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Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein

Shawn M. Sumida, Diana M. Truitt, Angelique A. C. Lemckert, Ronald Vogels, Jerome H. H. V. Custers, Marylyn M. Addo, Shahin Lockman, Trevor Peter, Fred W. Peyerl, Michael G. Kishko, Shawn S. Jackson, Darci A. Gorgone, Michelle A. Lifton, Myron Essex, Bruce D. Walker, Jaap Goudsmit, Menzo J. E. Havenga and Dan H. Barouch
J Immunol June 1, 2005, 174 (11) 7179-7185; DOI: https://doi.org/10.4049/jimmunol.174.11.7179
Shawn M. Sumida
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Diana M. Truitt
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Angelique A. C. Lemckert
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Ronald Vogels
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Jerome H. H. V. Custers
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Marylyn M. Addo
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Shahin Lockman
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Trevor Peter
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Fred W. Peyerl
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Michael G. Kishko
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Shawn S. Jackson
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Darci A. Gorgone
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Michelle A. Lifton
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Myron Essex
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Bruce D. Walker
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Jaap Goudsmit
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Menzo J. E. Havenga
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Dan H. Barouch
*Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Article Information

vol. 174 no. 11 7179-7185
DOI 
https://doi.org/10.4049/jimmunol.174.11.7179
PubMed 
15905562

Published By 
The American Association of Immunologists, Inc.
Print ISSN 
0022-1767
Online ISSN 
1550-6606
History 
  • Received November 19, 2004
  • Accepted March 21, 2005
  • Published online May 19, 2005.

Copyright & Usage 
Copyright © 2005 by The American Association of Immunologists

Author Information

  1. Shawn M. Sumida*,
  2. Diana M. Truitt*,
  3. Angelique A. C. Lemckert†,
  4. Ronald Vogels†,
  5. Jerome H. H. V. Custers†,
  6. Marylyn M. Addo‡,
  7. Shahin Lockman§,
  8. Trevor Peter§,
  9. Fred W. Peyerl*,
  10. Michael G. Kishko*,
  11. Shawn S. Jackson*,
  12. Darci A. Gorgone*,
  13. Michelle A. Lifton*,
  14. Myron Essex§,
  15. Bruce D. Walker‡,
  16. Jaap Goudsmit†,
  17. Menzo J. E. Havenga† and
  18. Dan H. Barouch2,*
  1. *Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; †Crucell, Leiden, The Netherlands; ‡Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; and §Harvard School of Public Health, Boston, MA 02115
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Article usage

Article usage: May 2005 to July 2022

AbstractFullPdf
May 2005389079
Jun 20052512056
Jul 2005137335
Aug 2005126730
Sep 200544620
Oct 200544621
Nov 200563132
Dec 2005133318
Total 2005115506291
Jan 200612159
Feb 2006111812
Mar 200682213
Apr 200661613
May 2006122323
Jun 200644341
Jul 200663120
Aug 200693625
Sep 200633034
Oct 200652117
Nov 2006103721
Dec 200622520
Total 200688317248
Jan 200752621
Feb 200743323
Mar 200742926
Apr 200753328
May 200731813
Jun 200752825
Jul 200793431
Aug 200762013
Sep 2007112617
Oct 200762218
Nov 200752122
Dec 2007121817
Total 200775308254
Jan 200882116
Feb 2008133219
Mar 2008192424
Apr 2008194830
May 2008102723
Jun 2008192618
Jul 2008152110
Aug 2008201619
Sep 2008231216
Oct 200871612
Nov 2008122018
Dec 200891014
Total 2008174273219
Jan 200993315
Feb 2009132113
Mar 2009152012
Apr 2009213018
May 2009173614
Jun 2009113023
Jul 2009132121
Aug 200991513
Sep 2009331715
Oct 2009141113
Nov 2009121517
Dec 200934133
Total 2009201262177
Jan 201091610
Feb 201082110
Mar 2010111613
Apr 2010192621
May 2010341617
Jun 2010112817
Jul 2010213223
Aug 2010152910
Sep 201015218
Oct 2010193223
Nov 201010119
Dec 20108158
Total 2010180263169
Jan 201142812
Feb 20118219518
Mar 20111459416
Apr 2011133715
May 2011103121
Jun 201162115
Jul 2011101115
Aug 2011113430
Sep 2011152014
Oct 2011142118
Nov 2011101513
Dec 201191411
Total 20111243021198
Jan 2012143123
Feb 2012133220
Mar 2012122426
Apr 2012151315
May 2012111723
Jun 201282324
Jul 2012142212
Aug 20128129
Sep 2012111513
Oct 20121496
Nov 2012171515
Dec 20126164
Total 2012143229190
Jan 2013161213
Feb 2013161815
Mar 2013203217
Apr 2013111715
May 201319119
Jun 2013798
Jul 201381410
Aug 201391312
Sep 201392612
Oct 20138138
Nov 2013141610
Dec 201314168
Total 2013151197137
Jan 2014141212
Feb 2014132211
Mar 201491211
Apr 20141197
May 201410197
Jun 2014171613
Jul 2014232913
Aug 201412512
Sep 2014161923
Oct 2014131320
Nov 2014111164
Dec 201481540
Total 2014157182233
Jan 2015161829
Feb 2015191543
Mar 2015181930
Apr 2015251331
May 201531214
Jun 2015101226
Jul 20159818
Aug 201561217
Sep 2015171222
Oct 201581133
Nov 20153721
Dec 2015151119
Total 2015149150303
Jan 201681827
Feb 201671119
Mar 2016182035
Apr 2016191959
May 2016191023
Jun 201681016
Jul 20164814
Aug 201651120
Sep 20164310
Oct 2016232223
Nov 2016151116
Dec 20163514
Total 2016133148276
Jan 2017458
Feb 2017689
Mar 201772220
Apr 201724016
May 201792936
Jun 2017295
Jul 20177123
Aug 20174108
Sep 2017299
Oct 201791011
Nov 20175166
Dec 201731211
Total 201760182142
Jan 201851810
Feb 201831713
Mar 20184135
Apr 201863419
May 201863013
Jun 201862412
Jul 201842418
Aug 20181204
Sep 201843422
Oct 201832313
Nov 201832416
Dec 20182184
Total 201847279149
Jan 201922720
Feb 201972123
Mar 201942419
Apr 201982224
May 201972921
Jun 201942212
Jul 201993023
Aug 201933121
Sep 201922417
Oct 201942312
Nov 20194128
Dec 201932318
Total 201957288218
Jan 202053016
Feb 202072424
Mar 202053365
Apr 202052936
May 202034136
Jun 2020103438
Jul 202092738
Aug 2020144259
Sep 202052910
Oct 202093620
Nov 202032920
Dec 202072612
Total 202082380374
Jan 2021138127
Feb 20211119140
Mar 202187145
Apr 202164623
May 202134312
Jun 202153320
Jul 202142516
Aug 202142314
Sep 202173931
Oct 202153737
Nov 2021135033
Dec 202173011
Total 202186669309
Jan 202243119
Feb 202282821
Mar 202295123
Apr 202285740
May 2022105626
Jun 202252621
Jul 202281514
Total 202252264164
Total207479184051

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The Journal of Immunology: 174 (11)
The Journal of Immunology
Vol. 174, Issue 11
1 Jun 2005
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Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein
Shawn M. Sumida, Diana M. Truitt, Angelique A. C. Lemckert, Ronald Vogels, Jerome H. H. V. Custers, Marylyn M. Addo, Shahin Lockman, Trevor Peter, Fred W. Peyerl, Michael G. Kishko, Shawn S. Jackson, Darci A. Gorgone, Michelle A. Lifton, Myron Essex, Bruce D. Walker, Jaap Goudsmit, Menzo J. E. Havenga, Dan H. Barouch
The Journal of Immunology June 1, 2005, 174 (11) 7179-7185; DOI: 10.4049/jimmunol.174.11.7179

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Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein
Shawn M. Sumida, Diana M. Truitt, Angelique A. C. Lemckert, Ronald Vogels, Jerome H. H. V. Custers, Marylyn M. Addo, Shahin Lockman, Trevor Peter, Fred W. Peyerl, Michael G. Kishko, Shawn S. Jackson, Darci A. Gorgone, Michelle A. Lifton, Myron Essex, Bruce D. Walker, Jaap Goudsmit, Menzo J. E. Havenga, Dan H. Barouch
The Journal of Immunology June 1, 2005, 174 (11) 7179-7185; DOI: 10.4049/jimmunol.174.11.7179
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