Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

^*Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, and
^†Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115; and
^‡Wyeth Research, Cambridge, MA 02140

View Full Text

Article usage

Article usage: January 2003 to April 2021

	Abstract	Full	Pdf
Jan 2003	258	162	419
Feb 2003	89	269	277
Mar 2003	30	176	177
Apr 2003	12	151	128
May 2003	14	151	126
Jun 2003	10	118	74
Jul 2003	20	124	102
Aug 2003	16	99	65
Sep 2003	20	72	74
Oct 2003	19	89	55
Nov 2003	19	62	56
Dec 2003	24	95	73
Total 2003	531	1568	1626
Jan 2004	27	68	52
Feb 2004	17	55	58
Mar 2004	22	66	54
Apr 2004	23	58	64
May 2004	16	89	63
Jun 2004	18	82	73
Jul 2004	15	73	54
Aug 2004	21	67	50
Sep 2004	12	55	35
Oct 2004	17	71	65
Nov 2004	13	56	57
Dec 2004	15	56	73
Total 2004	216	796	698
Jan 2005	12	67	54
Feb 2005	14	85	59
Mar 2005	28	88	64
Apr 2005	8	60	54
May 2005	7	83	57
Jun 2005	12	57	35
Jul 2005	1	70	42
Aug 2005	12	68	38
Sep 2005	9	49	40
Oct 2005	9	65	48
Nov 2005	10	63	48
Dec 2005	8	65	45
Total 2005	130	820	584
Jan 2006	5	75	48
Feb 2006	10	74	42
Mar 2006	12	92	58
Apr 2006	16	73	72
May 2006	18	91	77
Jun 2006	12	57	54
Jul 2006	5	67	41
Aug 2006	13	87	55
Sep 2006	23	96	83
Oct 2006	9	119	96
Nov 2006	11	104	92
Dec 2006	6	63	44
Total 2006	140	998	762
Jan 2007	8	74	73
Feb 2007	17	96	75
Mar 2007	17	93	85
Apr 2007	16	82	75
May 2007	15	76	76
Jun 2007	19	69	60
Jul 2007	15	86	59
Aug 2007	10	74	51
Sep 2007	17	82	68
Oct 2007	16	102	76
Nov 2007	15	73	56
Dec 2007	18	53	57
Total 2007	183	960	811
Jan 2008	11	56	54
Feb 2008	23	52	52
Mar 2008	31	77	74
Apr 2008	23	60	92
May 2008	23	106	88
Jun 2008	18	70	52
Jul 2008	45	70	48
Aug 2008	41	45	39
Sep 2008	104	51	53
Oct 2008	169	52	54
Nov 2008	35	61	44
Dec 2008	13	64	54
Total 2008	536	764	704
Jan 2009	27	52	51
Feb 2009	15	72	59
Mar 2009	42	50	46
Apr 2009	35	66	53
May 2009	16	55	50
Jun 2009	9	45	42
Jul 2009	16	56	57
Aug 2009	17	47	33
Sep 2009	31	47	43
Oct 2009	77	37	42
Nov 2009	38	70	75
Dec 2009	19	40	42
Total 2009	342	637	593
Jan 2010	9	50	41
Feb 2010	16	66	44
Mar 2010	29	64	68
Apr 2010	15	31	39
May 2010	15	55	40
Jun 2010	14	40	23
Jul 2010	17	54	49
Aug 2010	32	43	48
Sep 2010	15	59	49
Oct 2010	13	43	48
Nov 2010	21	47	51
Dec 2010	19	38	26
Total 2010	215	590	526
Jan 2011	17	44	46
Feb 2011	17	55	51
Mar 2011	19	63	50
Apr 2011	13	49	28
May 2011	19	64	36
Jun 2011	31	61	48
Jul 2011	19	53	46
Aug 2011	17	43	42
Sep 2011	19	48	29
Oct 2011	27	63	35
Nov 2011	35	75	58
Dec 2011	27	39	36
Total 2011	260	657	505
Jan 2012	35	47	38
Feb 2012	30	67	49
Mar 2012	29	74	62
Apr 2012	31	72	50
May 2012	42	67	54
Jun 2012	36	70	37
Jul 2012	26	68	52
Aug 2012	24	67	41
Sep 2012	30	59	61
Oct 2012	27	61	37
Nov 2012	33	91	78
Dec 2012	28	48	54
Total 2012	371	791	613
Jan 2013	28	85	63
Feb 2013	34	59	44
Mar 2013	53	73	57
Apr 2013	29	77	77
May 2013	30	73	58
Jun 2013	36	56	59
Jul 2013	43	100	51
Aug 2013	31	88	91
Sep 2013	37	93	60
Oct 2013	39	68	68
Nov 2013	37	81	64
Dec 2013	30	78	47
Total 2013	427	931	739
Jan 2014	43	119	73
Feb 2014	50	126	76
Mar 2014	29	103	64
Apr 2014	37	72	51
May 2014	41	93	62
Jun 2014	53	93	74
Jul 2014	70	117	84
Aug 2014	48	118	131
Sep 2014	41	91	77
Oct 2014	69	149	118
Nov 2014	37	168	104
Dec 2014	41	131	91
Total 2014	559	1380	1005
Jan 2015	59	110	75
Feb 2015	57	104	86
Mar 2015	46	146	83
Apr 2015	42	128	93
May 2015	44	175	120
Jun 2015	31	122	101
Jul 2015	47	132	90
Aug 2015	39	124	103
Sep 2015	83	124	111
Oct 2015	63	135	86
Nov 2015	49	143	102
Dec 2015	49	124	89
Total 2015	609	1567	1139
Jan 2016	59	146	125
Feb 2016	68	102	124
Mar 2016	67	176	94
Apr 2016	97	168	109
May 2016	52	166	113
Jun 2016	68	155	139
Jul 2016	41	103	95
Aug 2016	41	158	129
Sep 2016	39	122	131
Oct 2016	60	108	120
Nov 2016	62	129	139
Dec 2016	47	95	132
Total 2016	701	1628	1450
Jan 2017	24	185	144
Feb 2017	11	165	126
Mar 2017	23	182	124
Apr 2017	15	140	74
May 2017	27	179	112
Jun 2017	35	162	142
Jul 2017	18	140	81
Aug 2017	18	153	96
Sep 2017	17	151	95
Oct 2017	12	152	106
Nov 2017	15	182	87
Dec 2017	15	154	92
Total 2017	230	1945	1279
Jan 2018	23	183	122
Feb 2018	21	141	92
Mar 2018	11	175	107
Apr 2018	19	145	76
May 2018	24	177	104
Jun 2018	19	118	67
Jul 2018	15	181	89
Aug 2018	10	107	69
Sep 2018	18	153	74
Oct 2018	22	271	103
Nov 2018	13	209	86
Dec 2018	20	205	82
Total 2018	215	2065	1071
Jan 2019	13	167	71
Feb 2019	11	182	67
Mar 2019	24	183	77
Apr 2019	18	184	78
May 2019	27	169	102
Jun 2019	15	157	65
Jul 2019	17	149	64
Aug 2019	17	583	75
Sep 2019	15	405	72
Oct 2019	21	543	65
Nov 2019	8	167	57
Dec 2019	13	116	58
Total 2019	199	3005	851
Jan 2020	12	139	64
Feb 2020	14	234	64
Mar 2020	19	200	56
Apr 2020	20	110	73
May 2020	15	119	56
Jun 2020	3	103	55
Jul 2020	9	102	34
Aug 2020	11	93	60
Sep 2020	25	118	64
Oct 2020	13	137	87
Nov 2020	23	101	80
Dec 2020	14	111	76
Total 2020	178	1567	769
Jan 2021	23	108	57
Feb 2021	10	97	64
Mar 2021	20	164	76
Apr 2021	17	353	71
Total 2021	70	722	268
Total	6112	23391	15993