On the cover: In mice deficient for the major lysosomal membrane protein LAMP-2 severe periodontitis develops early in life. Isolated neutrophils from these animals show an accumulation of autophagic vacuoles and a reduced bacterial killing capacity, which underlines the importance of LAMP-2 for maturation of phagosomes and anti-microbial activity in neutrophils needed to prevent periodontal disease. Beertsen, W., M. Willenborg, V. Everts, A. Zirogianni, R. Podschun, B. Schröder, E.-L. Eskelinen, and P. Saftig. 2008. Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice. J. Immunol. 180: 475–482.