On the Cover: Tie2-tmTNF-transgenic mice are protected from Con A-induced DNA damage in the liver. Confocal laser imaging of double-immunofluorescent TUNEL (green)- and PECAM-1 (red)-stained liver sections of Con A-treated (20 mg/kg) wild-type mice (B) and tie2-tmTNF-transgenic mice (C). A, DNase I treatment (positive control). Arrows point to TUNEL-positive endothelial cells (yellow). Quantification of TUNEL-positive endothelial cells revealed (±SD): wild-type, untreated, 1.8 ± 1.2 cells/mm²; wild-type, 8 h Con A, 17.1 ± 8.2 cells/mm²; tie2-tmTNF, untreated, 1.0 ± 1.0 cells/mm²; and tie2-tmTNF, 8 h Con A, 8.2 ± 4.1 cells/mm². (Figure 6 from Willuweit, A., G. Sass, A. Schöneberg, U. Eisel, G. Tiegs, and M. Clauss. Chronic Inflammation and Protection from Acute Hepatitis in Transgenic Mice Expressing TNF in Endothelial Cells. 3944)