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Visualizing the Site and Dynamics of IgG Salvage by the MHC Class I-Related Receptor, FcRn

Raimund J. Ober, Cruz Martinez, Carlos Vaccaro, Jinchun Zhou and E. Sally Ward
J Immunol February 15, 2004, 172 (4) 2021-2029; DOI: https://doi.org/10.4049/jimmunol.172.4.2021
Raimund J. Ober
*Cancer Immunobiology Center and
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Cruz Martinez
†Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390
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Carlos Vaccaro
†Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390
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Jinchun Zhou
†Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390
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E. Sally Ward
*Cancer Immunobiology Center and
†Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390
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Abstract

The MHC class I-related receptor, FcRn, plays a central role in regulating the serum levels of IgG. FcRn is expressed in endothelial cells, suggesting that these cells may be involved in maintaining IgG levels. We have used live cell imaging of FcRn-green fluorescent protein transfected human endothelial cells to analyze the intracellular events that control IgG homeostasis. We show that segregation of FcRn-IgG complexes from unbound IgG occurs in the sorting endosome. FcRn or FcRn-IgG complexes are gradually depleted from sorting endosomes to ultimately generate multivesicular bodies whose contents are destined for lysosomal degradation. In addition, the pathways taken by FcRn and the transferrin receptor overlap, despite distinct mechanisms of ligand uptake. The studies provide a dynamic view of the trafficking of FcRn and its ligand and have relevance to understanding how FcRn functions to maintain IgG homeostasis.

  • Received September 4, 2003.
  • Accepted November 24, 2003.
  • Copyright © 2004 by The American Association of Immunologists
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The Journal of Immunology: 172 (4)
The Journal of Immunology
Vol. 172, Issue 4
15 Feb 2004
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Visualizing the Site and Dynamics of IgG Salvage by the MHC Class I-Related Receptor, FcRn
Raimund J. Ober, Cruz Martinez, Carlos Vaccaro, Jinchun Zhou, E. Sally Ward
The Journal of Immunology February 15, 2004, 172 (4) 2021-2029; DOI: 10.4049/jimmunol.172.4.2021

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Visualizing the Site and Dynamics of IgG Salvage by the MHC Class I-Related Receptor, FcRn
Raimund J. Ober, Cruz Martinez, Carlos Vaccaro, Jinchun Zhou, E. Sally Ward
The Journal of Immunology February 15, 2004, 172 (4) 2021-2029; DOI: 10.4049/jimmunol.172.4.2021
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