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On the cover: The purinergic P2X7 receptor localizes to the cell membrane of adjacent HEK 293 cells stably expressing the rat P2X7 coupled to GFP. The intensity of GFP-P2X7 fluorescence is shown on a rainbow scale going from blue (low level) to yellow and red (high level). 2006. Lemaire, I., S. Falzoni, N. Leduc, B. Zhang, P. Pellegatti, E. Adinolfi, P. Chiozzi, and F. Di Virgilio. Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells. J. Immunol. 177: 7257–7265.