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Cutting Edge: γδ T Cells Provide Help to B Cells with Altered Clonotypes and Are Capable of Inducing Ig Gene Hypermutation

Biao Zheng, Ekaterina Marinova, Jin Han, Tse-Hua Tan and Shuhua Han
J Immunol November 15, 2003, 171 (10) 4979-4983; DOI: https://doi.org/10.4049/jimmunol.171.10.4979
Biao Zheng
Department of Immunology, Baylor College of Medicine, Houston, TX 77030
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Ekaterina Marinova
Department of Immunology, Baylor College of Medicine, Houston, TX 77030
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Jin Han
Department of Immunology, Baylor College of Medicine, Houston, TX 77030
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Tse-Hua Tan
Department of Immunology, Baylor College of Medicine, Houston, TX 77030
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Shuhua Han
Department of Immunology, Baylor College of Medicine, Houston, TX 77030
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Abstract

It has not been resolved whether γδ T cells can collaborate with germinal center B cells and support Ig hypermutation during an Ab response to a truly defined T-dependent Ag. In this study, we show that in the absence of αβ T cells, immunization with the well-defined T-dependent Ag, (4-hydroxy-3-nitrophenyl) acetyl (NP) conjugate, was able to induce Ig hypermutation. However, the clonotypes of B cells responding to NP were dramatically altered in TCR β−/− mice. Unlike B cells in wild-type mice that use canonical VDJ rearrangements, most NP-responding B cells in mutant mice use analog genes of the J558 gene family. In addition, the majority of anti-NP Abs produced in mutant mice use κL chain instead of λ1L chain, which dominates in mice of Ighb background. Thus, the B cell population that collaborates with γδ T cells is distinct from B cells interacting with conventional αβ Th cells.

  • Received June 16, 2003.
  • Accepted September 9, 2003.
  • Copyright © 2003 by The American Association of Immunologists
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The Journal of Immunology: 171 (10)
The Journal of Immunology
Vol. 171, Issue 10
15 Nov 2003
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Cutting Edge: γδ T Cells Provide Help to B Cells with Altered Clonotypes and Are Capable of Inducing Ig Gene Hypermutation
Biao Zheng, Ekaterina Marinova, Jin Han, Tse-Hua Tan, Shuhua Han
The Journal of Immunology November 15, 2003, 171 (10) 4979-4983; DOI: 10.4049/jimmunol.171.10.4979

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Cutting Edge: γδ T Cells Provide Help to B Cells with Altered Clonotypes and Are Capable of Inducing Ig Gene Hypermutation
Biao Zheng, Ekaterina Marinova, Jin Han, Tse-Hua Tan, Shuhua Han
The Journal of Immunology November 15, 2003, 171 (10) 4979-4983; DOI: 10.4049/jimmunol.171.10.4979
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Print ISSN 0022-1767        Online ISSN 1550-6606