The Journal of Immunology: 180 (7)

April 1, 2008; Volume 180,Issue 7

IN THIS ISSUE

Open Access
IN THIS ISSUE

The Journal of Immunology April 1, 2008, 180 (7) 4349-4350; DOI: https://doi.org/10.4049/jimmunol.180.7.4349

PILLARS OF IMMUNOLOGY

Open Access
More Than Just Vanilla
Pamela J. Fink

The Journal of Immunology April 1, 2008, 180 (7) 4351-4352; DOI: https://doi.org/10.4049/jimmunol.180.7.4351
Open Access
Pillars Article: Theta Isoantigen as a Marker of Thymus-Derived Lymphocytes in Mice. Nature 1969. 224: 378–379.
Martin C. Raff

The Journal of Immunology April 1, 2008, 180 (7) 4353-4354;

BRIEF REVIEWS

Open Access
Modulation of Dendritic Cell Function by Leishmania Parasites
Lynn Soong

The Journal of Immunology April 1, 2008, 180 (7) 4355-4360; DOI: https://doi.org/10.4049/jimmunol.180.7.4355

CUTTING EDGE

Open Access
Cutting Edge: Langerin⁺ Dendritic Cells in the Mesenteric Lymph Node Set the Stage for Skin and Gut Immune System Cross-Talk
Sun-Young Chang, Hye-Ran Cha, Osamu Igarashi, Paul D. Rennert, Adrien Kissenpfennig, Bernard Malissen, Masanobu Nanno, Hiroshi Kiyono and Mi-Na Kweon

The Journal of Immunology April 1, 2008, 180 (7) 4361-4365; DOI: https://doi.org/10.4049/jimmunol.180.7.4361
Open Access
Cutting Edge: Autoimmune Disease in Day 3 Thymectomized Mice Is Actively Controlled by Endogenous Disease-Specific Regulatory T Cells
Eileen T. Samy, Karen M. Wheeler, Randall J. Roper, Cory Teuscher and Kenneth S. K. Tung

The Journal of Immunology April 1, 2008, 180 (7) 4366-4370; DOI: https://doi.org/10.4049/jimmunol.180.7.4366

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

Open Access
Dendritic Cell Differentiation State and Their Interaction with NKT Cells Determine Th1/Th2 Differentiation in the Murine Model of Leishmania major Infection
Carsten Wiethe, Andrea Debus, Markus Mohrs, Alexander Steinkasserer, Manfred Lutz and André Gessner

The Journal of Immunology April 1, 2008, 180 (7) 4371-4381; DOI: https://doi.org/10.4049/jimmunol.180.7.4371
Open Access
CD40 on APCs Is Needed for Optimal Programming, Maintenance, and Recall of CD8⁺ T Cell Memory Even in the Absence of CD4⁺ T Cell Help
Maria Genevive H. Hernandez, Lianjun Shen and Kenneth L. Rock

The Journal of Immunology April 1, 2008, 180 (7) 4382-4390; DOI: https://doi.org/10.4049/jimmunol.180.7.4382
Open Access
IL-15 Transpresentation Augments CD8⁺ T Cell Activation and Is Required for Optimal Recall Responses by Central Memory CD8⁺ T Cells
Andy I. Kokaji, Deanna L. Hockley and Kevin P. Kane

The Journal of Immunology April 1, 2008, 180 (7) 4391-4401; DOI: https://doi.org/10.4049/jimmunol.180.7.4391
Open Access
AML1/Runx1 Negatively Regulates Quiescent Hematopoietic Stem Cells in Adult Hematopoiesis
Motoshi Ichikawa, Susumu Goyama, Takashi Asai, Masahito Kawazu, Masahiro Nakagawa, Masataka Takeshita, Shigeru Chiba, Seishi Ogawa and Mineo Kurokawa

The Journal of Immunology April 1, 2008, 180 (7) 4402-4408; DOI: https://doi.org/10.4049/jimmunol.180.7.4402
Open Access
Lack of TIM-3 Immunoregulation in Multiple Sclerosis
Li Yang, David E. Anderson, Juhi Kuchroo and David A. Hafler

The Journal of Immunology April 1, 2008, 180 (7) 4409-4414; DOI: https://doi.org/10.4049/jimmunol.180.7.4409
Open Access
Innate-Like Effector Differentiation of Human Invariant NKT Cells Driven by IL-7
Claudia de Lalla, Nicola Festuccia, Inka Albrecht, Hyun-Dong Chang, Grazia Andolfi, Ulrike Benninghoff, Ferdinando Bombelli, Giovanna Borsellino, Alessandro Aiuti, Andreas Radbruch, Paolo Dellabona and Giulia Casorati

The Journal of Immunology April 1, 2008, 180 (7) 4415-4424; DOI: https://doi.org/10.4049/jimmunol.180.7.4415
Open Access
Inhibition of TLR Activation and Up-Regulation of IL-1R-Associated Kinase-M Expression by Exogenous Gangliosides
Weiping Shen, Kelly Stone, Alessandra Jales, David Leitenberg and Stephan Ladisch

The Journal of Immunology April 1, 2008, 180 (7) 4425-4432; DOI: https://doi.org/10.4049/jimmunol.180.7.4425
Open Access
CD4⁺CD25⁺ Regulatory T Cells Specific for a Thymus-Expressed Antigen Prevent the Development of Anaphylaxis to Self
Stefano Scabeni, Marilena Lapilla, Silvia Musio, Barbara Gallo, Emilio Ciusani, Lawrence Steinman, Renato Mantegazza and Rosetta Pedotti

The Journal of Immunology April 1, 2008, 180 (7) 4433-4440; DOI: https://doi.org/10.4049/jimmunol.180.7.4433
Open Access
Gastrointestinal Dendritic Cells Promote Th2 Skewing via OX40L
Ana Belén Blázquez and M. Cecilia Berin

The Journal of Immunology April 1, 2008, 180 (7) 4441-4450; DOI: https://doi.org/10.4049/jimmunol.180.7.4441
Open Access
Loss of IFN-γ Enables the Expansion of Autoreactive CD4⁺ T Cells to Induce Experimental Autoimmune Encephalomyelitis by a Nonencephalitogenic Myelin Variant Antigen
Joseph J. Sabatino Jr., John Shires, John D. Altman, Mandy L. Ford and Brian D. Evavold

The Journal of Immunology April 1, 2008, 180 (7) 4451-4457; DOI: https://doi.org/10.4049/jimmunol.180.7.4451
Open Access
Autoimmunity to Both Proinsulin and IGRP Is Required for Diabetes in Nonobese Diabetic 8.3 TCR Transgenic Mice
Balasubramanian Krishnamurthy, Lina Mariana, Shane A. Gellert, Peter G. Colman, Leonard C. Harrison, Andrew M. Lew, Pere Santamaria, Helen E. Thomas and Thomas W. H. Kay

The Journal of Immunology April 1, 2008, 180 (7) 4458-4464; DOI: https://doi.org/10.4049/jimmunol.180.7.4458
Open Access
Impact of Post-Thymic Cellular Longevity on the Development of Age-Associated CD4⁺ T Cell Defects
Stephen C. Jones, Karen Clise-Dwyer, Gail Huston, John Dibble, Sheri Eaton, Laura Haynes and Susan L. Swain

The Journal of Immunology April 1, 2008, 180 (7) 4465-4475; DOI: https://doi.org/10.4049/jimmunol.180.7.4465
Open Access
Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
Sarah R. Jacobs, Catherine E. Herman, Nancie J. MacIver, Jessica A. Wofford, Heather L. Wieman, Jeremy J. Hammen and Jeffrey C. Rathmell

The Journal of Immunology April 1, 2008, 180 (7) 4476-4486; DOI: https://doi.org/10.4049/jimmunol.180.7.4476
Open Access
De Novo Production of K-α1 Tubulin-Specific Antibodies: Role in Chronic Lung Allograft Rejection
Trudie A. Goers, Sabarinathan Ramachandran, Aviva Aloush, Elbert Trulock, G. Alexander Patterson and Thalachallour Mohanakumar

The Journal of Immunology April 1, 2008, 180 (7) 4487-4494; DOI: https://doi.org/10.4049/jimmunol.180.7.4487
Open Access
In Vivo Regulation of Experimental Autoimmune Encephalomyelitis by NK Cells: Alteration of Primary Adaptive Responses
Robin Winkler-Pickett, Howard A. Young, James M. Cherry, John Diehl, John Wine, Timothy Back, William E. Bere, Anna T. Mason and John R. Ortaldo

The Journal of Immunology April 1, 2008, 180 (7) 4495-4506; DOI: https://doi.org/10.4049/jimmunol.180.7.4495
Open Access
Brief Antigenic Stimulation Generates Effector CD8 T Cells with Low Cytotoxic Activity and High IL-2 Production
David Usharauli and Tirumalai Kamala

The Journal of Immunology April 1, 2008, 180 (7) 4507-4513; DOI: https://doi.org/10.4049/jimmunol.180.7.4507
Open Access
Assessment of Bet v 1-Specific CD4⁺ T Cell Responses in Allergic and Nonallergic Individuals Using MHC Class II Peptide Tetramers
Laurence Van Overtvelt, Erik Wambre, Bernard Maillère, Eric von Hofe, Anne Louise, Anne Marie Balazuc, Barbara Bohle, Didier Ebo, Christophe Leboulaire, Gilles Garcia and Philippe Moingeon

The Journal of Immunology April 1, 2008, 180 (7) 4514-4522; DOI: https://doi.org/10.4049/jimmunol.180.7.4514
Open Access
Selective Roles of MAPKs during the Macrophage Response to IFN-γ
Annabel F. Valledor, Ester Sánchez-Tilló, Luis Arpa, Jin Mo Park, Carme Caelles, Jorge Lloberas and Antonio Celada

The Journal of Immunology April 1, 2008, 180 (7) 4523-4529; DOI: https://doi.org/10.4049/jimmunol.180.7.4523
Open Access
Aberrant Genetic Control of Invariant TCR-Bearing NKT Cell Function in New Zealand Mouse Strains: Possible Involvement in Systemic Lupus Erythematosus Pathogenesis
Kazuyuki Tsukamoto, Mareki Ohtsuji, Wakana Shiroiwa, Qingshun Lin, Kazuhiro Nakamura, Hiromichi Tsurui, Yi Jiang, Katsuko Sudo, Hiroyuki Nishimura, Toshikazu Shirai and Sachiko Hirose

The Journal of Immunology April 1, 2008, 180 (7) 4530-4539; DOI: https://doi.org/10.4049/jimmunol.180.7.4530
Open Access
Inducing Antitumor T Cell Immunity: Comparative Functional Analysis of Interstitial Versus Langerhans Dendritic Cells in a Human Cell Line Model
Saskia J. A. M. Santegoets, Hetty J. Bontkes, Anita G. M. Stam, Farien Bhoelan, Janneke J. Ruizendaal, Alfons J. M. van den Eertwegh, Erik Hooijberg, Rik J. Scheper and Tanja D. de Gruijl

The Journal of Immunology April 1, 2008, 180 (7) 4540-4549; DOI: https://doi.org/10.4049/jimmunol.180.7.4540
Open Access
Human Cytomegalovirus Infection Induces a Rapid and Sustained Change in the Expression of NK Cell Receptors on CD8⁺ T Cells
Amber van Stijn, Ajda T. Rowshani, Sila L. Yong, Frank Baas, Eddy Roosnek, Ineke J. M. ten Berge and René A. W. van Lier

The Journal of Immunology April 1, 2008, 180 (7) 4550-4560; DOI: https://doi.org/10.4049/jimmunol.180.7.4550
Open Access
Dendritic Cell-Dependent Inhibition of B Cell Proliferation Requires CD22
Lorna Santos, Kevin E. Draves, Mark Boton, Prabhjit K. Grewal, Jamey D. Marth and Edward A. Clark

The Journal of Immunology April 1, 2008, 180 (7) 4561-4569; DOI: https://doi.org/10.4049/jimmunol.180.7.4561
Open Access
TRAIL Deficiency Does Not Rescue Impaired CD8⁺ T Cell Memory Generated in the Absence of CD4⁺ T Cell Help
Jilian A. Sacks and Michael J. Bevan

The Journal of Immunology April 1, 2008, 180 (7) 4570-4576; DOI: https://doi.org/10.4049/jimmunol.180.7.4570
Open Access
Immunodominance in the TCR Repertoire of αTCR Peptide-Specific CD4⁺ Treg Population That Controls Experimental Autoimmune Encephalomyelitis
Loui Thomas Madakamutil, Igor Maricic, Eli E. Sercarz and Vipin Kumar

The Journal of Immunology April 1, 2008, 180 (7) 4577-4585; DOI: https://doi.org/10.4049/jimmunol.180.7.4577
Open Access
Activation and Function of the mTORC1 Pathway in Mast Cells
Mi-Sun Kim, Hye Sun Kuehn, Dean D. Metcalfe and Alasdair M. Gilfillan

The Journal of Immunology April 1, 2008, 180 (7) 4586-4595; DOI: https://doi.org/10.4049/jimmunol.180.7.4586
Open Access
Induction of Antitumor Immune Response by Homeostatic Proliferation and CD28 Signaling
Toshihiro Suzuki, Shuhei Ogawa, Kazunari Tanabe, Hideaki Tahara, Ryo Abe and Hidehiro Kishimoto

The Journal of Immunology April 1, 2008, 180 (7) 4596-4605; DOI: https://doi.org/10.4049/jimmunol.180.7.4596
Open Access
Intracellular Retention of the NKG2D Ligand MHC Class I Chain-Related Gene A in Human Melanomas Confers Immune Privilege and Prevents NK Cell-Mediated Cytotoxicity
Mercedes B. Fuertes, María V. Girart, Luciana L. Molinero, Carolina I. Domaica, Lucas E. Rossi, María M. Barrio, José Mordoh, Gabriel A. Rabinovich and Norberto W. Zwirner

The Journal of Immunology April 1, 2008, 180 (7) 4606-4614; DOI: https://doi.org/10.4049/jimmunol.180.7.4606
Open Access
Invariant NKT Cells Promote CD8⁺ Cytotoxic T Cell Responses by Inducing CD70 Expression on Dendritic Cells
Vadim Y. Taraban, Sonya Martin, Kathrine E. Attfield, Martin J. Glennie, Tim Elliott, Dirk Elewaut, Serge Van Calenbergh, Bruno Linclau and Aymen Al-Shamkhani

The Journal of Immunology April 1, 2008, 180 (7) 4615-4620; DOI: https://doi.org/10.4049/jimmunol.180.7.4615
Open Access
NK Cells Contribute to Intracellular Bacterial Infection-Mediated Inhibition of Allergic Responses
Xiaobing Han, Yijun Fan, Shuhe Wang, Lei Jiao, Hongyu Qiu and Xi Yang

The Journal of Immunology April 1, 2008, 180 (7) 4621-4628; DOI: https://doi.org/10.4049/jimmunol.180.7.4621
Open Access
Villous B Cells of the Small Intestine Are Specialized for Invariant NK T Cell Dependence
Peter Velázquez, Bo Wei, Michael McPherson, Lesley Marie A. Mendoza, Sandra L. Nguyen, Olga Turovskaya, Mitchell Kronenberg, Tiffany T. Huang, Matthew Schrage, Lynn N. Lobato, Daisuke Fujiwara, Sarah Brewer, Moshe Arditi, Genhong Cheng, R. Balfour Sartor, Rodney D. Newberry and Jonathan Braun

The Journal of Immunology April 1, 2008, 180 (7) 4629-4638; DOI: https://doi.org/10.4049/jimmunol.180.7.4629
Open Access
Multivectorial Abnormal Cell Migration in the NOD Mouse Thymus
Daniella A. Mendes-da-Cruz, Salete Smaniotto, Alexandre C. Keller, Mireille Dardenne and Wilson Savino

The Journal of Immunology April 1, 2008, 180 (7) 4639-4647; DOI: https://doi.org/10.4049/jimmunol.180.7.4639
Open Access
Mast Cell Migration from the Skin to the Draining Lymph Nodes upon Ultraviolet Irradiation Represents a Key Step in the Induction of Immune Suppression
Scott N. Byrne, Alberto Y. Limón-Flores and Stephen E. Ullrich

The Journal of Immunology April 1, 2008, 180 (7) 4648-4655; DOI: https://doi.org/10.4049/jimmunol.180.7.4648
Open Access
Developmental Control of Integrin Expression Regulates Th2 Effector Homing
Seung-Hyo Lee, Joseph E. Prince, Muhammad Rais, Farrah Kheradmand, Christie M. Ballantyne, Gabriele Weitz-Schmidt, C. Wayne Smith and David B. Corry

The Journal of Immunology April 1, 2008, 180 (7) 4656-4667; DOI: https://doi.org/10.4049/jimmunol.180.7.4656
Open Access
Protein Kinase Cα and ζ Differentially Regulate Death-Inducing Signaling Complex Formation in Cigarette Smoke Extract-Induced Apoptosis
Jeong-Woong Park, Hong Pyo Kim, Seon-Jin Lee, Xue Wang, Yong Wang, Emeka Ifedigbo, Simon C. Watkins, Motoi Ohba, Stefan W. Ryter, Yatin M. Vyas and Augustine M. K. Choi

The Journal of Immunology April 1, 2008, 180 (7) 4668-4678; DOI: https://doi.org/10.4049/jimmunol.180.7.4668
Open Access
Regulatory T Cells Control Dendritic Cell/NK Cell Cross-Talk in Lymph Nodes at the Steady State by Inhibiting CD4⁺ Self-Reactive T Cells
Magali Terme, Nathalie Chaput, Behazine Combadiere, Averil Ma, Toshiaki Ohteki and Laurence Zitvogel

The Journal of Immunology April 1, 2008, 180 (7) 4679-4686; DOI: https://doi.org/10.4049/jimmunol.180.7.4679
Open Access
Renal Cell Carcinoma Tumors Induce T Cell Apoptosis through Receptor-Dependent and Receptor-Independent Pathways
Tanya Das, Gaurisankar Sa, Ewa Paszkiewicz-Kozik, Cynthia Hilston, Luis Molto, Patricia Rayman, Daisuke Kudo, Kaushik Biswas, Ronald M. Bukowski, James H. Finke and Charles S. Tannenbaum

The Journal of Immunology April 1, 2008, 180 (7) 4687-4696; DOI: https://doi.org/10.4049/jimmunol.180.7.4687
Open Access
Hypoxia and Hypoxia-Inducible Factor-1α Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function
Jonathan Jantsch, Dipshikha Chakravortty, Nadine Turza, Alexander T. Prechtel, Björn Buchholz, Roman G. Gerlach, Melanie Volke, Joachim Gläsner, Christina Warnecke, Michael S. Wiesener, Kai-Uwe Eckardt, Alexander Steinkasserer, Michael Hensel and Carsten Willam

The Journal of Immunology April 1, 2008, 180 (7) 4697-4705; DOI: https://doi.org/10.4049/jimmunol.180.7.4697
Open Access
TIM-4 Expressed on APCs Induces T Cell Expansion and Survival
Roselynn Rodriguez-Manzanet, Jennifer Hartt Meyers, Savithri Balasubramanian, Jacqueline Slavik, Nasim Kassam, Valerie Dardalhon, Edward A. Greenfield, Ana C. Anderson, Raymond A. Sobel, David A. Hafler, Terry B. Strom and Vijay K. Kuchroo

The Journal of Immunology April 1, 2008, 180 (7) 4706-4713; DOI: https://doi.org/10.4049/jimmunol.180.7.4706
Open Access
Combined CXCR3/CCR5 Blockade Attenuates Acute and Chronic Rejection
Gabriel T. Schnickel, Sam Bastani, George R. Hsieh, Ali Shefizadeh, Rubina Bhatia, Michael C. Fishbein, John Belperio and Abbas Ardehali

The Journal of Immunology April 1, 2008, 180 (7) 4714-4721; DOI: https://doi.org/10.4049/jimmunol.180.7.4714
Open Access
Langerin Expressing Cells Promote Skin Immune Responses under Defined Conditions
Liangchun Wang, Laura S. Bursch, Adrien Kissenpfennig, Bernard Malissen, Stephen C. Jameson and Kristin A. Hogquist

The Journal of Immunology April 1, 2008, 180 (7) 4722-4727; DOI: https://doi.org/10.4049/jimmunol.180.7.4722
Open Access
B Cell Receptor Basal Signaling Regulates Antigen-Induced Ig Light Chain Rearrangements
Brian R. Schram, Lina E. Tze, Laura B. Ramsey, Jiabin Liu, Lydia Najera, Amanda L. Vegoe, Richard R. Hardy, Keli L. Hippen, Michael A. Farrar and Timothy W. Behrens

The Journal of Immunology April 1, 2008, 180 (7) 4728-4741; DOI: https://doi.org/10.4049/jimmunol.180.7.4728
Open Access
Homeostasis and Effector Function of Lymphopenia-Induced “Memory-Like” T Cells in Constitutively T Cell-Depleted Mice
David Voehringer, Hong-Erh Liang and Richard M. Locksley

The Journal of Immunology April 1, 2008, 180 (7) 4742-4753; DOI: https://doi.org/10.4049/jimmunol.180.7.4742
Open Access
CD4⁺ T Lymphocytes Are Not Necessary for the Acute Rejection of Vascularized Mouse Lung Transplants
Andrew E. Gelman, Mikio Okazaki, Jiaming Lai, Christopher G. Kornfeld, Friederike H. Kreisel, Steven B. Richardson, Seiichiro Sugimoto, Jeremy R. Tietjens, G. Alexander Patterson, Alexander S. Krupnick and Daniel Kreisel

The Journal of Immunology April 1, 2008, 180 (7) 4754-4762; DOI: https://doi.org/10.4049/jimmunol.180.7.4754
Open Access
TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity
Vicky Lampropoulou, Kai Hoehlig, Toralf Roch, Patricia Neves, Elisabeth Calderón Gómez, Claire H. Sweenie, Yi Hao, Antonio A. Freitas, Ulrich Steinhoff, Stephen M. Anderton and Simon Fillatreau

The Journal of Immunology April 1, 2008, 180 (7) 4763-4773; DOI: https://doi.org/10.4049/jimmunol.180.7.4763

MOLECULAR AND STRUCTURAL IMMUNOLOGY

Open Access
Doc2α and Munc13-4 Regulate Ca²⁺-Dependent Secretory Lysosome Exocytosis in Mast Cells
Hironori Higashio, Noriyuki Nishimura, Hiroyoshi Ishizaki, Jun Miyoshi, Satoshi Orita, Ayuko Sakane and Takuya Sasaki

The Journal of Immunology April 1, 2008, 180 (7) 4774-4784; DOI: https://doi.org/10.4049/jimmunol.180.7.4774
Open Access
Isoform-Specific Inhibition of RORα-Mediated Transcriptional Activation by Human FOXP3
Jianguang Du, Chunjian Huang, Baohua Zhou and Steven F. Ziegler

The Journal of Immunology April 1, 2008, 180 (7) 4785-4792; DOI: https://doi.org/10.4049/jimmunol.180.7.4785
Open Access
Intercellular Adhesion Molecule-3 Binding of Integrin α_Lβ₂ Requires Both Extension and Opening of the Integrin Headpiece
Xiao-Yan Tang, Yan-Feng Li and Suet-Mien Tan

The Journal of Immunology April 1, 2008, 180 (7) 4793-4804; DOI: https://doi.org/10.4049/jimmunol.180.7.4793
Open Access
STAT3-Mediated Up-Regulation of BLIMP1 Is Coordinated with BCL6 Down-Regulation to Control Human Plasma Cell Differentiation
Sean A. Diehl, Heike Schmidlin, Maho Nagasawa, Simon D. van Haren, Mark J. Kwakkenbos, Etsuko Yasuda, Tim Beaumont, Ferenc A. Scheeren and Hergen Spits

The Journal of Immunology April 1, 2008, 180 (7) 4805-4815; DOI: https://doi.org/10.4049/jimmunol.180.7.4805
Open Access
Nonhuman Primate IgA: Genetic Heterogeneity and Interactions with CD89
Kenneth A. Rogers, Lakshmi Jayashankar, Franco Scinicariello and Roberta Attanasio

The Journal of Immunology April 1, 2008, 180 (7) 4816-4824; DOI: https://doi.org/10.4049/jimmunol.180.7.4816

HOST DEFENSE

Open Access
Leishmania major-Specific B Cells Are Necessary for Th2 Cell Development and Susceptibility to L. major LV39 in BALB/c Mice
Catherine Ronet, Heike Voigt, Hayo Himmelrich, Marie-Agnès Doucey, Yazmin Hauyon-La Torre, Mélanie Revaz-Breton, Fabienne Tacchini-Cottier, Claude Bron, Jacques Louis and Pascal Launois

The Journal of Immunology April 1, 2008, 180 (7) 4825-4835; DOI: https://doi.org/10.4049/jimmunol.180.7.4825
Open Access
Dendritic Cell Programming by Cytomegalovirus Stunts Naive T Cell Responses via the PD-L1/PD-1 Pathway
Chris A. Benedict, Andrea Loewendorf, Zacarias Garcia, Bruce R. Blazar and Edith M. Janssen

The Journal of Immunology April 1, 2008, 180 (7) 4836-4847; DOI: https://doi.org/10.4049/jimmunol.180.7.4836
Open Access
Age-Related Dysregulation of CD8⁺ T Cell Memory Specific for a Persistent Virus Is Independent of Viral Replication
Anna Lang, James D. Brien, Ilhem Messaoudi and Janko Nikolich-Žugich

The Journal of Immunology April 1, 2008, 180 (7) 4848-4857; DOI: https://doi.org/10.4049/jimmunol.180.7.4848
Open Access
Complement Factor H-Binding Protein, a Putative Virulence Determinant of Borrelia hermsii, Is an Antigenic Target for Protective B1b Lymphocytes
Matthew J. Colombo and Kishore R. Alugupalli

The Journal of Immunology April 1, 2008, 180 (7) 4858-4864; DOI: https://doi.org/10.4049/jimmunol.180.7.4858
Open Access
TLR2-Dependent MyD88 Signaling Contributes to Early Host Defense in Murine Enterococcus faecium Peritonitis
Masja Leendertse, Rob J. L. Willems, Ida A. J. Giebelen, Petra S. van den Pangaart, W. Joost Wiersinga, Alex F. de Vos, Sandrine Florquin, Marc J. M. Bonten and Tom van der Poll

The Journal of Immunology April 1, 2008, 180 (7) 4865-4874; DOI: https://doi.org/10.4049/jimmunol.180.7.4865
Open Access
Blockade of PD-1/B7-H1 Interaction Restores Effector CD8⁺ T Cell Responses in a Hepatitis C Virus Core Murine Model
John R. Lukens, Michael W. Cruise, Matthew G. Lassen and Young S. Hahn

The Journal of Immunology April 1, 2008, 180 (7) 4875-4884; DOI: https://doi.org/10.4049/jimmunol.180.7.4875
Open Access
Mouse Mast Cell Tryptase mMCP-6 Is a Critical Link between Adaptive and Innate Immunity in the Chronic Phase of Trichinella spiralis Infection
Kichul Shin, Gerald F. M. Watts, Hans C. Oettgen, Daniel S. Friend, Alan D. Pemberton, Michael F. Gurish and David M. Lee

The Journal of Immunology April 1, 2008, 180 (7) 4885-4891; DOI: https://doi.org/10.4049/jimmunol.180.7.4885
Open Access
Relative Levels of M-CSF and GM-CSF Influence the Specific Generation of Macrophage Populations during Infection with Mycobacterium tuberculosis
David M. Higgins, Joaquin Sanchez-Campillo, Adrian G. Rosas-Taraco, Jonathan R. Higgins, Eric J. Lee, Ian M. Orme and Mercedes Gonzalez-Juarrero

The Journal of Immunology April 1, 2008, 180 (7) 4892-4900; DOI: https://doi.org/10.4049/jimmunol.180.7.4892
Open Access
Retargeting of Human T Cells to Tumor-Associated MUC1: The Evolution of a Chimeric Antigen Receptor
Scott Wilkie, Gianfranco Picco, Julie Foster, David M. Davies, Sylvain Julien, Lucienne Cooper, Sefina Arif, Stephen J. Mather, Joyce Taylor-Papadimitriou, Joy M. Burchell and John Maher

The Journal of Immunology April 1, 2008, 180 (7) 4901-4909; DOI: https://doi.org/10.4049/jimmunol.180.7.4901
Open Access
MDA5 Participates in the Detection of Paramyxovirus Infection and Is Essential for the Early Activation of Dendritic Cells in Response to Sendai Virus Defective Interfering Particles
Jacob S. Yount, Leonid Gitlin, Thomas M. Moran and Carolina B. López

The Journal of Immunology April 1, 2008, 180 (7) 4910-4918; DOI: https://doi.org/10.4049/jimmunol.180.7.4910
Open Access
CD209⁺ Macrophages Mediate Host Defense against Propionibacterium acnes
Philip T. Liu, Jenny Phan, Dominic Tang, Melissa Kanchanapoomi, Brian Hall, Stephan R. Krutzik and Jenny Kim

The Journal of Immunology April 1, 2008, 180 (7) 4919-4923; DOI: https://doi.org/10.4049/jimmunol.180.7.4919
Open Access
Maturation of Paneth Cells Induces the Refractory State of Newborn Mice to Shigella Infection
Maria-Isabel Fernandez, Béatrice Regnault, Céline Mulet, Myriam Tanguy, Philippe Jay, Philippe J. Sansonetti and Thierry Pédron

The Journal of Immunology April 1, 2008, 180 (7) 4924-4930; DOI: https://doi.org/10.4049/jimmunol.180.7.4924
Open Access
Adenoviral Expression of Suppressor of Cytokine Signaling-1 Reduces Adenovirus Vector-Induced Innate Immune Responses
Haruna Sakurai, Katsuhisa Tashiro, Kenji Kawabata, Tomoko Yamaguchi, Fuminori Sakurai, Shinsaku Nakagawa and Hiroyuki Mizuguchi

The Journal of Immunology April 1, 2008, 180 (7) 4931-4938; DOI: https://doi.org/10.4049/jimmunol.180.7.4931
Open Access
IL-13 Attenuates Gastrointestinal Candidiasis in Normal and Immunodeficient RAG-2^−/− Mice via Peroxisome Proliferator-Activated Receptor-γ Activation
Agnès Coste, Céline Lagane, Cédric Filipe, Hélène Authier, Amandine Galès, José Bernad, Victorine Douin-Echinard, Jean-Claude Lepert, Patricia Balard, Marie-Denise Linas, Jean-François Arnal, Johan Auwerx and Bernard Pipy

The Journal of Immunology April 1, 2008, 180 (7) 4939-4947; DOI: https://doi.org/10.4049/jimmunol.180.7.4939
Open Access
IL-4Rα Expression by Bone Marrow-Derived Cells Is Necessary and Sufficient for Host Protection against Acute Schistosomiasis
De’Broski R. Herbert, Tatyana Orekov, Charles Perkins, Marc E. Rothenberg and Fred D. Finkelman

The Journal of Immunology April 1, 2008, 180 (7) 4948-4955; DOI: https://doi.org/10.4049/jimmunol.180.7.4948
Open Access
Protection against Influenza A Virus by Memory CD8 T Cells Requires Reactivation by Bone Marrow-Derived Dendritic Cells
Paola Castiglioni, De Shon Hall, Erica L. Jacovetty, Elizabeth Ingulli and Maurizio Zanetti

The Journal of Immunology April 1, 2008, 180 (7) 4956-4964; DOI: https://doi.org/10.4049/jimmunol.180.7.4956
Open Access
Differential Initiation of Innate Immune Responses Induced by Human Cytomegalovirus Entry into Fibroblast Cells
Laura K. Juckem, Karl W. Boehme, Adam L. Feire and Teresa Compton

The Journal of Immunology April 1, 2008, 180 (7) 4965-4977; DOI: https://doi.org/10.4049/jimmunol.180.7.4965

INFLAMMATION

Open Access
Apoptotic Cells Protect Mice against Lipopolysaccharide-Induced Shock
Yi Ren, Yi Xie, Guoping Jiang, Jianqing Fan, Joseph Yeung, Wen Li, Paul K. H. Tam and John Savill

The Journal of Immunology April 1, 2008, 180 (7) 4978-4985; DOI: https://doi.org/10.4049/jimmunol.180.7.4978
Open Access
TLR2 Regulates Gap Junction Intercellular Communication in Airway Cells
Francis J. Martin and Alice S. Prince

The Journal of Immunology April 1, 2008, 180 (7) 4986-4993; DOI: https://doi.org/10.4049/jimmunol.180.7.4986
Open Access
Suppression of Proteoglycan-Induced Arthritis by Anti-CD20 B Cell Depletion Therapy Is Mediated by Reduction in Autoantibodies and CD4⁺ T Cell Reactivity
Keith Hamel, Paul Doodes, Yanxia Cao, Yumei Wang, Jeffrey Martinson, Robert Dunn, Marilyn R. Kehry, Balint Farkas and Alison Finnegan

The Journal of Immunology April 1, 2008, 180 (7) 4994-5003; DOI: https://doi.org/10.4049/jimmunol.180.7.4994
Open Access
The Synthetic Peroxisome Proliferator-Activated Receptor-γ Agonist Ciglitazone Attenuates Neuroinflammation and Accelerates Encapsulation in Bacterial Brain Abscesses
Tammy Kielian, Mohsin Md. Syed, Shuliang Liu, Nirmal K. Phulwani, Napoleon Phillips, Gail Wagoner, Paul D. Drew and Nilufer Esen

The Journal of Immunology April 1, 2008, 180 (7) 5004-5016; DOI: https://doi.org/10.4049/jimmunol.180.7.5004
Open Access
Molecular Characterization of Helicobacter pylori VacA Induction of IL-8 in U937 Cells Reveals a Prominent Role for p38MAPK in Activating Transcription Factor-2, cAMP Response Element Binding Protein, and NF-κB Activation
Junzo Hisatsune, Masaaki Nakayama, Hajime Isomoto, Hisao Kurazono, Naofumi Mukaida, Asish K. Mukhopadhyay, Takeshi Azuma, Yoshio Yamaoka, Jan Sap, Eiki Yamasaki, Kinnosuke Yahiro, Joel Moss and Toshiya Hirayama

The Journal of Immunology April 1, 2008, 180 (7) 5017-5027; DOI: https://doi.org/10.4049/jimmunol.180.7.5017
Open Access
Phosphatidylinositol 3-Kinase and Xanthine Oxidase Regulate Nitric Oxide and Reactive Oxygen Species Productions by Apoptotic Lymphocyte Microparticles in Endothelial Cells
H. Ahmed Mostefai, Abdelali Agouni, Nunzia Carusio, M. Letizia Mastronardi, Christophe Heymes, Daniel Henrion, Ramaroson Andriantsitohaina and M. Carmen Martinez

The Journal of Immunology April 1, 2008, 180 (7) 5028-5035; DOI: https://doi.org/10.4049/jimmunol.180.7.5028
Open Access
Macrophages Produce TGF-β-Induced (β-ig-h3) following Ingestion of Apoptotic Cells and Regulate MMP14 Levels and Collagen Turnover in Fibroblasts
Natalia Nacu, Irina G. Luzina, Kendrick Highsmith, Virginia Lockatell, Kerill Pochetuhen, Zachary A. Cooper, Michael P. Gillmeister, Nevins W. Todd and Sergei P. Atamas

The Journal of Immunology April 1, 2008, 180 (7) 5036-5044; DOI: https://doi.org/10.4049/jimmunol.180.7.5036
Open Access
Salmonella Secreted Factor L Deubiquitinase of Salmonella typhimurium Inhibits NF-κB, Suppresses IκBα Ubiquitination and Modulates Innate Immune Responses
Gaëlle Le Negrate, Benjamin Faustin, Kate Welsh, Markus Loeffler, Maryla Krajewska, Patty Hasegawa, Sohini Mukherjee, Kim Orth, Stan Krajewski, Adam Godzik, Donald G. Guiney and John C. Reed

The Journal of Immunology April 1, 2008, 180 (7) 5045-5056; DOI: https://doi.org/10.4049/jimmunol.180.7.5045
Open Access
Complement Receptors 1 and 2 Influence the Immune Environment in a B Cell Receptor-Independent Manner
Amanda C. Jacobson, Janis J. Weis and John H. Weis

The Journal of Immunology April 1, 2008, 180 (7) 5057-5066; DOI: https://doi.org/10.4049/jimmunol.180.7.5057
Open Access
High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-α Production in Human Monocytes
Ju Ho Youn, Young Joo Oh, Eun Sook Kim, Ji Eun Choi and Jeon-Soo Shin

The Journal of Immunology April 1, 2008, 180 (7) 5067-5074; DOI: https://doi.org/10.4049/jimmunol.180.7.5067
Open Access
Macrophage Deletion of p38α Partially Impairs Lipopolysaccharide-Induced Cellular Activation
Young Jun Kang, Jianming Chen, Motoyuki Otsuka, Johann Mols, Shuxun Ren, Yinbin Wang and Jiahuai Han

The Journal of Immunology April 1, 2008, 180 (7) 5075-5082; DOI: https://doi.org/10.4049/jimmunol.180.7.5075
Open Access
Destructive Arthritis in the Absence of Both FcγRI and FcγRIII
Peter Boross, Peter L. van Lent, Javier Martin-Ramirez, Jos van der Kaa, Melissa H. C. M. Mulder, Jill W. C. Claassens, Wim B. van den Berg, Victoria L. Arandhara and J. Sjef Verbeek

The Journal of Immunology April 1, 2008, 180 (7) 5083-5091; DOI: https://doi.org/10.4049/jimmunol.180.7.5083

CLINICAL IMMUNOLOGY

Open Access
Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes
Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund and Annika C. Karlsson

The Journal of Immunology April 1, 2008, 180 (7) 5092-5100; DOI: https://doi.org/10.4049/jimmunol.180.7.5092
Open Access
A Novel Type I IFN-Producing Cell Subset in Murine Lupus
Pui Y. Lee, Jason S. Weinstein, Dina C. Nacionales, Philip O. Scumpia, Yi Li, Edward Butfiloski, Nico van Rooijen, Lyle Moldawer, Minoru Satoh and Westley H. Reeves

The Journal of Immunology April 1, 2008, 180 (7) 5101-5108; DOI: https://doi.org/10.4049/jimmunol.180.7.5101
Open Access
Human CD4⁺ T Cells Recognize an Epitope within α-Fetoprotein Sequence and Develop into TGF-β-Producing CD4⁺ T Cells
Akeel Alisa, Sandra Boswell, Ansar A. Pathan, Lakshmana Ayaru, Roger Williams and Shahriar Behboudi

The Journal of Immunology April 1, 2008, 180 (7) 5109-5117; DOI: https://doi.org/10.4049/jimmunol.180.7.5109
Open Access
IL-2/Anti-IL-2 Antibody Complex Enhances Vaccine-Mediated Antigen-Specific CD8⁺ T Cell Responses and Increases the Ratio of Effector/Memory CD8⁺ T Cells to Regulatory T Cells
Sven Mostböck, M. E. Christine Lutsiak, Diane E. Milenic, Kwamena Baidoo, Jeffrey Schlom and Helen Sabzevari

The Journal of Immunology April 1, 2008, 180 (7) 5118-5129; DOI: https://doi.org/10.4049/jimmunol.180.7.5118
Open Access
CXCL13, CCL21, and CXCL12 Expression in Salivary Glands of Patients with Sjögren’s Syndrome and MALT Lymphoma: Association with Reactive and Malignant Areas of Lymphoid Organization
Francesca Barone, Michele Bombardieri, Manuela Maria Rosado, Peter Roger Morgan, Stephen J. Challacombe, Salvatore De Vita, Rita Carsetti, Jo Spencer, Guido Valesini and Costantino Pitzalis

The Journal of Immunology April 1, 2008, 180 (7) 5130-5140; DOI: https://doi.org/10.4049/jimmunol.180.7.5130
Open Access
The Presence of Activated CD4⁺ T Cells Is Essential for the Formation of Colony-Forming Unit-Endothelial Cells by CD14⁺ Cells
Rachel T. van Beem, Willy A. Noort, Carlijn Voermans, Marion Kleijer, Anja ten Brinke, S. Marieke van Ham, C. Ellen van der Schoot and Jaap Jan Zwaginga

The Journal of Immunology April 1, 2008, 180 (7) 5141-5148; DOI: https://doi.org/10.4049/jimmunol.180.7.5141

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PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

HOST DEFENSE

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