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The Central Memory CD4+ T Cell Population Generated during Leishmania major Infection Requires IL-12 to Produce IFN-γ

Nazzy Pakpour, Colby Zaph and Phillip Scott
J Immunol June 15, 2008, 180 (12) 8299-8305; DOI: https://doi.org/10.4049/jimmunol.180.12.8299
Nazzy Pakpour
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104
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Colby Zaph
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104
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Phillip Scott
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104
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Abstract

Central memory CD4+ T cells provide a pool of lymph node-homing, Ag-experienced cells that are capable of responding rapidly after a secondary infection. We have previously described a population of central memory CD4+ T cells in Leishmania major-infected mice that were capable of mediating immunity to a secondary infection. In this study, we show that the Leishmania-specific central memory CD4+ T cells require IL-12 to produce IFN-γ, demonstrating that this population needs additional signals to develop into Th1 cells. In contrast, effector cells isolated from immune mice produced IFN-γ in vitro or in vivo in the absence of IL-12. In addition, we found that when central memory CD4+ T cells were adoptively transferred into IL-12-deficient hosts, many of the cells became IL-4 producers. These studies indicate that the central memory CD4+ T cell population generated during L. major infection is capable of developing into either Th1 or Th2 effectors. Thus, continued IL-12 production may be required to ensure the development of Th1 cells from this central memory T cell pool, a finding that has direct relevance to the design of vaccines dependent upon central memory CD4+ T cells.

  • Received February 13, 2008.
  • Accepted April 13, 2008.
  • Copyright © 2008 by The American Association of Immunologists
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The Journal of Immunology: 180 (12)
The Journal of Immunology
Vol. 180, Issue 12
15 Jun 2008
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The Central Memory CD4+ T Cell Population Generated during Leishmania major Infection Requires IL-12 to Produce IFN-γ
Nazzy Pakpour, Colby Zaph, Phillip Scott
The Journal of Immunology June 15, 2008, 180 (12) 8299-8305; DOI: 10.4049/jimmunol.180.12.8299

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The Central Memory CD4+ T Cell Population Generated during Leishmania major Infection Requires IL-12 to Produce IFN-γ
Nazzy Pakpour, Colby Zaph, Phillip Scott
The Journal of Immunology June 15, 2008, 180 (12) 8299-8305; DOI: 10.4049/jimmunol.180.12.8299
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