Chemokines Regulate IL-6 and IL-8 Production by Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis

^*Department of Bioregulatory Medicine and Rheumatology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan;
^†Department of Orthopedic Surgery, Osaka University Medical School, Osaka, Japan; and
^‡Inflammation Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamonouchi Pharmaceutical Co., Ltd., Ibaraki, Japan

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Article usage

Article usage: October 2001 to July 2022

	Abstract	Full	Pdf
Oct 2001	108	109	173
Nov 2001	38	149	131
Dec 2001	7	57	52
Total 2001	153	315	356
Jan 2002	11	77	50
Feb 2002	2	74	50
Mar 2002	2	102	57
Apr 2002	4	63	28
May 2002	4	71	56
Jun 2002	3	32	23
Jul 2002	1	69	37
Aug 2002	2	49	31
Sep 2002	5	53	29
Oct 2002	1	40	35
Nov 2002	1	47	39
Dec 2002	1	14	9
Total 2002	37	691	444
Jan 2003	1	45	37
Feb 2003	1	30	40
Mar 2003	1	25	22
Apr 2003	0	35	25
May 2003	3	36	34
Jun 2003	2	31	22
Jul 2003	9	47	40
Aug 2003	6	37	23
Sep 2003	8	43	26
Oct 2003	11	31	28
Nov 2003	5	40	31
Dec 2003	11	47	38
Total 2003	58	447	366
Jan 2004	8	35	29
Feb 2004	5	31	16
Mar 2004	8	40	26
Apr 2004	5	48	41
May 2004	7	44	36
Jun 2004	7	38	18
Jul 2004	6	25	7
Aug 2004	19	41	36
Sep 2004	10	47	17
Oct 2004	5	35	26
Nov 2004	7	52	28
Dec 2004	7	36	17
Total 2004	94	472	297
Jan 2005	3	29	19
Feb 2005	4	20	22
Mar 2005	8	47	24
Apr 2005	5	34	27
May 2005	3	33	20
Jun 2005	3	37	24
Jul 2005	3	29	13
Aug 2005	5	30	25
Sep 2005	0	32	20
Oct 2005	4	25	17
Nov 2005	4	34	17
Dec 2005	7	29	16
Total 2005	49	379	244
Jan 2006	3	29	15
Feb 2006	3	27	21
Mar 2006	6	33	16
Apr 2006	6	25	18
May 2006	2	29	16
Jun 2006	6	40	23
Jul 2006	7	20	14
Aug 2006	5	9	10
Sep 2006	6	22	12
Oct 2006	3	35	19
Nov 2006	10	26	12
Dec 2006	3	9	10
Total 2006	60	304	186
Jan 2007	7	26	24
Feb 2007	6	12	15
Mar 2007	6	19	18
Apr 2007	8	24	15
May 2007	6	13	15
Jun 2007	10	24	13
Jul 2007	9	21	9
Aug 2007	4	15	10
Sep 2007	6	18	12
Oct 2007	3	17	14
Nov 2007	3	22	24
Dec 2007	4	8	9
Total 2007	72	219	178
Jan 2008	5	15	13
Feb 2008	5	33	23
Mar 2008	33	21	17
Apr 2008	11	22	17
May 2008	15	13	9
Jun 2008	16	19	20
Jul 2008	14	16	12
Aug 2008	33	19	21
Sep 2008	28	23	15
Oct 2008	47	22	16
Nov 2008	14	14	12
Dec 2008	6	14	10
Total 2008	227	231	185
Jan 2009	3	20	19
Feb 2009	8	15	12
Mar 2009	27	14	38
Apr 2009	12	10	16
May 2009	13	14	13
Jun 2009	5	15	16
Jul 2009	8	6	16
Aug 2009	4	8	10
Sep 2009	22	16	17
Oct 2009	31	15	17
Nov 2009	18	13	15
Dec 2009	6	12	18
Total 2009	157	158	207
Jan 2010	4	22	12
Feb 2010	4	11	5
Mar 2010	15	18	13
Apr 2010	3	12	10
May 2010	9	16	10
Jun 2010	5	23	23
Jul 2010	8	29	21
Aug 2010	4	15	9
Sep 2010	9	14	14
Oct 2010	8	27	16
Nov 2010	9	34	16
Dec 2010	4	10	7
Total 2010	82	231	156
Jan 2011	6	14	13
Feb 2011	8	21	8
Mar 2011	7	19	19
Apr 2011	9	26	12
May 2011	9	16	14
Jun 2011	13	16	19
Jul 2011	8	14	7
Aug 2011	12	9	7
Sep 2011	9	14	10
Oct 2011	17	24	12
Nov 2011	15	11	5
Dec 2011	12	9	8
Total 2011	125	193	134
Jan 2012	12	11	8
Feb 2012	17	20	11
Mar 2012	19	18	9
Apr 2012	22	12	18
May 2012	9	24	8
Jun 2012	14	24	4
Jul 2012	13	22	13
Aug 2012	9	20	19
Sep 2012	8	18	54
Oct 2012	13	17	9
Nov 2012	13	17	16
Dec 2012	9	22	14
Total 2012	158	225	183
Jan 2013	9	23	14
Feb 2013	17	13	11
Mar 2013	16	17	16
Apr 2013	12	25	16
May 2013	14	15	10
Jun 2013	6	9	10
Jul 2013	12	11	5
Aug 2013	7	7	10
Sep 2013	8	10	5
Oct 2013	14	5	6
Nov 2013	10	11	7
Dec 2013	11	11	3
Total 2013	136	157	113
Jan 2014	15	12	4
Feb 2014	6	9	6
Mar 2014	24	11	6
Apr 2014	10	14	9
May 2014	20	14	16
Jun 2014	22	11	8
Jul 2014	10	16	8
Aug 2014	7	9	6
Sep 2014	5	5	8
Oct 2014	8	26	19
Nov 2014	7	14	29
Dec 2014	12	5	5
Total 2014	146	146	124
Jan 2015	5	8	11
Feb 2015	13	9	10
Mar 2015	20	2	9
Apr 2015	5	8	8
May 2015	6	13	10
Jun 2015	5	17	10
Jul 2015	6	9	13
Aug 2015	3	9	9
Sep 2015	25	10	9
Oct 2015	3	9	7
Nov 2015	6	10	12
Dec 2015	46	8	13
Total 2015	143	112	121
Jan 2016	11	12	8
Feb 2016	16	13	14
Mar 2016	14	8	17
Apr 2016	16	6	13
May 2016	14	15	17
Jun 2016	11	8	8
Jul 2016	7	9	10
Aug 2016	10	13	22
Sep 2016	11	5	9
Oct 2016	16	13	17
Nov 2016	12	8	9
Dec 2016	7	7	15
Total 2016	145	117	159
Jan 2017	7	3	11
Feb 2017	7	28	17
Mar 2017	13	28	10
Apr 2017	5	10	4
May 2017	6	9	13
Jun 2017	12	11	19
Jul 2017	7	19	13
Aug 2017	6	8	9
Sep 2017	8	19	6
Oct 2017	4	20	4
Nov 2017	5	12	16
Dec 2017	3	13	6
Total 2017	83	180	128
Jan 2018	4	10	6
Feb 2018	2	10	2
Mar 2018	9	19	7
Apr 2018	4	21	6
May 2018	5	43	11
Jun 2018	5	30	11
Jul 2018	3	16	6
Aug 2018	5	24	17
Sep 2018	7	38	19
Oct 2018	3	75	16
Nov 2018	4	69	11
Dec 2018	2	50	2
Total 2018	53	405	114
Jan 2019	4	51	15
Feb 2019	3	35	8
Mar 2019	3	30	8
Apr 2019	5	33	13
May 2019	4	20	9
Jun 2019	6	20	8
Jul 2019	2	20	7
Aug 2019	6	27	11
Sep 2019	5	25	11
Oct 2019	10	43	16
Nov 2019	3	23	9
Dec 2019	5	30	9
Total 2019	56	357	124
Jan 2020	3	38	6
Feb 2020	1	19	15
Mar 2020	3	32	6
Apr 2020	4	29	13
May 2020	2	21	12
Jun 2020	5	16	18
Jul 2020	3	23	11
Aug 2020	1	18	3
Sep 2020	11	34	24
Oct 2020	3	24	5
Nov 2020	14	27	11
Dec 2020	4	19	3
Total 2020	54	300	127
Jan 2021	9	27	15
Feb 2021	3	11	5
Mar 2021	3	28	16
Apr 2021	4	22	13
May 2021	3	15	6
Jun 2021	2	23	10
Jul 2021	4	10	10
Aug 2021	4	19	15
Sep 2021	7	38	12
Oct 2021	5	27	22
Nov 2021	7	15	21
Dec 2021	2	25	16
Total 2021	53	260	161
Jan 2022	7	14	9
Feb 2022	5	19	4
Mar 2022	7	29	15
Apr 2022	1	35	11
May 2022	1	18	12
Jun 2022	6	11	7
Jul 2022	1	11	5
Total 2022	28	137	63
Total	2169	6036	4170