On the cover: The purinergic P2X₇ receptor localizes to the cell membrane of adjacent HEK 293 cells stably expressing the rat P2X₇ coupled to GFP. The intensity of GFP-P2X₇ fluorescence is shown on a rainbow scale going from blue (low level) to yellow and red (high level). 2006. Lemaire, I., S. Falzoni, N. Leduc, B. Zhang, P. Pellegatti, E. Adinolfi, P. Chiozzi, and F. Di Virgilio. Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells. J. Immunol. 177: 7257–7265.