOI: https://doi.org/10.4049/jimmunol.0990045

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PILLARS OF IMMUNOLOGY

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

IMMUNOGENETICS

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

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