Heat-Killed Brucella abortus Induces TNF and IL-12p40 by Distinct MyD88-Dependent Pathways: TNF, Unlike IL-12p40 Secretion, Is Toll-Like Receptor 2 Dependent

Li-Yun Huang; Julio Aliberti; Cynthia A. Leifer; David M. Segal; Alan Sher; Douglas T. Golenbock; Basil Golding

doi:10.4049/jimmunol.171.3.1441

Heat-Killed Brucella abortus Induces TNF and IL-12p40 by Distinct MyD88-Dependent Pathways: TNF, Unlike IL-12p40 Secretion, Is Toll-Like Receptor 2 Dependent

Li-Yun Huang, Julio Aliberti, Cynthia A. Leifer, David M. Segal, Alan Sher, Douglas T. Golenbock and Basil Golding

J Immunol August 1, 2003, 171 (3) 1441-1446; DOI: https://doi.org/10.4049/jimmunol.171.3.1441

Li-Yun Huang

*Laboratory of Plasma Derivatives, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892;

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Julio Aliberti

†Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and

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Cynthia A. Leifer

‡Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and

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David M. Segal

‡Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and

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Alan Sher

†Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and

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Douglas T. Golenbock

§Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605

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Basil Golding

*Laboratory of Plasma Derivatives, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892;

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The Journal of Immunology

Vol. 171, Issue 3

1 Aug 2003

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Heat-Killed Brucella abortus Induces TNF and IL-12p40 by Distinct MyD88-Dependent Pathways: TNF, Unlike IL-12p40 Secretion, Is Toll-Like Receptor 2 Dependent

Li-Yun Huang, Julio Aliberti, Cynthia A. Leifer, David M. Segal, Alan Sher, Douglas T. Golenbock, Basil Golding

The Journal of Immunology August 1, 2003, 171 (3) 1441-1446; DOI: 10.4049/jimmunol.171.3.1441

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Heat-Killed Brucella abortus Induces TNF and IL-12p40 by Distinct MyD88-Dependent Pathways: TNF, Unlike IL-12p40 Secretion, Is Toll-Like Receptor 2 Dependent