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Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma

Steven A. Rosenberg, Richard M. Sherry, Kathleen E. Morton, William J. Scharfman, James C. Yang, Suzanne L. Topalian, Richard E. Royal, Udai Kammula, Nicholas P. Restifo, Marybeth S. Hughes, Douglas Schwartzentruber, David M. Berman, Susan L. Schwarz, Lien T. Ngo, Sharon A. Mavroukakis, Donald E. White and Seth M. Steinberg
J Immunol November 1, 2005, 175 (9) 6169-6176; DOI: https://doi.org/10.4049/jimmunol.175.9.6169
Steven A. Rosenberg
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Richard M. Sherry
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Kathleen E. Morton
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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William J. Scharfman
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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James C. Yang
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Suzanne L. Topalian
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Richard E. Royal
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Udai Kammula
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Nicholas P. Restifo
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Marybeth S. Hughes
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Douglas Schwartzentruber
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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David M. Berman
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Susan L. Schwarz
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Lien T. Ngo
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Sharon A. Mavroukakis
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Donald E. White
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Seth M. Steinberg
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
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Article Information

vol. 175 no. 9 6169-6176
DOI 
https://doi.org/10.4049/jimmunol.175.9.6169
PubMed 
16237114

Published By 
The American Association of Immunologists, Inc.
Print ISSN 
0022-1767
Online ISSN 
1550-6606
History 
  • Received June 7, 2005
  • Accepted August 9, 2005
  • Published online October 19, 2005.

Copyright & Usage 
Copyright © 2005 by The American Association of Immunologists

Author Information

  1. Steven A. Rosenberg1,
  2. Richard M. Sherry,
  3. Kathleen E. Morton,
  4. William J. Scharfman2,
  5. James C. Yang,
  6. Suzanne L. Topalian,
  7. Richard E. Royal,
  8. Udai Kammula,
  9. Nicholas P. Restifo,
  10. Marybeth S. Hughes,
  11. Douglas Schwartzentruber,
  12. David M. Berman3,
  13. Susan L. Schwarz,
  14. Lien T. Ngo,
  15. Sharon A. Mavroukakis,
  16. Donald E. White and
  17. Seth M. Steinberg4
  1. Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
View Full Text

Article usage

Article usage: October 2005 to January 2021

AbstractFullPdf
Oct 2005190178279
Nov 200598294254
Dec 200532145137
Total 2005320617670
Jan 200623100107
Feb 2006248076
Mar 2006229473
Apr 20065176102
May 2006197559
Jun 2006124645
Jul 2006115535
Aug 200683124
Sep 2006242634
Oct 2006103747
Nov 2006155036
Dec 200625721
Total 2006221727659
Jan 200752827
Feb 200782733
Mar 200743625
Apr 200764022
May 2007152922
Jun 200762623
Jul 200783526
Aug 2007122323
Sep 2007133529
Oct 200793734
Nov 2007143338
Dec 2007143029
Total 2007114379331
Jan 2008112523
Feb 2008123220
Mar 2008212020
Apr 2008303334
May 2008253417
Jun 2008102410
Jul 2008372114
Aug 200816913
Sep 2008251015
Oct 2008171619
Nov 2008122221
Dec 20084813
Total 2008220254219
Jan 200992520
Feb 2009121613
Mar 2009131625
Apr 2009101821
May 200971113
Jun 2009111111
Jul 200931017
Aug 20098108
Sep 2009102725
Oct 2009242220
Nov 20091496
Dec 2009211014
Total 2009142185193
Jan 201091615
Feb 201016814
Mar 20101186
Apr 201012209
May 2010112415
Jun 2010101412
Jul 2010221313
Aug 2010261919
Sep 2010141011
Oct 201051623
Nov 2010182631
Dec 201015824
Total 2010169182192
Jan 201141917
Feb 2011111113
Mar 2011141214
Apr 2011181729
May 201192022
Jun 2011131211
Jul 201191012
Aug 2011112125
Sep 201171115
Oct 201162521
Nov 201118916
Dec 2011111425
Total 2011131181220
Jan 2012101819
Feb 2012111012
Mar 201282115
Apr 2012102118
May 201291314
Jun 20121275
Jul 20125149
Aug 201251313
Sep 201281813
Oct 20127810
Nov 20125127
Dec 20127118
Total 201297166143
Jan 201381612
Feb 2013121114
Mar 2013151618
Apr 2013162125
May 2013111418
Jun 201351919
Jul 201353218
Aug 201383118
Sep 2013132211
Oct 201391819
Nov 201312912
Dec 201314715
Total 2013128216199
Jan 20141774
Feb 2014122814
Mar 2014141511
Apr 201412107
May 2014131615
Jun 201412116
Jul 201447613
Aug 201471212
Sep 201491030
Oct 2014151530
Nov 2014111517
Dec 201472028
Total 2014176165187
Jan 2015222222
Feb 20156910
Mar 201510810
Apr 2015211723
May 2015122128
Jun 2015101612
Jul 2015133138
Aug 201512836
Sep 2015611818
Oct 2015421214
Nov 2015122118
Dec 2015171215
Total 2015238195244
Jan 2016131627
Feb 201671623
Mar 2016192115
Apr 2016252620
May 2016331723
Jun 2016171811
Jul 20161169
Aug 2016141417
Sep 2016131314
Oct 20161697
Nov 201624107
Dec 201616108
Total 2016208176181
Jan 2017123119
Feb 201762613
Mar 20173219
Apr 201731522
May 20174207
Jun 201761717
Jul 2017162419
Aug 201741611
Sep 20177189
Oct 201781711
Nov 201733114
Dec 201752311
Total 201777259162
Jan 201873417
Feb 20186269
Mar 201883914
Apr 201875817
May 20182377
Jun 201832212
Jul 201842512
Aug 201883010
Sep 20180239
Oct 2018145124
Nov 201825516
Dec 201874014
Total 201868440161
Jan 201933416
Feb 201953416
Mar 201943324
Apr 201963328
May 201924134
Jun 201932717
Jul 201933525
Aug 201963927
Sep 201924514
Oct 201928834
Nov 201962313
Dec 201912618
Total 201943458266
Jan 202023211
Feb 20200278
Mar 202033518
Apr 202022922
May 202032713
Jun 202022417
Jul 20203155
Aug 202063810
Sep 202032712
Oct 20206229
Nov 202042113
Dec 2020103114
Total 202044328152
Jan 202163119
Total 202163119
Total240249594198

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The Journal of Immunology: 175 (9)
The Journal of Immunology
Vol. 175, Issue 9
1 Nov 2005
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Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma
Steven A. Rosenberg, Richard M. Sherry, Kathleen E. Morton, William J. Scharfman, James C. Yang, Suzanne L. Topalian, Richard E. Royal, Udai Kammula, Nicholas P. Restifo, Marybeth S. Hughes, Douglas Schwartzentruber, David M. Berman, Susan L. Schwarz, Lien T. Ngo, Sharon A. Mavroukakis, Donald E. White, Seth M. Steinberg
The Journal of Immunology November 1, 2005, 175 (9) 6169-6176; DOI: 10.4049/jimmunol.175.9.6169

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Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma
Steven A. Rosenberg, Richard M. Sherry, Kathleen E. Morton, William J. Scharfman, James C. Yang, Suzanne L. Topalian, Richard E. Royal, Udai Kammula, Nicholas P. Restifo, Marybeth S. Hughes, Douglas Schwartzentruber, David M. Berman, Susan L. Schwarz, Lien T. Ngo, Sharon A. Mavroukakis, Donald E. White, Seth M. Steinberg
The Journal of Immunology November 1, 2005, 175 (9) 6169-6176; DOI: 10.4049/jimmunol.175.9.6169
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