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About the Cover

February 15, 2002; Volume 168,Issue 4

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On the Cover: MBP-specific transduced CD4+ T cells traffic to the CNS. Splenocytes from MBP TCR-Tg mice were transduced with the GFP-luciferase retroviral vector. CD4+ cells were isolated by MACS and analyzed by FACS for GFP expression. Cell suspensions with 1 X 106 GFP+ cells were transferred i.v. to PL/J recipients. Recipients were anesthetized, and luciferin substrate was administered. Pseudocolor images range from least (blue) to most (red) luciferase photon intensity, and organs demostrating luciferase-positive cells are labeled as follows: LG, lung; CLN, cervical lymph node; ALN, axillary lymph node; BLN, branchial lymph node; ILN, inguinal lymph node; SPL, spleen; MLN, mesenteric lymph node; PLN, periaortic lymph node; IMM, sites of MBP/CFA immunization; and SC, spinal cord. A, A total of 1 X 106 CD4+ cells transduced to express GFP- luciferase were transferred to naive or MBP-immunized mice 11 days after EAE induction but before EAE clinical signs. Data are representative of three experiments (n = 2-3/group). B, A total of 1 X 106 CD4+ cells transduced to express GFP-luciferase were transferred to naive (n = 2) or MBP-immunized (n = 6) mice during EAE clinical signs (26 days after EAE induction, clinical score = 2). (Figure 4 from Costa, G. L., M. R. Sandora, A. Nakajima, E. V. Nguyen, C. Taylor-Edwards, A. J. Slavin, C. H. Contag, C. G. Fathman, and J. M. Benson. Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit. 2379)

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This Issue

The Journal of Immunology: 168 (4)
The Journal of Immunology
Vol. 168, Issue 4
15 Feb 2002
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  • CUTTING EDGE
  • CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
  • MOLECULAR AND STRUCTURAL IMMUNOLOGY
  • HOST DEFENSE
  • INFLAMMATION
  • CLINICAL IMMUNOLOGY
  • ERRATA
  • Highlights
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Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
Natural and Induced Tolerogenic Dendritic Cells
Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

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Print ISSN 0022-1767        Online ISSN 1550-6606