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Fullerene Nanomaterials Inhibit the Allergic Response

John J. Ryan, Henry R. Bateman, Alex Stover, Greg Gomez, Sarah K. Norton, Wei Zhao, Lawrence B. Schwartz, Robert Lenk and Christopher L. Kepley
J Immunol July 1, 2007, 179 (1) 665-672; DOI: https://doi.org/10.4049/jimmunol.179.1.665
John J. Ryan
*Department of Biology, [s]
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Henry R. Bateman
‡Department of Internal Medicine, Virginia Commonwealth University Health Systems, Richmond, VA 23294; and
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Alex Stover
‡Department of Internal Medicine, Virginia Commonwealth University Health Systems, Richmond, VA 23294; and
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Greg Gomez
‡Department of Internal Medicine, Virginia Commonwealth University Health Systems, Richmond, VA 23294; and
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Sarah K. Norton
*Department of Biology, [s]
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Wei Zhao
†Department of Pediatrics, and [s]
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Lawrence B. Schwartz
‡Department of Internal Medicine, Virginia Commonwealth University Health Systems, Richmond, VA 23294; and
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Robert Lenk
§Luna Innovations, Danville, VA 24541
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Christopher L. Kepley
‡Department of Internal Medicine, Virginia Commonwealth University Health Systems, Richmond, VA 23294; and
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Abstract

Fullerenes are a class of novel carbon allotropes that may have practical applications in biotechnology and medicine. Human mast cells (MC) and peripheral blood basophils are critical cells involved in the initiation and propagation of several inflammatory conditions, mainly type I hypersensitivity. We report an unanticipated role of fullerenes as a negative regulator of allergic mediator release that suppresses Ag-driven type I hypersensitivity. Human MC and peripheral blood basophils exhibited a significant inhibition of IgE dependent mediator release when preincubated with C60 fullerenes. Protein microarray demonstrated that inhibition of mediator release involves profound reductions in the activation of signaling molecules involved in mediator release and oxidative stress. Follow-up studies demonstrated that the tyrosine phosphorylation of Syk was dramatically inhibited in Ag-challenged cells first incubated with fullerenes. In addition, fullerene preincubation significantly inhibited IgE-induced elevation in cytoplasmic reactive oxygen species levels. Furthermore, fullerenes prevented the in vivo release of histamine and drop in core body temperature in vivo using a MC-dependent model of anaphylaxis. These findings identify a new biological function for fullerenes and may represent a novel way to control MC-dependent diseases including asthma, inflammatory arthritis, heart disease, and multiple sclerosis.

  • Received January 26, 2007.
  • Accepted April 15, 2007.
  • Copyright © 2007 by The American Association of Immunologists
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The Journal of Immunology: 179 (1)
The Journal of Immunology
Vol. 179, Issue 1
1 Jul 2007
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Fullerene Nanomaterials Inhibit the Allergic Response
John J. Ryan, Henry R. Bateman, Alex Stover, Greg Gomez, Sarah K. Norton, Wei Zhao, Lawrence B. Schwartz, Robert Lenk, Christopher L. Kepley
The Journal of Immunology July 1, 2007, 179 (1) 665-672; DOI: 10.4049/jimmunol.179.1.665

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Fullerene Nanomaterials Inhibit the Allergic Response
John J. Ryan, Henry R. Bateman, Alex Stover, Greg Gomez, Sarah K. Norton, Wei Zhao, Lawrence B. Schwartz, Robert Lenk, Christopher L. Kepley
The Journal of Immunology July 1, 2007, 179 (1) 665-672; DOI: 10.4049/jimmunol.179.1.665
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