Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons

User menu

  • Subscribe
  • Log in

Search

  • Advanced search
The Journal of Immunology
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons
  • Subscribe
  • Log in
The Journal of Immunology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Follow The Journal of Immunology on Twitter
  • Follow The Journal of Immunology on RSS

IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37

A. R. Martineau, K. A. Wilkinson, S. M. Newton, R. A. Floto, A. W. Norman, K. Skolimowska, R. N. Davidson, O. E. Sørensen, B. Kampmann, C. J. Griffiths and R. J. Wilkinson
J Immunol December 15, 2007, 179 (12) 8569-8570; DOI: https://doi.org/10.4049/jimmunol.179.12.8569-c
A. R. Martineau
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. A. Wilkinson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. M. Newton
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. A. Floto
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. W. Norman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. Skolimowska
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. N. Davidson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
O. E. Sørensen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B. Kampmann
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. J. Griffiths
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. J. Wilkinson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Martineau, A. R., K. A. Wilkinson, S. M. Newton, R. A. Floto, A. W. Norman, K. Skolimowska, R. N. Davidson, O. E. Sørensen, B. Kampmann, C. J. Griffiths, and R. J. Wilkinson. 2007. IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J. Immunol. 178: 7190–7198 .

In the Introduction, Materials and Methods, Discussion, Fig. 4D, and the Fig. 4 legend, all but one reference made to IRGC should be to IRGM. The sentence on page 7191, repeated on page 7194, “There has been no investigation of the human homolog of LRG-47 (IRGC) in humans” is incorrect. There are two human homologs; the one under investigation in our publication was in fact IRGM. Materials and Methods correctly describe primers to detect the transcript of IRGM, not IRGC. Furthermore, although the statement on page 7197 “Humans have only one intact p47 GTPase (IRGC) whose expression has been reported from testis but not THP-1 cells” is correct, it has little relevance to our work because we only measured the transcript of IRGM.

The authors wish to clarify that the sole IRG-family (p47) GTPase transcript measured in this work was the product of IRGM. The human IRGM gene product is a 181-aa fragment expressed constitutively in many cell types under the probable control of the long terminal repeat of an endogenous retrovirus (Bekpen, C., J. P. Hunn, C. Rohde, I. Parvanova, L. Guethlein, D. M. Dunn, E. Glowalla, M. Leptin, and J. C. Howard. 2005. The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol. 6: 492). It has been implicated in autophagy and intrinsic resistance to mycobacterial infection in human macrophages (Singh, S. B., A. S. Davis, G. A. Taylor, and V. Deretic. 2006. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313: 1438–1441) and has recently been implicated in a genetic screen as a major susceptibility factor in Crohn’s Disease (Parkes, M., J. C. Barrett, N. J. Prescott, M. Tremelling, C. A. Anderson, S. A. Fisher, R. G. Roberts, E. R. Nimmo, F. R. Cummings, D. Soars et al. 2007. Nat. Genet. 39: 830–832).

The authors apologize for any confusion caused and are grateful to colleagues in the field for bringing the errors to their attention. In particular, the authors wish to acknowledge Dr. Jonathan Howard of the University of Cologne Institute for Genetics (Cologne, Germany) for pointing out these errors and for helpful discussion and advice on preparing the erratum. Overall, the findings with IRGM were modest and do not form a major part of the conclusions, particularly those concerning Cathelicidin LL-37 and its role in resistance to tuberculosis.

  • Copyright © 2007 by The American Association of Immunologists
PreviousNext
Back to top

In this issue

The Journal of Immunology: 179 (12)
The Journal of Immunology
Vol. 179, Issue 12
15 Dec 2007
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Advertising (PDF)
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Immunology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37
(Your Name) has forwarded a page to you from The Journal of Immunology
(Your Name) thought you would like to see this page from the The Journal of Immunology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37
A. R. Martineau, K. A. Wilkinson, S. M. Newton, R. A. Floto, A. W. Norman, K. Skolimowska, R. N. Davidson, O. E. Sørensen, B. Kampmann, C. J. Griffiths, R. J. Wilkinson
The Journal of Immunology December 15, 2007, 179 (12) 8569-8570; DOI: 10.4049/jimmunol.179.12.8569-c

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37
A. R. Martineau, K. A. Wilkinson, S. M. Newton, R. A. Floto, A. W. Norman, K. Skolimowska, R. N. Davidson, O. E. Sørensen, B. Kampmann, C. J. Griffiths, R. J. Wilkinson
The Journal of Immunology December 15, 2007, 179 (12) 8569-8570; DOI: 10.4049/jimmunol.179.12.8569-c
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Correction: Myeloid-Specific Deficiency of Long-Chain Acyl CoA Synthetase 4 Reduces Inflammation by Remodeling Phospholipids and Reducing Production of Arachidonic Acid–Derived Proinflammatory Lipid Mediators
  • Correction: African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1
  • Correction: Loss of Invariant Chain Protects Nonobese Diabetic Mice against Type 1 Diabetes
Show more CORRECTIONS

Similar Articles

Navigate

  • Home
  • Current Issue
  • Next in The JI
  • Archive
  • Brief Reviews
  • Pillars of Immunology
  • Translating Immunology

For Authors

  • Submit a Manuscript
  • Instructions for Authors
  • About the Journal
  • Journal Policies
  • Editors

General Information

  • Advertisers
  • Subscribers
  • Rights and Permissions
  • Accessibility Statement
  • FAR 889
  • Privacy Policy
  • Disclaimer

Journal Services

  • Email Alerts
  • RSS Feeds
  • ImmunoCasts
  • Twitter

Copyright © 2022 by The American Association of Immunologists, Inc.

Print ISSN 0022-1767        Online ISSN 1550-6606