About the Cover
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On the cover: Integrin αLβ2 mediates leukocyte adhesion and migration on cells expressing the intercellular adhesion molecules (ICAMs). Transition of αLβ2 from a bent conformation (illustrated) to an extended conformation is a hallmark of αLβ2 activation and the opening of the αLβ2 headpiece could fine regulate the binding of αLβ2 to different ICAMs.Tang, X.-Y., Y.-F. Li, and S.-M. Tan. 2008. Intercellular adhesion molecule-3 binding of integrin αLβ2 requires both extension and opening of the integrin headpiece. J. Immunol. 180: 4793–4804.